ENSG00000146826

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316937 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding protein_coding 25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 7.0271302 11.9513336 1.423648 1.7491989 0.95383103 -3.06061575 0.27370000 0.373766667 0.09186667 -0.281900000 0.478240139 0.004120489 FALSE TRUE
ENST00000457641 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding protein_coding 25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 4.2408961 5.0343227 4.516122 1.1159057 0.74192454 -0.15638525 0.16468750 0.141333333 0.25346667 0.112133333 0.066374698 0.004120489 FALSE TRUE
ENST00000470260 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding retained_intron 25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 2.0458361 2.2057757 2.267323 0.4850665 0.27599429 0.03952722 0.08270417 0.062100000 0.12773333 0.065633333 0.004120489 0.004120489 FALSE FALSE
ENST00000472061 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding retained_intron 25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 1.5468395 1.8557779 1.038835 0.6652207 0.18912158 -0.83098989 0.06040417 0.051100000 0.05903333 0.007933333 0.930735279 0.004120489 FALSE FALSE
ENST00000498638 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding retained_intron 25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 4.2567400 5.1711944 3.909476 1.1842394 0.50410775 -0.40262390 0.17383333 0.145766667 0.21996667 0.074200000 0.150009308 0.004120489 FALSE TRUE
ENST00000584344 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding miRNA 25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 1.7463221 3.2814242 0.000000 3.2814242 0.00000000 -8.36256818 0.06007083 0.073466667 0.00000000 -0.073466667 0.950844398 0.004120489   FALSE
MSTRG.30332.11 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding   25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 0.8287579 0.2419112 1.995890 0.2419112 0.65811011 2.99325535 0.03580417 0.007066667 0.10813333 0.101066667 0.088343413 0.004120489 TRUE TRUE
MSTRG.30332.9 ENSG00000146826 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC14 protein_coding   25.50468 34.8421 17.63275 5.501259 1.49888 -0.9821702 2.0556799 3.1914091 1.973008 0.9378603 0.03460738 -0.69101657 0.08474167 0.088233333 0.11326667 0.025033333 0.727408009 0.004120489 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146826 E001 0.4762370 0.0212665691 7.895903e-01   7 100154333 100154419 87 - 0.187 0.142 -0.470
ENSG00000146826 E002 0.9159572 0.0303687995 7.130961e-01   7 100154420 100154422 3 - 0.317 0.249 -0.476
ENSG00000146826 E003 0.9159572 0.0303687995 7.130961e-01   7 100154423 100154423 1 - 0.317 0.249 -0.476
ENSG00000146826 E004 18.1688997 0.0109504501 5.445445e-01 7.323298e-01 7 100154424 100154474 51 - 1.190 1.253 0.224
ENSG00000146826 E005 106.2155310 0.0028028213 9.607124e-01 9.822556e-01 7 100154475 100154726 252 - 1.977 1.981 0.012
ENSG00000146826 E006 88.8189375 0.0104698636 6.855405e-01 8.261976e-01 7 100154727 100154823 97 - 1.877 1.909 0.111
ENSG00000146826 E007 55.0442559 0.0008417807 4.654376e-02 1.714073e-01 7 100154824 100154844 21 - 1.616 1.726 0.376
ENSG00000146826 E008 233.9826092 0.0031951412 7.989290e-01 8.956526e-01 7 100154845 100155164 320 - 2.310 2.320 0.034
ENSG00000146826 E009 192.8796436 0.0013207751 8.894067e-01 9.463944e-01 7 100155262 100155446 185 - 2.235 2.236 0.003
ENSG00000146826 E010 65.1289745 0.1626068214 5.010685e-01 7.015487e-01 7 100155447 100155455 9 - 1.735 1.776 0.139
ENSG00000146826 E011 23.6515436 0.0473827940 1.155311e-01 3.083682e-01 7 100155456 100155670 215 - 1.485 1.276 -0.724
ENSG00000146826 E012 154.6359199 1.0455791356 4.402775e-01 6.589179e-01 7 100155671 100155825 155 - 2.020 2.170 0.502
ENSG00000146826 E013 47.8135855 0.5736440427 8.269705e-01 9.120694e-01 7 100155826 100155919 94 - 1.724 1.597 -0.434
ENSG00000146826 E014 24.4310414 0.3182021696 8.768686e-01 9.396294e-01 7 100155920 100155931 12 - 1.418 1.327 -0.316
ENSG00000146826 E015 42.5290367 0.0466829858 1.554846e-02 8.015562e-02 7 100156265 100156385 121 - 1.759 1.502 -0.873
ENSG00000146826 E016 175.3734400 0.0004125842 1.040100e-01 2.888565e-01 7 100156386 100156549 164 - 2.159 2.207 0.161
ENSG00000146826 E017 3.9911215 0.4066364180 5.479634e-01 7.348503e-01 7 100156605 100156633 29 - 0.681 0.635 -0.199
ENSG00000146826 E018 121.6522004 0.0008071162 2.901100e-01 5.307095e-01 7 100156634 100156716 83 - 2.006 2.044 0.128
ENSG00000146826 E019 123.7024584 0.0004914151 7.988185e-01 8.956163e-01 7 100156845 100156938 94 - 2.039 2.048 0.030
ENSG00000146826 E020 105.5219642 0.0025496843 7.823872e-01 8.860954e-01 7 100156939 100156992 54 - 1.965 1.979 0.046
ENSG00000146826 E021 7.2548581 0.0038797476 1.562478e-02 8.045135e-02 7 100156993 100156996 4 - 1.070 0.781 -1.093
ENSG00000146826 E022 8.5209580 0.0084331767 2.524672e-01 4.905619e-01 7 100156997 100157093 97 - 1.028 0.891 -0.511
ENSG00000146826 E023 138.9897467 0.0014642725 9.995814e-01 1.000000e+00 7 100157094 100157214 121 - 2.095 2.096 0.002
ENSG00000146826 E024 2.4575557 0.0324924170 3.419861e-01 5.797276e-01 7 100157293 100157372 80 - 0.626 0.465 -0.749
ENSG00000146826 E025 116.3197257 0.0005625191 6.907246e-01 8.295323e-01 7 100157373 100157459 87 - 2.033 2.017 -0.051
ENSG00000146826 E026 171.7766206 0.0003877936 2.036202e-04 2.715090e-03 7 100157633 100157762 130 - 2.262 2.153 -0.365
ENSG00000146826 E027 152.4899177 0.0063571584 1.203273e-01 3.163602e-01 7 100157843 100157938 96 - 2.182 2.110 -0.242
ENSG00000146826 E028 49.4220951 0.0771382979 1.521130e-02 7.887960e-02 7 100157939 100158088 150 - 1.840 1.553 -0.972
ENSG00000146826 E029 177.0563979 0.0189110259 1.428016e-01 3.516471e-01 7 100158089 100158588 500 - 2.114 2.219 0.351
ENSG00000146826 E030 39.4711178 0.0012004305 1.626553e-09 9.116376e-08 7 100158589 100158723 135 - 1.175 1.638 1.603