ENSG00000147364

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350302 ENSG00000147364 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO25 protein_coding protein_coding 6.327646 2.884832 9.165319 0.1340346 0.6564654 1.664279 0.94891663 0.6100725 1.1705786 0.06737758 0.0408632 0.9289853 0.1763875 0.21070000 0.1287333 -0.08196667 2.558189e-01 6.688516e-11 FALSE TRUE
ENST00000352684 ENSG00000147364 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO25 protein_coding protein_coding 6.327646 2.884832 9.165319 0.1340346 0.6564654 1.664279 1.93490517 1.3076562 1.8831028 0.40829350 0.1040587 0.5227788 0.3111125 0.46533333 0.2075667 -0.25776667 5.262832e-01 6.688516e-11 FALSE TRUE
ENST00000518240 ENSG00000147364 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO25 protein_coding protein_coding 6.327646 2.884832 9.165319 0.1340346 0.6564654 1.664279 1.30821451 0.0000000 1.9086873 0.00000000 0.1610591 7.5839758 0.1689042 0.00000000 0.2087333 0.20873333 6.688516e-11 6.688516e-11 FALSE FALSE
ENST00000519376 ENSG00000147364 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO25 protein_coding processed_transcript 6.327646 2.884832 9.165319 0.1340346 0.6564654 1.664279 0.13289272 0.3135462 0.1183413 0.31354617 0.1183413 -1.3339858 0.0289000 0.10300000 0.0138000 -0.08920000 9.369248e-01 6.688516e-11 FALSE TRUE
ENST00000524015 ENSG00000147364 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO25 protein_coding retained_intron 6.327646 2.884832 9.165319 0.1340346 0.6564654 1.664279 0.05786858 0.1705783 0.0000000 0.17057835 0.0000000 -4.1745530 0.0126500 0.05703333 0.0000000 -0.05703333 7.580018e-01 6.688516e-11   FALSE
ENST00000524125 ENSG00000147364 HEK293_OSMI2_6hA HEK293_TMG_6hB FBXO25 protein_coding processed_transcript 6.327646 2.884832 9.165319 0.1340346 0.6564654 1.664279 1.64798414 0.2858817 3.8923843 0.28588173 0.5555896 3.7212633 0.2326667 0.09390000 0.4210000 0.32710000 2.030137e-01 6.688516e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147364 E001 0.1779838 0.036939155 0.66335802   8 406428 406678 251 + 0.106 0.000 -8.777
ENSG00000147364 E002 0.9624527 0.137726226 0.29163567   8 406808 406954 147 + 0.193 0.397 1.419
ENSG00000147364 E003 1.1404365 0.411475864 0.52080122   8 406955 406957 3 + 0.269 0.393 0.781
ENSG00000147364 E004 19.4639196 0.002387774 0.28492189 0.52552095 8 406958 407066 109 + 1.278 1.351 0.257
ENSG00000147364 E005 0.0000000       8 413072 413072 1 +      
ENSG00000147364 E006 44.2246814 0.002295050 0.60252433 0.77189186 8 413073 413213 141 + 1.671 1.634 -0.125
ENSG00000147364 E007 0.0000000       8 420397 420448 52 +      
ENSG00000147364 E008 46.9303495 0.001246402 0.13750257 0.34370261 8 431341 431444 104 + 1.717 1.631 -0.291
ENSG00000147364 E009 23.3166725 0.001680996 0.03331424 0.13692308 8 432886 432935 50 + 1.452 1.289 -0.569
ENSG00000147364 E010 0.2027342 0.038028997 0.35269805   8 435448 435614 167 + 0.000 0.139 9.639
ENSG00000147364 E011 46.2171892 0.011674762 0.42945636 0.65060410 8 435615 435707 93 + 1.703 1.640 -0.213
ENSG00000147364 E012 38.3605848 0.044530085 0.78287459 0.88633599 8 449990 450083 94 + 1.618 1.562 -0.190
ENSG00000147364 E013 54.8534058 0.106988498 0.60284197 0.77209874 8 451269 451453 185 + 1.729 1.761 0.109
ENSG00000147364 E014 49.6139903 0.002040868 0.01115101 0.06300945 8 458369 458509 141 + 1.647 1.765 0.402
ENSG00000147364 E015 29.2286477 0.002446557 0.01022981 0.05910045 8 458510 458551 42 + 1.399 1.557 0.543
ENSG00000147364 E016 42.8697722 0.005992695 0.07742399 0.23970637 8 463007 463150 144 + 1.593 1.692 0.337
ENSG00000147364 E017 0.7685209 0.017267182 0.41959483   8 467720 467746 27 + 0.191 0.328 1.031
ENSG00000147364 E018 1.3106546 0.013696863 0.64438706   8 467747 467950 204 + 0.323 0.399 0.447
ENSG00000147364 E019 1.4229294 0.011868978 0.87208867 0.93705569 8 467951 468180 230 + 0.377 0.399 0.125
ENSG00000147364 E020 42.6587634 0.036587466 0.57654951 0.75480504 8 468715 468880 166 + 1.615 1.663 0.164
ENSG00000147364 E021 46.3775039 0.009500306 0.07111852 0.22697488 8 468881 470565 1685 + 1.721 1.591 -0.441
ENSG00000147364 E022 150.4318079 0.040514548 0.61782932 0.78232578 8 470566 477967 7402 + 2.195 2.148 -0.158