ENSG00000146872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343388 ENSG00000146872 HEK293_OSMI2_6hA HEK293_TMG_6hB TLK2 protein_coding protein_coding 28.5274 20.45722 32.31408 5.335038 1.15535 0.6592941 4.7410515 4.7710035 5.318261 1.5855836 0.2708351 0.1563514 0.17681250 0.21963333 0.1649000 -0.05473333 0.641804386 0.006642948 FALSE TRUE
ENST00000581041 ENSG00000146872 HEK293_OSMI2_6hA HEK293_TMG_6hB TLK2 protein_coding protein_coding 28.5274 20.45722 32.31408 5.335038 1.15535 0.6592941 3.0649180 0.8486062 6.527030 0.8486062 1.2634538 2.9285668 0.08620833 0.03153333 0.1998000 0.16826667 0.165947787 0.006642948 FALSE TRUE
ENST00000583310 ENSG00000146872 HEK293_OSMI2_6hA HEK293_TMG_6hB TLK2 protein_coding retained_intron 28.5274 20.45722 32.31408 5.335038 1.15535 0.6592941 10.2069527 7.7479393 9.028838 2.2152057 0.7799284 0.2204638 0.35697083 0.37120000 0.2796333 -0.09156667 0.330623340 0.006642948   FALSE
MSTRG.14865.11 ENSG00000146872 HEK293_OSMI2_6hA HEK293_TMG_6hB TLK2 protein_coding   28.5274 20.45722 32.31408 5.335038 1.15535 0.6592941 3.3704083 2.9645984 1.458891 0.4917162 0.3142908 -1.0179680 0.11457500 0.15996667 0.0446000 -0.11536667 0.006642948 0.006642948 TRUE TRUE
MSTRG.14865.27 ENSG00000146872 HEK293_OSMI2_6hA HEK293_TMG_6hB TLK2 protein_coding   28.5274 20.45722 32.31408 5.335038 1.15535 0.6592941 0.5399934 0.2390288 2.959303 0.2390288 0.3162267 3.5757394 0.01869167 0.00970000 0.0916000 0.08190000 0.111922732 0.006642948 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146872 E001 0.0000000       17 62458658 62458765 108 +      
ENSG00000146872 E002 0.0000000       17 62470917 62470932 16 +      
ENSG00000146872 E003 0.0000000       17 62470933 62470941 9 +      
ENSG00000146872 E004 0.0000000       17 62470942 62470958 17 +      
ENSG00000146872 E005 0.0000000       17 62470959 62471078 120 +      
ENSG00000146872 E006 0.7119354 1.0946172880 0.4779150101   17 62477496 62477697 202 + 0.339 0.000 -12.250
ENSG00000146872 E007 0.0000000       17 62477768 62477838 71 +      
ENSG00000146872 E008 0.3559677 0.5273225976 0.4499968474   17 62477839 62478065 227 + 0.196 0.000 -13.525
ENSG00000146872 E009 0.4986023 0.0401116887 0.1465491307   17 62478066 62478081 16 + 0.263 0.000 -15.233
ENSG00000146872 E010 6.4600173 0.0649441313 0.0093652609 0.055388894 17 62478825 62478987 163 + 0.605 1.092 1.906
ENSG00000146872 E011 2.6844774 0.0093686107 0.0001575731 0.002190321 17 62478988 62479024 37 + 0.191 0.822 3.350
ENSG00000146872 E012 2.3454532 0.0095243355 0.0005957770 0.006543567 17 62479025 62479117 93 + 0.191 0.770 3.144
ENSG00000146872 E013 1.9536565 0.0110158724 0.1067458824 0.293567835 17 62479118 62479129 12 + 0.323 0.604 1.448
ENSG00000146872 E014 2.1563908 0.0102532944 0.0621676759 0.207677654 17 62479130 62479149 20 + 0.323 0.643 1.619
ENSG00000146872 E015 2.6376171 0.0088503600 0.0425687170 0.161416257 17 62479150 62479168 19 + 0.377 0.711 1.585
ENSG00000146872 E016 2.7684853 0.0081811327 0.0250622335 0.112423891 17 62479169 62479178 10 + 0.377 0.742 1.710
ENSG00000146872 E017 4.5760769 0.0076490324 0.0676268957 0.219733714 17 62479179 62479183 5 + 0.606 0.870 1.077
ENSG00000146872 E018 5.5026329 0.0053655070 0.0737785126 0.232327264 17 62479184 62479205 22 + 0.688 0.931 0.960
ENSG00000146872 E019 4.8540215 0.0061187267 0.1486036503 0.360302643 17 62479206 62479208 3 + 0.662 0.869 0.832
ENSG00000146872 E020 11.5834544 0.0033993240 0.2571148428 0.495891871 17 62479209 62479245 37 + 1.040 1.163 0.445
ENSG00000146872 E021 11.2746025 0.0033469026 0.2616359164 0.500706148 17 62479246 62479257 12 + 1.028 1.151 0.445
ENSG00000146872 E022 15.4032770 0.0042480711 0.0534659574 0.187815433 17 62479258 62479290 33 + 1.128 1.312 0.650
ENSG00000146872 E023 0.3559677 0.5273225976 0.4499968474   17 62479302 62479443 142 + 0.196 0.000 -13.525
ENSG00000146872 E024 0.4514866 0.0217681645 0.7521379951   17 62479444 62479516 73 + 0.191 0.139 -0.556
ENSG00000146872 E025 0.4514866 0.0217681645 0.7521379951   17 62479517 62479613 97 + 0.191 0.139 -0.556
ENSG00000146872 E026 9.3020769 0.0878842822 0.1246055212 0.323116253 17 62481121 62481123 3 + 0.895 1.128 0.856
ENSG00000146872 E027 13.9569526 0.0059021595 0.1103763182 0.299637730 17 62481124 62481125 2 + 1.101 1.262 0.573
ENSG00000146872 E028 18.6372872 0.0027378981 0.8406930658 0.919826422 17 62481126 62481137 12 + 1.284 1.313 0.101
ENSG00000146872 E029 46.0780997 0.0042171086 0.4421661326 0.660201332 17 62481138 62481206 69 + 1.649 1.703 0.184
ENSG00000146872 E030 0.0000000       17 62486004 62486097 94 +      
ENSG00000146872 E031 0.1723744 0.1014664723 0.3671967839   17 62507381 62507449 69 + 0.000 0.139 13.325
ENSG00000146872 E032 5.7609585 0.0390729197 0.5292456453 0.721527773 17 62508408 62508553 146 + 0.868 0.791 -0.302
ENSG00000146872 E033 66.8354757 0.0008112058 0.0211640683 0.099870667 17 62520773 62520844 72 + 1.869 1.781 -0.296
ENSG00000146872 E034 81.0198210 0.0023810103 0.0016089045 0.014390349 17 62522204 62522273 70 + 1.966 1.838 -0.431
ENSG00000146872 E035 61.0652588 0.0125483463 0.0432578680 0.163223075 17 62523134 62523177 44 + 1.843 1.719 -0.420
ENSG00000146872 E036 23.4982120 0.0016041000 0.4213236671 0.644605352 17 62524236 62524331 96 + 1.403 1.359 -0.155
ENSG00000146872 E037 78.2098669 0.0004887576 0.0028256408 0.022346037 17 62536170 62536337 168 + 1.938 1.830 -0.363
ENSG00000146872 E038 51.7489376 0.0010820262 0.0040678468 0.029556067 17 62552302 62552397 96 + 1.771 1.639 -0.450
ENSG00000146872 E039 0.3447487 0.9539003090 0.3277092505   17 62552687 62552874 188 + 0.000 0.249 13.273
ENSG00000146872 E040 0.3807181 0.0302103412 0.8426801170   17 62553444 62553662 219 + 0.106 0.139 0.448
ENSG00000146872 E041 73.2149385 0.0008220153 0.0008585623 0.008761711 17 62553663 62553755 93 + 1.918 1.789 -0.435
ENSG00000146872 E042 103.7706117 0.0022049614 0.0002174557 0.002866044 17 62560016 62560126 111 + 2.072 1.935 -0.461
ENSG00000146872 E043 0.0000000       17 62560127 62560309 183 +      
ENSG00000146872 E044 0.1614157 0.0354342129 0.6562843422   17 62564760 62565000 241 + 0.106 0.000 -13.710
ENSG00000146872 E045 139.2821012 0.0003835887 0.0071681711 0.045425790 17 62565001 62565137 137 + 2.171 2.103 -0.228
ENSG00000146872 E046 1.1438171 0.0302608424 0.4578574154   17 62572847 62573214 368 + 0.262 0.399 0.865
ENSG00000146872 E047 178.8508291 0.0011773632 0.1200776016 0.315977726 17 62573215 62573367 153 + 2.267 2.233 -0.115
ENSG00000146872 E048 0.8569551 0.0170749972 0.4568908157   17 62574345 62574410 66 + 0.191 0.329 1.033
ENSG00000146872 E049 125.4435826 0.0003446788 0.0088404669 0.053108161 17 62576709 62576775 67 + 2.128 2.058 -0.233
ENSG00000146872 E050 157.1221283 0.0002981184 0.0001798212 0.002446741 17 62578477 62578574 98 + 2.234 2.140 -0.313
ENSG00000146872 E051 1.3388170 0.0413572692 0.0070923150   17 62578575 62580110 1536 + 0.508 0.000 -16.569
ENSG00000146872 E052 119.6123587 0.0003526536 0.0489158325 0.177048525 17 62580111 62580192 82 + 2.098 2.048 -0.169
ENSG00000146872 E053 0.1308682 0.0326491905 0.3691955506   17 62585596 62586134 539 + 0.000 0.139 13.737
ENSG00000146872 E054 109.2543517 0.0004443400 0.9652424253 0.984527456 17 62586135 62586226 92 + 2.034 2.048 0.044
ENSG00000146872 E055 0.4576437 0.2983778377 0.8752304585   17 62586227 62586703 477 + 0.188 0.140 -0.517
ENSG00000146872 E056 112.2024176 0.0003995204 0.0941449717 0.271443501 17 62596585 62596674 90 + 2.020 2.091 0.238
ENSG00000146872 E057 0.3032425 0.0249141878 0.1335804725   17 62597220 62597258 39 + 0.000 0.244 14.788
ENSG00000146872 E058 4.0837196 0.0062073124 0.9262275838 0.965233076 17 62597259 62599741 2483 + 0.688 0.711 0.099
ENSG00000146872 E059 0.9466924 0.0160199128 0.6301235031   17 62600278 62600592 315 + 0.323 0.244 -0.555
ENSG00000146872 E060 148.7770280 0.0003582036 0.6765752146 0.820583007 17 62600651 62600820 170 + 2.160 2.187 0.090
ENSG00000146872 E061 120.5582623 0.0003874603 0.1444804898 0.354122854 17 62602042 62602180 139 + 2.093 2.060 -0.113
ENSG00000146872 E062 0.4054685 0.3715249715 0.2066421983   17 62606096 62606129 34 + 0.000 0.253 13.733
ENSG00000146872 E063 98.5789948 0.0004225477 0.1590069819 0.375271592 17 62606130 62606241 112 + 1.966 2.031 0.219
ENSG00000146872 E064 0.7970432 0.0172157844 0.2891474373   17 62607387 62608040 654 + 0.323 0.139 -1.553
ENSG00000146872 E065 126.9881937 0.0005032341 0.1190879072 0.314386669 17 62608041 62608148 108 + 2.075 2.140 0.217
ENSG00000146872 E066 3.0751628 0.0082946804 0.0472707570 0.173192850 17 62611946 62612391 446 + 0.712 0.399 -1.461
ENSG00000146872 E067 212.4966379 0.0003227056 0.0005506735 0.006137496 17 62612392 62612676 285 + 2.281 2.381 0.333
ENSG00000146872 E068 340.5648152 0.0055831907 0.0001343378 0.001912614 17 62612677 62614523 1847 + 2.448 2.616 0.560
ENSG00000146872 E069 19.3738220 0.0290078337 0.1081227851 0.295927922 17 62614524 62614618 95 + 1.213 1.399 0.651
ENSG00000146872 E070 40.2688553 0.0402577932 0.0502486210 0.180282539 17 62614619 62615147 529 + 1.504 1.718 0.729
ENSG00000146872 E071 24.1331130 0.0438536137 0.0703770146 0.225481290 17 62615148 62615481 334 + 1.290 1.500 0.726
ENSG00000146872 E072 0.3503582 0.0574170956 0.8318900652   17 62616420 62616477 58 + 0.106 0.139 0.445