ENSG00000146918

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356309 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding protein_coding 43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 11.434186 14.5246476 11.678524 4.7951807 0.6885091 -0.3144033 0.30953750 0.47590000 0.19406667 -0.28183333 6.885911e-02 1.981328e-23 FALSE TRUE
ENST00000409423 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding protein_coding 43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 6.450169 2.0662032 8.839522 0.1901481 2.1335766 2.0916519 0.13632917 0.07650000 0.14553333 0.06903333 4.508466e-01 1.981328e-23 FALSE TRUE
ENST00000441982 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding protein_coding 43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 3.100839 5.3166552 0.000000 1.6244474 0.0000000 -9.0570861 0.11357917 0.17420000 0.00000000 -0.17420000 1.981328e-23 1.981328e-23 FALSE TRUE
ENST00000467785 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding retained_intron 43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 2.617544 1.4669825 4.367639 0.4303474 0.8260887 1.5675001 0.05989583 0.06183333 0.07343333 0.01160000 8.852085e-01 1.981328e-23 TRUE TRUE
MSTRG.31002.5 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding   43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 2.250971 1.7045513 4.693963 1.1544839 1.3699488 1.4560456 0.05108333 0.06070000 0.07940000 0.01870000 8.942411e-01 1.981328e-23 FALSE TRUE
MSTRG.31002.6 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding   43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 10.525714 0.9488532 20.727441 0.9488532 0.6011546 4.4347842 0.18438750 0.05360000 0.34500000 0.29140000 1.245343e-01 1.981328e-23 FALSE TRUE
MSTRG.31002.8 ENSG00000146918 HEK293_OSMI2_6hA HEK293_TMG_6hB NCAPG2 protein_coding   43.20294 28.75195 60.12412 5.524384 1.67073 1.064022 4.653006 1.6034790 7.568120 0.6873927 1.0721532 2.2316653 0.08672500 0.05356667 0.12506667 0.07150000 1.907586e-01 1.981328e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146918 E001 0.1614157 0.0344376482 8.080338e-01   7 158614476 158614512 37 - 0.097 0.000 -8.722
ENSG00000146918 E002 7.7031704 0.0563744505 2.322101e-02 1.066608e-01 7 158631169 158631212 44 - 0.757 1.098 1.290
ENSG00000146918 E003 9.3178278 0.0033860969 3.911430e-03 2.865250e-02 7 158631213 158631310 98 - 0.860 1.168 1.136
ENSG00000146918 E004 5.8326713 0.0806401854 1.054886e-01 2.914804e-01 7 158631311 158631313 3 - 0.680 0.996 1.234
ENSG00000146918 E005 36.0531462 0.0021535737 2.551513e-02 1.137942e-01 7 158631314 158631389 76 - 1.498 1.635 0.467
ENSG00000146918 E006 48.0627960 0.0091383053 2.184326e-02 1.020627e-01 7 158631390 158631435 46 - 1.608 1.767 0.537
ENSG00000146918 E007 349.6370161 0.0002068064 8.777470e-05 1.339759e-03 7 158631436 158631665 230 - 2.500 2.577 0.259
ENSG00000146918 E008 277.9076194 0.0001998598 2.785210e-02 1.208674e-01 7 158631666 158631717 52 - 2.413 2.461 0.160
ENSG00000146918 E009 55.8181845 0.0268838107 1.917216e-01 4.190289e-01 7 158639796 158641430 1635 - 1.693 1.803 0.373
ENSG00000146918 E010 28.1882139 0.0036499704 6.578891e-02 2.157014e-01 7 158641431 158641554 124 - 1.505 1.370 -0.466
ENSG00000146918 E011 353.7101650 0.0001741578 5.106756e-05 8.474150e-04 7 158644289 158644388 100 - 2.506 2.585 0.263
ENSG00000146918 E012 299.1728781 0.0002263940 8.137066e-04 8.392718e-03 7 158645519 158645619 101 - 2.438 2.509 0.239
ENSG00000146918 E013 294.0238859 0.0001890749 2.880007e-09 1.522701e-07 7 158646460 158646563 104 - 2.406 2.532 0.420
ENSG00000146918 E014 293.2853555 0.0009605441 1.287218e-09 7.380120e-08 7 158650832 158650972 141 - 2.391 2.545 0.514
ENSG00000146918 E015 471.3744099 0.0009942611 3.838946e-04 4.578240e-03 7 158652293 158652480 188 - 2.629 2.708 0.262
ENSG00000146918 E016 335.0283434 0.0019206383 6.304746e-01 7.907672e-01 7 158654595 158654694 100 - 2.509 2.519 0.033
ENSG00000146918 E017 0.6603779 0.1116734086 5.960196e-01   7 158654695 158654789 95 - 0.175 0.265 0.764
ENSG00000146918 E018 415.0793560 0.0002925296 7.409034e-01 8.609916e-01 7 158655118 158655258 141 - 2.608 2.601 -0.026
ENSG00000146918 E019 21.0098584 0.1332372169 6.048113e-01 7.733625e-01 7 158655259 158655338 80 - 1.369 1.257 -0.391
ENSG00000146918 E020 318.5997717 0.0001781237 1.531816e-01 3.668715e-01 7 158655339 158655455 117 - 2.480 2.509 0.097
ENSG00000146918 E021 366.0611899 0.0001444960 5.521738e-01 7.378030e-01 7 158656260 158656433 174 - 2.549 2.560 0.036
ENSG00000146918 E022 200.6184854 0.0002146073 1.044921e-02 6.007370e-02 7 158656552 158656601 50 - 2.267 2.332 0.219
ENSG00000146918 E023 231.9370804 0.0002477490 9.938722e-03 5.788742e-02 7 158656602 158656705 104 - 2.332 2.394 0.208
ENSG00000146918 E024 185.8172120 0.0024276619 3.789638e-02 1.493507e-01 7 158658338 158658408 71 - 2.232 2.307 0.248
ENSG00000146918 E025 135.3822226 0.0028641345 1.535017e-01 3.673385e-01 7 158662194 158662225 32 - 2.101 2.159 0.193
ENSG00000146918 E026 99.7157893 0.0009014885 4.401109e-01 6.588207e-01 7 158662226 158662239 14 - 1.981 2.011 0.099
ENSG00000146918 E027 280.3497713 0.0011176128 2.034307e-01 4.338346e-01 7 158662240 158662367 128 - 2.452 2.418 -0.114
ENSG00000146918 E028 329.6023159 0.0004533162 1.376833e-03 1.274004e-02 7 158664184 158664296 113 - 2.535 2.462 -0.242
ENSG00000146918 E029 458.1737851 0.0005795443 1.022579e-01 2.858324e-01 7 158664528 158664750 223 - 2.663 2.630 -0.112
ENSG00000146918 E030 0.0000000       7 158665083 158665314 232 -      
ENSG00000146918 E031 0.0000000       7 158665315 158665386 72 -      
ENSG00000146918 E032 0.0000000       7 158667136 158667192 57 -      
ENSG00000146918 E033 0.0000000       7 158667193 158667238 46 -      
ENSG00000146918 E034 0.0000000       7 158668163 158668395 233 -      
ENSG00000146918 E035 0.5530924 0.0286123502 3.106174e-01   7 158668396 158668492 97 - 0.097 0.264 1.740
ENSG00000146918 E036 401.8817491 0.0001342373 1.939973e-02 9.384494e-02 7 158671514 158671666 153 - 2.609 2.565 -0.146
ENSG00000146918 E037 349.9935793 0.0001582327 1.790699e-01 4.027278e-01 7 158675477 158675616 140 - 2.543 2.516 -0.091
ENSG00000146918 E038 182.8632065 0.0002417723 3.234177e-01 5.627491e-01 7 158675617 158675656 40 - 2.243 2.269 0.088
ENSG00000146918 E039 0.3447487 0.7599377364 2.333824e-01   7 158679947 158679959 13 - 0.000 0.268 11.181
ENSG00000146918 E040 277.7708412 0.0002377248 3.540664e-01 5.909079e-01 7 158679960 158680085 126 - 2.425 2.446 0.068
ENSG00000146918 E041 245.3386360 0.0010068290 6.957960e-01 8.328024e-01 7 158680721 158680816 96 - 2.384 2.373 -0.037
ENSG00000146918 E042 241.0197685 0.0029774045 4.565503e-01 6.706600e-01 7 158683300 158683386 87 - 2.382 2.356 -0.086
ENSG00000146918 E043 256.6973510 0.0029194304 1.762135e-02 8.771742e-02 7 158686172 158686241 70 - 2.430 2.350 -0.266
ENSG00000146918 E044 274.9039440 0.0011279377 2.431608e-06 6.191976e-05 7 158687348 158687442 95 - 2.475 2.347 -0.427
ENSG00000146918 E045 343.3705892 0.0017309746 2.669815e-07 8.907583e-06 7 158689819 158689953 135 - 2.576 2.431 -0.484
ENSG00000146918 E046 313.6313527 0.0002922243 3.800341e-07 1.214729e-05 7 158690568 158690722 155 - 2.527 2.415 -0.376
ENSG00000146918 E047 221.2366139 0.0002374484 1.206752e-06 3.342590e-05 7 158692842 158692956 115 - 2.378 2.252 -0.418
ENSG00000146918 E048 226.9398927 0.0002385108 3.879260e-04 4.613681e-03 7 158693309 158693411 103 - 2.377 2.287 -0.301
ENSG00000146918 E049 227.6904137 0.0002237457 4.218071e-05 7.197081e-04 7 158693412 158693497 86 - 2.383 2.279 -0.346
ENSG00000146918 E050 3.9154925 0.4463237692 2.529447e-01 4.911876e-01 7 158696141 158696651 511 - 0.762 0.498 -1.153
ENSG00000146918 E051 222.5323712 0.0003973489 2.708947e-04 3.435966e-03 7 158701822 158701938 117 - 2.369 2.272 -0.321
ENSG00000146918 E052 1.3955902 0.1929535722 4.947312e-01 6.972545e-01 7 158702248 158702348 101 - 0.438 0.262 -1.073
ENSG00000146918 E053 10.2699455 0.0319226904 1.065703e-01 2.932581e-01 7 158703650 158703702 53 - 1.114 0.884 -0.848
ENSG00000146918 E054 0.0000000       7 158703703 158703704 2 -      
ENSG00000146918 E055 122.3231999 0.0004545062 4.929607e-02 1.779187e-01 7 158704724 158704804 81 - 2.101 2.034 -0.226