ENSG00000148606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372371 ENSG00000148606 HEK293_OSMI2_6hA HEK293_TMG_6hB POLR3A protein_coding protein_coding 29.79822 30.2999 31.71911 4.778701 0.9905822 0.06601772 25.750943 30.06679 23.669154 4.842661 1.155229 -0.3450329 0.8691833 0.9913 0.7454000 -0.2459000 2.735517e-10 1.081903e-38 FALSE TRUE
MSTRG.4245.2 ENSG00000148606 HEK293_OSMI2_6hA HEK293_TMG_6hB POLR3A protein_coding   29.79822 30.2999 31.71911 4.778701 0.9905822 0.06601772 3.706388 0.00000 7.733318 0.000000 0.284901 9.5968081 0.1194333 0.0000 0.2443667 0.2443667 1.081903e-38 1.081903e-38 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148606 E001 1276.8085116 1.8979334778 4.371448e-01 6.565542e-01 10 77975149 77977271 2123 - 2.881 3.235 1.177
ENSG00000148606 E002 405.9796763 1.5481265247 4.436273e-01 6.611304e-01 10 77977272 77977626 355 - 2.419 2.724 1.014
ENSG00000148606 E003 334.1504999 0.0142024701 1.281722e-02 6.970441e-02 10 77980141 77980273 133 - 2.401 2.607 0.688
ENSG00000148606 E004 362.7533909 0.0020849616 1.227863e-01 3.201350e-01 10 77981428 77981559 132 - 2.496 2.603 0.355
ENSG00000148606 E005 397.9711063 0.0019439891 5.614497e-01 7.442750e-01 10 77982154 77982318 165 - 2.551 2.631 0.267
ENSG00000148606 E006 359.9252583 0.0041811584 6.297375e-01 7.903282e-01 10 77982653 77982817 165 - 2.505 2.590 0.286
ENSG00000148606 E007 208.2928741 0.0088931104 4.645665e-01 6.762924e-01 10 77983920 77984012 93 - 2.254 2.363 0.364
ENSG00000148606 E008 261.1068611 0.0056135768 7.584294e-01 8.716164e-01 10 77984205 77984298 94 - 2.384 2.438 0.183
ENSG00000148606 E009 292.7937433 0.0066418414 7.733719e-01 8.806946e-01 10 77985170 77985340 171 - 2.419 2.500 0.268
ENSG00000148606 E010 189.0046155 0.0036581316 2.929875e-01 5.336795e-01 10 77985903 77985985 83 - 2.215 2.319 0.345
ENSG00000148606 E011 195.5603334 0.0040431878 4.316518e-01 6.524762e-01 10 77986073 77986159 87 - 2.239 2.331 0.306
ENSG00000148606 E012 176.3913032 0.0011524742 8.217114e-01 9.089550e-01 10 77991054 77991108 55 - 2.207 2.272 0.216
ENSG00000148606 E013 194.1475545 0.0022441604 6.146361e-01 7.799922e-01 10 77991109 77991167 59 - 2.260 2.304 0.149
ENSG00000148606 E014 321.7437915 0.0056029449 5.808390e-01 7.577302e-01 10 77993197 77993367 171 - 2.479 2.525 0.152
ENSG00000148606 E015 283.1886121 0.0038732531 6.265494e-01 7.882579e-01 10 77999981 78000118 138 - 2.422 2.470 0.159
ENSG00000148606 E016 222.8329592 0.0002355195 6.299559e-01 7.903910e-01 10 78000976 78001094 119 - 2.318 2.361 0.144
ENSG00000148606 E017 196.7223213 0.0019090048 3.222963e-01 5.617419e-01 10 78002197 78002308 112 - 2.275 2.303 0.095
ENSG00000148606 E018 254.3830277 0.0005612383 8.980051e-04 9.077495e-03 10 78004716 78004888 173 - 2.415 2.390 -0.083
ENSG00000148606 E019 293.1112629 0.0043183899 4.517028e-02 1.680421e-01 10 78007702 78007866 165 - 2.472 2.460 -0.042
ENSG00000148606 E020 311.9732705 0.0047621523 4.719825e-03 3.311033e-02 10 78009537 78009675 139 - 2.516 2.471 -0.150
ENSG00000148606 E021 290.5726611 0.0035368407 4.651574e-04 5.357370e-03 10 78009864 78009991 128 - 2.493 2.432 -0.204
ENSG00000148606 E022 169.4738998 0.0015013264 8.502462e-03 5.161627e-02 10 78010471 78010540 70 - 2.241 2.213 -0.095
ENSG00000148606 E023 0.5474829 0.0395604496 1.333104e-01   10 78013086 78013649 564 - 0.000 0.282 10.606
ENSG00000148606 E024 238.3229095 0.0003790261 5.556940e-02 1.926343e-01 10 78013650 78013790 141 - 2.367 2.376 0.030
ENSG00000148606 E025 236.1673256 0.0001949369 1.733105e-02 8.665678e-02 10 78017575 78017716 142 - 2.369 2.368 -0.004
ENSG00000148606 E026 216.1436484 0.0002788466 4.004510e-07 1.274233e-05 10 78019162 78019265 104 - 2.366 2.295 -0.237
ENSG00000148606 E027 3.6277346 0.0901713654 9.187175e-01 9.615452e-01 10 78019266 78020173 908 - 0.645 0.672 0.118
ENSG00000148606 E028 219.3031298 0.0008498694 1.285390e-08 5.880624e-07 10 78021546 78021682 137 - 2.386 2.288 -0.327
ENSG00000148606 E029 222.7586379 0.0113575444 2.898560e-03 2.278899e-02 10 78021860 78022022 163 - 2.398 2.296 -0.340
ENSG00000148606 E030 251.8077309 0.0049246945 1.174957e-06 3.265708e-05 10 78022145 78022384 240 - 2.463 2.333 -0.435
ENSG00000148606 E031 207.4659567 0.0029283845 5.607577e-08 2.211041e-06 10 78024549 78024703 155 - 2.380 2.248 -0.441
ENSG00000148606 E032 222.2939046 0.0041272915 3.777735e-09 1.945848e-07 10 78024971 78025142 172 - 2.426 2.259 -0.558
ENSG00000148606 E033 201.5039382 0.0045833242 3.630767e-07 1.166896e-05 10 78025622 78025759 138 - 2.375 2.229 -0.490
ENSG00000148606 E034 167.7513709 0.0055856100 1.196266e-04 1.734131e-03 10 78026094 78026229 136 - 2.282 2.169 -0.377
ENSG00000148606 E035 122.9021773 0.0038653738 1.754017e-04 2.396784e-03 10 78029364 78029567 204 - 2.142 2.039 -0.347