ENSG00000146122

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274867 ENSG00000146122 HEK293_OSMI2_6hA HEK293_TMG_6hB DAAM2 protein_coding protein_coding 3.254377 4.221186 2.189085 0.3646146 0.03692512 -0.9441587 2.5114301 3.1586897 1.988183 0.1898331 0.09343228 -0.6651977 0.78589167 0.7520667 0.9078667 0.1558 0.1880684221 0.0002888775 FALSE TRUE
ENST00000405961 ENSG00000146122 HEK293_OSMI2_6hA HEK293_TMG_6hB DAAM2 protein_coding protein_coding 3.254377 4.221186 2.189085 0.3646146 0.03692512 -0.9441587 0.3264821 0.6565083 0.000000 0.1855794 0.00000000 -6.0585509 0.07878333 0.1501000 0.0000000 -0.1501 0.0002888775 0.0002888775 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000146122 E001 0.8876225 0.142070837 0.539069534   6 39792298 39792373 76 + 0.171 0.312 1.122
ENSG00000146122 E002 0.8876225 0.142070837 0.539069534   6 39792374 39792375 2 + 0.171 0.312 1.122
ENSG00000146122 E003 0.8876225 0.142070837 0.539069534   6 39792376 39792378 3 + 0.171 0.312 1.122
ENSG00000146122 E004 3.2080178 0.009174929 0.608538997 0.77593097 6 39792379 39792395 17 + 0.534 0.626 0.418
ENSG00000146122 E005 9.3801001 0.007606982 0.051361679 0.18298985 6 39792396 39792465 70 + 0.800 1.054 0.959
ENSG00000146122 E006 0.0000000       6 39792997 39793017 21 +      
ENSG00000146122 E007 0.4054685 0.521719295 0.689279897   6 39793018 39793143 126 + 0.000 0.164 9.700
ENSG00000146122 E008 0.6783511 0.019387492 0.188051138   6 39848566 39848936 371 + 0.000 0.270 11.480
ENSG00000146122 E009 23.8458826 0.012601629 0.012309507 0.06768017 6 39856247 39856470 224 + 1.176 1.431 0.894
ENSG00000146122 E010 21.3415862 0.055144122 0.821097091 0.90863669 6 39860928 39861017 90 + 1.280 1.331 0.181
ENSG00000146122 E011 7.1973999 0.034302812 0.007810773 0.04843529 6 39861018 39861122 105 + 0.533 0.988 1.856
ENSG00000146122 E012 1.0412158 0.016676636 0.331854055   6 39861123 39861328 206 + 0.171 0.360 1.416
ENSG00000146122 E013 0.6434498 0.020014506 0.004143508   6 39861329 39862819 1491 + 0.467 0.000 -13.753
ENSG00000146122 E014 13.8954544 0.101526872 0.181639085 0.40615282 6 39864433 39864507 75 + 1.284 1.050 -0.837
ENSG00000146122 E015 15.2737464 0.017095268 0.005347617 0.03643232 6 39864980 39865074 95 + 1.347 1.072 -0.977
ENSG00000146122 E016 0.0000000       6 39867313 39867509 197 +      
ENSG00000146122 E017 31.2646091 0.029151324 0.029392851 0.12554597 6 39867510 39867843 334 + 1.604 1.399 -0.702
ENSG00000146122 E018 0.0000000       6 39867844 39868822 979 +      
ENSG00000146122 E019 19.3320317 0.002414121 0.213533809 0.44582491 6 39868823 39868933 111 + 1.338 1.245 -0.324
ENSG00000146122 E020 16.5385451 0.002104016 0.040117241 0.15500023 6 39870340 39870443 104 + 1.318 1.151 -0.591
ENSG00000146122 E021 15.0735613 0.002676558 0.012502188 0.06844070 6 39871506 39871572 67 + 1.308 1.094 -0.758
ENSG00000146122 E022 18.9341794 0.003791134 0.100546815 0.28278094 6 39873238 39873355 118 + 1.347 1.218 -0.452
ENSG00000146122 E023 20.5857696 0.024098145 0.153249561 0.36700841 6 39875330 39875468 139 + 1.385 1.253 -0.461
ENSG00000146122 E024 13.3262163 0.050164257 0.345067932 0.58264286 6 39878203 39878261 59 + 1.202 1.094 -0.384
ENSG00000146122 E025 16.8408099 0.002266288 0.114085038 0.30589171 6 39878404 39878588 185 + 1.308 1.182 -0.444
ENSG00000146122 E026 18.0087122 0.084167514 0.908640001 0.95644235 6 39879178 39879477 300 + 1.257 1.241 -0.056
ENSG00000146122 E027 1.6360021 0.013912921 0.978177099 0.99085754 6 39879478 39880017 540 + 0.389 0.399 0.058
ENSG00000146122 E028 14.6695760 0.162821619 0.883772198 0.94323744 6 39883962 39884069 108 + 1.178 1.154 -0.085
ENSG00000146122 E029 1.6906799 0.356367725 0.639944913 0.79686588 6 39885924 39886420 497 + 0.294 0.443 0.870
ENSG00000146122 E030 1.0011825 0.025149741 0.881788723   6 39886421 39886447 27 + 0.294 0.270 -0.164
ENSG00000146122 E031 2.3077891 0.293270479 0.738141725 0.85936521 6 39886448 39887404 957 + 0.581 0.481 -0.470
ENSG00000146122 E032 0.1426347 0.030681572 0.210472315   6 39887405 39887485 81 + 0.171 0.000 -11.779
ENSG00000146122 E033 15.2621913 0.232263197 0.517728332 0.71343252 6 39887486 39887592 107 + 1.112 1.203 0.323
ENSG00000146122 E034 1.4697848 0.069754774 0.883435411 0.94304356 6 39887593 39888678 1086 + 0.388 0.362 -0.149
ENSG00000146122 E035 16.9396767 0.107371346 0.229768404 0.46489125 6 39888679 39888763 85 + 1.088 1.266 0.635
ENSG00000146122 E036 16.3713645 0.055816332 0.068850614 0.22248811 6 39891341 39891447 107 + 1.020 1.267 0.884
ENSG00000146122 E037 14.1969346 0.015074552 0.104258828 0.28932101 6 39891634 39891722 89 + 1.006 1.196 0.685
ENSG00000146122 E038 19.0773644 0.046906965 0.474391221 0.68311783 6 39896812 39896980 169 + 1.211 1.291 0.283
ENSG00000146122 E039 19.5093554 0.091908342 0.745883523 0.86428663 6 39897175 39897282 108 + 1.274 1.282 0.027
ENSG00000146122 E040 18.8181924 0.002061600 0.935120012 0.96977122 6 39898877 39898937 61 + 1.264 1.266 0.005
ENSG00000146122 E041 10.6458201 0.020400596 0.607194412 0.77502751 6 39900077 39900079 3 + 1.066 1.019 -0.171
ENSG00000146122 E042 22.0052293 0.001734977 0.276720092 0.51672369 6 39900080 39900208 129 + 1.375 1.300 -0.260
ENSG00000146122 E043 24.9996900 0.022014239 0.446631067 0.66316831 6 39901302 39901472 171 + 1.418 1.363 -0.191
ENSG00000146122 E044 35.1050773 0.001194425 0.906694161 0.95544352 6 39901813 39902079 267 + 1.523 1.525 0.007
ENSG00000146122 E045 71.1725218 0.000744049 0.628505512 0.78961076 6 39902080 39902759 680 + 1.798 1.829 0.103
ENSG00000146122 E046 127.4646458 0.001112844 0.179467337 0.40328263 6 39902760 39904070 1311 + 2.034 2.090 0.186
ENSG00000146122 E047 64.6121045 0.075810494 0.062277527 0.20789740 6 39904071 39904877 807 + 1.616 1.838 0.754