ENSG00000145349

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296402 ENSG00000145349 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMK2D protein_coding protein_coding 5.662171 2.221086 8.883334 0.6407081 0.7553618 1.994978 0.2430558 0.2303211 0.000000 0.2303211 0.0000000 -4.586891 0.10015417 0.09506667 0.0000000 -0.09506667 0.6809362682 0.0002188677 FALSE TRUE
ENST00000342666 ENSG00000145349 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMK2D protein_coding protein_coding 5.662171 2.221086 8.883334 0.6407081 0.7553618 1.994978 0.4674542 0.0000000 0.972214 0.0000000 0.2507233 6.617965 0.05210833 0.00000000 0.1063000 0.10630000 0.0002188677 0.0002188677 FALSE TRUE
ENST00000394524 ENSG00000145349 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMK2D protein_coding protein_coding 5.662171 2.221086 8.883334 0.6407081 0.7553618 1.994978 2.8688818 1.5892877 4.296273 0.5111287 0.3679174 1.429010 0.55222083 0.71646667 0.4865667 -0.22990000 0.2026491939 0.0002188677 FALSE TRUE
ENST00000513132 ENSG00000145349 HEK293_OSMI2_6hA HEK293_TMG_6hB CAMK2D protein_coding protein_coding 5.662171 2.221086 8.883334 0.6407081 0.7553618 1.994978 1.6025685 0.2248600 2.972709 0.1622996 0.4180191 3.666751 0.21039583 0.09976667 0.3351333 0.23536667 0.3722589905 0.0002188677 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145349 E001 0.0000000       4 113418054 113419361 1308 -      
ENSG00000145349 E002 0.0000000       4 113420331 113420483 153 -      
ENSG00000145349 E003 143.9532338 0.0072120927 3.924824e-09 2.014280e-07 4 113451032 113452960 1929 - 2.003 2.298 0.988
ENSG00000145349 E004 163.4151327 0.0059002635 1.277195e-01 3.282432e-01 4 113452961 113454104 1144 - 2.122 2.221 0.329
ENSG00000145349 E005 56.8448035 0.0008568803 8.244761e-01 9.105838e-01 4 113454105 113454515 411 - 1.693 1.708 0.053
ENSG00000145349 E006 3.1570616 0.1509467562 8.338068e-01 9.159211e-01 4 113455726 113455754 29 - 0.565 0.592 0.122
ENSG00000145349 E007 4.1405311 0.0102423881 2.504637e-01 4.885091e-01 4 113455755 113455821 67 - 0.697 0.519 -0.785
ENSG00000145349 E008 6.6711073 0.0049991634 3.141146e-01 5.543431e-01 4 113456609 113457182 574 - 0.865 0.748 -0.461
ENSG00000145349 E009 0.6953672 0.2972117818 3.860186e-01   4 113457183 113457187 5 - 0.241 0.000 -11.112
ENSG00000145349 E010 2.2713424 0.0991166266 8.513253e-01 9.257515e-01 4 113457188 113457290 103 - 0.452 0.515 0.314
ENSG00000145349 E011 5.3584953 0.0354793483 1.300348e-01 3.318987e-01 4 113457291 113457330 40 - 0.681 0.950 1.060
ENSG00000145349 E012 3.8037023 0.0749021779 9.559291e-02 2.740787e-01 4 113457331 113457334 4 - 0.526 0.886 1.507
ENSG00000145349 E013 52.4633982 0.0006917183 8.493266e-01 9.245512e-01 4 113457335 113457563 229 - 1.656 1.693 0.127
ENSG00000145349 E014 32.6321858 0.0013545115 2.466605e-01 4.843568e-01 4 113460147 113460241 95 - 1.476 1.420 -0.191
ENSG00000145349 E015 36.1894998 0.0039074075 7.606296e-03 4.751186e-02 4 113465529 113465604 76 - 1.544 1.369 -0.601
ENSG00000145349 E016 34.3341493 0.0098937990 7.526105e-02 2.353439e-01 4 113500463 113500508 46 - 1.514 1.388 -0.435
ENSG00000145349 E017 21.9202467 0.0181814905 9.191622e-02 2.672537e-01 4 113500509 113500511 3 - 1.335 1.168 -0.586
ENSG00000145349 E018 0.3228314 0.3786714871 1.000000e+00   4 113502936 113502977 42 - 0.134 0.000 -10.079
ENSG00000145349 E019 0.0000000       4 113504976 113505035 60 -      
ENSG00000145349 E020 0.1614157 0.0343547140 1.000000e+00   4 113508236 113508268 33 - 0.072 0.000 -9.086
ENSG00000145349 E021 29.0474344 0.0176634238 2.733509e-01 5.132156e-01 4 113509638 113509672 35 - 1.437 1.346 -0.316
ENSG00000145349 E022 17.4598895 0.0132463193 2.777545e-01 5.178489e-01 4 113509673 113509675 3 - 1.228 1.134 -0.336
ENSG00000145349 E023 27.5319708 0.0028147687 2.939861e-01 5.346193e-01 4 113513328 113513370 43 - 1.405 1.348 -0.198
ENSG00000145349 E024 34.1354298 0.0013159586 3.781018e-01 6.105971e-01 4 113513830 113513913 84 - 1.491 1.457 -0.120
ENSG00000145349 E025 41.3836332 0.0011997028 2.966256e-01 5.371434e-01 4 113515069 113515191 123 - 1.576 1.536 -0.136
ENSG00000145349 E026 29.8254175 0.0020944995 8.655142e-02 2.575039e-01 4 113517563 113517657 95 - 1.452 1.348 -0.360
ENSG00000145349 E027 25.6626231 0.0018498198 6.568725e-01 8.078858e-01 4 113531216 113531299 84 - 1.366 1.359 -0.025
ENSG00000145349 E028 28.4916740 0.0015621244 4.506784e-01 6.661522e-01 4 113537341 113537443 103 - 1.411 1.381 -0.105
ENSG00000145349 E029 0.7860845 0.0169512403 1.984066e-01   4 113547644 113547716 73 - 0.280 0.000 -11.391
ENSG00000145349 E030 27.2293884 0.0015982089 3.768748e-02 1.488073e-01 4 113548657 113548729 73 - 1.417 1.275 -0.493
ENSG00000145349 E031 35.6331705 0.0012666089 3.635634e-03 2.712316e-02 4 113552031 113552096 66 - 1.542 1.359 -0.628
ENSG00000145349 E032 33.4877860 0.0032636769 1.391139e-01 3.461856e-01 4 113609152 113609206 55 - 1.496 1.410 -0.295
ENSG00000145349 E033 28.4117585 0.0021509098 4.148576e-01 6.397083e-01 4 113661713 113661772 60 - 1.417 1.380 -0.127
ENSG00000145349 E034 1.1320506 0.0356323380 1.251565e-02   4 113754739 113755090 352 - 0.134 0.589 2.992
ENSG00000145349 E035 0.2852693 0.3270027078 1.000000e+00   4 113759115 113759319 205 - 0.132 0.000 -10.056
ENSG00000145349 E036 34.3125256 0.0021214789 1.801469e-01 4.041892e-01 4 113759320 113759414 95 - 1.499 1.430 -0.240
ENSG00000145349 E037 48.1080428 0.0009449558 8.168348e-01 9.063596e-01 4 113761004 113761927 924 - 1.620 1.634 0.047