ENSG00000149262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000529807 ENSG00000149262 HEK293_OSMI2_6hA HEK293_TMG_6hB INTS4 protein_coding protein_coding 14.65037 11.28435 18.38665 2.79437 0.3368603 0.7038422 0.9352726 0.3056721 1.824575 0.08060861 0.2845442 2.5389474 0.05977500 0.02906667 0.09876667 0.06970000 0.03937551 0.03937551 FALSE  
ENST00000533180 ENSG00000149262 HEK293_OSMI2_6hA HEK293_TMG_6hB INTS4 protein_coding retained_intron 14.65037 11.28435 18.38665 2.79437 0.3368603 0.7038422 1.0633562 1.7296399 2.446321 1.20389845 0.2232668 0.4977104 0.07038333 0.13473333 0.13273333 -0.00200000 0.94009437 0.03937551 FALSE  
ENST00000534064 ENSG00000149262 HEK293_OSMI2_6hA HEK293_TMG_6hB INTS4 protein_coding protein_coding 14.65037 11.28435 18.38665 2.79437 0.3368603 0.7038422 10.1684406 7.7245348 11.085321 1.98479561 0.2402565 0.5205650 0.69515000 0.67903333 0.60296667 -0.07606667 0.76396037 0.03937551 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000149262 E001 1.8078290 0.0656231501 2.260315e-01 0.4606260582 11 77874306 77874417 112 - 0.331 0.552 1.170
ENSG00000149262 E002 1.8443459 0.0108647759 1.917271e-01 0.4190288989 11 77874418 77874490 73 - 0.329 0.553 1.185
ENSG00000149262 E003 0.9989696 0.0153787590 2.631502e-01   11 77874491 77874493 3 - 0.195 0.393 1.378
ENSG00000149262 E004 8.7881249 0.2758429573 4.718674e-01 0.6814226479 11 77874494 77876542 2049 - 0.871 1.094 0.830
ENSG00000149262 E005 2.3791052 0.0126325696 5.553806e-01 0.7400267401 11 77876543 77877030 488 - 0.550 0.454 -0.471
ENSG00000149262 E006 0.7733225 0.0298937496 1.083068e-01   11 77877760 77878417 658 - 0.108 0.392 2.370
ENSG00000149262 E007 0.1779838 0.0330975867 6.195465e-01   11 77878418 77878719 302 - 0.108 0.000 -11.775
ENSG00000149262 E008 0.1614157 0.0330617324 6.193095e-01   11 77878720 77878721 2 - 0.108 0.000 -11.773
ENSG00000149262 E009 6.3888385 0.3290748854 4.463754e-01 0.6630003673 11 77878722 77878748 27 - 0.779 0.963 0.707
ENSG00000149262 E010 8.2409913 0.3043288634 2.250919e-01 0.4595236501 11 77878749 77878759 11 - 0.798 1.113 1.182
ENSG00000149262 E011 11.6857731 0.0753141035 1.801422e-01 0.4041840358 11 77878760 77878782 23 - 0.987 1.219 0.838
ENSG00000149262 E012 24.6782968 0.0249037832 1.149606e-01 0.3074141086 11 77878783 77878844 62 - 1.329 1.498 0.582
ENSG00000149262 E013 108.9939310 0.0019365586 1.023350e-05 0.0002140251 11 77878845 77879125 281 - 1.953 2.127 0.583
ENSG00000149262 E014 41.4949253 0.0015283212 3.302470e-03 0.0252128800 11 77879126 77879127 2 - 1.543 1.711 0.570
ENSG00000149262 E015 84.1176725 0.0034091832 1.097472e-03 0.0106543187 11 77883832 77883952 121 - 1.852 2.005 0.517
ENSG00000149262 E016 0.9419927 0.0235408135 1.029077e-01   11 77890964 77891318 355 - 0.108 0.394 2.385
ENSG00000149262 E017 105.9139233 0.0005512901 1.642523e-04 0.0022681593 11 77891319 77891462 144 - 1.958 2.093 0.454
ENSG00000149262 E018 90.4924529 0.0004878716 2.539613e-02 0.1134273237 11 77891681 77891809 129 - 1.915 2.003 0.295
ENSG00000149262 E019 43.3369657 0.0008514962 1.161362e-01 0.3093885357 11 77891810 77891840 31 - 1.597 1.685 0.302
ENSG00000149262 E020 46.7101100 0.0010776967 9.132733e-01 0.9587309422 11 77894290 77894349 60 - 1.665 1.676 0.035
ENSG00000149262 E021 0.0000000       11 77894350 77894726 377 -      
ENSG00000149262 E022 0.1723744 0.0412793605 3.803620e-01   11 77894727 77895008 282 - 0.000 0.136 12.494
ENSG00000149262 E023 0.7198573 0.4092328872 6.255926e-02   11 77895009 77895515 507 - 0.000 0.403 14.551
ENSG00000149262 E024 0.6412370 0.0222574021 6.632270e-02   11 77901357 77901420 64 - 0.329 0.000 -13.773
ENSG00000149262 E025 103.0311164 0.0005033081 4.959229e-01 0.6981548161 11 77901421 77901551 131 - 1.994 2.023 0.098
ENSG00000149262 E026 86.8938074 0.0005398675 6.926401e-01 0.8307934114 11 77903540 77903620 81 - 1.926 1.946 0.067
ENSG00000149262 E027 86.6841771 0.0005533630 1.034074e-01 0.2879234462 11 77907717 77907810 94 - 1.903 1.970 0.226
ENSG00000149262 E028 4.5038868 0.1478858592 2.641722e-01 0.5034169892 11 77910970 77911152 183 - 0.836 0.593 -1.006
ENSG00000149262 E029 0.1614157 0.0330617324 6.193095e-01   11 77917910 77918030 121 - 0.108 0.000 -11.773
ENSG00000149262 E030 0.3228314 0.4357749860 3.984830e-01   11 77918031 77918059 29 - 0.196 0.000 -12.779
ENSG00000149262 E031 1.2812224 0.5888135391 9.493763e-01   11 77918060 77918264 205 - 0.327 0.425 0.561
ENSG00000149262 E032 95.0866956 0.0008475651 5.177946e-02 0.1839424318 11 77918821 77918978 158 - 1.937 2.016 0.264
ENSG00000149262 E033 80.6036739 0.0023750301 9.908375e-01 0.9971617753 11 77921340 77921473 134 - 1.901 1.906 0.018
ENSG00000149262 E034 0.6294705 0.0217681645 4.449916e-01   11 77922281 77922355 75 - 0.267 0.136 -1.211
ENSG00000149262 E035 46.6726812 0.0010939220 9.793227e-01 0.9914366650 11 77922356 77922471 116 - 1.666 1.672 0.021
ENSG00000149262 E036 15.0224178 0.0240385610 2.706890e-01 0.5106080598 11 77922472 77923367 896 - 1.250 1.120 -0.462
ENSG00000149262 E037 2.6481662 0.0149245020 9.851543e-01 0.9943528179 11 77924434 77924441 8 - 0.550 0.554 0.021
ENSG00000149262 E038 6.2539541 0.0051561024 1.085584e-01 0.2966803632 11 77924442 77924582 141 - 0.936 0.734 -0.791
ENSG00000149262 E039 7.9440570 0.0036464207 2.516336e-02 0.1127078068 11 77924583 77924667 85 - 1.049 0.788 -0.986
ENSG00000149262 E040 6.5412647 0.0227737885 9.713625e-02 0.2767594320 11 77924668 77924705 38 - 0.964 0.733 -0.896
ENSG00000149262 E041 5.6548595 0.0257550919 1.093289e-01 0.2979987981 11 77924706 77924749 44 - 0.907 0.671 -0.941
ENSG00000149262 E042 13.3390521 0.0106815073 2.786842e-01 0.5187826786 11 77924750 77924779 30 - 1.196 1.093 -0.371
ENSG00000149262 E043 31.5742287 0.0022067876 1.166518e-01 0.3102463329 11 77924780 77924892 113 - 1.544 1.445 -0.337
ENSG00000149262 E044 63.6362344 0.0007917692 8.685646e-01 0.9351269603 11 77928342 77928545 204 - 1.803 1.801 -0.008
ENSG00000149262 E045 25.0816679 0.0014483302 7.968365e-01 0.8944899964 11 77928546 77928547 2 - 1.399 1.421 0.076
ENSG00000149262 E046 80.2286308 0.0006075274 2.945078e-01 0.5350599471 11 77938651 77938825 175 - 1.920 1.883 -0.124
ENSG00000149262 E047 60.9100925 0.0055236069 2.584199e-02 0.1147877309 11 77941180 77941251 72 - 1.835 1.713 -0.412
ENSG00000149262 E048 72.5153714 0.0048285401 7.404449e-02 0.2328473743 11 77955942 77956062 121 - 1.895 1.809 -0.292
ENSG00000149262 E049 53.8671260 0.0008030680 4.182399e-03 0.0301749673 11 77958746 77958834 89 - 1.788 1.651 -0.463
ENSG00000149262 E050 46.8264133 0.0008885373 2.251389e-02 0.1042729335 11 77960341 77960391 51 - 1.718 1.602 -0.395
ENSG00000149262 E051 84.8718449 0.0005646773 9.376851e-05 0.0014164783 11 77960953 77961138 186 - 1.991 1.841 -0.502
ENSG00000149262 E052 0.1308682 0.0326491905 3.827235e-01   11 77977586 77977888 303 - 0.000 0.136 12.489
ENSG00000149262 E053 2.0940260 0.0736916702 4.313138e-01 0.6521801181 11 77977889 77978928 1040 - 0.431 0.588 0.758
ENSG00000149262 E054 0.5657866 0.0225186430 8.099337e-01   11 77978929 77978995 67 - 0.195 0.239 0.373
ENSG00000149262 E055 63.8678575 0.0006074752 1.163467e-04 0.0016955590 11 77978996 77979100 105 - 1.875 1.704 -0.575
ENSG00000149262 E056 32.0418294 0.0029289961 1.760712e-03 0.0154383075 11 77979101 77979102 2 - 1.594 1.390 -0.700
ENSG00000149262 E057 0.9327130 0.0181006844 7.635059e-01   11 77979103 77979472 370 - 0.267 0.322 0.373
ENSG00000149262 E058 60.3844979 0.0005905807 5.849994e-04 0.0064481311 11 77981459 77981576 118 - 1.844 1.689 -0.525
ENSG00000149262 E059 0.1723744 0.0412793605 3.803620e-01   11 77984711 77984860 150 - 0.000 0.136 12.494
ENSG00000149262 E060 4.9546541 0.0057832444 9.641175e-01 0.9839356674 11 77987016 77987528 513 - 0.764 0.762 -0.008
ENSG00000149262 E061 4.1983093 0.0067674390 2.307758e-01 0.4660496207 11 77987529 77987603 75 - 0.614 0.789 0.727
ENSG00000149262 E062 4.2525097 0.0067707533 3.144577e-01 0.5546834027 11 77987604 77987698 95 - 0.643 0.789 0.601
ENSG00000149262 E063 81.6368799 0.0005723729 3.822916e-03 0.0281571320 11 77991108 77991299 192 - 1.955 1.844 -0.375
ENSG00000149262 E064 1.1267014 0.0881441823 9.474813e-01   11 77992574 77992629 56 - 0.330 0.322 -0.052
ENSG00000149262 E065 42.7258930 0.0008767228 6.091668e-02 0.2048541548 11 77994590 77994715 126 - 1.679 1.581 -0.331