ENSG00000146247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000275034 ENSG00000146247 HEK293_OSMI2_6hA HEK293_TMG_6hB PHIP protein_coding protein_coding 6.710558 1.27523 15.01741 0.2823592 0.8187042 3.547498 4.205097 1.22737165 8.374625 0.272623414 1.6631256 2.760467 0.785550 0.962000000 0.5491333 -0.4128667 1.473401e-04 2.699297e-05 FALSE TRUE
MSTRG.28553.2 ENSG00000146247 HEK293_OSMI2_6hA HEK293_TMG_6hB PHIP protein_coding   6.710558 1.27523 15.01741 0.2823592 0.8187042 3.547498 2.196396 0.01303712 5.890552 0.006622675 0.9783236 8.000746 0.178875 0.008366667 0.4009667 0.3926000 2.699297e-05 2.699297e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146247 E001 569.95384 0.820712798 1.532144e-01 3.669347e-01 6 78934419 78940545 6127 - 2.422 2.921 1.661
ENSG00000146247 E002 132.86423 1.070425644 5.500732e-01 7.362997e-01 6 78940546 78941330 785 - 1.845 2.030 0.620
ENSG00000146247 E003 61.23103 0.477336307 3.825684e-01 6.143022e-01 6 78945300 78945497 198 - 1.507 1.764 0.876
ENSG00000146247 E004 62.14547 0.929224844 4.743863e-01 6.831178e-01 6 78946001 78946260 260 - 1.514 1.761 0.838
ENSG00000146247 E005 54.58571 0.006219762 1.453671e-01 3.554443e-01 6 78946711 78946874 164 - 1.489 1.520 0.105
ENSG00000146247 E006 73.99170 0.017355727 2.267112e-02 1.048667e-01 6 78947623 78947775 153 - 1.617 1.574 -0.146
ENSG00000146247 E007 75.72327 0.019724113 1.116336e-01 3.017678e-01 6 78954814 78954963 150 - 1.622 1.644 0.077
ENSG00000146247 E008 42.95917 0.033420494 1.198290e-01 3.155731e-01 6 78955232 78955282 51 - 1.388 1.379 -0.030
ENSG00000146247 E009 35.32238 0.044194750 9.693389e-02 2.763440e-01 6 78955613 78955682 70 - 1.310 1.264 -0.161
ENSG00000146247 E010 24.78041 0.011039199 1.001178e-01 2.820275e-01 6 78955683 78958474 2792 - 1.164 1.120 -0.159
ENSG00000146247 E011 51.17066 0.021730088 7.084118e-02 2.264003e-01 6 78958475 78958600 126 - 1.461 1.439 -0.075
ENSG00000146247 E012 63.19393 0.018514868 3.913340e-01 6.214857e-01 6 78961690 78961810 121 - 1.540 1.633 0.317
ENSG00000146247 E013 70.62593 0.038637126 1.766754e-01 3.993337e-01 6 78963097 78963252 156 - 1.593 1.625 0.108
ENSG00000146247 E014 48.26948 0.063422966 2.820288e-01 5.223654e-01 6 78965703 78965764 62 - 1.432 1.487 0.191
ENSG00000146247 E015 50.87812 0.019326629 8.806433e-02 2.601292e-01 6 78965945 78966056 112 - 1.458 1.455 -0.010
ENSG00000146247 E016 54.58151 0.013296216 5.856374e-03 3.903399e-02 6 78969835 78969917 83 - 1.495 1.384 -0.380
ENSG00000146247 E017 55.93209 0.015429124 3.065800e-03 2.381064e-02 6 78970049 78970173 125 - 1.506 1.364 -0.490
ENSG00000146247 E018 44.96222 0.032558625 1.626156e-02 8.275655e-02 6 78970781 78970888 108 - 1.414 1.271 -0.498
ENSG00000146247 E019 34.60096 0.048204247 5.906273e-03 3.928178e-02 6 78978592 78978711 120 - 1.312 1.038 -0.977
ENSG00000146247 E020 60.58424 0.025867351 3.275474e-02 1.353672e-01 6 78982886 78983117 232 - 1.536 1.471 -0.222
ENSG00000146247 E021 55.05292 0.011386124 3.949984e-02 1.534621e-01 6 78985352 78985428 77 - 1.493 1.472 -0.073
ENSG00000146247 E022 71.99365 0.014563260 1.856583e-02 9.095095e-02 6 78988209 78988349 141 - 1.607 1.560 -0.161
ENSG00000146247 E023 65.27756 0.027553034 1.296394e-02 7.030282e-02 6 78990868 78990982 115 - 1.568 1.472 -0.331
ENSG00000146247 E024 28.29210 0.062889307 2.077322e-01 4.390718e-01 6 78990983 78990985 3 - 1.214 1.211 -0.013
ENSG00000146247 E025 75.08005 0.023499762 9.041530e-04 9.128231e-03 6 78997414 78997597 184 - 1.633 1.468 -0.564
ENSG00000146247 E026 69.88479 0.027421129 5.203697e-04 5.859352e-03 6 78998254 78998391 138 - 1.605 1.381 -0.767
ENSG00000146247 E027 71.79695 0.026711795 2.503899e-03 2.035712e-02 6 79001899 79002124 226 - 1.613 1.454 -0.545
ENSG00000146247 E028 45.55753 0.040332202 1.787187e-02 8.861213e-02 6 79003730 79003858 129 - 1.421 1.270 -0.525
ENSG00000146247 E029 55.83587 0.024561760 1.539937e-03 1.388682e-02 6 79015082 79015216 135 - 1.509 1.299 -0.725
ENSG00000146247 E030 60.39332 0.025103389 4.931876e-02 1.779558e-01 6 79015630 79015783 154 - 1.532 1.490 -0.144
ENSG00000146247 E031 47.25470 0.034571493 1.547545e-02 7.986784e-02 6 79016544 79016642 99 - 1.437 1.293 -0.500
ENSG00000146247 E032 32.83173 0.031880217 3.453382e-02 1.403057e-01 6 79017346 79017386 41 - 1.284 1.153 -0.462
ENSG00000146247 E033 41.79537 0.032672916 6.376846e-02 2.111716e-01 6 79017483 79017583 101 - 1.380 1.298 -0.284
ENSG00000146247 E034 32.77171 0.038078270 2.977912e-01 5.382705e-01 6 79019089 79019159 71 - 1.271 1.296 0.091
ENSG00000146247 E035 43.03866 0.027391021 8.138904e-02 2.475903e-01 6 79025519 79025619 101 - 1.389 1.344 -0.157
ENSG00000146247 E036 71.94845 0.027423608 1.198433e-01 3.156008e-01 6 79025943 79026164 222 - 1.601 1.602 0.003
ENSG00000146247 E037 61.41006 0.027358835 2.928863e-01 5.335614e-01 6 79042843 79043003 161 - 1.530 1.587 0.194
ENSG00000146247 E038 41.08138 0.050507008 5.122943e-01 7.096832e-01 6 79060478 79060576 99 - 1.358 1.444 0.299
ENSG00000146247 E039 41.13269 0.042740721 4.915777e-01 6.950450e-01 6 79060668 79060818 151 - 1.358 1.457 0.344
ENSG00000146247 E040 27.45626 0.001879414 2.477940e-06 6.298626e-05 6 79077448 79077507 60 - 1.126 1.677 1.913
ENSG00000146247 E041 20.71351 0.010522242 5.269696e-08 2.090924e-06 6 79077700 79077729 30 - 0.981 1.665 2.402
ENSG00000146247 E042 22.94848 0.502173072 3.209452e-02 1.334930e-01 6 79077855 79077913 59 - 0.992 1.745 2.632
ENSG00000146247 E043 28.30061 0.606647579 6.375921e-02 2.111584e-01 6 79078029 79078411 383 - 1.095 1.790 2.404