ENSG00000149231

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423339 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding protein_coding 6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.18393216 0.00000000 0.6382495 0.00000000 0.05901212 6.018477 0.02550417 0.00000000 0.05573333 0.05573333 0.0065043874 0.0001521861 FALSE TRUE
ENST00000538597 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding protein_coding 6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.68996900 0.00000000 1.7017050 0.00000000 0.43106941 7.419290 0.06087083 0.00000000 0.14740000 0.14740000 0.0001521861 0.0001521861 FALSE FALSE
ENST00000646818 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding protein_coding 6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 1.93029716 0.88348632 2.6542566 0.07299995 0.56773651 1.576216 0.35692500 0.49636667 0.23546667 -0.26090000 0.1609911644 0.0001521861 FALSE TRUE
ENST00000679708 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding protein_coding 6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.02251389 0.15311962 0.0000000 0.15311962 0.00000000 -4.027858 0.01220000 0.08586667 0.00000000 -0.08586667 0.6313198189 0.0001521861 FALSE TRUE
ENST00000681238 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding processed_transcript 6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.14615623 0.10890134 0.0000000 0.10890134 0.00000000 -3.571693 0.04112083 0.05460000 0.00000000 -0.05460000 0.6303583015 0.0001521861 FALSE TRUE
MSTRG.6209.28 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding   6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.58245993 0.00000000 0.9399412 0.00000000 0.31333612 6.569766 0.05983333 0.00000000 0.07980000 0.07980000 0.0188756172 0.0001521861 FALSE TRUE
MSTRG.6209.32 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding   6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.71632012 0.07788276 1.3580613 0.07788276 0.46538186 3.960409 0.08114583 0.04790000 0.12393333 0.07603333 0.5763204266 0.0001521861 FALSE TRUE
MSTRG.6209.33 ENSG00000149231 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC82 protein_coding   6.326164 1.801479 11.42546 0.106825 0.5907265 2.658275 0.80248538 0.30631760 1.4008808 0.20462694 0.88813539 2.157150 0.09721667 0.16203333 0.11596667 -0.04606667 0.9792650977 0.0001521861 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000149231 E001 0.0000000       11 96349241 96352152 2912 -      
ENSG00000149231 E002 0.0000000       11 96352153 96352768 616 -      
ENSG00000149231 E003 0.4161375 0.1480238879 5.543301e-01   11 96352769 96352772 4 - 0.118 0.218 1.063
ENSG00000149231 E004 0.5775531 0.0217346893 7.779292e-01   11 96352773 96352776 4 - 0.168 0.220 0.478
ENSG00000149231 E005 0.7201878 0.0846507490 1.000000e+00   11 96352777 96352778 2 - 0.211 0.219 0.066
ENSG00000149231 E006 1.0290398 0.0192767696 5.653686e-01   11 96352779 96352780 2 - 0.252 0.365 0.739
ENSG00000149231 E007 1.0290398 0.0192767696 5.653686e-01   11 96352781 96352786 6 - 0.252 0.365 0.739
ENSG00000149231 E008 1.0290398 0.0192767696 5.653686e-01   11 96352787 96352788 2 - 0.252 0.365 0.739
ENSG00000149231 E009 1.0290398 0.0192767696 5.653686e-01   11 96352789 96352804 16 - 0.252 0.365 0.739
ENSG00000149231 E010 20.9764696 0.0140441946 7.495096e-02 0.2347113416 11 96352805 96353249 445 - 1.212 1.389 0.619
ENSG00000149231 E011 10.8942145 0.0407090707 3.917656e-01 0.6218414424 11 96353250 96353446 197 - 0.960 1.081 0.442
ENSG00000149231 E012 2.5155828 0.0330480099 2.190824e-01 0.4523333115 11 96353447 96353447 1 - 0.413 0.634 1.058
ENSG00000149231 E013 7.9179985 0.0484391908 2.717704e-01 0.5116328772 11 96353448 96353538 91 - 0.821 0.980 0.606
ENSG00000149231 E014 5.0364128 0.0103142331 2.117428e-01 0.4438042664 11 96353539 96353565 27 - 0.651 0.841 0.769
ENSG00000149231 E015 13.5140666 0.0043551126 1.520214e-01 0.3652891287 11 96353566 96353645 80 - 1.039 1.190 0.544
ENSG00000149231 E016 23.3505146 0.0015657158 5.086714e-02 0.1817383819 11 96353646 96353714 69 - 1.256 1.416 0.555
ENSG00000149231 E017 0.3206185 0.0274424043 1.000000e+00   11 96353715 96353812 98 - 0.119 0.000 -10.454
ENSG00000149231 E018 9.3829026 0.0033129199 6.850177e-01 0.8259188915 11 96353813 96358248 4436 - 0.934 0.881 -0.201
ENSG00000149231 E019 0.4279040 0.6834157511 1.000000e+00   11 96358249 96358614 366 - 0.162 0.000 -10.051
ENSG00000149231 E020 0.1426347 0.0328420667 1.000000e+00   11 96358615 96358619 5 - 0.064 0.000 -9.503
ENSG00000149231 E021 0.3206185 0.0274424043 1.000000e+00   11 96358620 96358661 42 - 0.119 0.000 -10.454
ENSG00000149231 E022 39.2296398 0.0016426536 7.268097e-02 0.2301575260 11 96358993 96359097 105 - 1.482 1.601 0.404
ENSG00000149231 E023 29.3737254 0.0013159769 8.891985e-02 0.2617729645 11 96359098 96359178 81 - 1.360 1.487 0.436
ENSG00000149231 E024 3.2266134 0.2676833945 5.737727e-01 0.7528261912 11 96359179 96359640 462 - 0.540 0.627 0.389
ENSG00000149231 E025 0.8192208 0.0633000696 3.408073e-01   11 96363128 96363131 4 - 0.253 0.000 -11.519
ENSG00000149231 E026 3.4703057 0.0104289032 1.927353e-01 0.4204298540 11 96363132 96363856 725 - 0.618 0.365 -1.256
ENSG00000149231 E027 1.9247401 0.0359998907 3.092071e-01 0.5496882964 11 96363857 96364286 430 - 0.437 0.220 -1.395
ENSG00000149231 E028 0.7956878 0.5510223734 4.271252e-01   11 96364287 96364648 362 - 0.174 0.352 1.339
ENSG00000149231 E029 1.4868009 0.0136968632 8.321298e-01 0.9150793317 11 96364649 96364979 331 - 0.323 0.365 0.256
ENSG00000149231 E030 34.6564447 0.0011274538 1.399537e-01 0.3474137616 11 96364980 96365126 147 - 1.437 1.539 0.351
ENSG00000149231 E031 20.2607753 0.0017512720 1.647697e-01 0.3837069598 11 96365127 96365150 24 - 1.208 1.331 0.431
ENSG00000149231 E032 35.6079151 0.0014570426 2.302672e-01 0.4654320047 11 96371013 96371137 125 - 1.447 1.531 0.288
ENSG00000149231 E033 0.0000000       11 96371691 96371772 82 -      
ENSG00000149231 E034 33.0437414 0.0015462829 4.524305e-01 0.6674801253 11 96373375 96373457 83 - 1.422 1.477 0.191
ENSG00000149231 E035 19.2709580 0.0021116446 4.993091e-01 0.7003257859 11 96373458 96373467 10 - 1.196 1.259 0.224
ENSG00000149231 E036 0.0000000       11 96373468 96373543 76 -      
ENSG00000149231 E037 0.4466850 0.0262538696 6.675750e-01   11 96380539 96380547 9 - 0.168 0.000 -10.981
ENSG00000149231 E038 17.3007545 0.0020106319 4.804884e-01 0.6874136192 11 96380548 96383268 2721 - 1.182 1.110 -0.259
ENSG00000149231 E039 53.2827896 0.0008662426 4.821427e-01 0.6885068542 11 96383269 96383473 205 - 1.627 1.668 0.138
ENSG00000149231 E040 0.1426347 0.0328420667 1.000000e+00   11 96383474 96383960 487 - 0.064 0.000 -9.503
ENSG00000149231 E041 0.0000000       11 96383961 96383961 1 -      
ENSG00000149231 E042 84.2161544 0.0007234148 2.355538e-01 0.4714710884 11 96383962 96384293 332 - 1.841 1.785 -0.189
ENSG00000149231 E043 23.8154125 0.0019418233 4.739921e-01 0.6828186005 11 96384294 96384362 69 - 1.307 1.243 -0.225
ENSG00000149231 E044 93.3105899 0.0005641099 3.092467e-05 0.0005545053 11 96384363 96384761 399 - 1.908 1.708 -0.673
ENSG00000149231 E045 21.3260918 0.0018764457 1.192678e-01 0.3146658025 11 96384762 96385936 1175 - 1.282 1.131 -0.535
ENSG00000149231 E046 3.4645246 0.0499867125 5.290098e-01 0.7213131904 11 96385937 96385965 29 - 0.602 0.472 -0.607
ENSG00000149231 E047 4.2999377 0.0060696953 8.376392e-02 0.2523112717 11 96385966 96386020 55 - 0.694 0.365 -1.581
ENSG00000149231 E048 8.0900540 0.0041763946 1.518251e-01 0.3649609592 11 96386021 96386253 233 - 0.908 0.695 -0.843
ENSG00000149231 E049 21.3209487 0.0225871512 6.776136e-01 0.8212265195 11 96386254 96386293 40 - 1.265 1.211 -0.188
ENSG00000149231 E050 12.4609113 0.0029096693 2.273518e-01 0.4622018058 11 96386294 96387139 846 - 1.064 0.917 -0.544
ENSG00000149231 E051 4.1688092 0.0541990268 6.354007e-01 0.7938222833 11 96387140 96387529 390 - 0.650 0.563 -0.385
ENSG00000149231 E052 21.0274767 0.0018771425 9.479208e-01 0.9762322569 11 96387530 96387613 84 - 1.249 1.243 -0.020
ENSG00000149231 E053 1.6050450 0.1363718744 5.053130e-01 0.7045285683 11 96387614 96387653 40 - 0.322 0.477 0.864
ENSG00000149231 E054 11.8011494 0.0073098087 1.256600e-01 0.3248981016 11 96387654 96388382 729 - 1.046 0.842 -0.766
ENSG00000149231 E055 4.2742932 0.0080799590 6.078153e-01 0.7754157937 11 96388383 96388694 312 - 0.651 0.561 -0.396
ENSG00000149231 E056 1.9932256 0.0120861574 2.963058e-01 0.5368436155 11 96388695 96388829 135 - 0.438 0.220 -1.398
ENSG00000149231 E057 6.6491309 0.0048842104 3.179745e-02 0.1326147169 11 96388830 96389364 535 - 0.845 0.474 -1.601
ENSG00000149231 E058 7.0753018 0.0124683104 7.904855e-01 0.8908067259 11 96389365 96389523 159 - 0.835 0.796 -0.151
ENSG00000149231 E059 5.1867729 0.0607609622 8.411460e-01 0.9201085794 11 96389524 96389843 320 - 0.730 0.691 -0.160
ENSG00000149231 E060 8.3598364 0.0212146272 4.932232e-01 0.6961152666 11 96389844 96389956 113 - 0.902 0.796 -0.407