ENSG00000146830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275732 ENSG00000146830 HEK293_OSMI2_6hA HEK293_TMG_6hB GIGYF1 protein_coding protein_coding 22.94172 31.43593 20.33575 5.668356 0.5810104 -0.6281454 4.522825 4.8330273 4.707934 2.0993784 0.6481363 -0.03775389 0.2031625 0.13966667 0.23240000 0.09273333 5.929305e-01 2.069379e-09 FALSE TRUE
ENST00000646601 ENSG00000146830 HEK293_OSMI2_6hA HEK293_TMG_6hB GIGYF1 protein_coding protein_coding 22.94172 31.43593 20.33575 5.668356 0.5810104 -0.6281454 4.437603 7.8652521 0.000000 1.9194230 0.0000000 -9.62118229 0.1831375 0.27646667 0.00000000 -0.27646667 2.069379e-09 2.069379e-09 FALSE TRUE
ENST00000678049 ENSG00000146830 HEK293_OSMI2_6hA HEK293_TMG_6hB GIGYF1 protein_coding protein_coding 22.94172 31.43593 20.33575 5.668356 0.5810104 -0.6281454 5.565846 8.7787741 4.993028 1.8194895 0.9046162 -0.81286030 0.2400917 0.27970000 0.24463333 -0.03506667 8.910086e-01 2.069379e-09 FALSE TRUE
MSTRG.30351.12 ENSG00000146830 HEK293_OSMI2_6hA HEK293_TMG_6hB GIGYF1 protein_coding   22.94172 31.43593 20.33575 5.668356 0.5810104 -0.6281454 2.360997 2.6153736 3.452197 1.4965222 0.1948522 0.39916519 0.1090250 0.07376667 0.16993333 0.09616667 2.605811e-01 2.069379e-09 TRUE TRUE
MSTRG.30351.8 ENSG00000146830 HEK293_OSMI2_6hA HEK293_TMG_6hB GIGYF1 protein_coding   22.94172 31.43593 20.33575 5.668356 0.5810104 -0.6281454 1.012697 0.4698975 3.550359 0.4698975 0.4499250 2.89122472 0.0546250 0.01113333 0.17463333 0.16350000 5.441564e-02 2.069379e-09 FALSE TRUE
MSTRG.30351.9 ENSG00000146830 HEK293_OSMI2_6hA HEK293_TMG_6hB GIGYF1 protein_coding   22.94172 31.43593 20.33575 5.668356 0.5810104 -0.6281454 2.418669 3.2783298 1.264907 0.6555469 0.2481688 -1.36696291 0.1008250 0.10370000 0.06266667 -0.04103333 3.632953e-01 2.069379e-09 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146830 E001 0.1723744 0.031763885 1.00000000   7 100679451 100679495 45 - 0.000 0.086 7.606
ENSG00000146830 E002 0.4646582 0.021768165 0.85790997   7 100679496 100679506 11 - 0.169 0.158 -0.113
ENSG00000146830 E003 172.3376133 0.469364007 0.16348986 0.38192913 7 100679507 100679739 233 - 1.964 2.282 1.065
ENSG00000146830 E004 264.9470178 0.910082841 0.32979100 0.56873985 7 100679740 100679960 221 - 2.204 2.455 0.838
ENSG00000146830 E005 613.4160037 1.292935257 0.45144835 0.66668099 7 100679961 100680593 633 - 2.623 2.804 0.604
ENSG00000146830 E006 234.3140605 0.888023386 0.36647809 0.60109727 7 100680594 100680701 108 - 2.184 2.394 0.700
ENSG00000146830 E007 603.1031724 1.257708009 0.41706665 0.64146056 7 100680702 100681300 599 - 2.585 2.805 0.732
ENSG00000146830 E008 189.3749229 0.857526768 0.45982618 0.67300001 7 100681301 100681469 169 - 2.153 2.283 0.433
ENSG00000146830 E009 109.1885587 0.460649815 0.44305985 0.66076889 7 100681470 100681486 17 - 1.945 2.035 0.302
ENSG00000146830 E010 85.7968694 0.416116689 0.56544134 0.74702004 7 100681487 100681491 5 - 1.890 1.913 0.079
ENSG00000146830 E011 268.7144548 1.004228915 0.48138828 0.68801970 7 100681492 100681771 280 - 2.306 2.433 0.425
ENSG00000146830 E012 20.5620842 0.051850169 0.25202600 0.49007605 7 100681772 100681788 17 - 1.152 1.358 0.726
ENSG00000146830 E013 168.9127835 0.520716719 0.26634120 0.50584751 7 100681864 100681993 130 - 2.028 2.256 0.766
ENSG00000146830 E014 196.7322815 0.799887505 0.34455867 0.58211867 7 100682072 100682235 164 - 2.097 2.321 0.751
ENSG00000146830 E015 201.0643475 0.885987003 0.42888686 0.65026267 7 100682322 100682482 161 - 2.152 2.317 0.552
ENSG00000146830 E016 208.5488885 0.884599230 0.45094050 0.66632990 7 100682590 100682774 185 - 2.182 2.329 0.492
ENSG00000146830 E017 71.1212674 0.329555352 0.54905861 0.73563743 7 100682775 100682777 3 - 1.772 1.848 0.255
ENSG00000146830 E018 110.8748045 0.528257704 0.64606695 0.80088929 7 100682778 100683011 234 - 1.988 2.028 0.132
ENSG00000146830 E019 175.1886574 0.766798501 0.36784732 0.60230180 7 100683012 100683230 219 - 2.061 2.267 0.688
ENSG00000146830 E020 193.0155603 0.873069628 0.48687649 0.69182296 7 100683304 100683444 141 - 2.168 2.289 0.404
ENSG00000146830 E021 167.9741650 0.870669255 0.58823011 0.76250276 7 100683550 100683632 83 - 2.165 2.207 0.142
ENSG00000146830 E022 143.9869311 0.589789351 0.54419942 0.73210146 7 100683818 100683878 61 - 2.101 2.140 0.129
ENSG00000146830 E023 110.5931599 0.452880491 0.42731808 0.64895739 7 100683879 100683918 40 - 1.938 2.046 0.363
ENSG00000146830 E024 1.6150125 0.313688426 0.39910655 0.62749945 7 100684013 100684019 7 - 0.527 0.350 -0.934
ENSG00000146830 E025 136.2297742 0.497378609 0.34450042 0.58208976 7 100684020 100684157 138 - 1.994 2.147 0.513
ENSG00000146830 E026 6.0634048 0.005658365 0.74155382 0.86143038 7 100684158 100684236 79 - 0.759 0.867 0.424
ENSG00000146830 E027 116.8872368 0.417985524 0.28530742 0.52589504 7 100684237 100684337 101 - 1.900 2.089 0.636
ENSG00000146830 E028 109.4328525 0.412062201 0.32795124 0.56697781 7 100684450 100684509 60 - 1.890 2.055 0.555
ENSG00000146830 E029 188.6266817 0.806936946 0.38210520 0.61393870 7 100684510 100684616 107 - 2.102 2.297 0.650
ENSG00000146830 E030 170.4440825 0.533914089 0.28347777 0.52394358 7 100684723 100684837 115 - 2.043 2.257 0.718
ENSG00000146830 E031 134.8589899 0.404194071 0.17962128 0.40345773 7 100684838 100684894 57 - 1.887 2.170 0.951
ENSG00000146830 E032 171.3731639 0.535351731 0.27252834 0.51237062 7 100685049 100685146 98 - 2.041 2.261 0.734
ENSG00000146830 E033 140.3243403 0.517448510 0.36931864 0.60352314 7 100685344 100685396 53 - 2.017 2.156 0.464
ENSG00000146830 E034 179.1795132 0.801364123 0.39196804 0.62201156 7 100685397 100685481 85 - 2.095 2.270 0.583
ENSG00000146830 E035 211.1124367 0.039096812 0.24186489 0.47863128 7 100685974 100686079 106 - 2.288 2.296 0.027
ENSG00000146830 E036 18.5530266 0.150193371 0.06605573 0.21623359 7 100686080 100686179 100 - 1.413 1.166 -0.867
ENSG00000146830 E037 158.1681025 0.088301187 0.21690678 0.44976256 7 100686180 100686316 137 - 2.202 2.153 -0.165
ENSG00000146830 E038 90.0025176 0.074591948 0.95335209 0.97860685 7 100686317 100686433 117 - 1.822 1.966 0.487
ENSG00000146830 E039 91.0635183 0.070058090 0.96909003 0.98636199 7 100686649 100686711 63 - 1.824 1.973 0.499
ENSG00000146830 E040 152.5884228 0.103211302 0.36496149 0.59990761 7 100686712 100686819 108 - 2.154 2.153 -0.006
ENSG00000146830 E041 147.8666388 0.116562875 0.20677466 0.43786044 7 100687006 100687046 41 - 2.187 2.116 -0.237
ENSG00000146830 E042 145.4418644 0.113492482 0.22042904 0.45405904 7 100687298 100687358 61 - 2.175 2.112 -0.213
ENSG00000146830 E043 118.3241677 0.098838767 0.10971443 0.29855268 7 100687359 100687406 48 - 2.118 2.005 -0.377
ENSG00000146830 E044 126.2261995 0.105716905 0.24952657 0.48738523 7 100687505 100687597 93 - 2.112 2.052 -0.200
ENSG00000146830 E045 53.0671429 0.043559018 0.23549141 0.47140753 7 100687598 100687616 19 - 1.718 1.693 -0.084
ENSG00000146830 E046 135.5057557 0.097409435 0.12689898 0.32684106 7 100687788 100687883 96 - 2.173 2.066 -0.359
ENSG00000146830 E047 132.3165883 0.094374296 0.12346378 0.32122978 7 100687981 100688110 130 - 2.156 2.059 -0.325
ENSG00000146830 E048 119.5249919 0.094985506 0.21189331 0.44396617 7 100688204 100688307 104 - 2.081 2.032 -0.164
ENSG00000146830 E049 4.5362082 0.046168642 0.80497622 0.89918159 7 100688308 100688450 143 - 0.682 0.718 0.149
ENSG00000146830 E050 93.5257936 0.082491341 0.12211125 0.31920233 7 100688451 100688515 65 - 2.006 1.910 -0.322
ENSG00000146830 E051 17.2852148 0.108655292 0.04410259 0.16537517 7 100688516 100688591 76 - 1.362 1.156 -0.724
ENSG00000146830 E052 71.6667437 0.077107864 0.13989309 0.34731028 7 100688592 100688597 6 - 1.882 1.802 -0.270
ENSG00000146830 E053 133.1237705 0.094850929 0.11189581 0.30225208 7 100688598 100688718 121 - 2.164 2.058 -0.355
ENSG00000146830 E054 275.5908279 0.119951658 0.01595784 0.08164888 7 100688719 100689276 558 - 2.560 2.318 -0.807
ENSG00000146830 E055 51.7375488 0.130852088 0.02765765 0.12027619 7 100689277 100689301 25 - 1.833 1.604 -0.777
ENSG00000146830 E056 126.5512870 0.109538608 0.10537399 0.29131073 7 100689302 100689555 254 - 2.152 2.031 -0.404
ENSG00000146830 E057 6.9361880 0.004602116 0.74718769 0.86501964 7 100693937 100694109 173 - 0.855 0.880 0.097
ENSG00000146830 E058 16.6697517 0.003192890 0.36429234 0.59924498 7 100694110 100694439 330 - 1.093 1.254 0.575