ENSG00000147894

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379997 ENSG00000147894 HEK293_OSMI2_6hA HEK293_TMG_6hB C9orf72 protein_coding protein_coding 4.3294 0.9329076 8.131019 0.2582745 0.2904513 3.110021 0.5758606 0.1091767 1.0255989 0.04990102 0.07668243 3.1192908 0.11673333 0.10156667 0.1258000 0.024233333 0.94172472 0.01515758 FALSE TRUE
ENST00000380003 ENSG00000147894 HEK293_OSMI2_6hA HEK293_TMG_6hB C9orf72 protein_coding protein_coding 4.3294 0.9329076 8.131019 0.2582745 0.2904513 3.110021 2.7401942 0.6146377 4.9750592 0.22842195 0.28069522 2.9965192 0.66765000 0.60006667 0.6114333 0.011366667 1.00000000 0.01515758 FALSE TRUE
ENST00000488117 ENSG00000147894 HEK293_OSMI2_6hA HEK293_TMG_6hB C9orf72 protein_coding processed_transcript 4.3294 0.9329076 8.131019 0.2582745 0.2904513 3.110021 0.4076871 0.0371273 0.8663552 0.01892911 0.06296166 4.2168808 0.08430417 0.05736667 0.1073333 0.049966667 0.58521766 0.01515758 TRUE TRUE
ENST00000644136 ENSG00000147894 HEK293_OSMI2_6hA HEK293_TMG_6hB C9orf72 protein_coding protein_coding 4.3294 0.9329076 8.131019 0.2582745 0.2904513 3.110021 0.4200155 0.0551639 0.9262526 0.03641762 0.30941939 3.8447529 0.06652917 0.11030000 0.1125333 0.002233333 0.90008628 0.01515758 FALSE TRUE
ENST00000673600 ENSG00000147894 HEK293_OSMI2_6hA HEK293_TMG_6hB C9orf72 protein_coding nonsense_mediated_decay 4.3294 0.9329076 8.131019 0.2582745 0.2904513 3.110021 0.1250265 0.1168020 0.1883944 0.02739499 0.04042562 0.6457933 0.05395833 0.13076667 0.0236000 -0.107166667 0.01515758 0.01515758 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147894 E001 1.8337471 0.0425591916 3.544801e-06 8.576559e-05 9 27535640 27536286 647 - 0.126 0.928 4.473
ENSG00000147894 E002 0.1614157 0.0383265547 6.732152e-01   9 27546546 27546554 9 - 0.046 0.000 -9.754
ENSG00000147894 E003 39.5617886 0.0009370367 4.491216e-04 5.215123e-03 9 27546555 27547107 553 - 1.376 1.630 0.871
ENSG00000147894 E004 95.3278692 0.0004754828 4.458558e-03 3.170445e-02 9 27547108 27548114 1007 - 1.766 1.902 0.460
ENSG00000147894 E005 49.2559029 0.0008108470 4.062008e-01 6.331903e-01 9 27548115 27548418 304 - 1.497 1.559 0.210
ENSG00000147894 E006 13.0650908 0.0026034164 2.808482e-01 5.211028e-01 9 27548419 27548422 4 - 0.979 0.817 -0.618
ENSG00000147894 E007 30.5672700 0.0016556811 8.215479e-01 9.088692e-01 9 27548557 27548666 110 - 1.308 1.330 0.078
ENSG00000147894 E008 18.5830655 0.0021914440 5.199774e-01 7.149771e-01 9 27550650 27550707 58 - 1.099 1.173 0.265
ENSG00000147894 E009 1.3933773 0.0133859539 3.272928e-01 5.664054e-01 9 27554593 27554625 33 - 0.252 0.455 1.238
ENSG00000147894 E010 0.1308682 0.0326491905 3.601829e-02   9 27556456 27556560 105 - 0.000 0.284 13.577
ENSG00000147894 E011 35.1774329 0.0011797908 1.653516e-01 3.844222e-01 9 27556561 27556796 236 - 1.378 1.247 -0.458
ENSG00000147894 E012 27.4866331 0.0013008050 7.587240e-02 2.365065e-01 9 27558491 27558607 117 - 1.281 1.083 -0.702
ENSG00000147894 E013 19.8768211 0.0022798318 9.235376e-02 2.681036e-01 9 27558608 27560226 1619 - 1.147 0.925 -0.814
ENSG00000147894 E014 23.7910360 0.0018723101 3.908075e-01 6.210026e-01 9 27560227 27560299 73 - 1.211 1.115 -0.343
ENSG00000147894 E015 15.8807147 0.0021615588 6.845483e-01 8.256420e-01 9 27560501 27561548 1048 - 1.032 1.084 0.187
ENSG00000147894 E016 2.0895524 0.0099365553 1.868396e-01 4.128348e-01 9 27561549 27561584 36 - 0.391 0.000 -13.128
ENSG00000147894 E017 23.6896566 0.0020295770 9.495143e-01 9.767835e-01 9 27561585 27561649 65 - 1.205 1.199 -0.021
ENSG00000147894 E018 30.8503241 0.0016726839 4.789508e-01 6.864130e-01 9 27562381 27562476 96 - 1.317 1.248 -0.244
ENSG00000147894 E019 27.2427341 0.0015396621 2.378657e-02 1.084460e-01 9 27565531 27565590 60 - 1.278 1.012 -0.954
ENSG00000147894 E020 64.8146448 0.0011898256 5.689356e-03 3.818734e-02 9 27566677 27567164 488 - 1.636 1.431 -0.702
ENSG00000147894 E021 0.3393995 0.0255753829 1.000000e+00   9 27571136 27571260 125 - 0.088 0.000 -10.740
ENSG00000147894 E022 14.9834160 0.0037195074 4.740755e-01 6.828874e-01 9 27573431 27573494 64 - 1.023 0.925 -0.366
ENSG00000147894 E023 0.4986023 0.0388115642 1.000000e+00   9 27573709 27573723 15 - 0.126 0.000 -11.258
ENSG00000147894 E024 0.4986023 0.0388115642 1.000000e+00   9 27573724 27573786 63 - 0.126 0.000 -11.258
ENSG00000147894 E025 0.3393995 0.0255753829 1.000000e+00   9 27573787 27573866 80 - 0.088 0.000 -10.740