ENSG00000146842

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397622 ENSG00000146842 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM209 protein_coding protein_coding 19.4423 6.812653 33.44001 1.49916 1.536345 2.293602 13.832933 6.0074108 23.808522 1.3745419 0.7396255 1.984869 0.8010167 0.87723333 0.7138 -0.1634333 0.0064395725 0.0003069238 FALSE TRUE
ENST00000473456 ENSG00000146842 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM209 protein_coding protein_coding 19.4423 6.812653 33.44001 1.49916 1.536345 2.293602 4.864177 0.5835134 9.017649 0.1579102 1.1875224 3.926998 0.1598875 0.08506667 0.2681 0.1830333 0.0003069238 0.0003069238 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146842 E001 429.0389515 0.0270072074 0.097735189 0.27779014 7 130164713 130166077 1365 - 2.501 2.671 0.569
ENSG00000146842 E002 221.3142647 0.0048221581 0.852932472 0.92663614 7 130166078 130166505 428 - 2.248 2.285 0.125
ENSG00000146842 E003 100.5672537 0.0022370249 0.476549697 0.68467461 7 130170400 130170473 74 - 1.904 1.972 0.230
ENSG00000146842 E004 117.8410222 0.0542501788 0.176842537 0.39953079 7 130173632 130173729 98 - 1.946 2.107 0.539
ENSG00000146842 E005 123.4681671 0.3861765009 0.303269574 0.54386257 7 130173825 130173939 115 - 1.960 2.142 0.612
ENSG00000146842 E006 0.0000000       7 130175176 130175511 336 -      
ENSG00000146842 E007 125.9963287 0.0632553573 0.544221374 0.73211219 7 130175512 130175609 98 - 1.998 2.069 0.238
ENSG00000146842 E008 88.6314771 0.0227895676 0.692864913 0.83096326 7 130178402 130178458 57 - 1.866 1.851 -0.050
ENSG00000146842 E009 87.1456059 0.0489576389 0.946271352 0.97546856 7 130178459 130178527 69 - 1.858 1.847 -0.038
ENSG00000146842 E010 102.2021221 0.5205551749 0.487310630 0.69212537 7 130181623 130181719 97 - 1.906 1.983 0.259
ENSG00000146842 E011 0.5705386 0.7051122155 0.829567831   7 130181720 130182057 338 - 0.209 0.001 -8.716
ENSG00000146842 E012 96.7017846 0.0756264013 0.497588484 0.69921466 7 130184184 130184255 72 - 1.883 1.959 0.256
ENSG00000146842 E013 157.3247601 0.0003313167 0.186766762 0.41274910 7 130185192 130185367 176 - 2.115 2.104 -0.038
ENSG00000146842 E014 192.1665451 0.0099196283 0.046289018 0.17077120 7 130192622 130192823 202 - 2.209 2.139 -0.237
ENSG00000146842 E015 161.9857446 0.0188019186 0.171286079 0.39221103 7 130201850 130201982 133 - 2.135 2.069 -0.219
ENSG00000146842 E016 131.4980109 0.0218249654 0.073324899 0.23144728 7 130201983 130202091 109 - 2.052 1.940 -0.377
ENSG00000146842 E017 139.9134439 0.0237404985 0.122713110 0.32002685 7 130202532 130202663 132 - 2.075 1.982 -0.312
ENSG00000146842 E018 77.2810317 0.0282405009 0.450811031 0.66624966 7 130203788 130203814 27 - 1.811 1.770 -0.139
ENSG00000146842 E019 78.5409042 0.0281723667 0.192374039 0.41994931 7 130203815 130203846 32 - 1.827 1.733 -0.316
ENSG00000146842 E020 103.9597460 0.0156730250 0.205365034 0.43632028 7 130203974 130204110 137 - 1.942 1.883 -0.199
ENSG00000146842 E021 2.0699635 0.0103828172 0.576969887 0.75509938 7 130204967 130205082 116 - 0.445 0.358 -0.483
ENSG00000146842 E022 2.7013188 0.0599862804 0.008475941 0.05150714 7 130205083 130205372 290 - 0.362 0.862 2.271
ENSG00000146842 E023 51.7841632 0.0099602358 0.478360689 0.68598707 7 130205373 130205406 34 - 1.635 1.617 -0.062
ENSG00000146842 E024 0.0000000       7 130206877 130206978 102 -      
ENSG00000146842 E025 0.0000000       7 130207739 130207770 32 -