ENSG00000147454

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000290075 ENSG00000147454 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A37 protein_coding nonsense_mediated_decay 10.37728 9.918029 11.93638 0.9921342 0.4069798 0.2669942 1.3055656 1.2074226 1.3677764 0.1447584 0.26044166 0.1785117 0.1263167 0.12513333 0.11590000 -0.009233333 0.97544794 0.02799937 FALSE TRUE
ENST00000518881 ENSG00000147454 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A37 protein_coding retained_intron 10.37728 9.918029 11.93638 0.9921342 0.4069798 0.2669942 3.9393783 3.6599281 3.9286005 0.8489309 0.03063188 0.1019313 0.3791500 0.36013333 0.33006667 -0.030066667 0.92588747 0.02799937 FALSE TRUE
ENST00000519192 ENSG00000147454 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A37 protein_coding processed_transcript 10.37728 9.918029 11.93638 0.9921342 0.4069798 0.2669942 1.2767901 1.6924916 0.7681765 0.4667515 0.22142034 -1.1294784 0.1340417 0.18240000 0.06360000 -0.118800000 0.43967237 0.02799937   FALSE
ENST00000519973 ENSG00000147454 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A37 protein_coding protein_coding 10.37728 9.918029 11.93638 0.9921342 0.4069798 0.2669942 0.8393373 0.8823629 0.7538821 0.1235712 0.19522671 -0.2242806 0.0833375 0.09056667 0.06223333 -0.028333333 0.73554771 0.02799937 FALSE TRUE
ENST00000520654 ENSG00000147454 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC25A37 protein_coding retained_intron 10.37728 9.918029 11.93638 0.9921342 0.4069798 0.2669942 2.6342219 1.9816550 4.8689581 0.5446508 0.23145336 1.2926054 0.2427458 0.19353333 0.40773333 0.214200000 0.02799937 0.02799937 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147454 E001 8.3562589 0.2468603439 5.046185e-02 0.1807471098 8 23528956 23528966 11 + 0.632 1.173 2.081
ENSG00000147454 E002 9.0554211 0.0539634145 1.230770e-04 0.0017758113 8 23528967 23528974 8 + 0.577 1.234 2.540
ENSG00000147454 E003 22.5681474 0.3426547916 7.983439e-02 0.2444854436 8 23528975 23529052 78 + 1.080 1.555 1.664
ENSG00000147454 E004 19.1294460 0.3208476121 1.120170e-01 0.3024430026 8 23529053 23529059 7 + 1.058 1.469 1.449
ENSG00000147454 E005 64.2325554 0.8177662820 3.514474e-01 0.5885920247 8 23529060 23529212 153 + 1.662 1.932 0.914
ENSG00000147454 E006 7.7827233 0.1072640058 6.384865e-02 0.2113474492 8 23531685 23531925 241 + 0.726 1.094 1.401
ENSG00000147454 E007 0.1308682 0.0329838131 4.984703e-01   8 23541470 23541561 92 + 0.000 0.125 10.988
ENSG00000147454 E008 0.1308682 0.0329838131 4.984703e-01   8 23541562 23541686 125 + 0.000 0.125 10.988
ENSG00000147454 E009 0.1723744 0.0326491905 5.009708e-01   8 23541687 23541839 153 + 0.000 0.125 10.995
ENSG00000147454 E010 0.0000000       8 23541840 23541856 17 +      
ENSG00000147454 E011 2.3747833 0.0094642483 5.016764e-01 0.7020005321 8 23543088 23543211 124 + 0.457 0.603 0.689
ENSG00000147454 E012 96.9454350 0.0175009246 3.112255e-01 0.5515996553 8 23566108 23566336 229 + 2.006 1.979 -0.089
ENSG00000147454 E013 71.1425336 0.0034930035 3.901153e-04 0.0046351743 8 23566337 23566512 176 + 1.912 1.790 -0.410
ENSG00000147454 E014 62.5068737 0.0005926126 3.231510e-04 0.0039652079 8 23566513 23566653 141 + 1.851 1.745 -0.360
ENSG00000147454 E015 34.7850673 0.0011370625 7.347229e-03 0.0463064939 8 23566654 23566682 29 + 1.601 1.493 -0.370
ENSG00000147454 E016 54.6517980 0.0009383688 8.490444e-02 0.2544331482 8 23566683 23566775 93 + 1.756 1.726 -0.101
ENSG00000147454 E017 48.7411422 0.0132616080 1.612408e-01 0.3786445911 8 23566776 23566813 38 + 1.717 1.665 -0.174
ENSG00000147454 E018 57.4445887 0.0194351666 2.633204e-01 0.5025100148 8 23566814 23566940 127 + 1.776 1.749 -0.093
ENSG00000147454 E019 33.4528233 0.0092817517 5.875517e-01 0.7620293870 8 23566941 23566965 25 + 1.525 1.536 0.036
ENSG00000147454 E020 286.2921437 0.0021072034 1.330198e-05 0.0002688625 8 23566966 23568258 1293 + 2.483 2.427 -0.187
ENSG00000147454 E021 47.0396210 0.0041469806 2.276991e-01 0.4626253176 8 23568259 23568321 63 + 1.685 1.674 -0.035
ENSG00000147454 E022 55.7100085 0.0006848876 4.080436e-01 0.6345074470 8 23568322 23568378 57 + 1.744 1.758 0.046
ENSG00000147454 E023 45.9491065 0.0010097167 1.396725e-02 0.0742118713 8 23568379 23568965 587 + 1.703 1.629 -0.253
ENSG00000147454 E024 70.9037478 0.0005731131 4.899567e-01 0.6939710713 8 23571335 23571474 140 + 1.812 1.894 0.277
ENSG00000147454 E025 623.4692231 0.0059518192 1.211347e-03 0.0115182576 8 23571475 23575463 3989 + 2.720 2.861 0.469