ENSG00000147121

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298190 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding protein_coding 7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 0.9484964 0.2448687 2.0782313 0.24486874 0.2252556 3.0344552 0.10878333 0.05196667 0.21686667 0.16490000 2.511841e-01 1.109587e-07 FALSE TRUE
ENST00000344302 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding protein_coding 7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 0.7775241 0.9936249 0.3890176 0.25745203 0.1988329 -1.3306958 0.11200417 0.20423333 0.04136667 -0.16286667 3.463401e-01 1.109587e-07 FALSE TRUE
ENST00000377919 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding protein_coding 7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 2.2792823 1.8063758 2.3340716 0.07803557 0.4144530 0.3679540 0.32050833 0.37383333 0.24573333 -0.12810000 4.565378e-01 1.109587e-07 FALSE TRUE
ENST00000476762 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding protein_coding 7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 1.0963626 0.2708968 2.1093506 0.13727302 0.6912570 2.9155100 0.11291667 0.05566667 0.21616667 0.16050000 4.793415e-01 1.109587e-07 FALSE FALSE
MSTRG.34156.1 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding   7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 0.8633386 0.5704919 0.8412005 0.17563125 0.1702789 0.5522231 0.10452083 0.11986667 0.08713333 -0.03273333 9.036226e-01 1.109587e-07 FALSE FALSE
MSTRG.34156.2 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding   7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 0.7881700 0.1163424 1.0383900 0.11634240 0.1730223 3.0527647 0.09854167 0.02466667 0.10940000 0.08473333 2.887767e-01 1.109587e-07 FALSE FALSE
MSTRG.34156.4 ENSG00000147121 HEK293_OSMI2_6hA HEK293_TMG_6hB KRBOX4 protein_coding   7.805683 4.830882 9.596087 0.1169409 0.2700877 0.9886789 0.3026503 0.2908034 0.0000000 0.01351607 0.0000000 -4.9107490 0.04824583 0.06013333 0.00000000 -0.06013333 1.109587e-07 1.109587e-07 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000147121 E001 0.1308682 0.0326491905 0.3021726013   X 46447179 46447179 1 + 0.000 0.150 10.323
ENSG00000147121 E002 0.1308682 0.0326491905 0.3021726013   X 46447180 46447217 38 + 0.000 0.150 12.413
ENSG00000147121 E003 0.5775531 0.0216800454 0.5925232009   X 46447218 46447240 23 + 0.244 0.150 -0.875
ENSG00000147121 E004 0.5775531 0.0216800454 0.5925232009   X 46447241 46447254 14 + 0.244 0.150 -0.875
ENSG00000147121 E005 1.5604025 0.0120406487 0.0479256021 0.174845207 X 46447255 46447282 28 + 0.515 0.150 -2.461
ENSG00000147121 E006 2.2016395 0.0091184716 0.0084000407 0.051153588 X 46447283 46447291 9 + 0.631 0.150 -2.991
ENSG00000147121 E007 2.0590048 0.0095701939 0.0129762251 0.070346085 X 46447292 46447293 2 + 0.605 0.150 -2.876
ENSG00000147121 E008 2.2016395 0.0091184716 0.0084000407 0.051153588 X 46447294 46447296 3 + 0.631 0.150 -2.991
ENSG00000147121 E009 4.1567394 0.0065907576 0.0004687279 0.005390086 X 46447297 46447300 4 + 0.848 0.261 -2.875
ENSG00000147121 E010 22.4326813 0.0489422764 0.2546878028 0.493196423 X 46447301 46447346 46 + 1.402 1.256 -0.508
ENSG00000147121 E011 30.1530868 0.0058052447 0.3625243416 0.597793617 X 46448200 46448232 33 + 1.499 1.433 -0.227
ENSG00000147121 E012 41.2174078 0.0042419742 0.3469084934 0.584470592 X 46448233 46448310 78 + 1.630 1.573 -0.196
ENSG00000147121 E013 0.0000000       X 46448311 46448668 358 +      
ENSG00000147121 E014 37.0019471 0.0019698365 0.3433474665 0.581009533 X 46450431 46450475 45 + 1.584 1.527 -0.194
ENSG00000147121 E015 47.6304521 0.0007868030 0.2711695433 0.511159331 X 46462748 46462874 127 + 1.694 1.639 -0.188
ENSG00000147121 E016 40.3569900 0.0012701876 0.2959501249 0.536457595 X 46463198 46463293 96 + 1.629 1.572 -0.197
ENSG00000147121 E017 10.2519978 0.0042505570 0.1970378303 0.425871245 X 46463294 46463308 15 + 0.993 1.126 0.484
ENSG00000147121 E018 3.8577239 0.1164631541 0.3905980302 0.620896642 X 46463309 46463449 141 + 0.730 0.544 -0.803
ENSG00000147121 E019 15.0505560 0.0048151093 0.4407879800 0.659302939 X 46471142 46471185 44 + 1.172 1.242 0.247
ENSG00000147121 E020 16.1053145 0.0023934379 0.1280975747 0.328775277 X 46472025 46472143 119 + 1.172 1.300 0.452
ENSG00000147121 E021 15.3851739 0.0027034249 0.0083054721 0.050730503 X 46472144 46472239 96 + 1.109 1.335 0.798
ENSG00000147121 E022 17.9752232 0.0309862884 0.0009027571 0.009115764 X 46472240 46472526 287 + 1.090 1.457 1.290
ENSG00000147121 E023 15.1950388 0.0021114561 0.9883077819 0.995934112 X 46472750 46472752 3 + 1.201 1.200 -0.003
ENSG00000147121 E024 150.1471661 0.0007157691 0.1131395953 0.304402154 X 46472753 46474639 1887 + 2.154 2.194 0.136
ENSG00000147121 E025 1.3192282 0.0175435873 0.4427374116   X 46497122 46497422 301 + 0.401 0.261 -0.879
ENSG00000147121 E026 0.6370325 0.0211799878 0.1382594680   X 46505295 46505426 132 + 0.098 0.350 2.295