ENSG00000146263

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369251 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding protein_coding 10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 0.7043673 0.00000000 1.7330205 0.00000000 0.37474597 7.445446 0.04069167 0.00000000 0.07616667 0.07616667 0.0003583522 0.0003583522 FALSE TRUE
ENST00000496119 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding nonsense_mediated_decay 10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 1.0464556 0.09939554 2.3340999 0.09939554 0.04430959 4.421408 0.06805417 0.03706667 0.10566667 0.06860000 0.4081140703 0.0003583522 FALSE TRUE
ENST00000506256 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding processed_transcript 10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 1.2471117 0.35799539 1.8554485 0.03482651 0.22191166 2.341763 0.12069167 0.14756667 0.08290000 -0.06466667 0.3322137291 0.0003583522 FALSE TRUE
ENST00000511335 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding retained_intron 10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 0.6962856 0.23911836 0.9625214 0.01263689 0.04397829 1.964899 0.08900417 0.09766667 0.04393333 -0.05373333 0.1967878654 0.0003583522   FALSE
ENST00000683635 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding protein_coding 10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 3.0203251 1.37968158 5.8071059 0.24552634 0.19541690 2.065547 0.36847083 0.54590000 0.26280000 -0.28310000 0.0075999137 0.0003583522 FALSE TRUE
MSTRG.28676.13 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding   10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 1.1585794 0.22552670 1.3172956 0.12267406 0.20849375 2.494527 0.11017083 0.09243333 0.05926667 -0.03316667 0.9523223731 0.0003583522 FALSE TRUE
MSTRG.28676.4 ENSG00000146263 HEK293_OSMI2_6hA HEK293_TMG_6hB MMS22L protein_coding   10.7862 2.49985 22.28316 0.2672044 1.639268 3.150928 2.0975807 0.12584169 5.8402677 0.07572862 0.17453682 5.428504 0.12402500 0.05020000 0.26473333 0.21453333 0.0099354619 0.0003583522 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146263 E001 388.8979356 0.0111791383 1.557070e-07 5.514627e-06 6 97142161 97146544 4384 - 2.367 2.668 1.001
ENSG00000146263 E002 19.4784518 0.0020453831 9.373582e-02 2.707089e-01 6 97146545 97146736 192 - 1.110 1.326 0.762
ENSG00000146263 E003 45.2088608 0.0041561963 9.803253e-02 2.783165e-01 6 97146737 97146887 151 - 1.471 1.643 0.587
ENSG00000146263 E004 66.2407416 0.0021358691 6.499540e-01 8.035435e-01 6 97149853 97150020 168 - 1.646 1.726 0.270
ENSG00000146263 E005 0.1779838 0.0350191355 1.000000e+00   6 97151578 97151770 193 - 0.051 0.000 -8.814
ENSG00000146263 E006 56.4039423 0.0059357070 6.510208e-01 8.042417e-01 6 97151771 97151867 97 - 1.576 1.659 0.283
ENSG00000146263 E007 71.2382959 0.0007547696 2.904594e-01 5.311255e-01 6 97162002 97162165 164 - 1.692 1.681 -0.037
ENSG00000146263 E008 47.5895267 0.0007826521 1.895368e-01 4.163609e-01 6 97165246 97165339 94 - 1.528 1.483 -0.155
ENSG00000146263 E009 44.8992886 0.0009244761 6.920543e-01 8.303606e-01 6 97165340 97165457 118 - 1.495 1.517 0.078
ENSG00000146263 E010 62.9316424 0.0014637063 8.197864e-01 9.079552e-01 6 97168071 97168240 170 - 1.630 1.696 0.226
ENSG00000146263 E011 58.0054303 0.0016919307 4.594371e-01 6.727404e-01 6 97173063 97173222 160 - 1.589 1.689 0.340
ENSG00000146263 E012 58.9673186 0.0006655074 7.150535e-02 2.278369e-01 6 97178443 97178585 143 - 1.620 1.549 -0.239
ENSG00000146263 E013 59.9543949 0.0008305818 6.694380e-02 2.182324e-01 6 97179408 97179559 152 - 1.622 1.550 -0.248
ENSG00000146263 E014 53.3637141 0.0011798256 1.148126e-03 1.103317e-02 6 97181904 97182054 151 - 1.590 1.390 -0.688
ENSG00000146263 E015 61.9221870 0.0008800677 2.925298e-03 2.295140e-02 6 97186497 97186690 194 - 1.651 1.495 -0.532
ENSG00000146263 E016 108.9159828 0.0005495168 6.409604e-04 6.927373e-03 6 97228894 97229403 510 - 1.888 1.764 -0.419
ENSG00000146263 E017 1.4896339 0.0136968632 7.921394e-01 8.916871e-01 6 97230269 97231425 1157 - 0.299 0.265 -0.238
ENSG00000146263 E018 68.9548240 0.0046369668 1.006599e-02 5.844629e-02 6 97231426 97231652 227 - 1.693 1.559 -0.456
ENSG00000146263 E019 47.2330262 0.0010789765 1.552996e-04 2.161801e-03 6 97233861 97233980 120 - 1.542 1.270 -0.940
ENSG00000146263 E020 1.2327695 0.0153787590 2.519919e-01   6 97245979 97246156 178 - 0.299 0.000 -11.810
ENSG00000146263 E021 34.9290551 0.0010698827 8.587581e-05 1.316336e-03 6 97246628 97246690 63 - 1.426 1.076 -1.232
ENSG00000146263 E022 0.1426347 0.0320557957 1.000000e+00   6 97253465 97254556 1092 - 0.051 0.000 -8.811
ENSG00000146263 E023 62.4859115 0.0007483831 3.464544e-04 4.203767e-03 6 97254557 97254733 177 - 1.660 1.458 -0.691
ENSG00000146263 E024 46.4024797 0.0025831485 4.098106e-05 7.026985e-04 6 97258663 97259371 709 - 1.450 1.770 1.092
ENSG00000146263 E025 23.6667676 0.0197915247 1.524263e-02 7.899382e-02 6 97259372 97259662 291 - 1.175 1.482 1.072
ENSG00000146263 E026 5.1995143 0.0051557615 8.939498e-01 9.486844e-01 6 97259663 97259669 7 - 0.650 0.716 0.274
ENSG00000146263 E027 44.6860968 0.0014250842 5.493482e-03 3.718293e-02 6 97259670 97261084 1415 - 1.459 1.696 0.811
ENSG00000146263 E028 25.1818634 0.0366260489 1.054042e-02 6.042001e-02 6 97261085 97261974 890 - 1.194 1.552 1.244
ENSG00000146263 E029 12.9900482 0.0029213897 7.725747e-02 2.393217e-01 6 97261975 97262178 204 - 0.957 1.207 0.907
ENSG00000146263 E030 65.4394624 0.0053517295 5.198639e-01 7.149135e-01 6 97263335 97263448 114 - 1.656 1.665 0.028
ENSG00000146263 E031 6.2402798 0.0097720485 2.408814e-02 1.093483e-01 6 97263449 97265719 2271 - 0.638 1.011 1.468
ENSG00000146263 E032 7.0563189 0.0044783722 5.709001e-01 7.509254e-01 6 97265720 97267871 2152 - 0.766 0.716 -0.202
ENSG00000146263 E033 44.3099447 0.0023474613 3.097826e-01 5.502548e-01 6 97267872 97267903 32 - 1.498 1.470 -0.094
ENSG00000146263 E034 60.9104078 0.0005993795 1.550023e-01 3.694623e-01 6 97267904 97268002 99 - 1.630 1.589 -0.140
ENSG00000146263 E035 65.1808081 0.0006319890 2.452343e-03 2.002136e-02 6 97269902 97269992 91 - 1.671 1.517 -0.523
ENSG00000146263 E036 0.3393995 0.0274424043 1.000000e+00   6 97269993 97270106 114 - 0.096 0.000 -9.814
ENSG00000146263 E037 4.3408803 0.0061906841 2.723650e-01 5.122347e-01 6 97270107 97270283 177 - 0.612 0.428 -0.882
ENSG00000146263 E038 8.2187902 0.0353132272 3.288150e-01 5.677947e-01 6 97270284 97272703 2420 - 0.778 0.975 0.759
ENSG00000146263 E039 82.8401692 0.0006695449 6.227899e-04 6.774102e-03 6 97272704 97272881 178 - 1.772 1.616 -0.528
ENSG00000146263 E040 56.4230261 0.0049204142 2.905687e-03 2.283445e-02 6 97272975 97273062 88 - 1.611 1.419 -0.660
ENSG00000146263 E041 0.2027342 0.0355261500 6.018335e-02   6 97273063 97273105 43 - 0.000 0.265 14.294
ENSG00000146263 E042 44.6305287 0.0020750800 5.521563e-03 3.732836e-02 6 97278849 97278898 50 - 1.510 1.326 -0.638
ENSG00000146263 E043 68.6589468 0.0036598273 2.563234e-01 4.951047e-01 6 97281237 97281362 126 - 1.681 1.657 -0.082
ENSG00000146263 E044 100.5511708 0.0004342203 1.486598e-01 3.603700e-01 6 97282314 97282553 240 - 1.843 1.823 -0.068
ENSG00000146263 E045 1.1137175 0.0153787590 1.000000e+00   6 97282987 97283044 58 - 0.242 0.265 0.173
ENSG00000146263 E046 4.3434691 0.0056814337 6.278512e-01 7.891087e-01 6 97283045 97283077 33 - 0.599 0.547 -0.239
ENSG00000146263 E047 6.3718562 0.0055174231 7.887178e-01 8.897474e-01 6 97283078 97283095 18 - 0.718 0.716 -0.006
ENSG00000146263 E048 47.3650201 0.0012401787 5.308317e-01 7.226337e-01 6 97283096 97283221 126 - 1.521 1.528 0.023