ENSG00000146909

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275820 ENSG00000146909 HEK293_OSMI2_6hA HEK293_TMG_6hB NOM1 protein_coding protein_coding 20.85867 18.29695 25.19187 0.4064609 1.377386 0.461139 10.8892079 8.7018015 13.60689521 1.1048207 0.39004967 0.64435480 0.52388750 0.47456667 0.5417000 0.06713333 0.78831316 7.443637e-06 FALSE  
ENST00000469271 ENSG00000146909 HEK293_OSMI2_6hA HEK293_TMG_6hB NOM1 protein_coding retained_intron 20.85867 18.29695 25.19187 0.4064609 1.377386 0.461139 1.9436147 1.6641484 2.57139009 0.1424444 0.21158154 0.62472078 0.09230000 0.09123333 0.1023667 0.01113333 0.89821116 7.443637e-06 FALSE  
ENST00000485661 ENSG00000146909 HEK293_OSMI2_6hA HEK293_TMG_6hB NOM1 protein_coding retained_intron 20.85867 18.29695 25.19187 0.4064609 1.377386 0.461139 3.3645613 3.1954672 3.11648263 1.0256300 0.56883811 -0.03599416 0.16133750 0.17286667 0.1221000 -0.05076667 0.88648422 7.443637e-06 FALSE  
MSTRG.30987.7 ENSG00000146909 HEK293_OSMI2_6hA HEK293_TMG_6hB NOM1 protein_coding   20.85867 18.29695 25.19187 0.4064609 1.377386 0.461139 0.4175121 1.0966997 0.07747561 0.3857933 0.07747561 -3.66123916 0.02510000 0.06033333 0.0034000 -0.05693333 0.04673966 7.443637e-06 TRUE  
MSTRG.30987.8 ENSG00000146909 HEK293_OSMI2_6hA HEK293_TMG_6hB NOM1 protein_coding   20.85867 18.29695 25.19187 0.4064609 1.377386 0.461139 1.4325865 0.6843344 2.79799465 0.3425521 0.41068179 2.01583771 0.06601667 0.03826667 0.1106667 0.07240000 0.58183910 7.443637e-06 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146909 E001 0.0000000       7 156949599 156949705 107 +      
ENSG00000146909 E002 0.0000000       7 156949706 156949711 6 +      
ENSG00000146909 E003 0.1308682 0.0326491905 4.355340e-01   7 156949712 156949721 10 + 0.000 0.126 9.149
ENSG00000146909 E004 62.8209290 0.0104316507 6.858949e-02 2.218977e-01 7 156949722 156949932 211 + 1.748 1.865 0.396
ENSG00000146909 E005 44.7172003 0.0011176901 4.591003e-02 1.698322e-01 7 156949933 156949974 42 + 1.612 1.711 0.335
ENSG00000146909 E006 54.2356543 0.0052433730 3.368403e-02 1.380291e-01 7 156949975 156950048 74 + 1.681 1.799 0.397
ENSG00000146909 E007 160.9845387 0.0002878172 2.189904e-02 1.022423e-01 7 156950049 156950426 378 + 2.182 2.238 0.185
ENSG00000146909 E008 260.4348827 0.0003292397 6.848001e-01 8.258459e-01 7 156950427 156950724 298 + 2.427 2.409 -0.059
ENSG00000146909 E009 3.6404152 0.0340179790 7.723488e-01 8.800638e-01 7 156952471 156952473 3 + 0.641 0.677 0.154
ENSG00000146909 E010 154.9879889 0.0003407084 1.339926e-01 3.380836e-01 7 156952474 156952585 112 + 2.175 2.210 0.115
ENSG00000146909 E011 65.8584630 0.0084194420 7.835014e-01 8.866908e-01 7 156952586 156952598 13 + 1.821 1.831 0.033
ENSG00000146909 E012 65.3365616 0.0006977930 1.865661e-01 4.125204e-01 7 156954103 156954111 9 + 1.798 1.848 0.168
ENSG00000146909 E013 182.1607517 0.0004993857 8.320027e-01 9.149854e-01 7 156954112 156954298 187 + 2.265 2.263 -0.009
ENSG00000146909 E014 14.8629529 0.0478669842 7.988562e-01 8.956267e-01 7 156958606 156958856 251 + 1.222 1.174 -0.170
ENSG00000146909 E015 160.5203677 0.0002695515 6.026434e-01 7.719784e-01 7 156959851 156959995 145 + 2.219 2.196 -0.078
ENSG00000146909 E016 179.9346010 0.0002607476 1.961758e-01 4.247674e-01 7 156959996 156960174 179 + 2.247 2.272 0.085
ENSG00000146909 E017 14.7992889 0.1119842776 4.248886e-01 6.471934e-01 7 156960175 156960253 79 + 1.261 1.124 -0.485
ENSG00000146909 E018 79.6852906 0.0008503397 7.353629e-01 8.575084e-01 7 156962151 156962167 17 + 1.906 1.911 0.017
ENSG00000146909 E019 76.5610075 0.0011142859 9.300628e-01 9.670364e-01 7 156962168 156962170 3 + 1.893 1.887 -0.018
ENSG00000146909 E020 129.2120484 0.0009742962 9.761671e-02 2.776207e-01 7 156962171 156962261 91 + 2.094 2.141 0.156
ENSG00000146909 E021 155.9402832 0.0038739553 1.980072e-01 4.271509e-01 7 156963008 156963175 168 + 2.174 2.221 0.155
ENSG00000146909 E022 62.1018219 0.0266326454 6.165770e-01 7.814183e-01 7 156963176 156963904 729 + 1.824 1.771 -0.178
ENSG00000146909 E023 130.7362956 0.0003873595 9.483766e-01 9.764766e-01 7 156963905 156964026 122 + 2.125 2.119 -0.021
ENSG00000146909 E024 16.9545792 0.1384272447 8.369817e-01 9.177583e-01 7 156964027 156964235 209 + 1.205 1.300 0.332
ENSG00000146909 E025 12.4485018 0.2125975650 9.851456e-01 9.943525e-01 7 156966159 156966269 111 + 1.082 1.169 0.312
ENSG00000146909 E026 149.5528954 0.0003534874 1.593755e-01 3.758278e-01 7 156966270 156966402 133 + 2.161 2.193 0.108
ENSG00000146909 E027 151.4694795 0.0028642275 7.172202e-01 8.464009e-01 7 156966961 156967092 132 + 2.181 2.185 0.015
ENSG00000146909 E028 8.4008445 0.1900688415 7.580972e-01 8.713997e-01 7 156968755 156969086 332 + 0.992 0.947 -0.168
ENSG00000146909 E029 137.4377000 0.0021798006 6.223251e-01 7.854359e-01 7 156969087 156969196 110 + 2.139 2.150 0.038
ENSG00000146909 E030 303.0695376 0.0038730164 8.423912e-02 2.532348e-01 7 156969529 156970605 1077 + 2.517 2.445 -0.238
ENSG00000146909 E031 610.9709850 0.0012974643 9.647169e-07 2.753001e-05 7 156970606 156972635 2030 + 2.835 2.726 -0.360
ENSG00000146909 E032 117.8284589 0.0004675315 8.053059e-02 2.459172e-01 7 156972636 156973176 541 + 2.051 2.100 0.163