ENSG00000145675

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336483 ENSG00000145675 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3R1 protein_coding protein_coding 3.940026 1.966327 6.970539 0.6504647 0.4431663 1.820517 0.1218854 0.0000000 0.3097597 0.0000000 0.1555680 4.998916 0.05521250 0.0000000 0.04673333 0.04673333 0.61545496 0.04625295 FALSE TRUE
ENST00000521381 ENSG00000145675 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3R1 protein_coding protein_coding 3.940026 1.966327 6.970539 0.6504647 0.4431663 1.820517 3.0515532 1.2867705 5.1858301 0.3482120 0.3029255 2.002431 0.62895417 0.7250667 0.75300000 0.02793333 0.97331253 0.04625295 FALSE TRUE
ENST00000521657 ENSG00000145675 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3R1 protein_coding protein_coding 3.940026 1.966327 6.970539 0.6504647 0.4431663 1.820517 0.1878795 0.0000000 0.2829157 0.0000000 0.1696873 4.872413 0.08636667 0.0000000 0.03880000 0.03880000 0.60787908 0.04625295 FALSE TRUE
ENST00000523807 ENSG00000145675 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3R1 protein_coding protein_coding 3.940026 1.966327 6.970539 0.6504647 0.4431663 1.820517 0.1168299 0.0000000 0.9346389 0.0000000 0.4886910 6.561691 0.01572917 0.0000000 0.12583333 0.12583333 0.50134097 0.04625295 FALSE FALSE
ENST00000523872 ENSG00000145675 HEK293_OSMI2_6hA HEK293_TMG_6hB PIK3R1 protein_coding protein_coding 3.940026 1.966327 6.970539 0.6504647 0.4431663 1.820517 0.3217132 0.6661113 0.0000000 0.3485308 0.0000000 -6.079189 0.18397500 0.2547333 0.00000000 -0.25473333 0.04625295 0.04625295 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145675 E001 1.1690154 0.046714418 0.38607259   5 68215756 68215775 20 + 0.316 0.200 -0.870
ENSG00000145675 E002 9.1499198 0.003384154 0.14118382 0.34926887 5 68215776 68215949 174 + 0.964 0.903 -0.227
ENSG00000145675 E003 0.3206185 0.026758628 0.62201884   5 68215950 68215953 4 + 0.132 0.000 -17.728
ENSG00000145675 E004 0.0000000       5 68217466 68217798 333 +      
ENSG00000145675 E005 17.3142250 0.002784662 0.02002613 0.09596885 5 68226290 68226436 147 + 1.222 1.123 -0.354
ENSG00000145675 E006 53.2631968 0.058058139 0.03519451 0.14209589 5 68226437 68227009 573 + 1.697 1.550 -0.499
ENSG00000145675 E007 0.0000000       5 68239898 68239937 40 +      
ENSG00000145675 E008 17.3710746 0.056845231 0.68110516 0.82336044 5 68273390 68273482 93 + 1.182 1.240 0.205
ENSG00000145675 E009 0.3206185 0.026758628 0.62201884   5 68273483 68273681 199 + 0.132 0.000 -17.728
ENSG00000145675 E010 19.7502028 0.013009933 0.67636131 0.82042905 5 68273939 68274013 75 + 1.231 1.318 0.303
ENSG00000145675 E011 25.7486863 0.014806848 0.60612746 0.77428039 5 68279602 68279733 132 + 1.336 1.426 0.312
ENSG00000145675 E012 0.0000000       5 68280240 68280263 24 +      
ENSG00000145675 E013 0.0000000       5 68280307 68280527 221 +      
ENSG00000145675 E014 26.6345466 0.018605213 0.33297685 0.57159423 5 68280528 68280729 202 + 1.360 1.409 0.172
ENSG00000145675 E015 19.0650281 0.032694762 0.32626242 0.56543385 5 68280927 68281006 80 + 1.234 1.242 0.030
ENSG00000145675 E016 0.0000000       5 68288368 68288694 327 +      
ENSG00000145675 E017 0.3040503 0.024441170 0.62613587   5 68288695 68288751 57 + 0.132 0.000 -17.727
ENSG00000145675 E018 0.1614157 0.035523839 1.00000000   5 68290637 68290671 35 + 0.071 0.000 -16.728
ENSG00000145675 E019 0.1614157 0.035523839 1.00000000   5 68290672 68290681 10 + 0.071 0.000 -16.728
ENSG00000145675 E020 0.3393995 0.029673633 0.62033096   5 68290682 68290799 118 + 0.133 0.000 -17.730
ENSG00000145675 E021 0.1779838 0.138404827 1.00000000   5 68290800 68290834 35 + 0.072 0.000 -16.735
ENSG00000145675 E022 1.2922489 0.139184209 0.90321918   5 68290835 68292258 1424 + 0.316 0.338 0.139
ENSG00000145675 E023 30.5062209 0.037295113 0.03747332 0.14823740 5 68292259 68292361 103 + 1.455 1.344 -0.384
ENSG00000145675 E024 0.0000000       5 68292486 68292523 38 +      
ENSG00000145675 E025 0.0000000       5 68292568 68292682 115 +      
ENSG00000145675 E026 0.0000000       5 68292683 68292729 47 +      
ENSG00000145675 E027 0.1426347 0.033234357 1.00000000   5 68292730 68293100 371 + 0.071 0.000 -16.726
ENSG00000145675 E028 28.6023639 0.092394048 0.20131020 0.43136666 5 68293101 68293199 99 + 1.424 1.331 -0.322
ENSG00000145675 E029 0.1426347 0.033234357 1.00000000   5 68293200 68293302 103 + 0.071 0.000 -16.726
ENSG00000145675 E030 36.1476113 0.068886430 0.08537989 0.25533079 5 68293303 68293483 181 + 1.526 1.424 -0.352
ENSG00000145675 E031 26.7986208 0.020741934 0.03938225 0.15317607 5 68293709 68293834 126 + 1.395 1.328 -0.233
ENSG00000145675 E032 34.3559750 0.022490144 0.13473555 0.33928729 5 68294536 68294678 143 + 1.484 1.484 -0.003
ENSG00000145675 E033 43.5689540 0.046899374 0.19740569 0.42639498 5 68295148 68295324 177 + 1.584 1.581 -0.009
ENSG00000145675 E034 28.5025295 0.015059207 0.33094055 0.56983667 5 68295420 68295488 69 + 1.392 1.443 0.178
ENSG00000145675 E035 0.7013366 0.183099636 0.90298514   5 68295489 68295743 255 + 0.187 0.202 0.137
ENSG00000145675 E036 36.5314608 0.009797240 0.56971400 0.75003916 5 68296171 68296341 171 + 1.483 1.582 0.341
ENSG00000145675 E037 321.6995549 1.015812022 0.30534083 0.54595117 5 68297412 68301821 4410 + 2.336 2.664 1.092