ENSG00000145604

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000274254 ENSG00000145604 HEK293_OSMI2_6hA HEK293_TMG_6hB SKP2 protein_coding protein_coding 41.79608 18.70373 55.50353 4.150006 1.991697 1.568742 11.188117 6.0335624 8.452886 0.9469713 0.4472361 0.4857506 0.3115042 0.3411000 0.1521667 -0.18893333 0.01209685 0.01209685 FALSE TRUE
ENST00000274255 ENSG00000145604 HEK293_OSMI2_6hA HEK293_TMG_6hB SKP2 protein_coding protein_coding 41.79608 18.70373 55.50353 4.150006 1.991697 1.568742 20.204030 9.0701308 30.860565 2.8481128 0.8725239 1.7654469 0.4553208 0.4578667 0.5571000 0.09923333 0.68544859 0.01209685 FALSE TRUE
ENST00000509692 ENSG00000145604 HEK293_OSMI2_6hA HEK293_TMG_6hB SKP2 protein_coding nonsense_mediated_decay 41.79608 18.70373 55.50353 4.150006 1.991697 1.568742 2.700281 0.5322253 5.401774 0.3246038 0.5279217 3.3191373 0.0550000 0.0228000 0.0969000 0.07410000 0.29026523 0.01209685 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145604 E001 0.4043710 0.0693580159 1.824675e-01   5 36151192 36151247 56 + 0.082 0.300 2.269
ENSG00000145604 E002 2.5787733 0.0085711391 7.903908e-01 8.907698e-01 5 36151437 36151988 552 + 0.542 0.479 -0.306
ENSG00000145604 E003 2.9841894 0.1120843369 8.813661e-01 9.420294e-01 5 36151989 36152066 78 + 0.570 0.596 0.114
ENSG00000145604 E004 2.5021552 0.1740433116 6.485887e-01 8.026093e-01 5 36152067 36152069 3 + 0.491 0.592 0.474
ENSG00000145604 E005 3.0962765 0.0753639394 6.682999e-01 8.151045e-01 5 36152070 36152079 10 + 0.569 0.648 0.348
ENSG00000145604 E006 3.4051285 0.1213530604 7.041181e-01 8.382083e-01 5 36152080 36152082 3 + 0.594 0.688 0.405
ENSG00000145604 E007 2.9182927 0.0869216434 5.920032e-01 7.650368e-01 5 36152083 36152083 1 + 0.543 0.647 0.462
ENSG00000145604 E008 3.7151482 0.0184072308 3.647995e-01 5.997371e-01 5 36152084 36152094 11 + 0.613 0.740 0.533
ENSG00000145604 E009 4.2820324 0.0084214035 1.740703e-01 3.959593e-01 5 36152095 36152102 8 + 0.635 0.814 0.736
ENSG00000145604 E010 4.7523000 0.0175428483 2.055717e-01 4.365597e-01 5 36152103 36152106 4 + 0.675 0.845 0.687
ENSG00000145604 E011 5.1577685 0.0130115108 7.923259e-02 2.432921e-01 5 36152107 36152108 2 + 0.675 0.905 0.914
ENSG00000145604 E012 4.8349372 0.0071585166 3.725534e-02 1.476225e-01 5 36152109 36152110 2 + 0.635 0.905 1.085
ENSG00000145604 E013 7.7755455 0.0049526420 4.993161e-01 7.003258e-01 5 36152111 36152116 6 + 0.894 0.956 0.233
ENSG00000145604 E014 28.3248710 0.0015593797 1.937460e-01 4.217857e-01 5 36152117 36152121 5 + 1.465 1.344 -0.418
ENSG00000145604 E015 46.9311303 0.0008388610 9.237726e-01 9.642698e-01 5 36152122 36152127 6 + 1.650 1.620 -0.103
ENSG00000145604 E016 94.0300334 0.0004369474 3.491764e-01 5.865359e-01 5 36152128 36152167 40 + 1.935 1.947 0.040
ENSG00000145604 E017 95.5552246 0.0004621431 6.729145e-01 8.181773e-01 5 36152168 36152176 9 + 1.948 1.939 -0.030
ENSG00000145604 E018 134.2877757 0.0003408970 9.677133e-02 2.760631e-01 5 36152177 36152224 48 + 2.082 2.111 0.100
ENSG00000145604 E019 146.2079040 0.0003303979 1.910264e-01 4.182171e-01 5 36152225 36152270 46 + 2.121 2.138 0.054
ENSG00000145604 E020 2.6014985 0.0083187274 7.961624e-01 8.940712e-01 5 36152271 36152770 500 + 0.542 0.479 -0.304
ENSG00000145604 E021 161.5435557 0.0020547911 8.140657e-01 9.046843e-01 5 36152771 36152807 37 + 2.175 2.155 -0.066
ENSG00000145604 E022 285.5487660 0.0002553928 4.002688e-01 6.284765e-01 5 36152808 36152930 123 + 2.419 2.412 -0.022
ENSG00000145604 E023 291.6513050 0.0023648684 5.453657e-01 7.329587e-01 5 36152931 36153042 112 + 2.430 2.422 -0.029
ENSG00000145604 E024 0.3150090 0.0373965253 4.822723e-01   5 36159773 36159874 102 + 0.082 0.177 1.283
ENSG00000145604 E025 1.1386556 0.0843141537 4.448015e-01   5 36163372 36163644 273 + 0.351 0.177 -1.305
ENSG00000145604 E026 254.9861660 0.0003336961 1.357375e-02 7.266373e-02 5 36163645 36163756 112 + 2.359 2.394 0.116
ENSG00000145604 E027 8.0746897 0.0039830071 5.151362e-02 1.833197e-01 5 36163757 36164534 778 + 0.987 0.701 -1.113
ENSG00000145604 E028 3.2014871 0.0262624063 1.677430e-01 3.876014e-01 5 36164535 36164627 93 + 0.673 0.399 -1.303
ENSG00000145604 E029 3.8239431 0.0622615424 1.114858e-01 3.014833e-01 5 36164628 36164695 68 + 0.741 0.398 -1.589
ENSG00000145604 E030 11.6779342 0.0026742152 2.815103e-01 5.218298e-01 5 36164696 36166518 1823 + 1.100 0.956 -0.527
ENSG00000145604 E031 178.2877850 0.0003231271 2.453080e-01 4.827111e-01 5 36166519 36166555 37 + 2.210 2.219 0.027
ENSG00000145604 E032 291.9490725 0.0004626221 8.963950e-01 9.500030e-01 5 36166556 36166662 107 + 2.436 2.406 -0.100
ENSG00000145604 E033 290.2349425 0.0027806539 2.672053e-01 5.068100e-01 5 36168313 36168447 135 + 2.420 2.429 0.032
ENSG00000145604 E034 270.5000163 0.0004982792 3.806565e-01 6.127465e-01 5 36170344 36170442 99 + 2.393 2.389 -0.015
ENSG00000145604 E035 0.3032425 0.0274424043 4.552166e-02   5 36170443 36170453 11 + 0.000 0.302 21.193
ENSG00000145604 E036 294.3070276 0.0002267887 5.306307e-01 7.224633e-01 5 36171603 36171733 131 + 2.431 2.420 -0.038
ENSG00000145604 E037 12.8004307 0.0411269023 3.631397e-03 2.710021e-02 5 36171734 36174778 3045 + 1.195 0.702 -1.862
ENSG00000145604 E038 1.4273215 0.0126090023 3.123883e-02 1.310373e-01 5 36174779 36174848 70 + 0.457 0.000 -20.949
ENSG00000145604 E039 0.9099381 0.0327316701 1.045589e-01   5 36174849 36174877 29 + 0.350 0.000 -20.379
ENSG00000145604 E040 207.2317224 0.0002798501 1.953799e-01 4.238198e-01 5 36176965 36177016 52 + 2.276 2.286 0.032
ENSG00000145604 E041 307.5291357 0.0002340948 1.018992e-01 2.852053e-01 5 36177185 36177292 108 + 2.446 2.457 0.036
ENSG00000145604 E042 45.8773290 0.0619710719 2.873651e-02 1.235782e-01 5 36177293 36178597 1305 + 1.707 1.364 -1.174
ENSG00000145604 E043 15.5802912 0.0087128935 3.422255e-01 5.799481e-01 5 36178598 36178810 213 + 1.208 1.082 -0.451
ENSG00000145604 E044 58.5940370 0.0668275847 2.451134e-01 4.824457e-01 5 36178811 36180169 1359 + 1.785 1.590 -0.661
ENSG00000145604 E045 85.4091062 0.0517617125 2.077914e-02 9.861875e-02 5 36180170 36181817 1648 + 1.970 1.650 -1.081
ENSG00000145604 E046 178.7404727 0.0022761443 2.495113e-02 1.120765e-01 5 36181818 36181876 59 + 2.245 2.138 -0.356
ENSG00000145604 E047 1355.7867226 0.0129919467 9.323638e-02 2.697514e-01 5 36181877 36183839 1963 + 3.116 3.035 -0.269
ENSG00000145604 E048 215.7841451 0.0002494849 1.430089e-11 1.198136e-09 5 36183840 36184319 480 + 2.244 2.393 0.494
ENSG00000145604 E049 0.9998973 0.0799810044 3.201861e-02   5 36191412 36191522 111 + 0.150 0.540 2.579
ENSG00000145604 E050 1.3750059 0.0128903167 2.320525e-03   5 36191523 36191702 180 + 0.150 0.654 3.084
ENSG00000145604 E051 3.6575717 0.1910318302 7.955526e-01 8.937697e-01 5 36192621 36192695 75 + 0.645 0.651 0.023
ENSG00000145604 E052 34.6884413 0.0012958270 3.836445e-01 6.152650e-01 5 36194993 36196849 1857 + 1.509 1.540 0.107