ENSG00000148843

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369797 ENSG00000148843 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD11 protein_coding protein_coding 80.92565 103.564 67.02222 6.305929 1.786781 -0.6277351 49.502456 65.623499 47.4828691 2.979969 1.0867342 -0.4667214 0.63317500 0.63496667 0.708633333 0.07366667 1.343100e-01 2.846274e-52 FALSE TRUE
ENST00000478543 ENSG00000148843 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD11 protein_coding retained_intron 80.92565 103.564 67.02222 6.305929 1.786781 -0.6277351 7.103449 7.838033 3.6895264 1.175695 0.5839119 -1.0849905 0.07867917 0.07660000 0.054866667 -0.02173333 7.309446e-01 2.846274e-52 FALSE TRUE
ENST00000649849 ENSG00000148843 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD11 protein_coding protein_coding 80.92565 103.564 67.02222 6.305929 1.786781 -0.6277351 4.857700 0.000000 11.1480112 0.000000 0.3552458 10.1238642 0.07651250 0.00000000 0.166700000 0.16670000 2.846274e-52 2.846274e-52 FALSE TRUE
MSTRG.4586.11 ENSG00000148843 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD11 protein_coding   80.92565 103.564 67.02222 6.305929 1.786781 -0.6277351 4.269367 7.196828 0.4269424 1.840044 0.4269424 -4.0438492 0.04580833 0.06783333 0.006233333 -0.06160000 1.108336e-01 2.846274e-52 FALSE TRUE
MSTRG.4586.15 ENSG00000148843 HEK293_OSMI2_6hA HEK293_TMG_6hB PDCD11 protein_coding   80.92565 103.564 67.02222 6.305929 1.786781 -0.6277351 11.640730 19.046891 0.0000000 3.657913 0.0000000 -10.8960970 0.11794167 0.18133333 0.000000000 -0.18133333 8.845628e-26 2.846274e-52 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148843 E001 0.719380 5.580077e-02 9.335738e-01   10 103396622 103396625 4 + 0.259 0.245 -0.107
ENSG00000148843 E002 1.956503 3.001868e-01 7.903444e-01 8.907583e-01 10 103396626 103396634 9 + 0.474 0.476 0.012
ENSG00000148843 E003 14.893328 2.936301e-03 2.494260e-01 4.872519e-01 10 103396635 103396649 15 + 1.250 1.152 -0.347
ENSG00000148843 E004 32.317050 1.995092e-03 1.436400e-03 1.316000e-02 10 103396650 103396660 11 + 1.623 1.426 -0.676
ENSG00000148843 E005 194.733327 2.894118e-04 5.045804e-13 5.471862e-11 10 103396661 103396730 70 + 2.384 2.199 -0.619
ENSG00000148843 E006 304.236179 5.383140e-04 1.499551e-17 3.215382e-15 10 103398416 103398528 113 + 2.578 2.388 -0.636
ENSG00000148843 E007 2.136960 1.454715e-02 5.422410e-02 1.896079e-01 10 103399647 103399733 87 + 0.670 0.355 -1.539
ENSG00000148843 E008 10.301050 1.649750e-02 1.158297e-01 3.088936e-01 10 103399734 103399830 97 + 1.148 0.971 -0.645
ENSG00000148843 E009 383.447053 2.192585e-04 1.563119e-17 3.326487e-15 10 103400397 103400528 132 + 2.661 2.502 -0.530
ENSG00000148843 E010 414.553200 4.242997e-03 3.713685e-06 8.903984e-05 10 103403118 103403226 109 + 2.698 2.538 -0.533
ENSG00000148843 E011 374.494084 7.055924e-03 1.222173e-04 1.764907e-03 10 103403227 103403285 59 + 2.656 2.492 -0.544
ENSG00000148843 E012 574.473322 5.315668e-03 6.889050e-06 1.517996e-04 10 103405022 103405183 162 + 2.841 2.677 -0.544
ENSG00000148843 E013 2.713203 8.285506e-02 2.816125e-01 5.219510e-01 10 103405184 103405372 189 + 0.674 0.479 -0.888
ENSG00000148843 E014 502.869506 1.209741e-03 2.924354e-11 2.320666e-09 10 103405985 103406108 124 + 2.773 2.626 -0.489
ENSG00000148843 E015 578.653362 1.187182e-04 3.498169e-26 1.960626e-23 10 103406609 103406781 173 + 2.839 2.681 -0.527
ENSG00000148843 E016 212.727486 3.314875e-04 1.465890e-08 6.629609e-07 10 103406782 103406790 9 + 2.398 2.258 -0.468
ENSG00000148843 E017 424.995597 1.297874e-04 1.326278e-14 1.910370e-12 10 103409699 103409806 108 + 2.692 2.559 -0.443
ENSG00000148843 E018 548.743446 8.251161e-04 1.193568e-06 3.309312e-05 10 103413116 103413322 207 + 2.781 2.687 -0.314
ENSG00000148843 E019 218.218552 4.561115e-03 5.469409e-03 3.706667e-02 10 103413966 103413970 5 + 2.388 2.282 -0.355
ENSG00000148843 E020 464.974426 1.468046e-03 3.146964e-06 7.741951e-05 10 103413971 103414090 120 + 2.717 2.608 -0.363
ENSG00000148843 E021 394.115726 1.418444e-03 4.454276e-04 5.178957e-03 10 103414270 103414330 61 + 2.632 2.548 -0.278
ENSG00000148843 E022 515.060199 3.490033e-04 2.903409e-04 3.631892e-03 10 103415005 103415151 147 + 2.734 2.674 -0.200
ENSG00000148843 E023 686.685474 2.011237e-04 1.619846e-03 1.446118e-02 10 103416491 103416742 252 + 2.848 2.805 -0.142
ENSG00000148843 E024 540.569904 4.331251e-04 1.402349e-03 1.291886e-02 10 103417792 103417932 141 + 2.749 2.696 -0.177
ENSG00000148843 E025 683.717985 1.690052e-04 2.331893e-05 4.354141e-04 10 103418440 103418634 195 + 2.854 2.796 -0.193
ENSG00000148843 E026 645.293351 1.129423e-03 5.539832e-04 6.165886e-03 10 103419538 103419708 171 + 2.836 2.768 -0.224
ENSG00000148843 E027 713.894311 1.191677e-04 4.322587e-07 1.361667e-05 10 103421348 103421567 220 + 2.879 2.813 -0.222
ENSG00000148843 E028 4.262439 9.127840e-03 5.227892e-02 1.850157e-01 10 103422725 103422987 263 + 0.854 0.580 -1.131
ENSG00000148843 E029 518.514562 1.863582e-04 4.216348e-02 1.603513e-01 10 103422988 103423137 150 + 2.718 2.689 -0.098
ENSG00000148843 E030 462.865959 1.235636e-04 1.416276e-01 3.499228e-01 10 103423543 103423658 116 + 2.662 2.642 -0.069
ENSG00000148843 E031 1415.352835 6.329701e-05 1.463553e-03 1.336191e-02 10 103424984 103425525 542 + 3.152 3.125 -0.090
ENSG00000148843 E032 456.029762 1.329328e-04 5.550015e-01 7.397859e-01 10 103427329 103427391 63 + 2.633 2.648 0.051
ENSG00000148843 E033 504.984053 1.255392e-04 3.383401e-01 5.765407e-01 10 103432129 103432234 106 + 2.675 2.696 0.070
ENSG00000148843 E034 345.857178 1.505308e-03 6.704610e-01 8.165966e-01 10 103433948 103433992 45 + 2.514 2.532 0.060
ENSG00000148843 E035 288.115545 1.123576e-03 7.549207e-03 4.725503e-02 10 103433993 103434037 45 + 2.397 2.474 0.260
ENSG00000148843 E036 444.326114 1.060624e-03 2.587794e-03 2.088721e-02 10 103434248 103434350 103 + 2.584 2.661 0.256
ENSG00000148843 E037 20.242868 1.530258e-01 7.850993e-01 8.876160e-01 10 103434351 103434702 352 + 1.239 1.353 0.398
ENSG00000148843 E038 452.882502 9.331915e-04 5.266843e-02 1.858996e-01 10 103434798 103434896 99 + 2.610 2.659 0.166
ENSG00000148843 E039 479.794297 1.288731e-04 9.174737e-02 2.669270e-01 10 103434897 103434975 79 + 2.644 2.678 0.113
ENSG00000148843 E040 497.936020 3.542530e-04 6.652206e-01 8.131736e-01 10 103438015 103438071 57 + 2.674 2.688 0.044
ENSG00000148843 E041 702.816035 3.756576e-04 1.951224e-01 4.235047e-01 10 103438686 103438808 123 + 2.815 2.842 0.089
ENSG00000148843 E042 708.396347 7.145929e-04 6.165091e-02 2.065038e-01 10 103439746 103439868 123 + 2.809 2.850 0.137
ENSG00000148843 E043 627.516707 1.022641e-03 2.989496e-01 5.394135e-01 10 103440290 103440375 86 + 2.764 2.793 0.094
ENSG00000148843 E044 821.059307 9.907697e-04 1.036318e-02 5.969144e-02 10 103440376 103440581 206 + 2.863 2.921 0.191
ENSG00000148843 E045 561.300054 1.262990e-03 1.428553e-11 1.197439e-09 10 103440734 103440850 117 + 2.626 2.792 0.552
ENSG00000148843 E046 770.294873 1.436248e-04 2.907288e-26 1.656793e-23 10 103441826 103441975 150 + 2.765 2.924 0.530
ENSG00000148843 E047 70.298343 5.377082e-04 2.163826e-02 1.014179e-01 10 103442210 103442212 3 + 1.769 1.876 0.363
ENSG00000148843 E048 1044.175245 6.042488e-04 8.961616e-20 2.536481e-17 10 103442213 103442460 248 + 2.899 3.056 0.522
ENSG00000148843 E049 875.014073 9.635911e-04 5.406592e-14 7.079134e-12 10 103443165 103443333 169 + 2.825 2.980 0.514
ENSG00000148843 E050 729.759755 9.972699e-04 1.144456e-20 3.653288e-18 10 103443915 103444068 154 + 2.713 2.914 0.669
ENSG00000148843 E051 41.565629 6.213796e-02 4.965314e-01 6.985771e-01 10 103444313 103444516 204 + 1.652 1.590 -0.210
ENSG00000148843 E052 890.332733 2.404143e-04 6.268124e-24 2.861483e-21 10 103444517 103444682 166 + 2.833 2.985 0.504
ENSG00000148843 E053 2032.010428 9.852403e-04 3.618018e-15 5.636905e-13 10 103445378 103446294 917 + 3.202 3.341 0.461