ENSG00000147274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320676 ENSG00000147274 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMX protein_coding protein_coding 259.5824 148.6749 342.1761 31.97897 15.46489 1.202523 167.94604 119.645575 197.692243 28.3723575 9.1120951 0.7244416 0.67249167 0.79413333 0.57796667 -0.21616667 3.916526e-04 1.391554e-40 FALSE TRUE
ENST00000419968 ENSG00000147274 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMX protein_coding protein_coding 259.5824 148.6749 342.1761 31.97897 15.46489 1.202523 17.67637 0.000000 49.371788 0.0000000 7.5425802 12.2697634 0.05081667 0.00000000 0.14323333 0.14323333 1.391554e-40 1.391554e-40 FALSE TRUE
ENST00000496459 ENSG00000147274 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMX protein_coding processed_transcript 259.5824 148.6749 342.1761 31.97897 15.46489 1.202523 10.83332 5.557752 6.768437 2.8072292 1.2134306 0.2838576 0.05204167 0.03073333 0.01973333 -0.01100000 1.000000e+00 1.391554e-40 TRUE TRUE
MSTRG.34962.6 ENSG00000147274 HEK293_OSMI2_6hA HEK293_TMG_6hB RBMX protein_coding   259.5824 148.6749 342.1761 31.97897 15.46489 1.202523 32.04405 6.210804 44.416121 0.3343267 0.7783116 2.8362353 0.10099167 0.04806667 0.13023333 0.08216667 3.606079e-02 1.391554e-40 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147274 E001 18.4764250 1.266037e-02 3.507926e-06 8.501878e-05 X 136848004 136848582 579 - 1.065 1.498 1.524
ENSG00000147274 E002 0.2027342 3.340369e-02 2.593767e-01   X 136869187 136869191 5 - 0.000 0.159 11.174
ENSG00000147274 E003 8.9680219 3.813366e-03 9.008737e-01 9.523189e-01 X 136869192 136869193 2 - 0.976 0.993 0.063
ENSG00000147274 E004 65.2706806 1.205001e-03 2.786396e-01 5.187223e-01 X 136869194 136869258 65 - 1.822 1.773 -0.166
ENSG00000147274 E005 215.0485384 2.690645e-04 4.619743e-06 1.075256e-04 X 136869259 136869358 100 - 2.356 2.236 -0.402
ENSG00000147274 E006 1071.6997497 3.425533e-03 2.563703e-05 4.713389e-04 X 136869359 136869971 613 - 3.054 2.920 -0.446
ENSG00000147274 E007 906.4575342 9.376468e-03 3.777714e-03 2.789766e-02 X 136869972 136870417 446 - 2.986 2.835 -0.501
ENSG00000147274 E008 190.6699349 4.916012e-03 7.121385e-03 4.519170e-02 X 136872268 136872274 7 - 2.303 2.181 -0.407
ENSG00000147274 E009 313.3594512 3.879167e-03 9.050889e-04 9.133879e-03 X 136872275 136872345 71 - 2.520 2.391 -0.431
ENSG00000147274 E010 337.0968185 3.106196e-02 4.063278e-02 1.563878e-01 X 136872346 136873245 900 - 2.569 2.372 -0.656
ENSG00000147274 E011 325.6223446 2.928795e-03 1.376114e-16 2.587994e-14 X 136873246 136873448 203 - 2.577 2.281 -0.988
ENSG00000147274 E012 129.6713057 4.310374e-04 5.249014e-16 9.133230e-14 X 136873449 136873460 12 - 2.177 1.882 -0.989
ENSG00000147274 E013 2073.3023727 1.033541e-03 4.173924e-02 1.592515e-01 X 136873461 136873957 497 - 3.283 3.321 0.125
ENSG00000147274 E014 485.4981226 6.276838e-03 1.158060e-03 1.110977e-02 X 136873958 136873977 20 - 2.608 2.757 0.494
ENSG00000147274 E015 3100.6962367 1.475246e-03 2.701726e-06 6.782191e-05 X 136873978 136874452 475 - 3.438 3.528 0.297
ENSG00000147274 E016 231.2473706 5.366936e-02 9.696376e-03 5.681103e-02 X 136874453 136875085 633 - 2.434 2.117 -1.057
ENSG00000147274 E017 1669.4253457 6.715308e-05 9.563802e-01 9.800837e-01 X 136875086 136875168 83 - 3.202 3.204 0.009
ENSG00000147274 E018 1814.4932751 7.050728e-05 3.516947e-01 5.887989e-01 X 136875258 136875383 126 - 3.241 3.235 -0.022
ENSG00000147274 E019 1563.8242145 6.984284e-05 2.151700e-01 4.477393e-01 X 136875471 136875585 115 - 3.170 3.185 0.048
ENSG00000147274 E020 1347.1607725 5.620388e-04 4.414559e-01 6.597185e-01 X 136876503 136876599 97 - 3.105 3.119 0.048
ENSG00000147274 E021 1214.5843756 6.648884e-04 8.732069e-01 9.377361e-01 X 136876600 136876655 56 - 3.065 3.065 -0.001
ENSG00000147274 E022 822.7749337 1.014594e-03 1.340822e-01 3.382106e-01 X 136877915 136877915 1 - 2.885 2.917 0.106
ENSG00000147274 E023 1257.3947014 3.296890e-04 2.564770e-01 4.952550e-01 X 136877916 136877964 49 - 3.074 3.091 0.058
ENSG00000147274 E024 1545.5524456 8.573450e-05 8.396773e-01 9.192185e-01 X 136877965 136878086 122 - 3.170 3.170 0.001
ENSG00000147274 E025 1764.8344608 9.607824e-05 4.655281e-01 6.769771e-01 X 136879017 136879123 107 - 3.229 3.224 -0.018
ENSG00000147274 E026 7.5869604 1.034027e-02 3.737945e-01 6.071748e-01 X 136879124 136879158 35 - 0.943 0.831 -0.429
ENSG00000147274 E027 0.3040503 2.744240e-02 4.446413e-01   X 136879159 136879198 40 - 0.167 0.000 -10.384
ENSG00000147274 E028 0.1426347 3.275122e-02 1.000000e+00   X 136879199 136879318 120 - 0.092 0.000 -9.383
ENSG00000147274 E029 1812.9481194 7.420713e-04 1.871309e-01 4.132203e-01 X 136879319 136879453 135 - 3.233 3.251 0.061
ENSG00000147274 E030 942.3386025 1.675555e-03 5.629072e-04 6.246121e-03 X 136880597 136880771 175 - 2.927 3.002 0.249