ENSG00000148835

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369839 ENSG00000148835 HEK293_OSMI2_6hA HEK293_TMG_6hB TAF5 protein_coding protein_coding 9.491592 5.73546 12.81484 1.304501 0.9086199 1.158447 6.452936 3.530136 10.3858102 0.8952192 0.3718191 1.554126 0.6461958 0.6074000 0.8145 0.2071000 0.04542367 0.04542367 FALSE TRUE
ENST00000693184 ENSG00000148835 HEK293_OSMI2_6hA HEK293_TMG_6hB TAF5 protein_coding retained_intron 9.491592 5.73546 12.81484 1.304501 0.9086199 1.158447 1.595237 1.528381 0.4654964 0.4184587 0.4654964 -1.693906 0.2046333 0.2580667 0.0322 -0.2258667 0.11779533 0.04542367   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148835 E001 0.6129023 0.0190217343 0.8032909761   10 103367966 103367971 6 + 0.219 0.169 -0.471
ENSG00000148835 E002 1.3401046 0.0193590957 0.9186185442   10 103367972 103367975 4 + 0.364 0.384 0.111
ENSG00000148835 E003 2.8193435 0.0086012032 0.1575166053 0.372982647 10 103367976 103367980 5 + 0.632 0.384 -1.209
ENSG00000148835 E004 4.2548472 0.0057875061 0.0501850006 0.180146851 10 103367981 103367989 9 + 0.781 0.462 -1.408
ENSG00000148835 E005 40.0423653 0.0011466637 0.3985244084 0.627083470 10 103367990 103368548 559 + 1.575 1.621 0.157
ENSG00000148835 E006 0.0000000       10 103368549 103368567 19 +      
ENSG00000148835 E007 87.9305081 0.0008355382 0.0318228362 0.132681484 10 103373358 103373595 238 + 1.948 1.856 -0.311
ENSG00000148835 E008 6.4654520 0.0451245769 0.7942990800 0.892904915 10 103373596 103375103 1508 + 0.851 0.879 0.109
ENSG00000148835 E009 130.0122807 0.0024292301 0.0046332338 0.032651243 10 103378235 103378550 316 + 2.120 2.007 -0.378
ENSG00000148835 E010 57.4279136 0.0056728422 0.5638124402 0.745976487 10 103379608 103379771 164 + 1.748 1.714 -0.117
ENSG00000148835 E011 56.6428932 0.0021717053 0.7394223823 0.860057172 10 103379884 103380019 136 + 1.741 1.718 -0.075
ENSG00000148835 E012 63.0792787 0.0006250487 0.7979363541 0.895150915 10 103381721 103381841 121 + 1.786 1.770 -0.052
ENSG00000148835 E013 9.7732893 0.3280118972 0.2543811458 0.492849866 10 103381842 103383237 1396 + 1.073 0.806 -1.004
ENSG00000148835 E014 65.7755222 0.0007065217 0.7966194690 0.894342353 10 103383238 103383367 130 + 1.805 1.790 -0.050
ENSG00000148835 E015 42.8197837 0.0014248970 0.9341755037 0.969223779 10 103385326 103385369 44 + 1.619 1.611 -0.026
ENSG00000148835 E016 64.7661915 0.0006429566 0.4534619632 0.668317937 10 103385370 103385490 121 + 1.782 1.813 0.105
ENSG00000148835 E017 0.6246688 0.0191406587 0.1805644675   10 103385491 103385618 128 + 0.273 0.000 -11.812
ENSG00000148835 E018 0.3206185 0.0274424043 0.5356085146   10 103386941 103387115 175 + 0.158 0.000 -10.756
ENSG00000148835 E019 0.3032425 0.0274424043 0.0604632330   10 103387116 103387174 59 + 0.000 0.290 11.348
ENSG00000148835 E020 87.2196512 0.0004456084 0.3255033998 0.564735080 10 103387175 103387352 178 + 1.907 1.942 0.116
ENSG00000148835 E021 3.3202583 0.0092808630 0.5154845809 0.711971258 10 103387353 103387520 168 + 0.585 0.681 0.417
ENSG00000148835 E022 106.6666032 0.0012517686 0.7908535851 0.890999556 10 103387521 103387698 178 + 2.008 1.993 -0.051
ENSG00000148835 E023 2.9611271 0.3470559485 0.1301029076 0.331992999 10 103387699 103388005 307 + 0.363 0.834 2.155
ENSG00000148835 E024 237.5809892 0.0003064659 0.0000832459 0.001283438 10 103388006 103389065 1060 + 2.323 2.406 0.276