ENSG00000148358

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347136 ENSG00000148358 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR107 protein_coding protein_coding 26.8815 22.80151 33.37339 1.433438 1.233119 0.5493683 18.212142 17.3529920 21.075856 1.2429832 0.6768208 0.28026003 0.68595417 0.760233333 0.63263333 -0.12760000 2.630358e-02 1.617932e-20 FALSE TRUE
ENST00000372410 ENSG00000148358 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR107 protein_coding protein_coding 26.8815 22.80151 33.37339 1.433438 1.233119 0.5493683 3.115324 2.9544644 2.817991 0.1868837 0.6192170 -0.06799401 0.12064167 0.131133333 0.08363333 -0.04750000 4.722027e-01 1.617932e-20 FALSE TRUE
ENST00000610997 ENSG00000148358 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR107 protein_coding protein_coding 26.8815 22.80151 33.37339 1.433438 1.233119 0.5493683 1.076985 0.0000000 2.956037 0.0000000 0.1728601 8.21239286 0.03268333 0.000000000 0.08873333 0.08873333 1.617932e-20 1.617932e-20 FALSE TRUE
MSTRG.33520.11 ENSG00000148358 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR107 protein_coding   26.8815 22.80151 33.37339 1.433438 1.233119 0.5493683 1.790253 1.0517151 3.310098 0.3393589 0.4174041 1.64482904 0.06428333 0.045900000 0.09863333 0.05273333 3.571683e-01 1.617932e-20 FALSE TRUE
MSTRG.33520.8 ENSG00000148358 HEK293_OSMI2_6hA HEK293_TMG_6hB GPR107 protein_coding   26.8815 22.80151 33.37339 1.433438 1.233119 0.5493683 1.522014 0.1007557 1.883002 0.1007557 0.2551591 4.09522264 0.04716667 0.003933333 0.05606667 0.05213333 3.238467e-02 1.617932e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000148358 E001 0.0000000       9 130053426 130053428 3 +      
ENSG00000148358 E002 0.0000000       9 130053429 130053431 3 +      
ENSG00000148358 E003 0.0000000       9 130053432 130053482 51 +      
ENSG00000148358 E004 0.0000000       9 130053483 130053705 223 +      
ENSG00000148358 E005 4.4676485 1.217905e-01 9.115013e-01 9.579229e-01 9 130053706 130053905 200 + 0.762 0.731 -0.125
ENSG00000148358 E006 8.8990131 2.461788e-02 6.336666e-01 7.927735e-01 9 130053906 130053917 12 + 0.975 1.037 0.227
ENSG00000148358 E007 10.3430048 3.967916e-03 7.029954e-01 8.374925e-01 9 130053918 130053920 3 + 1.040 1.079 0.142
ENSG00000148358 E008 30.3304900 2.097502e-03 3.339094e-01 5.724994e-01 9 130053921 130053924 4 + 1.464 1.528 0.219
ENSG00000148358 E009 107.6752253 7.879380e-03 9.224068e-01 9.634944e-01 9 130053925 130054073 149 + 2.030 2.041 0.039
ENSG00000148358 E010 0.0000000       9 130058498 130058559 62 +      
ENSG00000148358 E011 154.5650041 4.444957e-04 6.104237e-03 4.023256e-02 9 130075636 130075749 114 + 2.225 2.145 -0.269
ENSG00000148358 E012 140.0205551 2.981723e-04 6.336962e-07 1.910120e-05 9 130076412 130076462 51 + 2.210 2.057 -0.511
ENSG00000148358 E013 168.0621376 4.406171e-04 2.107062e-05 3.995840e-04 9 130077299 130077374 76 + 2.276 2.154 -0.406
ENSG00000148358 E014 101.2872057 7.081069e-04 1.773035e-03 1.552214e-02 9 130077375 130077378 4 + 2.054 1.939 -0.386
ENSG00000148358 E015 238.2290271 2.315324e-03 3.952900e-04 4.685185e-03 9 130079630 130079769 140 + 2.425 2.314 -0.371
ENSG00000148358 E016 0.8405746 1.854314e-02 7.660656e-01   9 130083302 130083564 263 + 0.280 0.228 -0.393
ENSG00000148358 E017 155.3674901 2.462389e-03 1.845256e-03 1.602408e-02 9 130083565 130083602 38 + 2.242 2.129 -0.377
ENSG00000148358 E018 154.6823756 3.201571e-04 5.260775e-03 3.599205e-02 9 130086420 130086476 57 + 2.226 2.146 -0.270
ENSG00000148358 E019 173.5669757 1.584281e-03 6.108517e-02 2.052078e-01 9 130090876 130090983 108 + 2.268 2.208 -0.200
ENSG00000148358 E020 207.6049791 4.530329e-03 3.796389e-02 1.495181e-01 9 130092248 130092381 134 + 2.355 2.272 -0.277
ENSG00000148358 E021 153.3779368 3.388877e-04 3.152999e-03 2.432435e-02 9 130099457 130099532 76 + 2.222 2.136 -0.289
ENSG00000148358 E022 179.1722987 8.452313e-04 6.750053e-03 4.346610e-02 9 130100629 130100702 74 + 2.288 2.210 -0.262
ENSG00000148358 E023 213.1108879 2.571808e-04 1.611945e-02 8.223052e-02 9 130101106 130101223 118 + 2.354 2.295 -0.197
ENSG00000148358 E024 223.0387052 4.166091e-04 9.767878e-03 5.712354e-02 9 130104420 130104550 131 + 2.373 2.310 -0.213
ENSG00000148358 E025 134.0208943 4.085329e-03 3.792095e-01 6.115658e-01 9 130107496 130107518 23 + 2.140 2.107 -0.111
ENSG00000148358 E026 132.4395507 4.291145e-04 7.213201e-01 8.489745e-01 9 130107519 130107539 21 + 2.123 2.113 -0.035
ENSG00000148358 E027 16.7357149 8.319633e-03 6.188373e-01 7.830464e-01 9 130107540 130107723 184 + 1.224 1.269 0.160
ENSG00000148358 E028 33.1327230 1.807008e-02 9.743382e-01 9.890615e-01 9 130110370 130110422 53 + 1.526 1.531 0.020
ENSG00000148358 E029 12.7989942 3.098967e-03 5.842835e-01 7.598656e-01 9 130110423 130110426 4 + 1.107 1.160 0.189
ENSG00000148358 E030 0.0000000       9 130114573 130114576 4 +      
ENSG00000148358 E031 0.0000000       9 130114577 130114663 87 +      
ENSG00000148358 E032 114.3905166 3.549794e-04 6.372594e-02 2.110832e-01 9 130124915 130124964 50 + 2.085 2.023 -0.208
ENSG00000148358 E033 154.6232818 2.685294e-04 1.348040e-01 3.393790e-01 9 130127483 130127566 84 + 2.208 2.166 -0.143
ENSG00000148358 E034 206.0788828 2.898866e-04 4.881135e-01 6.927428e-01 9 130128640 130128761 122 + 2.320 2.303 -0.057
ENSG00000148358 E035 19.0278321 4.323964e-02 9.558363e-02 2.740678e-01 9 130128762 130129590 829 + 1.170 1.399 0.800
ENSG00000148358 E036 10.6180392 3.273313e-03 7.096684e-03 4.506020e-02 9 130129591 130129987 397 + 0.900 1.180 1.025
ENSG00000148358 E037 1.0470130 1.775529e-02 5.931326e-01   9 130129988 130130024 37 + 0.280 0.375 0.598
ENSG00000148358 E038 5.1961272 2.223727e-01 2.018825e-01 4.319847e-01 9 130130197 130130302 106 + 0.632 0.933 1.205
ENSG00000148358 E039 3.7449309 1.614572e-01 2.130360e-01 4.453056e-01 9 130130303 130130379 77 + 0.531 0.807 1.173
ENSG00000148358 E040 4.9362827 6.000576e-03 1.566072e-01 3.717011e-01 9 130132986 130133236 251 + 0.665 0.858 0.774
ENSG00000148358 E041 1469.6548275 8.877211e-05 8.252200e-01 9.110380e-01 9 130135025 130137165 2141 + 3.161 3.165 0.011
ENSG00000148358 E042 464.6830990 4.479092e-04 3.255757e-03 2.493697e-02 9 130137166 130137668 503 + 2.638 2.694 0.186
ENSG00000148358 E043 1366.4882944 1.740893e-04 3.460462e-42 6.678023e-39 9 130137669 130140169 2501 + 3.061 3.199 0.456