ENSG00000145734

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358731 ENSG00000145734 HEK293_OSMI2_6hA HEK293_TMG_6hB BDP1 protein_coding protein_coding 6.599871 2.446699 12.16907 0.1728506 0.1620139 2.30961 3.6604013 0.4614527 7.4417306 0.2311904 0.2037821 3.9823906 0.38012083 0.19770000 0.61210000 0.41440000 0.32983167 0.01563106 FALSE TRUE
ENST00000514903 ENSG00000145734 HEK293_OSMI2_6hA HEK293_TMG_6hB BDP1 protein_coding nonsense_mediated_decay 6.599871 2.446699 12.16907 0.1728506 0.1620139 2.30961 0.5790617 0.6776144 0.9506256 0.1116912 0.1463154 0.4823744 0.11617500 0.28453333 0.07786667 -0.20666667 0.01563106 0.01563106 TRUE TRUE
ENST00000525844 ENSG00000145734 HEK293_OSMI2_6hA HEK293_TMG_6hB BDP1 protein_coding nonsense_mediated_decay 6.599871 2.446699 12.16907 0.1728506 0.1620139 2.30961 0.7812040 0.8159024 0.7160361 0.2433834 0.3959956 -0.1859299 0.28893750 0.32193333 0.05936667 -0.26256667 0.35498765 0.01563106 TRUE TRUE
MSTRG.26356.12 ENSG00000145734 HEK293_OSMI2_6hA HEK293_TMG_6hB BDP1 protein_coding   6.599871 2.446699 12.16907 0.1728506 0.1620139 2.30961 0.2428957 0.0000000 0.8599849 0.0000000 0.6195088 6.4429184 0.02515833 0.00000000 0.07010000 0.07010000 0.59854243 0.01563106 FALSE TRUE
MSTRG.26356.13 ENSG00000145734 HEK293_OSMI2_6hA HEK293_TMG_6hB BDP1 protein_coding   6.599871 2.446699 12.16907 0.1728506 0.1620139 2.30961 0.2217302 0.0000000 0.6154713 0.0000000 0.3288024 5.9668717 0.03267083 0.00000000 0.05096667 0.05096667 0.58034274 0.01563106 FALSE TRUE
MSTRG.26356.14 ENSG00000145734 HEK293_OSMI2_6hA HEK293_TMG_6hB BDP1 protein_coding   6.599871 2.446699 12.16907 0.1728506 0.1620139 2.30961 0.4132307 0.2349839 0.4274508 0.1182508 0.2149401 0.8364339 0.07315417 0.08976667 0.03516667 -0.05460000 0.88102090 0.01563106 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145734 E001 0.0000000       5 71455603 71455650 48 +      
ENSG00000145734 E002 0.1426347 0.0320552152 1.000000e+00   5 71455651 71455666 16 + 0.048 0.000 -8.887
ENSG00000145734 E003 0.8048655 0.0183713330 5.098855e-01   5 71455667 71455677 11 + 0.201 0.000 -11.182
ENSG00000145734 E004 1.9461099 0.0113300511 8.418017e-01 9.204604e-01 5 71455678 71455685 8 + 0.338 0.443 0.590
ENSG00000145734 E005 1.9461099 0.0113300511 8.418017e-01 9.204604e-01 5 71455686 71455693 8 + 0.338 0.443 0.590
ENSG00000145734 E006 3.3670141 0.0073934347 2.703895e-01 5.103684e-01 5 71455694 71455735 42 + 0.460 0.735 1.235
ENSG00000145734 E007 4.3058841 0.0106771414 5.294757e-02 1.865850e-01 5 71455736 71455751 16 + 0.510 0.908 1.665
ENSG00000145734 E008 12.4451287 0.0120155778 1.248926e-01 3.235660e-01 5 71455752 71455894 143 + 0.913 1.205 1.064
ENSG00000145734 E009 24.4648203 0.0038665572 5.871813e-01 7.617616e-01 5 71455895 71456089 195 + 1.224 1.272 0.170
ENSG00000145734 E010 22.7935934 0.0016262658 7.985844e-04 8.271408e-03 5 71458579 71458664 86 + 1.227 0.908 -1.161
ENSG00000145734 E011 42.6434352 0.0016748636 1.639572e-05 3.225638e-04 5 71458665 71458855 191 + 1.484 1.181 -1.056
ENSG00000145734 E012 31.9665892 0.0234290425 3.489985e-02 1.413371e-01 5 71461817 71461926 110 + 1.354 1.204 -0.529
ENSG00000145734 E013 23.1345091 0.0195168764 2.952117e-01 5.357141e-01 5 71464058 71464117 60 + 1.207 1.180 -0.093
ENSG00000145734 E014 27.5471534 0.0098253228 3.453982e-02 1.403200e-01 5 71466096 71466221 126 + 1.289 1.155 -0.476
ENSG00000145734 E015 26.9732953 0.0013310732 3.092861e-03 2.397585e-02 5 71467354 71467487 134 + 1.289 1.066 -0.795
ENSG00000145734 E016 20.4782908 0.0207432004 1.213399e-02 6.698535e-02 5 71470395 71470489 95 + 1.180 0.908 -0.995
ENSG00000145734 E017 19.0959584 0.0079254095 1.395449e-03 1.286324e-02 5 71483842 71483896 55 + 1.159 0.800 -1.338
ENSG00000145734 E018 16.4461096 0.0044225250 7.074212e-02 2.262200e-01 5 71486484 71486530 47 + 1.089 0.952 -0.502
ENSG00000145734 E019 9.8690939 0.0104985616 6.775317e-01 8.211787e-01 5 71486531 71486534 4 + 0.872 0.907 0.130
ENSG00000145734 E020 25.6247691 0.0130743848 1.230732e-02 6.767182e-02 5 71486535 71486627 93 + 1.268 1.064 -0.728
ENSG00000145734 E021 62.6766709 0.0008112212 1.925344e-07 6.664648e-06 5 71489404 71489682 279 + 1.647 1.348 -1.028
ENSG00000145734 E022 36.6519953 0.0098634514 3.247880e-02 1.346396e-01 5 71490984 71491131 148 + 1.411 1.292 -0.414
ENSG00000145734 E023 0.3150090 0.0273711733 1.967485e-01   5 71494465 71495249 785 + 0.048 0.276 2.917
ENSG00000145734 E024 36.1921833 0.0060907935 4.100004e-02 1.573105e-01 5 71495250 71495408 159 + 1.403 1.310 -0.322
ENSG00000145734 E025 40.8294924 0.0165470511 8.762131e-02 2.592896e-01 5 71497270 71497426 157 + 1.447 1.365 -0.282
ENSG00000145734 E026 34.7299335 0.0121969824 1.808925e-02 8.932484e-02 5 71501562 71501653 92 + 1.386 1.230 -0.542
ENSG00000145734 E027 45.2790057 0.0098103028 2.909927e-02 1.246494e-01 5 71502599 71502791 193 + 1.493 1.395 -0.335
ENSG00000145734 E028 36.2826297 0.0143189119 3.982369e-01 6.268459e-01 5 71504621 71504751 131 + 1.387 1.409 0.076
ENSG00000145734 E029 100.5073290 0.0007370907 2.793311e-04 3.522713e-03 5 71509465 71510095 631 + 1.834 1.740 -0.315
ENSG00000145734 E030 44.2481633 0.0007955036 3.605246e-04 4.342474e-03 5 71510096 71510251 156 + 1.496 1.292 -0.704
ENSG00000145734 E031 45.8930602 0.0017955778 9.151477e-04 9.220594e-03 5 71510252 71510413 162 + 1.507 1.330 -0.612
ENSG00000145734 E032 44.1505857 0.0127140956 2.188074e-01 4.519787e-01 5 71510414 71510578 165 + 1.474 1.467 -0.025
ENSG00000145734 E033 102.0230864 0.0081884814 1.176743e-03 1.125224e-02 5 71510579 71511151 573 + 1.841 1.724 -0.396
ENSG00000145734 E034 0.1614157 0.0329618248 1.000000e+00   5 71511152 71511350 199 + 0.048 0.000 -8.859
ENSG00000145734 E035 40.3782119 0.0103401031 5.221646e-02 1.848652e-01 5 71512241 71512428 188 + 1.444 1.363 -0.282
ENSG00000145734 E036 48.8040137 0.0108418461 4.796992e-02 1.749355e-01 5 71513185 71513407 223 + 1.521 1.442 -0.272
ENSG00000145734 E037 53.6854132 0.0007748593 2.745689e-02 1.196667e-01 5 71514944 71515122 179 + 1.561 1.505 -0.189
ENSG00000145734 E038 65.8576229 0.0055793643 1.465656e-01 3.572793e-01 5 71516061 71516271 211 + 1.642 1.646 0.015
ENSG00000145734 E039 55.6038250 0.0507297576 6.090884e-01 7.762702e-01 5 71517322 71517452 131 + 1.563 1.627 0.218
ENSG00000145734 E040 33.7299927 0.0208346789 4.346749e-01 6.547497e-01 5 71522289 71522315 27 + 1.357 1.380 0.079
ENSG00000145734 E041 66.3376423 0.0127087547 9.458675e-01 9.753088e-01 5 71522316 71522490 175 + 1.629 1.741 0.381
ENSG00000145734 E042 28.3782764 0.0073292977 3.531909e-01 5.901661e-01 5 71522756 71522792 37 + 1.284 1.293 0.030
ENSG00000145734 E043 56.1915938 0.0007895254 2.963988e-01 5.369252e-01 5 71522793 71522949 157 + 1.549 1.719 0.578
ENSG00000145734 E044 107.8610830 0.0026267635 7.360623e-01 8.579941e-01 5 71523939 71524323 385 + 1.838 1.926 0.296
ENSG00000145734 E045 47.9331001 0.0052024448 5.118825e-01 7.094133e-01 5 71532308 71532373 66 + 1.501 1.552 0.173
ENSG00000145734 E046 48.8417473 0.0008598481 1.589918e-01 3.752462e-01 5 71532374 71532427 54 + 1.516 1.517 0.003
ENSG00000145734 E047 48.2418279 0.0008811381 1.336421e-01 3.375198e-01 5 71539042 71539078 37 + 1.512 1.505 -0.023
ENSG00000145734 E048 50.8405636 0.0007652604 2.983792e-01 5.388136e-01 5 71539557 71539649 93 + 1.530 1.561 0.107
ENSG00000145734 E049 19.6143648 0.0018039592 2.008097e-01 4.307289e-01 5 71541454 71541456 3 + 1.144 1.097 -0.166
ENSG00000145734 E050 33.6278266 0.0029757687 3.953827e-01 6.246401e-01 5 71541457 71541511 55 + 1.354 1.381 0.093
ENSG00000145734 E051 66.8969088 0.0006106775 6.628379e-01 8.116428e-01 5 71541512 71541682 171 + 1.640 1.719 0.269
ENSG00000145734 E052 73.4191064 0.0005816767 6.521785e-01 8.048450e-01 5 71542105 71542265 161 + 1.681 1.761 0.270
ENSG00000145734 E053 62.5049124 0.0007476825 9.770002e-01 9.902602e-01 5 71544357 71544507 151 + 1.608 1.712 0.351
ENSG00000145734 E054 56.1530798 0.0116658035 9.099191e-01 9.570968e-01 5 71545039 71545219 181 + 1.561 1.662 0.344
ENSG00000145734 E055 2.3198134 0.0101736582 9.808912e-01 9.922320e-01 5 71545220 71545477 258 + 0.382 0.443 0.330
ENSG00000145734 E056 41.5480115 0.0021170896 3.382238e-02 1.383919e-01 5 71548682 71548745 64 + 1.455 1.381 -0.257
ENSG00000145734 E057 64.1465374 0.0062516041 3.503151e-01 5.875246e-01 5 71549420 71549606 187 + 1.625 1.663 0.130
ENSG00000145734 E058 61.7291073 0.0073632791 2.721360e-01 5.120033e-01 5 71553116 71553320 205 + 1.587 1.773 0.633
ENSG00000145734 E059 35.5770684 0.0084369621 9.630236e-01 9.834604e-01 5 71556886 71556925 40 + 1.367 1.468 0.348
ENSG00000145734 E060 74.0140334 0.0109823199 2.614427e-01 5.005298e-01 5 71559982 71560237 256 + 1.663 1.850 0.635
ENSG00000145734 E061 59.4977129 0.0006943435 2.184089e-02 1.020550e-01 5 71562274 71562520 247 + 1.566 1.805 0.812
ENSG00000145734 E062 13.1906939 0.0025022094 5.525093e-01 7.380480e-01 5 71562775 71562895 121 + 0.959 1.127 0.615
ENSG00000145734 E063 390.1644319 1.8455979643 2.862095e-01 5.268799e-01 5 71564754 71567820 3067 + 2.293 2.832 1.795