ENSG00000147854

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276893 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding protein_coding 11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 2.4403762 1.1973206 3.8508984 0.25196086 0.46573821 1.67712770 0.20053333 0.22210000 0.171466667 -0.050633333 8.644204e-01 3.416084e-10 FALSE TRUE
ENST00000381373 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding protein_coding 11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 1.3156827 1.1369527 1.0930127 0.21836273 0.32178163 -0.05635637 0.17126250 0.20613333 0.048133333 -0.158000000 5.923670e-03 3.416084e-10 FALSE TRUE
ENST00000481243 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding processed_transcript 11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 0.5037727 0.7074969 0.1720491 0.42505048 0.05503691 -1.97864499 0.07395417 0.12510000 0.007466667 -0.117633333 5.014529e-01 3.416084e-10   FALSE
ENST00000484159 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding retained_intron 11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 1.6563595 0.4105865 3.9413526 0.05854179 0.32243036 3.23187220 0.11153750 0.07490000 0.175533333 0.100633333 4.625295e-02 3.416084e-10 FALSE TRUE
ENST00000485617 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding processed_transcript 11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 0.8608855 0.3682787 1.5772302 0.08665957 0.19029913 2.06899001 0.06909583 0.06813333 0.070266667 0.002133333 1.000000e+00 3.416084e-10   FALSE
ENST00000492853 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding processed_transcript 11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 0.7485896 0.3114899 1.6639649 0.07658658 0.18930363 2.38042389 0.05891250 0.05726667 0.074200000 0.016933333 8.824212e-01 3.416084e-10 TRUE FALSE
MSTRG.32374.12 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding   11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 0.6805081 0.3388733 1.3770510 0.19082870 0.24994802 1.99124584 0.06186250 0.06440000 0.060733333 -0.003666667 9.419291e-01 3.416084e-10 TRUE TRUE
MSTRG.32374.2 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding   11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 1.0201455 0.5762963 2.0192872 0.29926571 0.22629924 1.79127120 0.07770833 0.10683333 0.089300000 -0.017533333 9.805928e-01 3.416084e-10 FALSE TRUE
MSTRG.32374.5 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding   11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 0.9485009 0.0000000 3.3109686 0.00000000 0.61941965 8.37546027 0.05939167 0.00000000 0.144666667 0.144666667 3.416084e-10 3.416084e-10 FALSE TRUE
MSTRG.32374.6 ENSG00000147854 HEK293_OSMI2_6hA HEK293_TMG_6hB UHRF2 protein_coding   11.82153 5.461142 22.64718 0.1948135 0.8386834 2.050054 0.7438513 0.2312777 1.6929446 0.15487589 0.23223465 2.81926485 0.05010417 0.04090000 0.075666667 0.034766667 6.729947e-01 3.416084e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147854 E001 1.4317472 0.1443863388 1.488606e-01 3.606801e-01 9 6413151 6413192 42 + 0.385 0.000 -10.946
ENSG00000147854 E002 1.4317472 0.1443863388 1.488606e-01 3.606801e-01 9 6413193 6413198 6 + 0.385 0.000 -13.070
ENSG00000147854 E003 1.7655372 0.1903513701 4.842229e-01 6.899812e-01 9 6413199 6413209 11 + 0.413 0.220 -1.264
ENSG00000147854 E004 5.8124006 0.0140999046 9.712424e-01 9.874476e-01 9 6413210 6413355 146 + 0.759 0.748 -0.046
ENSG00000147854 E005 4.6910125 0.0054311154 2.061832e-03 1.747238e-02 9 6413356 6413394 39 + 0.548 0.980 1.753
ENSG00000147854 E006 4.6454422 0.0112841368 4.698411e-02 1.725198e-01 9 6413395 6413417 23 + 0.586 0.880 1.206
ENSG00000147854 E007 10.8098327 0.0029026190 9.637198e-01 9.837635e-01 9 6413418 6413482 65 + 0.980 0.980 -0.002
ENSG00000147854 E008 39.5944537 0.0147724447 1.420998e-01 3.505657e-01 9 6413483 6413643 161 + 1.486 1.601 0.395
ENSG00000147854 E009 0.0000000       9 6413777 6413911 135 +      
ENSG00000147854 E010 0.0000000       9 6414058 6414168 111 +      
ENSG00000147854 E011 56.1982497 0.0007639342 1.742047e-02 8.699798e-02 9 6420912 6421030 119 + 1.630 1.755 0.422
ENSG00000147854 E012 61.3046370 0.0007239925 4.464143e-03 3.173752e-02 9 6421031 6421142 112 + 1.664 1.807 0.483
ENSG00000147854 E013 10.8220192 0.1024375473 1.235741e-04 1.781622e-03 9 6422635 6422979 345 + 0.722 1.433 2.609
ENSG00000147854 E014 54.7221946 0.0009221173 2.487346e-02 1.118430e-01 9 6433914 6434087 174 + 1.677 1.529 -0.504
ENSG00000147854 E015 40.0916478 0.0008632719 6.611281e-02 2.163457e-01 9 6434088 6434173 86 + 1.543 1.403 -0.481
ENSG00000147854 E016 0.0000000       9 6434174 6434348 175 +      
ENSG00000147854 E017 75.5754684 0.0005508424 4.021699e-03 2.928687e-02 9 6460573 6460791 219 + 1.815 1.653 -0.548
ENSG00000147854 E018 3.2779124 0.0076781891 6.596406e-02 2.160632e-01 9 6464553 6464598 46 + 0.604 0.219 -2.197
ENSG00000147854 E019 11.9955610 0.0592775133 9.879836e-01 9.958188e-01 9 6465744 6465846 103 + 1.023 1.034 0.042
ENSG00000147854 E020 54.6549336 0.0102636704 4.973825e-02 1.790010e-01 9 6475391 6475500 110 + 1.678 1.514 -0.560
ENSG00000147854 E021 83.6099045 0.0107281157 1.523441e-01 3.657505e-01 9 6477622 6477808 187 + 1.852 1.744 -0.363
ENSG00000147854 E022 63.0491783 0.0009429994 1.186744e-01 3.136704e-01 9 6481643 6481766 124 + 1.730 1.634 -0.328
ENSG00000147854 E023 51.9989131 0.0009809037 4.633995e-02 1.708960e-01 9 6481992 6482050 59 + 1.655 1.521 -0.458
ENSG00000147854 E024 44.5826981 0.0008725204 1.062554e-03 1.039077e-02 9 6482051 6482099 49 + 1.602 1.356 -0.846
ENSG00000147854 E025 1.2437282 0.0150828824 6.248816e-01   9 6484597 6484686 90 + 0.324 0.219 -0.753
ENSG00000147854 E026 55.4092019 0.0025677627 1.290687e-02 7.007972e-02 9 6486821 6486870 50 + 1.685 1.512 -0.589
ENSG00000147854 E027 61.0546972 0.0042878905 1.543363e-02 7.971849e-02 9 6486871 6486925 55 + 1.725 1.554 -0.581
ENSG00000147854 E028 4.0643568 0.0061240269 3.408019e-01 5.787582e-01 9 6492303 6492401 99 + 0.652 0.473 -0.822
ENSG00000147854 E029 0.1614157 0.0322394535 1.000000e+00   9 6492402 6492844 443 + 0.064 0.000 -10.599
ENSG00000147854 E030 73.4792536 0.0017421746 6.142969e-02 2.059781e-01 9 6493826 6493932 107 + 1.796 1.684 -0.378
ENSG00000147854 E031 114.6347878 0.0136472451 7.442546e-03 4.676492e-02 9 6493933 6495584 1652 + 1.997 1.796 -0.675
ENSG00000147854 E032 88.4264761 0.0069393147 7.241603e-02 2.296104e-01 9 6495585 6496959 1375 + 1.875 1.758 -0.394
ENSG00000147854 E033 20.4599070 0.0018873738 7.596235e-01 8.723619e-01 9 6496960 6497048 89 + 1.235 1.257 0.078
ENSG00000147854 E034 16.2319937 0.0022925685 6.872044e-01 8.273061e-01 9 6497049 6497103 55 + 1.156 1.108 -0.173
ENSG00000147854 E035 60.7327423 0.0006392502 9.983130e-01 1.000000e+00 9 6497198 6497268 71 + 1.696 1.690 -0.021
ENSG00000147854 E036 64.0806517 0.0005903850 9.816924e-01 9.926285e-01 9 6497269 6497360 92 + 1.718 1.712 -0.017
ENSG00000147854 E037 78.9829978 0.0004619855 8.573755e-02 2.559182e-01 9 6498018 6498158 141 + 1.790 1.865 0.252
ENSG00000147854 E038 36.2243648 0.0208892654 6.014554e-01 7.711280e-01 9 6498352 6499834 1483 + 1.484 1.424 -0.206
ENSG00000147854 E039 68.6475964 0.0005370888 3.172210e-02 1.323980e-01 9 6499835 6499931 97 + 1.723 1.824 0.342
ENSG00000147854 E040 92.5393191 0.0005815470 7.400921e-02 2.328011e-01 9 6500552 6500709 158 + 1.857 1.930 0.243
ENSG00000147854 E041 2.0101536 0.0105203670 6.252436e-01 7.874690e-01 9 6504350 6504592 243 + 0.385 0.473 0.468
ENSG00000147854 E042 73.7918702 0.0013786416 1.101976e-02 6.245109e-02 9 6504593 6504691 99 + 1.753 1.872 0.404
ENSG00000147854 E043 263.3261962 0.0002793950 4.174875e-10 2.598936e-08 9 6506033 6507054 1022 + 2.290 2.435 0.485