ENSG00000145332

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273963 ENSG00000145332 HEK293_OSMI2_6hA HEK293_TMG_6hB KLHL8 protein_coding protein_coding 7.137211 1.771621 14.17177 0.4195113 0.6899812 2.992775 2.988554 1.2235733 5.14751293 0.3297503 1.34323962 2.063832 0.51167917 0.6760000 0.3556333 -0.32036667 9.428821e-02 2.833426e-10 FALSE TRUE
ENST00000425278 ENSG00000145332 HEK293_OSMI2_6hA HEK293_TMG_6hB KLHL8 protein_coding protein_coding 7.137211 1.771621 14.17177 0.4195113 0.6899812 2.992775 1.504611 0.4922376 2.92752068 0.1130106 0.20293813 2.548157 0.18837500 0.2808667 0.2088333 -0.07203333 6.715559e-01 2.833426e-10 FALSE TRUE
ENST00000498875 ENSG00000145332 HEK293_OSMI2_6hA HEK293_TMG_6hB KLHL8 protein_coding protein_coding 7.137211 1.771621 14.17177 0.4195113 0.6899812 2.992775 0.194046 0.0000000 0.04216291 0.0000000 0.04216291 2.383024 0.09481667 0.0000000 0.0028000 0.00280000 1.000000e+00 2.833426e-10 FALSE TRUE
ENST00000512111 ENSG00000145332 HEK293_OSMI2_6hA HEK293_TMG_6hB KLHL8 protein_coding protein_coding 7.137211 1.771621 14.17177 0.4195113 0.6899812 2.992775 2.286378 0.0000000 5.72971450 0.0000000 0.39742943 9.164835 0.18107500 0.0000000 0.4087333 0.40873333 2.833426e-10 2.833426e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145332 E001 2.795557 0.0257817945 0.481396694 0.688022679 4 87160103 87160248 146 - 0.421 0.657 1.115
ENSG00000145332 E002 55.627934 0.7809952931 0.157212440 0.372523258 4 87160249 87161042 794 - 1.461 1.989 1.789
ENSG00000145332 E003 192.638357 1.5183122846 0.341996503 0.579733605 4 87161043 87162443 1401 - 2.015 2.465 1.506
ENSG00000145332 E004 12.790430 0.4987372434 0.192308669 0.419828193 4 87162444 87162521 78 - 0.850 1.409 2.018
ENSG00000145332 E005 140.231652 1.4341741343 0.501508154 0.701894556 4 87162522 87163416 895 - 1.916 2.212 0.992
ENSG00000145332 E006 63.970093 0.8903795438 0.394254841 0.623775246 4 87163417 87163642 226 - 1.586 1.858 0.921
ENSG00000145332 E007 21.115198 0.4479316502 0.545038020 0.732695774 4 87163878 87163882 5 - 1.146 1.313 0.591
ENSG00000145332 E008 66.822866 0.0007783095 0.462864873 0.675056187 4 87163883 87164079 197 - 1.639 1.747 0.366
ENSG00000145332 E009 53.980686 0.0271449248 0.123381884 0.321120025 4 87170079 87170198 120 - 1.557 1.560 0.010
ENSG00000145332 E010 46.351650 0.0508670250 0.259034192 0.497908773 4 87170199 87170238 40 - 1.487 1.520 0.111
ENSG00000145332 E011 86.592244 0.0427309194 0.023009522 0.105984594 4 87170447 87170615 169 - 1.765 1.690 -0.255
ENSG00000145332 E012 86.302137 0.0386312499 0.013718632 0.073234606 4 87176757 87176868 112 - 1.766 1.666 -0.340
ENSG00000145332 E013 80.485274 0.0379864611 0.048919086 0.177050535 4 87178477 87178620 144 - 1.732 1.686 -0.153
ENSG00000145332 E014 68.680176 0.0366341583 0.043432231 0.163673702 4 87183203 87183389 187 - 1.664 1.619 -0.153
ENSG00000145332 E015 77.193491 0.0366877929 0.008614572 0.052117518 4 87185251 87185571 321 - 1.721 1.607 -0.389
ENSG00000145332 E016 68.358667 0.0387840600 0.000754692 0.007897225 4 87185572 87185799 228 - 1.678 1.452 -0.774
ENSG00000145332 E017 92.216894 0.0559783371 0.045043865 0.167722233 4 87195324 87195690 367 - 1.794 1.700 -0.317
ENSG00000145332 E018 1.473629 0.1753025633 0.722014353 0.849287970 4 87218094 87218187 94 - 0.289 0.276 -0.087
ENSG00000145332 E019 1.123868 0.2116010551 0.042286895   4 87219524 87220034 511 - 0.133 0.653 3.288
ENSG00000145332 E020 0.642642 0.0196991819 0.114471748   4 87220035 87220417 383 - 0.092 0.443 2.912
ENSG00000145332 E021 33.349776 0.0554358811 0.520126547 0.715046989 4 87220418 87221390 973 - 1.347 1.410 0.218
ENSG00000145332 E022 0.000000       4 87240258 87240314 57 -