ENSG00000146530

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275358 ENSG00000146530 HEK293_OSMI2_6hA HEK293_TMG_6hB VWDE protein_coding protein_coding 0.9762626 0.3998236 1.643098 0.0320614 0.3637809 2.012097 0.24662314 0.192225733 0.1874734 0.081153397 0.09640313 -0.03430822 0.29204167 0.4941333 0.10706667 -0.38706667 0.43039567 0.04749719 FALSE TRUE
ENST00000326715 ENSG00000146530 HEK293_OSMI2_6hA HEK293_TMG_6hB VWDE protein_coding nonsense_mediated_decay 0.9762626 0.3998236 1.643098 0.0320614 0.3637809 2.012097 0.07602396 0.009170254 0.1968615 0.009170254 0.05715234 3.43172393 0.06143333 0.0251000 0.12113333 0.09603333 0.42728657 0.04749719 TRUE FALSE
ENST00000452576 ENSG00000146530 HEK293_OSMI2_6hA HEK293_TMG_6hB VWDE protein_coding nonsense_mediated_decay 0.9762626 0.3998236 1.643098 0.0320614 0.3637809 2.012097 0.24326614 0.127009556 0.5238527 0.055861070 0.05273305 1.96216514 0.24490000 0.3176333 0.35056667 0.03293333 1.00000000 0.04749719 TRUE TRUE
ENST00000485526 ENSG00000146530 HEK293_OSMI2_6hA HEK293_TMG_6hB VWDE protein_coding retained_intron 0.9762626 0.3998236 1.643098 0.0320614 0.3637809 2.012097 0.19994525 0.000000000 0.4064217 0.000000000 0.19983130 5.37997323 0.17585417 0.0000000 0.22726667 0.22726667 0.04749719 0.04749719   FALSE
ENST00000521169 ENSG00000146530 HEK293_OSMI2_6hA HEK293_TMG_6hB VWDE protein_coding nonsense_mediated_decay 0.9762626 0.3998236 1.643098 0.0320614 0.3637809 2.012097 0.09526047 0.071418008 0.1082972 0.049769224 0.05576063 0.53899586 0.10901667 0.1631000 0.08693333 -0.07616667 0.86187532 0.04749719 FALSE TRUE
ENST00000649524 ENSG00000146530 HEK293_OSMI2_6hA HEK293_TMG_6hB VWDE protein_coding protein_coding 0.9762626 0.3998236 1.643098 0.0320614 0.3637809 2.012097 0.10643294 0.000000000 0.2201912 0.000000000 0.15012048 4.52476084 0.09560417 0.0000000 0.10696667 0.10696667 0.64997875 0.04749719 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146530 E001 0.0000000       7 12330885 12330886 2 -      
ENSG00000146530 E002 1.0423134 0.023811631 0.0009556909   7 12330887 12330917 31 - 0.000 0.557 13.838
ENSG00000146530 E003 7.0675108 0.019683536 0.0227168383 0.10502107 7 12330918 12331197 280 - 0.765 1.054 1.098
ENSG00000146530 E004 6.7987599 0.004806052 0.0615725163 0.20632667 7 12333465 12333568 104 - 0.782 1.004 0.847
ENSG00000146530 E005 0.9475002 0.017267182 0.0435775717   7 12333569 12333726 158 - 0.388 0.000 -12.182
ENSG00000146530 E006 6.2637270 0.015036152 0.0950177179 0.27298124 7 12336141 12336236 96 - 0.765 0.982 0.834
ENSG00000146530 E007 7.7945914 0.004345056 0.0025845097 0.02086864 7 12336988 12337083 96 - 0.782 1.118 1.262
ENSG00000146530 E008 5.9074518 0.006155557 0.1153829562 0.30812025 7 12337177 12337272 96 - 0.746 0.944 0.768
ENSG00000146530 E009 7.9061669 0.007237963 0.5363311943 0.72652951 7 12340322 12340417 96 - 0.952 0.875 -0.290
ENSG00000146530 E010 8.0620594 0.050577923 0.5359725675 0.72630221 7 12342059 12342154 96 - 0.976 0.872 -0.394
ENSG00000146530 E011 6.3689393 0.004478517 0.2701100984 0.51008495 7 12343083 12343178 96 - 0.902 0.760 -0.552
ENSG00000146530 E012 8.5849677 0.004485684 0.3440655893 0.58166176 7 12344195 12344290 96 - 1.006 0.899 -0.402
ENSG00000146530 E013 6.5789459 0.007299403 0.3296707401 0.56860761 7 12344374 12344469 96 - 0.914 0.791 -0.476
ENSG00000146530 E014 0.6622309 0.174129459 0.1685763238   7 12345739 12345960 222 - 0.294 0.000 -11.609
ENSG00000146530 E015 5.2361669 0.026623258 0.8168149710 0.90635475 7 12351573 12351713 141 - 0.764 0.794 0.118
ENSG00000146530 E016 6.1062051 0.026809921 0.9987903936 1.00000000 7 12353815 12354349 535 - 0.845 0.847 0.012
ENSG00000146530 E017 2.2428176 0.027505097 0.2008399400 0.43076664 7 12354350 12354487 138 - 0.428 0.647 1.035
ENSG00000146530 E018 6.9068532 0.005120664 0.2595272572 0.49849558 7 12356111 12356330 220 - 0.831 0.965 0.511
ENSG00000146530 E019 9.9569529 0.003485519 0.5247773646 0.71832722 7 12357265 12357515 251 - 1.006 1.072 0.242
ENSG00000146530 E020 5.1310065 0.030441326 0.7333334840 0.85625910 7 12359578 12359692 115 - 0.764 0.818 0.213
ENSG00000146530 E021 5.4181811 0.011710049 0.6958901268 0.83286220 7 12361147 12361251 105 - 0.815 0.760 -0.215
ENSG00000146530 E022 6.1606480 0.005777829 0.3886788961 0.61940821 7 12361366 12361521 156 - 0.874 0.761 -0.445
ENSG00000146530 E023 3.8452266 0.012953766 0.1268404973 0.32675638 7 12367357 12367493 137 - 0.745 0.501 -1.073
ENSG00000146530 E024 12.7325725 0.002990078 0.5390763264 0.72837151 7 12369545 12370509 965 - 1.146 1.088 -0.208
ENSG00000146530 E025 4.5680977 0.020493565 0.7134170686 0.84398904 7 12370656 12370864 209 - 0.707 0.761 0.219
ENSG00000146530 E026 6.2226614 0.123226610 0.4624288244 0.67481611 7 12372977 12373247 271 - 0.883 0.735 -0.582
ENSG00000146530 E027 4.0868714 0.012497503 0.9724734033 0.98821993 7 12374689 12374762 74 - 0.686 0.690 0.019
ENSG00000146530 E028 6.1037362 0.022463701 0.3209595872 0.56054918 7 12375010 12375227 218 - 0.876 0.728 -0.587
ENSG00000146530 E029 0.3088520 0.025794672 0.6674802089   7 12377564 12377775 212 - 0.094 0.156 0.845
ENSG00000146530 E030 4.3662439 0.006093551 0.1328967365 0.33634758 7 12377776 12377920 145 - 0.782 0.556 -0.961
ENSG00000146530 E031 2.5767481 0.008391536 0.1411358749 0.34923674 7 12379477 12379566 90 - 0.615 0.362 -1.267
ENSG00000146530 E032 4.4802364 0.006796907 0.0538484617 0.18872418 7 12380486 12380733 248 - 0.799 0.501 -1.288
ENSG00000146530 E033 2.1959598 0.010939338 0.1080630351 0.29582286 7 12383536 12383601 66 - 0.562 0.271 -1.611
ENSG00000146530 E034 2.1380731 0.014480897 0.0202643823 0.09680332 7 12388808 12388957 150 - 0.590 0.156 -2.738
ENSG00000146530 E035 4.1699564 0.007761580 0.4263248879 0.64827295 7 12389127 12389358 232 - 0.727 0.606 -0.514
ENSG00000146530 E036 2.7014886 0.009676551 0.0984180581 0.27899793 7 12393594 12393778 185 - 0.429 0.691 1.213
ENSG00000146530 E037 2.6455935 0.027636547 0.7414738403 0.86139904 7 12403659 12403941 283 - 0.562 0.501 -0.284