ENSG00000146670

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275517 ENSG00000146670 HEK293_OSMI2_6hA HEK293_TMG_6hB CDCA5 protein_coding protein_coding 117.2038 153.3279 78.98772 19.9586 5.105539 -0.9568312 82.28056 100.3244 58.29486 15.389374 2.486509 -0.7831282 0.6977875 0.6499333 0.7406667 0.09073333 0.357766810 0.003051667 FALSE  
MSTRG.5698.4 ENSG00000146670 HEK293_OSMI2_6hA HEK293_TMG_6hB CDCA5 protein_coding   117.2038 153.3279 78.98772 19.9586 5.105539 -0.9568312 24.86707 41.0416 13.30647 5.225589 1.264687 -1.6242265 0.2095333 0.2681667 0.1683000 -0.09986667 0.003051667 0.003051667 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146670 E001 0.2617363 3.7530899673 0.703084421   11 65066300 65066364 65 - 0.001 0.115 7.924
ENSG00000146670 E002 1.0709555 1.8925304220 0.910909970   11 65066365 65066473 109 - 0.000 0.337 11.621
ENSG00000146670 E003 0.6783511 1.9747630144 0.941582668   11 65066474 65066551 78 - 0.000 0.237 10.916
ENSG00000146670 E004 1.4219339 1.8562743878 0.708441226 0.84080980 11 65066552 65066679 128 - 0.339 0.342 0.016
ENSG00000146670 E005 0.8855973 2.2693067713 0.521303726   11 65066813 65066879 67 - 0.339 0.214 -0.898
ENSG00000146670 E006 0.0000000       11 65067655 65067753 99 -      
ENSG00000146670 E007 0.0000000       11 65068027 65068043 17 -      
ENSG00000146670 E008 0.0000000       11 65068044 65068118 75 -      
ENSG00000146670 E009 0.8148287 2.3514035445 0.963740000   11 65068488 65068601 114 - 0.210 0.228 0.156
ENSG00000146670 E010 3471.0216956 0.0004580050 0.235947303 0.47191406 11 65077453 65078632 1180 - 3.449 3.470 0.068
ENSG00000146670 E011 1702.6038854 0.0001077122 0.567559118 0.74844961 11 65078633 65079087 455 - 3.162 3.157 -0.018
ENSG00000146670 E012 500.9160220 0.0001802292 0.922561511 0.96358293 11 65079088 65079131 44 - 2.627 2.628 0.006
ENSG00000146670 E013 370.0501991 0.0001536367 0.869237152 0.93550322 11 65079132 65079140 9 - 2.500 2.496 -0.012
ENSG00000146670 E014 430.2044945 0.0001463746 0.879250322 0.94092738 11 65079141 65079165 25 - 2.564 2.561 -0.010
ENSG00000146670 E015 454.7806717 0.0001329955 0.727835705 0.85294204 11 65079166 65079187 22 - 2.592 2.585 -0.023
ENSG00000146670 E016 42.6057501 0.0817056873 0.751482227 0.86769582 11 65079188 65079352 165 - 1.591 1.557 -0.114
ENSG00000146670 E017 949.4970608 0.0001034054 0.409518155 0.63571121 11 65079353 65079549 197 - 2.915 2.904 -0.036
ENSG00000146670 E018 827.0774982 0.0005350575 0.893285785 0.94829390 11 65079550 65079787 238 - 2.845 2.846 0.003
ENSG00000146670 E019 12.3581350 0.2357144606 0.151061865 0.36384210 11 65083250 65083363 114 - 1.291 0.954 -1.213
ENSG00000146670 E020 434.6974307 0.0001552075 0.021487398 0.10093168 11 65083364 65083399 36 - 2.602 2.556 -0.155
ENSG00000146670 E021 18.2070696 0.0402112559 0.009337262 0.05525409 11 65083400 65083484 85 - 1.450 1.114 -1.180
ENSG00000146670 E022 452.2288494 0.0001288902 0.030779439 0.12969311 11 65083485 65083550 66 - 2.617 2.574 -0.141
ENSG00000146670 E023 475.2510273 0.0001303283 0.565789601 0.74722821 11 65083629 65083716 88 - 2.597 2.608 0.038
ENSG00000146670 E024 228.2380110 0.0002235712 0.726088639 0.85178811 11 65083717 65083723 7 - 2.295 2.285 -0.034
ENSG00000146670 E025 62.4934716 0.0073600752 0.133800224 0.33773472 11 65083724 65083932 209 - 1.807 1.708 -0.336
ENSG00000146670 E026 329.1811870 0.0001643833 0.026977350 0.11824482 11 65083933 65084048 116 - 2.405 2.458 0.177
ENSG00000146670 E027 79.1735706 0.0005207312 0.001051976 0.01030989 11 65084049 65084070 22 - 1.699 1.866 0.565
ENSG00000146670 E028 35.7794607 0.0048416143 0.020088943 0.09618440 11 65084071 65084075 5 - 1.335 1.534 0.687
ENSG00000146670 E029 27.2086525 0.0183509762 0.089055615 0.26200914 11 65084076 65084156 81 - 1.212 1.418 0.721
ENSG00000146670 E030 8.2716480 1.0007060887 0.489237052 0.69347955 11 65084157 65084219 63 - 0.340 0.981 2.850