ENSG00000148773

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368653 ENSG00000148773 HEK293_OSMI2_6hA HEK293_TMG_6hB MKI67 protein_coding protein_coding 55.91277 86.4675 46.5251 12.48395 5.015221 -0.8940056 22.704518 36.06616224 19.4655614 3.10163541 2.3539986 -0.8893810 0.40397500 0.425600000 0.41736667 -0.008233333 9.900728e-01 4.621861e-05 FALSE TRUE
ENST00000368654 ENSG00000148773 HEK293_OSMI2_6hA HEK293_TMG_6hB MKI67 protein_coding protein_coding 55.91277 86.4675 46.5251 12.48395 5.015221 -0.8940056 8.358052 10.12166201 8.2854213 2.30102372 0.9452759 -0.2884837 0.16018333 0.114300000 0.18360000 0.069300000 4.703048e-01 4.621861e-05 FALSE TRUE
ENST00000464771 ENSG00000148773 HEK293_OSMI2_6hA HEK293_TMG_6hB MKI67 protein_coding processed_transcript 55.91277 86.4675 46.5251 12.48395 5.015221 -0.8940056 14.695497 32.98276575 4.1457009 5.58394959 1.5866662 -2.9889860 0.24010833 0.378166667 0.08453333 -0.293633333 4.621861e-05 4.621861e-05 FALSE TRUE
MSTRG.4810.12 ENSG00000148773 HEK293_OSMI2_6hA HEK293_TMG_6hB MKI67 protein_coding   55.91277 86.4675 46.5251 12.48395 5.015221 -0.8940056 1.053579 0.03964872 3.2396205 0.03964872 1.6602171 6.0323709 0.02085417 0.000400000 0.06280000 0.062400000 3.230484e-01 4.621861e-05 FALSE TRUE
MSTRG.4810.5 ENSG00000148773 HEK293_OSMI2_6hA HEK293_TMG_6hB MKI67 protein_coding   55.91277 86.4675 46.5251 12.48395 5.015221 -0.8940056 3.677014 5.05489783 0.7422564 2.47676623 0.7422564 -2.7512368 0.06056250 0.052400000 0.02020000 -0.032200000 4.255654e-01 4.621861e-05 FALSE TRUE
MSTRG.4810.6 ENSG00000148773 HEK293_OSMI2_6hA HEK293_TMG_6hB MKI67 protein_coding   55.91277 86.4675 46.5251 12.48395 5.015221 -0.8940056 4.006497 0.52886386 9.3003671 0.52886386 2.0597232 4.1108453 0.08617500 0.008566667 0.19773333 0.189166667 3.853827e-02 4.621861e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148773 E001 458.9631582 0.936146158 2.326545e-01 0.468238404 10 128096659 128097366 708 - 2.369 2.745 1.253
ENSG00000148773 E002 393.9767379 0.913843720 2.684072e-01 0.508066700 10 128097367 128097909 543 - 2.341 2.669 1.094
ENSG00000148773 E003 1182.5653799 1.311513006 3.034197e-01 0.543970883 10 128097910 128098730 821 - 2.788 3.153 1.214
ENSG00000148773 E004 429.6721271 0.868781290 1.842718e-01 0.409538325 10 128098731 128098784 54 - 2.294 2.726 1.440
ENSG00000148773 E005 406.0702474 0.865868123 2.013298e-01 0.431378991 10 128098785 128098820 36 - 2.293 2.697 1.344
ENSG00000148773 E006 251.3557140 0.676747395 1.797811e-01 0.403682511 10 128098821 128098822 2 - 2.104 2.485 1.272
ENSG00000148773 E007 339.7808092 0.801765059 1.991408e-01 0.428632688 10 128098823 128098852 30 - 2.229 2.617 1.294
ENSG00000148773 E008 318.4875626 0.784177064 2.044477e-01 0.435166575 10 128098853 128098866 14 - 2.211 2.586 1.250
ENSG00000148773 E009 1098.8394273 1.274605655 2.888683e-01 0.529458920 10 128098867 128099255 389 - 2.748 3.123 1.249
ENSG00000148773 E010 954.8318784 0.068316779 6.036408e-01 0.772597431 10 128101258 128101483 226 - 2.789 3.034 0.816
ENSG00000148773 E011 672.8816911 0.111729211 9.627802e-01 0.983371461 10 128101484 128101625 142 - 2.672 2.871 0.664
ENSG00000148773 E012 427.8389145 0.008239365 1.233919e-02 0.067790602 10 128101626 128101701 76 - 2.444 2.687 0.812
ENSG00000148773 E013 2961.1451216 1.219776858 3.550241e-01 0.591786929 10 128102579 128104131 1553 - 3.269 3.529 0.866
ENSG00000148773 E014 297.9122571 0.909651045 4.129851e-01 0.638361415 10 128104132 128104183 52 - 2.342 2.510 0.559
ENSG00000148773 E015 755.2653506 1.244778865 4.195167e-01 0.643270342 10 128104184 128104497 314 - 2.714 2.924 0.697
ENSG00000148773 E016 306.6214841 0.899272136 3.772335e-01 0.610053353 10 128104498 128104549 52 - 2.330 2.531 0.672
ENSG00000148773 E017 1678.2046483 1.584664684 5.517241e-01 0.737492310 10 128104550 128105580 1031 - 3.128 3.245 0.388
ENSG00000148773 E018 627.8065084 1.277199408 5.863762e-01 0.761200423 10 128105581 128105860 280 - 2.749 2.796 0.156
ENSG00000148773 E019 330.8405623 1.048921419 5.978045e-01 0.768818551 10 128105861 128105946 86 - 2.490 2.509 0.063
ENSG00000148773 E020 405.8902186 1.106601547 5.660242e-01 0.747391445 10 128105947 128106105 159 - 2.556 2.609 0.177
ENSG00000148773 E021 537.7811187 1.228627376 6.008346e-01 0.770764138 10 128106106 128106471 366 - 2.693 2.724 0.104
ENSG00000148773 E022 1148.9431109 1.519900511 6.685986e-01 0.815293062 10 128106472 128107459 988 - 3.044 3.041 -0.009
ENSG00000148773 E023 579.7461418 1.281509448 6.503312e-01 0.803780733 10 128107460 128107929 470 - 2.750 2.743 -0.023
ENSG00000148773 E024 356.7624217 1.104149553 6.534639e-01 0.805741743 10 128107930 128108188 259 - 2.550 2.527 -0.077
ENSG00000148773 E025 413.4856005 1.189156261 7.197467e-01 0.848047559 10 128108189 128108502 314 - 2.644 2.572 -0.243
ENSG00000148773 E026 820.4919988 1.467746761 8.032934e-01 0.898248025 10 128108503 128109423 921 - 2.975 2.845 -0.434
ENSG00000148773 E027 201.0994887 0.040969063 8.749601e-05 0.001336346 10 128110378 128110533 156 - 2.433 2.180 -0.848
ENSG00000148773 E028 0.3206185 0.056084272 6.086598e-02   10 128111520 128111644 125 - 0.269 0.000 -10.289
ENSG00000148773 E029 230.4965931 0.143346545 6.642480e-03 0.042911055 10 128111645 128111816 172 - 2.534 2.191 -1.147
ENSG00000148773 E030 231.8795933 0.166711676 6.912909e-03 0.044236454 10 128111927 128112045 119 - 2.555 2.169 -1.288
ENSG00000148773 E031 409.6640762 0.176836359 1.099870e-02 0.062365020 10 128112133 128112445 313 - 2.790 2.432 -1.193
ENSG00000148773 E032 0.7201176 0.646323695 1.568360e-01   10 128112446 128112449 4 - 0.367 0.098 -2.389
ENSG00000148773 E033 276.1162520 0.174398207 9.948677e-03 0.057943418 10 128113427 128113602 176 - 2.623 2.255 -1.227
ENSG00000148773 E034 289.8236451 0.179508509 7.025585e-03 0.044761925 10 128114928 128115509 582 - 2.660 2.256 -1.347
ENSG00000148773 E035 227.5138401 0.177534296 7.885290e-03 0.048797596 10 128115510 128116007 498 - 2.551 2.156 -1.321
ENSG00000148773 E036 132.7581160 0.172294439 9.615801e-03 0.056455806 10 128116491 128116536 46 - 2.310 1.935 -1.256
ENSG00000148773 E037 127.1346861 0.201797329 1.579697e-02 0.081074030 10 128119253 128119319 67 - 2.297 1.908 -1.303
ENSG00000148773 E038 156.5106727 0.199688824 1.067445e-02 0.061007189 10 128122881 128122996 116 - 2.399 1.981 -1.398
ENSG00000148773 E039 109.8726363 0.208948524 8.540593e-03 0.051795912 10 128123091 128123169 79 - 2.253 1.820 -1.454
ENSG00000148773 E040 126.6622293 0.175485050 8.673054e-03 0.052352719 10 128125576 128125756 181 - 2.291 1.914 -1.264
ENSG00000148773 E041 54.4231818 0.124269836 5.481630e-03 0.037118018 10 128126099 128126154 56 - 1.907 1.582 -1.100
ENSG00000148773 E042 33.0929193 0.123730902 9.455300e-02 0.272179147 10 128126155 128126192 38 - 1.594 1.467 -0.433
ENSG00000148773 E043 46.7893792 0.184709974 4.017075e-01 0.629781262 10 128126193 128126423 231 - 1.653 1.667 0.047