ENSG00000145860

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274542 ENSG00000145860 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF145 protein_coding protein_coding 25.25419 16.93166 31.24805 0.8477077 1.440595 0.8836528 1.590964 1.6514374 0.000000 0.8595739 0.0000000 -7.3762881 0.07304167 0.10286667 0.0000000 -0.10286667 2.118372e-01 2.882552e-05 FALSE TRUE
ENST00000518284 ENSG00000145860 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF145 protein_coding processed_transcript 25.25419 16.93166 31.24805 0.8477077 1.440595 0.8836528 2.552996 0.7171997 3.563979 0.7171997 0.6050868 2.2971076 0.09556667 0.04516667 0.1138333 0.06866667 3.186145e-01 2.882552e-05 FALSE TRUE
ENST00000611185 ENSG00000145860 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF145 protein_coding protein_coding 25.25419 16.93166 31.24805 0.8477077 1.440595 0.8836528 10.486378 10.6285971 5.550574 1.0633927 0.8636195 -0.9360022 0.43884167 0.62973333 0.1759000 -0.45383333 2.882552e-05 2.882552e-05 FALSE TRUE
MSTRG.27245.4 ENSG00000145860 HEK293_OSMI2_6hA HEK293_TMG_6hB RNF145 protein_coding   25.25419 16.93166 31.24805 0.8477077 1.440595 0.8836528 7.483593 2.2982861 19.191408 2.2982861 0.5667992 3.0563182 0.27014167 0.12350000 0.6173667 0.49386667 1.203672e-01 2.882552e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145860 E001 0.8995767 0.016432481 8.519291e-01   5 159157409 159157410 2 - 0.274 0.315 0.275
ENSG00000145860 E002 0.8995767 0.016432481 8.519291e-01   5 159157411 159157412 2 - 0.274 0.315 0.275
ENSG00000145860 E003 102.2206667 0.766421112 3.550610e-01 5.918368e-01 5 159157413 159157620 208 - 1.930 2.093 0.545
ENSG00000145860 E004 200.7425992 1.289675979 4.998710e-01 7.006403e-01 5 159157621 159157823 203 - 2.247 2.362 0.385
ENSG00000145860 E005 227.4679018 1.331327341 4.955382e-01 6.978294e-01 5 159157824 159158140 317 - 2.295 2.421 0.420
ENSG00000145860 E006 183.1477580 1.254272016 4.908445e-01 6.945617e-01 5 159158141 159158290 150 - 2.204 2.325 0.402
ENSG00000145860 E007 88.5985509 0.744876242 4.221559e-01 6.452666e-01 5 159158291 159158298 8 - 1.902 2.003 0.338
ENSG00000145860 E008 172.3042479 1.236983910 5.056174e-01 7.046888e-01 5 159158299 159158426 128 - 2.188 2.290 0.341
ENSG00000145860 E009 120.9820508 1.124108631 5.459702e-01 7.334036e-01 5 159158427 159158520 94 - 2.059 2.114 0.183
ENSG00000145860 E010 229.0702365 1.352999152 5.403236e-01 7.292316e-01 5 159158521 159158839 319 - 2.319 2.405 0.286
ENSG00000145860 E011 171.7787296 1.248070339 5.310284e-01 7.227998e-01 5 159158840 159159035 196 - 2.198 2.278 0.267
ENSG00000145860 E012 3.3514260 0.006890098 1.069800e-01 2.939609e-01 5 159161141 159161265 125 - 0.732 0.496 -1.043
ENSG00000145860 E013 192.5175893 0.003552685 1.045211e-03 1.025500e-02 5 159161266 159161483 218 - 2.327 2.234 -0.309
ENSG00000145860 E014 175.6447096 0.041439864 7.845969e-02 2.417099e-01 5 159161484 159161622 139 - 2.296 2.176 -0.401
ENSG00000145860 E015 146.8663223 0.038122653 1.034944e-01 2.880323e-01 5 159162932 159163079 148 - 2.212 2.109 -0.347
ENSG00000145860 E016 123.8732214 0.042489010 2.339904e-01 4.697317e-01 5 159168873 159168991 119 - 2.125 2.055 -0.234
ENSG00000145860 E017 124.5523429 0.058344977 9.262944e-02 2.686467e-01 5 159168992 159169055 64 - 2.158 2.011 -0.491
ENSG00000145860 E018 155.3215042 0.056762841 6.329265e-02 2.101214e-01 5 159169679 159169819 141 - 2.260 2.096 -0.548
ENSG00000145860 E019 167.6473522 0.067063167 7.527090e-02 2.353704e-01 5 159173983 159174158 176 - 2.295 2.124 -0.572
ENSG00000145860 E020 237.1876579 0.034099776 2.327136e-01 4.682922e-01 5 159176632 159176867 236 - 2.397 2.348 -0.165
ENSG00000145860 E021 176.1243259 0.035422103 9.160366e-01 9.601950e-01 5 159181960 159182051 92 - 2.225 2.271 0.151
ENSG00000145860 E022 188.9058139 0.033785588 4.123390e-01 6.378576e-01 5 159194716 159194824 109 - 2.212 2.343 0.437
ENSG00000145860 E023 171.8777174 0.026180819 1.950648e-01 4.234390e-01 5 159203434 159203656 223 - 2.157 2.315 0.525
ENSG00000145860 E024 0.1723744 0.036727504 4.401224e-01   5 159207475 159207754 280 - 0.000 0.132 10.843
ENSG00000145860 E025 0.1723744 0.036727504 4.401224e-01   5 159207755 159207826 72 - 0.000 0.132 10.843
ENSG00000145860 E026 0.1614157 0.031998176 5.439747e-01   5 159207885 159207887 3 - 0.112 0.000 -10.322
ENSG00000145860 E027 2.0906971 0.146084749 6.372926e-01 7.952367e-01 5 159207888 159208132 245 - 0.524 0.445 -0.394
ENSG00000145860 E028 0.3336024 0.027442404 1.706702e-01   5 159208346 159208411 66 - 0.000 0.233 11.841
ENSG00000145860 E029 62.5832944 0.016931232 9.204421e-09 4.361391e-07 5 159209231 159209510 280 - 1.509 2.003 1.674
ENSG00000145860 E030 3.2066600 0.045065787 9.310009e-04 9.346499e-03 5 159209511 159209542 32 - 0.273 0.864 2.852
ENSG00000145860 E031 4.4882741 0.009912493 4.014376e-10 2.505451e-08 5 159209543 159209598 56 - 0.000 1.038 15.646
ENSG00000145860 E032 1.2555443 0.017986921 6.162455e-01   5 159209644 159209852 209 - 0.392 0.315 -0.464
ENSG00000145860 E033 0.9396778 0.017267182 1.342091e-01   5 159209853 159210053 201 - 0.392 0.132 -2.042