ENSG00000146463

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314607 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding protein_coding 17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 3.2774819 1.7108971 5.3180967 0.6600786 0.6419980 1.6304595 0.16285417 0.19266667 0.17680000 -0.01586667 9.610134e-01 6.828998e-14 FALSE TRUE
ENST00000441447 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding protein_coding 17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 0.9204549 0.0000000 2.5505983 0.0000000 0.9892379 8.0003371 0.03062083 0.00000000 0.08180000 0.08180000 1.664387e-05 6.828998e-14 FALSE FALSE
MSTRG.818.1 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding   17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 1.1389209 0.4922319 0.8045828 0.2640392 0.3346388 0.6977077 0.05425417 0.05163333 0.02686667 -0.02476667 7.297113e-01 6.828998e-14 FALSE TRUE
MSTRG.818.10 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding   17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 1.6657737 1.8072902 1.9687954 0.3276827 1.9687954 0.1228337 0.10921667 0.26436667 0.07470000 -0.18966667 2.252879e-01 6.828998e-14 FALSE TRUE
MSTRG.818.5 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding   17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 2.5099327 0.0000000 4.6481944 0.0000000 2.6114977 8.8636270 0.09765417 0.00000000 0.14443333 0.14443333 4.264092e-01 6.828998e-14 FALSE TRUE
MSTRG.818.6 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding   17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 3.2290546 0.0000000 8.0863177 0.0000000 1.0907142 9.6611221 0.14325833 0.00000000 0.27313333 0.27313333 6.828998e-14 6.828998e-14 FALSE TRUE
MSTRG.818.7 ENSG00000146463 HEK293_OSMI2_6hA HEK293_TMG_6hB ZMYM4 protein_coding   17.57407 8.058941 30.00993 2.177473 1.981559 1.895469 3.4946646 3.5044343 4.0953483 1.0232116 0.8000586 0.2242121 0.31629167 0.42616667 0.13430000 -0.29186667 3.839595e-05 6.828998e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146463 E001 0.6542209 0.0193874923 2.912054e-01   1 35268638 35268708 71 + 0.135 0.330 1.642
ENSG00000146463 E002 23.1328897 0.0101380509 1.077377e-01 2.952928e-01 1 35268709 35269032 324 + 1.279 1.450 0.593
ENSG00000146463 E003 26.0508611 0.0601353506 5.590280e-01 7.425630e-01 1 35269033 35269085 53 + 1.351 1.448 0.336
ENSG00000146463 E004 1.5217953 0.5335538042 6.596958e-01 8.097983e-01 1 35269086 35269094 9 + 0.409 0.202 -1.404
ENSG00000146463 E005 1.2846868 0.0133644838 6.691984e-02   1 35284673 35284706 34 + 0.391 0.000 -11.689
ENSG00000146463 E006 0.0000000       1 35294277 35294336 60 +      
ENSG00000146463 E007 12.0972687 0.1032190283 5.961807e-01 7.678001e-01 1 35295927 35295988 62 + 1.042 1.135 0.337
ENSG00000146463 E008 1.2681187 0.0129016093 6.704946e-02   1 35305564 35305686 123 + 0.391 0.000 -11.687
ENSG00000146463 E009 0.2852693 0.3032677869 1.000000e+00   1 35322711 35322832 122 + 0.133 0.000 -9.341
ENSG00000146463 E010 34.8067720 0.1915897210 5.475989e-01 7.345503e-01 1 35325360 35325405 46 + 1.470 1.561 0.310
ENSG00000146463 E011 173.0924759 0.0374148728 2.841995e-01 5.247128e-01 1 35358925 35359446 522 + 2.203 2.091 -0.373
ENSG00000146463 E012 70.4745349 0.0005808662 3.284565e-03 2.509920e-02 1 35361194 35361255 62 + 1.820 1.689 -0.441
ENSG00000146463 E013 85.1885528 0.0010234761 3.111506e-02 1.306899e-01 1 35361619 35361704 86 + 1.891 1.808 -0.278
ENSG00000146463 E014 54.0435857 0.0007748397 6.918951e-01 8.302746e-01 1 35361705 35361716 12 + 1.681 1.679 -0.007
ENSG00000146463 E015 82.2447457 0.0005011666 7.768313e-02 2.401584e-01 1 35361717 35361789 73 + 1.876 1.815 -0.204
ENSG00000146463 E016 93.3572733 0.0004568542 6.549528e-04 7.051227e-03 1 35370029 35370113 85 + 1.943 1.812 -0.443
ENSG00000146463 E017 142.7793557 0.0008326603 5.808451e-09 2.869278e-07 1 35370372 35370627 256 + 2.139 1.931 -0.697
ENSG00000146463 E018 2.1498242 0.0102530705 6.510951e-01 8.042867e-01 1 35370628 35370853 226 + 0.422 0.516 0.475
ENSG00000146463 E019 118.3726861 0.0008959801 8.691303e-05 1.328877e-03 1 35381259 35381433 175 + 2.046 1.904 -0.477
ENSG00000146463 E020 159.6047107 0.0004680939 6.784111e-03 4.363011e-02 1 35381546 35381758 213 + 2.163 2.093 -0.234
ENSG00000146463 E021 124.3668672 0.0003710847 2.616571e-01 5.007256e-01 1 35385442 35385592 151 + 2.043 2.022 -0.071
ENSG00000146463 E022 97.7841609 0.0005540388 1.598412e-01 3.765497e-01 1 35386074 35386189 116 + 1.943 1.904 -0.132
ENSG00000146463 E023 167.7252429 0.0033626066 3.159516e-01 5.559672e-01 1 35387003 35387278 276 + 2.169 2.147 -0.074
ENSG00000146463 E024 125.6257922 0.0005498339 2.091481e-02 9.906053e-02 1 35387454 35387604 151 + 2.054 1.986 -0.227
ENSG00000146463 E025 143.9348869 0.0003590992 8.464368e-02 2.540328e-01 1 35388910 35389082 173 + 2.107 2.067 -0.133
ENSG00000146463 E026 148.2680210 0.0002880198 3.796872e-02 1.495318e-01 1 35389948 35390098 151 + 2.124 2.073 -0.169
ENSG00000146463 E027 126.2736380 0.0004596985 2.936797e-01 5.343176e-01 1 35392212 35392352 141 + 2.051 2.033 -0.059
ENSG00000146463 E028 78.9962427 0.0005550838 9.912720e-01 9.973977e-01 1 35392647 35392679 33 + 1.837 1.858 0.072
ENSG00000146463 E029 63.0575620 0.0006195832 2.126543e-01 4.448472e-01 1 35392680 35392684 5 + 1.758 1.713 -0.150
ENSG00000146463 E030 144.5083591 0.0004030920 7.761593e-01 8.824607e-01 1 35393595 35393739 145 + 2.096 2.126 0.101
ENSG00000146463 E031 67.4973491 0.0006871085 4.017930e-01 6.298590e-01 1 35396552 35396554 3 + 1.758 1.819 0.207
ENSG00000146463 E032 148.9208312 0.0003332402 7.433725e-01 8.626075e-01 1 35396555 35396670 116 + 2.114 2.122 0.030
ENSG00000146463 E033 0.7721051 0.0236796340 8.206854e-01   1 35397052 35397123 72 + 0.238 0.196 -0.360
ENSG00000146463 E034 208.0758913 0.0002875245 4.188098e-01 6.427114e-01 1 35397377 35397545 169 + 2.260 2.258 -0.009
ENSG00000146463 E035 148.4150279 0.0003634742 2.172709e-01 4.501731e-01 1 35398413 35398466 54 + 2.118 2.096 -0.074
ENSG00000146463 E036 243.3127318 0.0002355188 5.636761e-02 1.944922e-01 1 35398864 35399043 180 + 2.333 2.302 -0.102
ENSG00000146463 E037 160.8523169 0.0003192659 3.880241e-01 6.189513e-01 1 35399482 35399576 95 + 2.150 2.143 -0.026
ENSG00000146463 E038 0.8323924 0.0174009589 8.244258e-01   1 35404844 35405022 179 + 0.238 0.196 -0.358
ENSG00000146463 E039 205.6474317 0.0002127939 7.835377e-01 8.867006e-01 1 35405023 35405194 172 + 2.251 2.263 0.042
ENSG00000146463 E040 125.1978960 0.0003489952 2.817184e-01 5.220685e-01 1 35405373 35405468 96 + 2.024 2.084 0.198
ENSG00000146463 E041 148.1471919 0.0054060480 3.213781e-01 5.608957e-01 1 35408008 35408159 152 + 2.093 2.159 0.220
ENSG00000146463 E042 132.9356496 0.0075497205 5.609681e-01 7.439946e-01 1 35413972 35414083 112 + 2.052 2.094 0.142
ENSG00000146463 E043 248.0480178 0.0002012522 2.060270e-01 4.370511e-01 1 35415466 35415714 249 + 2.320 2.372 0.175
ENSG00000146463 E044 193.7859807 0.0027050340 3.001179e-03 2.340616e-02 1 35418443 35418572 130 + 2.190 2.318 0.428
ENSG00000146463 E045 926.5828892 0.0020520751 5.014195e-11 3.772821e-09 1 35419470 35422058 2589 + 2.856 3.023 0.555