ENSG00000147996

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377384 ENSG00000147996 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD5 protein_coding protein_coding 24.53388 16.66714 32.94224 0.1932232 1.431291 0.9825051 9.586413 8.5766939 9.777364 0.5621945 0.7500169 0.1888176 0.41971667 0.51476667 0.29650000 -0.21826667 0.003709808 3.406494e-11 FALSE TRUE
ENST00000382405 ENSG00000147996 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD5 protein_coding protein_coding 24.53388 16.66714 32.94224 0.1932232 1.431291 0.9825051 3.590959 1.0281310 6.895482 0.6222509 0.6521357 2.7337537 0.13388333 0.06096667 0.20933333 0.14836667 0.487418797 3.406494e-11 FALSE TRUE
ENST00000497250 ENSG00000147996 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD5 protein_coding nonsense_mediated_decay 24.53388 16.66714 32.94224 0.1932232 1.431291 0.9825051 2.094633 0.3331911 2.793148 0.3331911 0.1722296 3.0299636 0.07617083 0.01973333 0.08470000 0.06496667 0.250436378 3.406494e-11 TRUE TRUE
MSTRG.32813.5 ENSG00000147996 HEK293_OSMI2_6hA HEK293_TMG_6hB CBWD5 protein_coding   24.53388 16.66714 32.94224 0.1932232 1.431291 0.9825051 1.691231 1.6616256 2.251723 0.1761746 1.1804138 0.4361706 0.07154167 0.09996667 0.06706667 -0.03290000 0.846108222 3.406494e-11 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147996 E001 0.6072928 0.0198002081 6.047710e-01   9 65668805 65669071 267 + 0.175 0.265 0.763
ENSG00000147996 E002 0.1614157 0.0340101539 8.203059e-01   9 65675834 65675836 3 + 0.096 0.000 -11.486
ENSG00000147996 E003 0.3393995 0.0274424043 3.954984e-01   9 65675837 65675857 21 + 0.175 0.000 -12.464
ENSG00000147996 E004 1.3333798 0.0138029284 4.596696e-01   9 65675858 65675874 17 + 0.299 0.429 0.766
ENSG00000147996 E005 4.6837425 0.0152995046 4.405321e-02 1.652438e-01 9 65675875 65675893 19 + 0.625 0.909 1.147
ENSG00000147996 E006 5.2070953 0.0219595762 6.793849e-02 2.204593e-01 9 65675894 65675895 2 + 0.673 0.931 1.024
ENSG00000147996 E007 15.4946411 0.0024812945 1.051034e-01 2.908230e-01 9 65675896 65675905 10 + 1.150 1.289 0.493
ENSG00000147996 E008 32.9573212 0.0015464693 6.802607e-02 2.206397e-01 9 65675906 65675923 18 + 1.477 1.588 0.382
ENSG00000147996 E009 37.3856875 0.0011004365 9.200191e-02 2.674250e-01 9 65675924 65675924 1 + 1.537 1.633 0.328
ENSG00000147996 E010 50.3527591 0.0007380675 1.761662e-01 3.986658e-01 9 65675925 65675927 3 + 1.675 1.742 0.226
ENSG00000147996 E011 55.8153788 0.0007158719 9.929656e-02 2.805531e-01 9 65675928 65675929 2 + 1.714 1.791 0.261
ENSG00000147996 E012 67.2488077 0.0006997273 1.656897e-01 3.847373e-01 9 65675930 65675937 8 + 1.802 1.862 0.201
ENSG00000147996 E013 86.0903468 0.0004814634 1.090287e-01 2.974515e-01 9 65675938 65675940 3 + 1.905 1.964 0.201
ENSG00000147996 E014 120.0207781 0.0003529022 4.971847e-02 1.789786e-01 9 65675941 65675986 46 + 2.047 2.108 0.204
ENSG00000147996 E015 121.6427512 0.0003694095 4.022773e-02 1.552741e-01 9 65675987 65676130 144 + 2.052 2.115 0.212
ENSG00000147996 E016 2.8332118 0.1028959894 1.959883e-02 9.454949e-02 9 65677128 65677225 98 + 0.349 0.808 2.139
ENSG00000147996 E017 0.0000000       9 65677226 65677229 4 +      
ENSG00000147996 E018 37.5929481 0.0029900012 1.771234e-04 2.415720e-03 9 65679166 65679252 87 + 1.477 1.700 0.762
ENSG00000147996 E019 0.0000000       9 65679253 65679544 292 +      
ENSG00000147996 E020 17.9623933 0.0024493564 4.008693e-02 1.549419e-01 9 65681574 65681614 41 + 1.193 1.359 0.582
ENSG00000147996 E021 20.3386290 0.0021791611 2.021954e-01 4.323722e-01 9 65681615 65681670 56 + 1.353 1.251 -0.358
ENSG00000147996 E022 13.5639941 0.0029055129 1.129559e-02 6.358772e-02 9 65681671 65682577 907 + 1.227 0.973 -0.917
ENSG00000147996 E023 42.5684629 0.0010228059 1.242257e-05 2.531060e-04 9 65682766 65682857 92 + 1.708 1.452 -0.873
ENSG00000147996 E024 0.1614157 0.0340101539 8.203059e-01   9 65682858 65683342 485 + 0.096 0.000 -11.486
ENSG00000147996 E025 0.0000000       9 65688401 65689021 621 +      
ENSG00000147996 E026 0.4952057 0.2997797296 1.000000e+00   9 65690556 65690601 46 + 0.175 0.153 -0.231
ENSG00000147996 E027 45.5932014 0.0010034789 2.869684e-07 9.475759e-06 9 65690967 65691026 60 + 1.746 1.452 -1.004
ENSG00000147996 E028 21.7853488 0.0015369458 1.861647e-05 3.595888e-04 9 65692571 65692608 38 + 1.447 1.091 -1.251
ENSG00000147996 E029 2.0653341 0.0691866557 7.317645e-01 8.553006e-01 9 65693386 65693392 7 + 0.506 0.430 -0.383
ENSG00000147996 E030 3.5463379 0.0190490651 9.796163e-01 9.916275e-01 9 65693393 65693473 81 + 0.649 0.641 -0.036
ENSG00000147996 E031 0.5365243 0.0237459082 3.030317e-01   9 65694905 65695044 140 + 0.096 0.265 1.766
ENSG00000147996 E032 0.0000000       9 65695045 65695049 5 +      
ENSG00000147996 E033 18.1813259 0.0019157268 1.704643e-03 1.504848e-02 9 65698515 65698561 47 + 1.353 1.076 -0.980
ENSG00000147996 E034 5.6145861 0.0051427036 1.618874e-01 3.795588e-01 9 65700251 65700286 36 + 0.872 0.679 -0.770
ENSG00000147996 E035 5.7179976 0.0054388380 1.034438e-01 2.879622e-01 9 65700287 65700337 51 + 0.899 0.679 -0.877
ENSG00000147996 E036 1.7836491 0.0164765308 1.865363e-01 4.124813e-01 9 65700338 65701415 1078 + 0.509 0.265 -1.403
ENSG00000147996 E037 6.6764877 0.0392828886 1.645106e-01 3.833919e-01 9 65702970 65703014 45 + 0.940 0.718 -0.867
ENSG00000147996 E038 6.8826161 0.0589437607 3.571973e-01 5.934299e-01 9 65703015 65704330 1316 + 0.937 0.784 -0.591
ENSG00000147996 E039 0.9654734 0.1041412790 8.577984e-01   9 65704331 65704414 84 + 0.300 0.264 -0.251
ENSG00000147996 E040 1.1496142 0.1260044451 6.773197e-01   9 65704415 65704547 133 + 0.350 0.266 -0.553
ENSG00000147996 E041 0.6841482 0.1510105897 6.348193e-01   9 65704548 65704588 41 + 0.176 0.266 0.765
ENSG00000147996 E042 1.1120522 0.0461809463 6.626087e-01   9 65704589 65704923 335 + 0.349 0.265 -0.551
ENSG00000147996 E043 5.6515485 0.0052935282 2.481368e-02 1.116540e-01 9 65706433 65707012 580 + 0.913 0.596 -1.288
ENSG00000147996 E044 2.6558865 0.0234419480 9.637309e-02 2.753936e-01 9 65707013 65707152 140 + 0.649 0.354 -1.457
ENSG00000147996 E045 3.6883229 0.0078317895 3.145897e-02 1.316590e-01 9 65707153 65708139 987 + 0.774 0.428 -1.560
ENSG00000147996 E046 10.1917619 0.0037628069 5.958730e-03 3.952861e-02 9 65708140 65708901 762 + 1.127 0.810 -1.183
ENSG00000147996 E047 2.9428212 0.0370752693 1.433013e-02 7.562633e-02 9 65708902 65708905 4 + 0.716 0.264 -2.330
ENSG00000147996 E048 5.2714140 0.0316672709 2.992695e-01 5.396996e-01 9 65708906 65708958 53 + 0.842 0.679 -0.655
ENSG00000147996 E049 2.1236458 0.0100927227 5.106435e-01 7.084713e-01 9 65719385 65719954 570 + 0.437 0.547 0.540
ENSG00000147996 E050 1.3375613 0.0246751999 3.388874e-02   9 65719955 65720040 86 + 0.175 0.547 2.346
ENSG00000147996 E051 8.4851928 0.0045929007 9.971230e-01 1.000000e+00 9 65720041 65720092 52 + 0.974 0.973 -0.002
ENSG00000147996 E052 0.1779838 0.0328030298 8.206366e-01   9 65723084 65723129 46 + 0.096 0.000 -11.493
ENSG00000147996 E053 0.1723744 0.0331379426 2.873854e-01   9 65731336 65731629 294 + 0.000 0.152 11.611
ENSG00000147996 E054 7.2868651 0.0044017251 9.756726e-01 9.896494e-01 9 65731630 65731698 69 + 0.913 0.910 -0.011
ENSG00000147996 E055 13.2732858 0.0023889128 6.960552e-01 8.329776e-01 9 65731802 65731867 66 + 1.158 1.120 -0.134
ENSG00000147996 E056 0.4341107 0.0217681645 2.977162e-02   9 65731868 65732692 825 + 0.000 0.354 13.167
ENSG00000147996 E057 1.5695579 0.0122305206 3.898439e-02 1.521407e-01 9 65732693 65732946 254 + 0.241 0.595 1.982
ENSG00000147996 E058 1.5753550 0.0131194598 4.199369e-01 6.436151e-01 9 65732947 65732992 46 + 0.350 0.491 0.758
ENSG00000147996 E059 22.4927606 0.0026335694 2.648415e-01 5.041607e-01 9 65732993 65733122 130 + 1.386 1.299 -0.303
ENSG00000147996 E060 1.4630802 0.0147500962 2.740914e-01 5.140592e-01 9 65733123 65733509 387 + 0.299 0.491 1.080
ENSG00000147996 E061 26.5217364 0.0061848280 1.459925e-03 1.333309e-02 9 65733510 65734041 532 + 1.503 1.241 -0.910