ENSG00000147533

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357743 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 4.121497 2.230924 4.829754 0.2322466 0.4156889 1.1108399 0.13618750 0.16430000 0.10466667 -0.0596333333 3.997283e-01 3.28238e-06 FALSE TRUE
ENST00000405786 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 7.452007 2.903633 12.068641 0.1761062 0.6298093 2.0515671 0.24187917 0.21190000 0.26180000 0.0499000000 6.006149e-01 3.28238e-06 FALSE FALSE
ENST00000520817 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 3.438890 2.171779 8.106055 2.1717792 4.1795163 1.8952736 0.11167500 0.14663333 0.16890000 0.0222666667 6.867760e-01 3.28238e-06 FALSE FALSE
ENST00000687203 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 4.748463 2.190027 3.223202 0.1608686 1.7356495 0.5554425 0.14393750 0.15906667 0.07130000 -0.0877666667 7.571646e-01 3.28238e-06 FALSE TRUE
ENST00000694875 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 3.954504 0.000000 11.352078 0.0000000 4.0756666 10.1500111 0.09571667 0.00000000 0.24896667 0.2489666667 3.282380e-06 3.28238e-06 FALSE TRUE
ENST00000694887 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 1.864902 0.526405 1.671449 0.5264050 1.2276425 1.6483106 0.06081250 0.03813333 0.03846667 0.0003333333 8.330855e-01 3.28238e-06 FALSE TRUE
ENST00000694913 ENSG00000147533 HEK293_OSMI2_6hA HEK293_TMG_6hB GOLGA7 protein_coding protein_coding 31.25118 13.75951 46.16776 0.6204525 1.80296 1.745721 2.075332 2.416124 0.000000 1.2110131 0.0000000 -7.9225097 0.09447917 0.18323333 0.00000000 -0.1832333333 1.604960e-01 3.28238e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147533 E001 0.0000000       8 41488200 41488461 262 +      
ENSG00000147533 E002 0.0000000       8 41490292 41490305 14 +      
ENSG00000147533 E003 0.0000000       8 41490306 41490395 90 +      
ENSG00000147533 E004 0.1426347 0.030603932 1.00000000   8 41490396 41490426 31 + 0.080 0.000 -23.314
ENSG00000147533 E005 0.3040503 0.024441170 0.54441324   8 41490427 41490447 21 + 0.148 0.000 -24.310
ENSG00000147533 E006 0.3040503 0.024441170 0.54441324   8 41490448 41490449 2 + 0.148 0.000 -24.310
ENSG00000147533 E007 0.3040503 0.024441170 0.54441324   8 41490450 41490455 6 + 0.148 0.000 -24.310
ENSG00000147533 E008 1.6176690 0.023397753 0.97716845 0.99035388 8 41490456 41490500 45 + 0.385 0.403 0.100
ENSG00000147533 E009 1.4750344 0.088748799 0.91417979 0.95919231 8 41490501 41490518 18 + 0.349 0.403 0.313
ENSG00000147533 E010 2.0823272 0.020038143 0.55214357 0.73778583 8 41490519 41490545 27 + 0.420 0.550 0.644
ENSG00000147533 E011 2.1011082 0.087871184 0.64353715 0.79921880 8 41490546 41490558 13 + 0.422 0.549 0.630
ENSG00000147533 E012 2.0823272 0.020038143 0.55214357 0.73778583 8 41490559 41490561 3 + 0.420 0.550 0.644
ENSG00000147533 E013 3.5096487 0.032886159 0.43700976 0.65646798 8 41490562 41490566 5 + 0.650 0.550 -0.445
ENSG00000147533 E014 2.2832965 0.152256798 0.21960267 0.45293283 8 41490567 41490567 1 + 0.541 0.304 -1.287
ENSG00000147533 E015 10.8233802 0.053922432 0.24913054 0.48692308 8 41490568 41490578 11 + 1.065 0.939 -0.468
ENSG00000147533 E016 11.7922502 0.072603977 0.24122002 0.47795907 8 41490579 41490581 3 + 1.103 0.962 -0.516
ENSG00000147533 E017 14.8218900 0.064226126 0.31300752 0.55331034 8 41490582 41490585 4 + 1.186 1.086 -0.358
ENSG00000147533 E018 33.5499320 0.029525802 0.07835841 0.24151973 8 41490586 41490592 7 + 1.533 1.399 -0.461
ENSG00000147533 E019 55.7676160 0.038788072 0.33771043 0.57606773 8 41490593 41490606 14 + 1.726 1.680 -0.156
ENSG00000147533 E020 62.5162283 0.037963350 0.35554630 0.59218787 8 41490607 41490611 5 + 1.773 1.733 -0.136
ENSG00000147533 E021 63.9309755 0.040101750 0.37511150 0.60826675 8 41490612 41490613 2 + 1.782 1.744 -0.128
ENSG00000147533 E022 63.7659755 0.037416083 0.43103638 0.65193480 8 41490614 41490615 2 + 1.777 1.752 -0.086
ENSG00000147533 E023 63.7659755 0.037416083 0.43103638 0.65193480 8 41490616 41490617 2 + 1.777 1.752 -0.086
ENSG00000147533 E024 2.0823272 0.020038143 0.55214357 0.73778583 8 41490618 41490648 31 + 0.420 0.550 0.644
ENSG00000147533 E025 2.0823272 0.020038143 0.55214357 0.73778583 8 41490649 41490657 9 + 0.420 0.550 0.644
ENSG00000147533 E026 2.5338139 0.033005641 0.59876674 0.76941095 8 41490658 41490689 32 + 0.483 0.608 0.580
ENSG00000147533 E027 1.7734752 0.013933859 0.66653455 0.81399790 8 41490690 41490701 12 + 0.385 0.483 0.517
ENSG00000147533 E028 10.8673978 0.007195848 0.01063593 0.06083616 8 41490702 41490791 90 + 0.921 1.226 1.110
ENSG00000147533 E029 14.6200950 0.007196329 0.29649166 0.53701542 8 41490792 41490822 31 + 1.114 1.251 0.488
ENSG00000147533 E030 14.7647548 0.002928017 0.19909173 0.42857050 8 41490823 41490832 10 + 1.115 1.264 0.530
ENSG00000147533 E031 110.0046682 0.039359840 0.54511691 0.73276703 8 41490833 41490869 37 + 2.004 2.004 0.000
ENSG00000147533 E032 192.6572479 0.031611849 0.36049573 0.59607487 8 41490870 41490965 96 + 2.249 2.235 -0.048
ENSG00000147533 E033 1.3769112 0.026226026 0.06414248   8 41497214 41497508 295 + 0.207 0.552 2.070
ENSG00000147533 E034 295.6797888 0.027370566 0.17145646 0.39246866 8 41497509 41497661 153 + 2.442 2.402 -0.132
ENSG00000147533 E035 0.4952057 0.157718028 0.88372854   8 41497662 41497709 48 + 0.149 0.180 0.328
ENSG00000147533 E036 0.1426347 0.030603932 1.00000000   8 41502557 41502568 12 + 0.080 0.000 -23.309
ENSG00000147533 E037 0.8192208 0.404459064 0.19936683   8 41502569 41502654 86 + 0.307 0.000 -25.648
ENSG00000147533 E038 0.6765862 0.561189463 0.32277972   8 41502655 41502656 2 + 0.264 0.000 -25.347
ENSG00000147533 E039 0.8545700 0.749907136 0.33269199   8 41502657 41502775 119 + 0.314 0.000 -25.689
ENSG00000147533 E040 2.9962456 0.132073382 0.57498250 0.75365658 8 41505273 41505910 638 + 0.515 0.662 0.660
ENSG00000147533 E041 245.0499496 0.005290077 0.14226042 0.35078758 8 41505911 41506012 102 + 2.354 2.341 -0.042
ENSG00000147533 E042 14.3264302 0.003036043 0.02260089 0.10459982 8 41506013 41507053 1041 + 1.195 0.986 -0.755
ENSG00000147533 E043 16.1503339 0.002444018 0.17327772 0.39487054 8 41507054 41507058 5 + 1.222 1.123 -0.355
ENSG00000147533 E044 194.2665543 0.010294570 0.23245471 0.46800977 8 41507059 41507121 63 + 2.224 2.309 0.284
ENSG00000147533 E045 1.4648835 0.022038599 0.02305442 0.10612808 8 41507122 41507195 74 + 0.453 0.000 -26.483
ENSG00000147533 E046 17.1788151 0.108235049 0.34504029 0.58261936 8 41507196 41509269 2074 + 1.244 1.136 -0.381
ENSG00000147533 E047 3.1412471 0.094155429 0.06986747 0.22453500 8 41509270 41509356 87 + 0.652 0.308 -1.759
ENSG00000147533 E048 4.8873112 0.159904219 0.84319211 0.92124897 8 41509357 41509583 227 + 0.725 0.751 0.108
ENSG00000147533 E049 776.9803610 0.973149264 0.42969724 0.65079489 8 41509584 41511095 1512 + 2.804 2.943 0.464