ENSG00000149115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358252 ENSG00000149115 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS1BP1 protein_coding protein_coding 22.84115 35.71911 13.08588 5.137546 0.7865275 -1.447987 13.142692 20.032515 9.7325269 2.9341003 0.3811662 -1.040696 0.6228375 0.56043333 0.74633333 0.1859000 0.005744221 0.005744221 FALSE TRUE
ENST00000427750 ENSG00000149115 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS1BP1 protein_coding retained_intron 22.84115 35.71911 13.08588 5.137546 0.7865275 -1.447987 1.918488 3.224943 0.9483284 0.5268535 0.0237144 -1.755148 0.0814875 0.09566667 0.07316667 -0.0225000 0.874033823 0.005744221 FALSE TRUE
MSTRG.5503.6 ENSG00000149115 HEK293_OSMI2_6hA HEK293_TMG_6hB TNKS1BP1 protein_coding   22.84115 35.71911 13.08588 5.137546 0.7865275 -1.447987 6.752285 11.434663 2.0159629 2.3657598 0.4441454 -2.497995 0.2540375 0.31383333 0.15160000 -0.1622333 0.058124957 0.005744221 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000149115 E001 1.5834695 0.135407538 0.530603052 0.72245243 11 57299638 57299641 4 - 0.217 0.405 1.248
ENSG00000149115 E002 1.8984785 0.039894924 0.748331001 0.86572019 11 57299642 57299643 2 - 0.361 0.438 0.428
ENSG00000149115 E003 11.4894950 0.003144826 0.449759783 0.66550573 11 57299644 57299675 32 - 0.943 1.033 0.333
ENSG00000149115 E004 178.3918648 0.273391356 0.265201672 0.50455226 11 57299676 57299961 286 - 2.082 2.169 0.292
ENSG00000149115 E005 174.7934844 0.232922938 0.186695342 0.41267719 11 57299962 57300081 120 - 2.031 2.168 0.459
ENSG00000149115 E006 158.4499954 0.001026226 0.371903308 0.60556239 11 57300528 57300600 73 - 2.081 2.113 0.107
ENSG00000149115 E007 3.4159241 0.333650631 0.218027940 0.45107282 11 57300601 57300679 79 - 0.745 0.505 -1.052
ENSG00000149115 E008 238.5744380 0.112610483 0.545331052 0.73293885 11 57300884 57301041 158 - 2.277 2.279 0.009
ENSG00000149115 E009 233.9585479 0.180104948 0.351744164 0.58885706 11 57301807 57301943 137 - 2.333 2.254 -0.263
ENSG00000149115 E010 236.9453978 0.226118501 0.379657129 0.61191289 11 57302074 57302224 151 - 2.351 2.256 -0.317
ENSG00000149115 E011 287.6521572 0.169841578 0.583446387 0.75927446 11 57302459 57302825 367 - 2.354 2.361 0.024
ENSG00000149115 E012 45.9028987 0.273214629 0.554676193 0.73955069 11 57302826 57303479 654 - 1.603 1.565 -0.131
ENSG00000149115 E013 358.0297569 0.741729979 0.362013023 0.59735120 11 57308395 57308890 496 - 2.380 2.471 0.304
ENSG00000149115 E014 685.3383835 1.066656329 0.443007894 0.66075413 11 57308891 57309831 941 - 2.687 2.747 0.198
ENSG00000149115 E015 200.3954280 0.375479823 0.432664016 0.65325623 11 57309832 57309988 157 - 2.209 2.202 -0.020
ENSG00000149115 E016 325.9750591 0.834149477 0.578382301 0.75604930 11 57309989 57310556 568 - 2.465 2.400 -0.215
ENSG00000149115 E017 0.9105353 0.017267182 0.448561860   11 57311238 57311484 247 - 0.361 0.215 -1.013
ENSG00000149115 E018 6.2283398 0.005015710 0.001534986 0.01384807 11 57311485 57311497 13 - 0.217 0.842 3.198
ENSG00000149115 E019 238.8968302 0.453206950 0.447306304 0.66372351 11 57312534 57312935 402 - 2.293 2.276 -0.055
ENSG00000149115 E020 290.6461419 0.687190142 0.409939921 0.63595381 11 57312936 57313508 573 - 2.327 2.373 0.154
ENSG00000149115 E021 179.7141743 0.293652830 0.318760187 0.55854239 11 57313509 57313889 381 - 2.112 2.167 0.184
ENSG00000149115 E022 74.0772493 0.000938453 0.090115051 0.26400553 11 57317818 57317887 70 - 1.858 1.770 -0.299
ENSG00000149115 E023 0.1426347 0.030897740 0.098219572   11 57320065 57320078 14 - 0.217 0.000 -10.692
ENSG00000149115 E024 161.1030142 0.353506482 0.598770313 0.76941095 11 57320079 57320376 298 - 2.180 2.091 -0.298
ENSG00000149115 E025 170.2521865 0.366055495 0.568833923 0.74941950 11 57320377 57320712 336 - 2.195 2.117 -0.261
ENSG00000149115 E026 77.3336913 0.066226954 0.906222535 0.95519051 11 57321792 57321950 159 - 1.848 1.783 -0.219
ENSG00000149115 E027 1.2264542 0.041460435 0.802775372   11 57321951 57322197 247 - 0.217 0.295 0.587
ENSG00000149115 E028 0.7379733 0.020203580 1.000000000   11 57322237 57322335 99 - 0.217 0.215 -0.015
ENSG00000149115 E029 27.5164774 0.004546984 0.799615633 0.89614681 11 57324840 57324952 113 - 1.349 1.365 0.055