ENSG00000148700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000277900 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding protein_coding 14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 2.5734841 0.78481203 5.312326 0.45790367 1.1918004 2.743371 0.12710417 0.24320000 0.19930000 -0.04390000 9.828635e-01 9.523969e-09 FALSE TRUE
ENST00000356080 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding protein_coding 14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 4.0129508 1.19591585 6.866915 0.12752055 0.3081326 2.511632 0.27501250 0.32016667 0.25650000 -0.06366667 7.094236e-01 9.523969e-09 FALSE TRUE
ENST00000472568 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding processed_transcript 14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 1.6315856 0.61157789 2.831355 0.31285937 0.3289769 2.192572 0.09254583 0.14880000 0.10553333 -0.04326667 1.000000e+00 9.523969e-09 FALSE FALSE
ENST00000475954 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding processed_transcript 14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 0.9002327 0.05147875 2.219495 0.05147875 0.6496416 5.180485 0.04885833 0.01516667 0.08356667 0.06840000 3.112208e-01 9.523969e-09 FALSE TRUE
ENST00000488799 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding processed_transcript 14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 0.5486272 0.58622901 0.000000 0.58622901 0.0000000 -5.897795 0.14310000 0.11913333 0.00000000 -0.11913333 6.847607e-01 9.523969e-09 FALSE TRUE
MSTRG.4625.12 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding   14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 1.5816302 0.26111431 2.439772 0.14755813 0.4296979 3.175674 0.06870417 0.06080000 0.09143333 0.03063333 7.618899e-01 9.523969e-09 FALSE FALSE
MSTRG.4625.7 ENSG00000148700 HEK293_OSMI2_6hA HEK293_TMG_6hB ADD3 protein_coding   14.67932 3.821858 26.74963 0.5536698 0.4091777 2.803942 2.3144926 0.00000000 4.688692 0.00000000 0.7531033 8.876115 0.16497500 0.00000000 0.17473333 0.17473333 9.523969e-09 9.523969e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148700 E001 0.1614157 0.0329175267 9.100116e-01   10 109996368 109996446 79 + 0.051 0.000 -9.510
ENSG00000148700 E002 0.0000000       10 110005804 110006151 348 +      
ENSG00000148700 E003 0.4820342 0.0213548117 1.000000e+00   10 110007964 110007983 20 + 0.137 0.000 -11.746
ENSG00000148700 E004 12.2808937 0.0993289173 3.049710e-01 0.5455482931 10 110007984 110008207 224 + 0.941 1.152 0.771
ENSG00000148700 E005 4.1147828 0.4708530013 2.727884e-01 0.5126060582 10 110008208 110008208 1 + 0.513 0.881 1.549
ENSG00000148700 E006 5.5669249 0.6037341726 4.073479e-01 0.6339712525 10 110008209 110008230 22 + 0.632 0.920 1.154
ENSG00000148700 E007 10.1069079 0.5236651356 3.052801e-01 0.5459051267 10 110008231 110008251 21 + 0.851 1.118 0.991
ENSG00000148700 E008 17.4846599 0.7192168019 5.160833e-01 0.7123174774 10 110008252 110008299 48 + 1.088 1.227 0.495
ENSG00000148700 E009 0.8040577 0.0182981259 1.526617e-01   10 110008934 110008982 49 + 0.137 0.428 2.176
ENSG00000148700 E010 0.4762370 0.0217681645 3.519623e-02   10 110016435 110016620 186 + 0.051 0.428 3.764
ENSG00000148700 E011 0.0000000       10 110075618 110075709 92 +      
ENSG00000148700 E012 0.0000000       10 110077005 110077118 114 +      
ENSG00000148700 E013 0.0000000       10 110079239 110079239 1 +      
ENSG00000148700 E014 0.7860845 0.0169843854 5.431434e-01   10 110079240 110079297 58 + 0.209 0.000 -12.455
ENSG00000148700 E015 40.3038568 0.0225458909 6.183282e-01 0.7826541408 10 110100625 110100675 51 + 1.457 1.441 -0.057
ENSG00000148700 E016 84.7440373 0.0005150414 1.562655e-03 0.0140580964 10 110100676 110100848 173 + 1.785 1.634 -0.512
ENSG00000148700 E017 0.1723744 0.0342273809 5.680921e-02   10 110106000 110106053 54 + 0.000 0.265 14.911
ENSG00000148700 E018 0.0000000       10 110112141 110112355 215 +      
ENSG00000148700 E019 88.0310483 0.0005646130 2.469391e-03 0.0201324718 10 110112777 110112915 139 + 1.797 1.658 -0.470
ENSG00000148700 E020 78.1742581 0.0004964415 1.553795e-02 0.0801160317 10 110116259 110116410 152 + 1.743 1.634 -0.371
ENSG00000148700 E021 62.6716926 0.0007022096 2.634561e-01 0.5026952840 10 110117342 110117422 81 + 1.643 1.607 -0.121
ENSG00000148700 E022 82.4727374 0.0005809248 7.345224e-02 0.2316866130 10 110118587 110118736 150 + 1.763 1.697 -0.224
ENSG00000148700 E023 73.4181906 0.0018766579 1.051082e-02 0.0603054055 10 110119211 110119314 104 + 1.722 1.589 -0.450
ENSG00000148700 E024 53.2461140 0.0007034741 1.805559e-03 0.0157405276 10 110119315 110119354 40 + 1.593 1.390 -0.697
ENSG00000148700 E025 65.9290391 0.0005970084 1.440587e-02 0.0759059159 10 110119466 110119564 99 + 1.675 1.550 -0.426
ENSG00000148700 E026 1.4868009 0.0159016954 5.021734e-01 0.7022897412 10 110119565 110119690 126 + 0.271 0.429 0.956
ENSG00000148700 E027 2.3046503 0.0102976919 1.578568e-01 0.3735241400 10 110121855 110122109 255 + 0.350 0.640 1.441
ENSG00000148700 E028 67.0730438 0.0006097275 3.480711e-02 0.1410818537 10 110122110 110122212 103 + 1.679 1.580 -0.340
ENSG00000148700 E029 71.4225201 0.0005959517 1.123552e-01 0.3030670760 10 110122213 110122292 80 + 1.702 1.642 -0.205
ENSG00000148700 E030 4.4579861 0.1332890153 1.276366e-01 0.3281067892 10 110123837 110124016 180 + 0.525 0.900 1.562
ENSG00000148700 E031 128.3326901 0.0009790450 9.061166e-01 0.9551517616 10 110124017 110124239 223 + 1.938 1.970 0.108
ENSG00000148700 E032 63.3713862 0.0013505704 8.169339e-01 0.9064096979 10 110124240 110124274 35 + 1.636 1.658 0.076
ENSG00000148700 E033 0.5061644 0.3414648222 7.131670e-02   10 110125755 110125825 71 + 0.051 0.432 3.782
ENSG00000148700 E034 78.5058379 0.0027430870 9.325006e-01 0.9684089673 10 110125826 110125901 76 + 1.727 1.758 0.106
ENSG00000148700 E035 57.9906324 0.0007112926 7.831461e-01 0.8864937159 10 110125902 110125924 23 + 1.595 1.650 0.187
ENSG00000148700 E036 58.4523949 0.0007917405 5.952836e-01 0.7672090880 10 110125925 110125945 21 + 1.595 1.666 0.242
ENSG00000148700 E037 92.7609745 0.0005169400 2.886471e-01 0.5293588493 10 110126417 110126503 87 + 1.789 1.880 0.305
ENSG00000148700 E038 105.7424657 0.0056692451 9.447096e-01 0.9746835208 10 110130363 110130486 124 + 1.853 1.886 0.109
ENSG00000148700 E039 34.2845828 0.0013029280 7.744509e-01 0.8813937427 10 110132305 110132400 96 + 1.372 1.432 0.209
ENSG00000148700 E040 3.0214575 0.0083644692 1.614605e-01 0.3789399217 10 110132401 110132727 327 + 0.437 0.716 1.275
ENSG00000148700 E041 481.1598016 0.0051092402 4.192767e-05 0.0007162541 10 110133326 110135565 2240 + 2.487 2.655 0.558