ENSG00000147526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000276520 ENSG00000147526 HEK293_OSMI2_6hA HEK293_TMG_6hB TACC1 protein_coding protein_coding 6.766722 3.570048 7.762986 0.4275973 0.6087694 1.11849 0.7923758 0.5951097 0.8829896 0.2642862 0.11907591 0.5614467 0.13207083 0.15753333 0.1158000 -0.04173333 0.951130508 0.008934524 FALSE TRUE
ENST00000317827 ENSG00000147526 HEK293_OSMI2_6hA HEK293_TMG_6hB TACC1 protein_coding protein_coding 6.766722 3.570048 7.762986 0.4275973 0.6087694 1.11849 2.4918449 0.7327093 2.8712711 0.1939755 0.54594155 1.9558359 0.31199583 0.22103333 0.3696333 0.14860000 0.615878672 0.008934524 FALSE TRUE
ENST00000521866 ENSG00000147526 HEK293_OSMI2_6hA HEK293_TMG_6hB TACC1 protein_coding protein_coding 6.766722 3.570048 7.762986 0.4275973 0.6087694 1.11849 0.1158053 0.2472214 0.1518764 0.1287647 0.15187641 -0.6681182 0.02155417 0.07873333 0.0195000 -0.05923333 0.663781418 0.008934524 FALSE TRUE
ENST00000522548 ENSG00000147526 HEK293_OSMI2_6hA HEK293_TMG_6hB TACC1 protein_coding retained_intron 6.766722 3.570048 7.762986 0.4275973 0.6087694 1.11849 0.5770327 0.6934543 0.1369186 0.3044738 0.06772904 -2.2594396 0.13234583 0.18163333 0.0167000 -0.16493333 0.008934524 0.008934524   FALSE
MSTRG.31422.11 ENSG00000147526 HEK293_OSMI2_6hA HEK293_TMG_6hB TACC1 protein_coding   6.766722 3.570048 7.762986 0.4275973 0.6087694 1.11849 1.2897583 0.9788231 2.2769448 0.3092224 0.34836575 1.2096372 0.19868750 0.26463333 0.2996667 0.03503333 0.951130508 0.008934524 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147526 E001 0.0000000       8 38728186 38728189 4 +      
ENSG00000147526 E002 0.0000000       8 38728190 38728343 154 +      
ENSG00000147526 E003 0.0000000       8 38728344 38728587 244 +      
ENSG00000147526 E004 0.0000000       8 38728588 38728616 29 +      
ENSG00000147526 E005 0.0000000       8 38728617 38728639 23 +      
ENSG00000147526 E006 0.0000000       8 38728640 38728671 32 +      
ENSG00000147526 E007 0.0000000       8 38728672 38728730 59 +      
ENSG00000147526 E008 0.0000000       8 38742351 38742451 101 +      
ENSG00000147526 E009 0.0000000       8 38744895 38745493 599 +      
ENSG00000147526 E010 0.0000000       8 38757239 38757276 38 +      
ENSG00000147526 E011 0.0000000       8 38757277 38757280 4 +      
ENSG00000147526 E012 0.0000000       8 38757281 38757298 18 +      
ENSG00000147526 E013 0.0000000       8 38757299 38757409 111 +      
ENSG00000147526 E014 0.0000000       8 38785674 38785736 63 +      
ENSG00000147526 E015 0.0000000       8 38785911 38785943 33 +      
ENSG00000147526 E016 2.1666999 0.010039412 4.777867e-01 6.856339e-01 8 38787236 38787262 27 + 0.438 0.587 0.720
ENSG00000147526 E017 11.7735687 0.074981822 7.854562e-01 8.878129e-01 8 38787263 38787513 251 + 1.060 1.137 0.277
ENSG00000147526 E018 8.4817626 0.038724354 8.387398e-01 9.187311e-01 8 38787514 38787556 43 + 0.954 0.959 0.019
ENSG00000147526 E019 22.5889160 0.024592657 8.820702e-01 9.424016e-01 8 38787557 38787743 187 + 1.329 1.385 0.194
ENSG00000147526 E020 0.5067846 0.022460474 1.000000e+00   8 38788106 38788162 57 + 0.157 0.170 0.141
ENSG00000147526 E021 0.6682002 0.024044420 7.240144e-01   8 38788163 38788246 84 + 0.218 0.170 -0.444
ENSG00000147526 E022 0.6847684 0.018674990 7.223350e-01   8 38788247 38788291 45 + 0.218 0.170 -0.446
ENSG00000147526 E023 0.6246688 0.019188181 1.469946e-01   8 38788322 38788360 39 + 0.272 0.000 -11.603
ENSG00000147526 E024 1.1611931 0.014284628 7.855762e-01   8 38788361 38788565 205 + 0.320 0.292 -0.182
ENSG00000147526 E025 0.8217936 0.018718557 7.599186e-01   8 38788566 38788703 138 + 0.218 0.292 0.557
ENSG00000147526 E026 21.7591160 0.001788257 2.402242e-01 4.768235e-01 8 38788704 38788819 116 + 1.344 1.293 -0.178
ENSG00000147526 E027 0.0000000       8 38805450 38805451 2 +      
ENSG00000147526 E028 0.0000000       8 38805452 38805644 193 +      
ENSG00000147526 E029 51.0140195 0.001066946 7.129962e-04 7.550237e-03 8 38819522 38819920 399 + 1.726 1.583 -0.484
ENSG00000147526 E030 49.9272522 0.014956061 2.676277e-01 5.073114e-01 8 38819921 38820243 323 + 1.694 1.650 -0.148
ENSG00000147526 E031 23.2129535 0.001525593 7.891015e-01 8.899369e-01 8 38820244 38820319 76 + 1.349 1.371 0.077
ENSG00000147526 E032 12.8503941 0.002788630 5.159535e-01 7.122135e-01 8 38820320 38820331 12 + 1.120 1.096 -0.085
ENSG00000147526 E033 39.9474916 0.000942841 2.663309e-01 5.058392e-01 8 38820332 38820546 215 + 1.589 1.567 -0.076
ENSG00000147526 E034 28.3879976 0.001664332 4.487561e-03 3.186932e-02 8 38820547 38820635 89 + 1.488 1.324 -0.568
ENSG00000147526 E035 0.9644282 0.043229496 9.916954e-01   8 38823990 38824025 36 + 0.271 0.293 0.150
ENSG00000147526 E036 0.4873834 0.269531299 3.080357e-01   8 38824652 38824762 111 + 0.085 0.294 2.168
ENSG00000147526 E037 17.8793703 0.008047210 1.136972e-02 6.388784e-02 8 38825308 38825310 3 + 1.304 1.096 -0.738
ENSG00000147526 E038 29.1600138 0.003350900 2.660809e-03 2.134366e-02 8 38825311 38825368 58 + 1.498 1.314 -0.637
ENSG00000147526 E039 35.6108738 0.001243452 6.204252e-04 6.755285e-03 8 38827168 38827288 121 + 1.580 1.397 -0.629
ENSG00000147526 E040 18.3441282 0.023181586 4.863624e-02 1.764560e-01 8 38827289 38827375 87 + 1.301 1.118 -0.648
ENSG00000147526 E041 6.1484937 0.481266797 5.940461e-01 7.663730e-01 8 38827376 38828067 692 + 0.798 0.878 0.313
ENSG00000147526 E042 24.8651880 0.001921656 3.295095e-02 1.359267e-01 8 38831125 38831177 53 + 1.415 1.294 -0.423
ENSG00000147526 E043 31.6274389 0.001483228 2.610446e-01 5.000833e-01 8 38836162 38836287 126 + 1.491 1.459 -0.111
ENSG00000147526 E044 0.0000000       8 38836288 38836291 4 +      
ENSG00000147526 E045 28.4070669 0.001423791 2.527810e-01 4.909595e-01 8 38838470 38838546 77 + 1.443 1.405 -0.131
ENSG00000147526 E046 0.5008152 0.038474299 2.549874e-01   8 38839284 38839326 43 + 0.218 0.000 -11.044
ENSG00000147526 E047 1.5077948 0.487761738 6.666829e-01 8.141145e-01 8 38839327 38840050 724 + 0.408 0.296 -0.676
ENSG00000147526 E048 0.5061644 0.299676872 3.234345e-01   8 38840051 38840223 173 + 0.086 0.294 2.154
ENSG00000147526 E049 22.4963887 0.001585149 5.711665e-01 7.511651e-01 8 38840224 38840267 44 + 1.336 1.334 -0.005
ENSG00000147526 E050 0.7013366 0.026411626 7.236821e-01   8 38840268 38840618 351 + 0.218 0.170 -0.446
ENSG00000147526 E051 16.8590438 0.002529423 3.608427e-01 5.963118e-01 8 38842287 38842289 3 + 1.227 1.187 -0.143
ENSG00000147526 E052 40.7435872 0.001552394 6.637094e-01 8.122356e-01 8 38842290 38842447 158 + 1.582 1.600 0.059
ENSG00000147526 E053 37.9095241 0.010477997 9.879276e-01 9.958027e-01 8 38843289 38843395 107 + 1.543 1.584 0.140
ENSG00000147526 E054 0.1779838 0.033210956 1.000000e+00   8 38843396 38843563 168 + 0.086 0.000 -9.549
ENSG00000147526 E055 0.7852767 0.016893548 7.637981e-01   8 38846469 38846698 230 + 0.218 0.291 0.551
ENSG00000147526 E056 40.0930415 0.001514064 9.916781e-01 9.975701e-01 8 38846699 38846819 121 + 1.567 1.610 0.146
ENSG00000147526 E057 624.8630694 0.003455925 2.610857e-07 8.724589e-06 8 38847955 38853028 5074 + 2.714 2.855 0.467