ENSG00000148814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000344079 ENSG00000148814 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC27 protein_coding protein_coding 5.119897 6.639331 3.741521 0.3720762 0.3016439 -0.8257336 0.7543367 1.2063750 0.7192520 0.16052396 0.14340669 -0.7380988 0.1410958 0.18080000 0.18910000 0.00830000 0.9941858693 0.0009344845 FALSE TRUE
ENST00000450442 ENSG00000148814 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC27 protein_coding processed_transcript 5.119897 6.639331 3.741521 0.3720762 0.3016439 -0.8257336 0.5690316 0.7180764 0.2178588 0.35982174 0.21785875 -1.6759501 0.1044917 0.10246667 0.05023333 -0.05223333 0.7800690750 0.0009344845 FALSE FALSE
ENST00000472556 ENSG00000148814 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC27 protein_coding processed_transcript 5.119897 6.639331 3.741521 0.3720762 0.3016439 -0.8257336 1.5360702 2.1085032 1.0592166 0.17319607 0.06595229 -0.9864912 0.2966292 0.31906667 0.28786667 -0.03120000 0.9110814700 0.0009344845 FALSE TRUE
ENST00000489204 ENSG00000148814 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC27 protein_coding processed_transcript 5.119897 6.639331 3.741521 0.3720762 0.3016439 -0.8257336 0.2557667 0.1901562 0.5174097 0.04153984 0.06785429 1.3977975 0.0524875 0.02816667 0.13850000 0.11033333 0.0009344845 0.0009344845   FALSE
ENST00000625755 ENSG00000148814 HEK293_OSMI2_6hA HEK293_TMG_6hB LRRC27 protein_coding protein_coding 5.119897 6.639331 3.741521 0.3720762 0.3016439 -0.8257336 1.1432744 1.4090739 0.6433666 0.37928013 0.11132659 -1.1189851 0.2331500 0.22016667 0.17790000 -0.04226667 0.9413458956 0.0009344845 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148814 E001 3.6649711 0.008149812 0.48332746 0.68929131 10 132332128 132332151 24 + 0.545 0.656 0.494
ENSG00000148814 E002 3.7958392 0.008508387 0.41115418 0.63691874 10 132332152 132332153 2 + 0.545 0.676 0.576
ENSG00000148814 E003 3.9267074 0.010240077 0.34996114 0.58719781 10 132332154 132332154 1 + 0.545 0.694 0.652
ENSG00000148814 E004 9.3156214 0.003436218 0.41432282 0.63929571 10 132332155 132332192 38 + 0.904 0.997 0.349
ENSG00000148814 E005 12.0227219 0.003451496 0.60344295 0.77248264 10 132332193 132332225 33 + 1.042 1.094 0.188
ENSG00000148814 E006 15.1525241 0.002630314 0.54664770 0.73389530 10 132332226 132332256 31 + 1.131 1.185 0.194
ENSG00000148814 E007 4.9928318 0.049684736 0.36954231 0.60368021 10 132332279 132332536 258 + 0.847 0.705 -0.567
ENSG00000148814 E008 32.0566420 0.022522507 0.51117015 0.70885450 10 132333477 132333734 258 + 1.440 1.497 0.197
ENSG00000148814 E009 0.1614157 0.032250183 0.20185124   10 132335108 132335241 134 + 0.176 0.000 -11.273
ENSG00000148814 E010 0.1779838 0.032264291 0.20178507   10 132336764 132336793 30 + 0.177 0.000 -11.274
ENSG00000148814 E011 0.1779838 0.032264291 0.20178507   10 132336794 132336828 35 + 0.177 0.000 -11.274
ENSG00000148814 E012 0.4812263 0.021768165 0.87893132   10 132337138 132337421 284 + 0.176 0.151 -0.272
ENSG00000148814 E013 15.2920826 0.002976640 0.60933887 0.77645832 10 132337565 132337665 101 + 1.205 1.155 -0.178
ENSG00000148814 E014 10.8277853 0.026020365 0.93422173 0.96925174 10 132337666 132337695 30 + 1.045 1.023 -0.079
ENSG00000148814 E015 12.0027496 0.120598977 0.43956607 0.65834504 10 132342213 132342271 59 + 1.006 1.101 0.347
ENSG00000148814 E016 27.4733644 0.002083847 0.49940210 0.70039253 10 132344498 132344650 153 + 1.381 1.428 0.161
ENSG00000148814 E017 2.7564968 0.008590851 0.01379148 0.07351028 10 132344651 132344867 217 + 0.779 0.390 -1.783
ENSG00000148814 E018 38.0734224 0.001225738 0.77750457 0.88322047 10 132347984 132348191 208 + 1.539 1.553 0.048
ENSG00000148814 E019 36.4573645 0.001365400 0.48008489 0.68713670 10 132348192 132348356 165 + 1.499 1.540 0.139
ENSG00000148814 E020 12.0219924 0.011883739 0.29927026 0.53969961 10 132348963 132349057 95 + 1.147 1.034 -0.412
ENSG00000148814 E021 14.7089965 0.054550135 0.47076604 0.68065983 10 132350400 132351606 1207 + 1.207 1.128 -0.281
ENSG00000148814 E022 26.0781165 0.001809171 0.75139413 0.86765126 10 132351607 132351753 147 + 1.407 1.381 -0.090
ENSG00000148814 E023 3.2103568 0.363198930 0.62816904 0.78934457 10 132352882 132352905 24 + 0.606 0.580 -0.117
ENSG00000148814 E024 9.3081177 0.010564994 0.44625016 0.66290431 10 132352906 132353396 491 + 0.904 0.997 0.347
ENSG00000148814 E025 16.9405084 0.002450417 0.93572396 0.97005989 10 132355790 132355886 97 + 1.205 1.209 0.015
ENSG00000148814 E026 17.8354193 0.001977768 0.89921988 0.95147085 10 132361457 132361575 119 + 1.244 1.230 -0.048
ENSG00000148814 E027 0.0000000       10 132361576 132361589 14 +      
ENSG00000148814 E028 14.4113808 0.003072707 0.39179070 0.62185798 10 132365424 132365470 47 + 1.205 1.122 -0.295
ENSG00000148814 E029 9.0316738 0.003932054 0.81884421 0.90735539 10 132365471 132365480 10 + 0.979 0.949 -0.108
ENSG00000148814 E030 11.1114080 0.051058865 0.44688853 0.66336799 10 132365481 132365550 70 + 1.115 1.004 -0.404
ENSG00000148814 E031 1.4628199 0.013280957 0.19333777 0.42127332 10 132366299 132366434 136 + 0.176 0.425 1.729
ENSG00000148814 E032 2.7977924 0.024176441 0.60400601 0.77286101 10 132366435 132366614 180 + 0.478 0.569 0.431
ENSG00000148814 E033 1.9636351 0.010864776 0.77300676 0.88048619 10 132366615 132366677 63 + 0.478 0.425 -0.271
ENSG00000148814 E034 1.6554033 0.011267220 0.48495686 0.69053328 10 132366678 132366843 166 + 0.478 0.352 -0.684
ENSG00000148814 E035 2.8301911 0.056918279 0.28658829 0.52727166 10 132366846 132367001 156 + 0.398 0.613 1.047
ENSG00000148814 E036 18.1238540 0.028189135 0.26778025 0.50742296 10 132375066 132381508 6443 + 1.326 1.194 -0.467