ENSG00000145147

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000503823 ENSG00000145147 HEK293_OSMI2_6hA HEK293_TMG_6hB SLIT2 protein_coding protein_coding 37.63543 44.88184 39.11094 12.20159 1.104348 -0.1985124 2.267128 2.605975 6.121638 1.577030 0.3983381 1.2289241 0.06349167 0.07013333 0.15623333 0.086100000 7.715970e-01 2.404098e-12 FALSE TRUE
ENST00000503837 ENSG00000145147 HEK293_OSMI2_6hA HEK293_TMG_6hB SLIT2 protein_coding protein_coding 37.63543 44.88184 39.11094 12.20159 1.104348 -0.1985124 5.414447 8.211171 5.394899 4.107944 0.7705186 -0.6050763 0.13572500 0.14386667 0.13740000 -0.006466667 9.582183e-01 2.404098e-12 FALSE TRUE
ENST00000504154 ENSG00000145147 HEK293_OSMI2_6hA HEK293_TMG_6hB SLIT2 protein_coding protein_coding 37.63543 44.88184 39.11094 12.20159 1.104348 -0.1985124 17.123726 23.210450 16.310151 6.147129 0.9678968 -0.5087415 0.45987917 0.52990000 0.41833333 -0.111566667 5.516002e-01 2.404098e-12 FALSE TRUE
MSTRG.24678.11 ENSG00000145147 HEK293_OSMI2_6hA HEK293_TMG_6hB SLIT2 protein_coding   37.63543 44.88184 39.11094 12.20159 1.104348 -0.1985124 1.348953 0.000000 2.812514 0.000000 0.8186287 8.1408370 0.03578333 0.00000000 0.07140000 0.071400000 2.404098e-12 2.404098e-12 FALSE TRUE
MSTRG.24678.3 ENSG00000145147 HEK293_OSMI2_6hA HEK293_TMG_6hB SLIT2 protein_coding   37.63543 44.88184 39.11094 12.20159 1.104348 -0.1985124 4.019755 4.868323 4.251368 1.357351 0.0646879 -0.1950684 0.10479583 0.10966667 0.10886667 -0.000800000 1.000000e+00 2.404098e-12 FALSE TRUE
MSTRG.24678.8 ENSG00000145147 HEK293_OSMI2_6hA HEK293_TMG_6hB SLIT2 protein_coding   37.63543 44.88184 39.11094 12.20159 1.104348 -0.1985124 2.266769 2.235783 1.897340 1.211081 0.9506860 -0.2356566 0.06471250 0.06590000 0.04946667 -0.016433333 1.000000e+00 2.404098e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145147 E001 99.8432946 0.0234189970 4.103877e-02 0.1574064346 4 20251905 20252166 262 + 1.887 2.069 0.614
ENSG00000145147 E002 672.3482752 0.0129525515 4.009487e-01 0.6290562152 4 20252167 20253259 1093 + 2.796 2.842 0.155
ENSG00000145147 E003 311.0398107 0.0167792088 4.133377e-01 0.6386055245 4 20253260 20253563 304 + 2.462 2.508 0.153
ENSG00000145147 E004 110.5655698 0.0072677460 1.768539e-01 0.3995402924 4 20253564 20253589 26 + 2.082 2.011 -0.240
ENSG00000145147 E005 221.9989931 0.0068869992 7.365107e-01 0.8582752430 4 20253590 20253815 226 + 2.335 2.350 0.051
ENSG00000145147 E006 237.7877766 0.0059978204 9.120350e-01 0.9581679194 4 20253816 20253994 179 + 2.375 2.372 -0.012
ENSG00000145147 E007 3.9146015 0.0070821764 8.768232e-01 0.9396085940 4 20254920 20255075 156 + 0.676 0.713 0.152
ENSG00000145147 E008 241.9309614 0.0027984039 1.304544e-01 0.3325451250 4 20256672 20256743 72 + 2.406 2.363 -0.143
ENSG00000145147 E009 256.1952168 0.0013492837 8.649677e-03 0.0522596432 4 20257868 20257939 72 + 2.442 2.382 -0.201
ENSG00000145147 E010 228.4826413 0.0002262342 1.172636e-02 0.0653434056 4 20268810 20268881 72 + 2.382 2.339 -0.142
ENSG00000145147 E011 69.0045427 0.0018564083 3.089614e-01 0.5494603168 4 20281429 20281821 393 + 1.798 1.863 0.219
ENSG00000145147 E012 193.9386608 0.0010067046 2.467381e-02 0.1112072943 4 20467752 20467823 72 + 2.315 2.263 -0.175
ENSG00000145147 E013 225.7484310 0.0003614791 1.154236e-01 0.3081816296 4 20480716 20480787 72 + 2.363 2.342 -0.071
ENSG00000145147 E014 234.0507482 0.0003718709 3.997709e-01 0.6280613484 4 20486200 20486271 72 + 2.369 2.366 -0.008
ENSG00000145147 E015 350.4735713 0.0001900041 3.782124e-01 0.6106943408 4 20488819 20488982 164 + 2.543 2.545 0.006
ENSG00000145147 E016 0.2027342 0.0345267457 6.321830e-01   4 20489943 20489954 12 + 0.000 0.107 8.835
ENSG00000145147 E017 23.9643390 0.0161383438 8.774997e-01 0.9399705927 4 20490803 20490814 12 + 1.392 1.410 0.063
ENSG00000145147 E018 326.2697755 0.0002923247 1.289101e-03 0.0120804329 4 20491761 20491899 139 + 2.541 2.493 -0.162
ENSG00000145147 E019 228.7442677 0.0007700937 4.359407e-03 0.0311472697 4 20510495 20510566 72 + 2.393 2.333 -0.200
ENSG00000145147 E020 218.9517438 0.0012836155 5.213533e-01 0.7157980685 4 20511066 20511137 72 + 2.343 2.338 -0.015
ENSG00000145147 E021 201.2358296 0.0002850335 3.896383e-01 0.6201951778 4 20519382 20519453 72 + 2.305 2.300 -0.015
ENSG00000145147 E022 306.4678966 0.0001852365 2.127338e-01 0.4449429539 4 20523760 20523903 144 + 2.489 2.481 -0.026
ENSG00000145147 E023 294.1285069 0.0002956360 7.542259e-01 0.8692569839 4 20524014 20524177 164 + 2.451 2.475 0.081
ENSG00000145147 E024 79.6511707 0.0006735618 1.276919e-03 0.0119868092 4 20525149 20525172 24 + 1.806 1.959 0.515
ENSG00000145147 E025 324.1029095 0.0023484942 8.122118e-01 0.9035554129 4 20528949 20529099 151 + 2.495 2.513 0.060
ENSG00000145147 E026 273.2500044 0.0017313413 1.693338e-01 0.3896973637 4 20531984 20532058 75 + 2.447 2.421 -0.086
ENSG00000145147 E027 0.0000000       4 20533399 20533571 173 +      
ENSG00000145147 E028 321.1885388 0.0020161818 7.323933e-02 0.2313054429 4 20533572 20533715 144 + 2.522 2.488 -0.114
ENSG00000145147 E029 4.6948659 0.0752921938 1.693549e-01 0.3897068086 4 20535489 20535742 254 + 0.602 0.846 1.006
ENSG00000145147 E030 28.0931300 0.0014693818 2.803646e-04 0.0035333846 4 20535743 20536098 356 + 1.287 1.562 0.950
ENSG00000145147 E031 215.9004885 0.0003000116 7.959903e-05 0.0012361908 4 20539441 20539584 144 + 2.378 2.299 -0.265
ENSG00000145147 E032 253.9386046 0.0001947544 5.556698e-06 0.0001263767 4 20541453 20541619 167 + 2.450 2.366 -0.282
ENSG00000145147 E033 218.8353704 0.0018836980 1.884098e-02 0.0919064667 4 20542494 20542618 125 + 2.371 2.316 -0.183
ENSG00000145147 E034 88.2919080 0.0141401288 1.966013e-01 0.4252904491 4 20542619 20542626 8 + 1.988 1.916 -0.241
ENSG00000145147 E035 145.3235604 0.0093933856 3.511692e-01 0.5883178347 4 20546031 20546099 69 + 2.175 2.150 -0.084
ENSG00000145147 E036 181.4985136 0.0022441570 2.326955e-01 0.4682781367 4 20548488 20548559 72 + 2.269 2.245 -0.079
ENSG00000145147 E037 187.3935813 0.0011955925 5.544701e-01 0.7394517235 4 20549057 20549128 72 + 2.269 2.268 -0.002
ENSG00000145147 E038 190.4607195 0.0003395975 6.567509e-01 0.8078005177 4 20550827 20550898 72 + 2.273 2.279 0.021
ENSG00000145147 E039 0.8100271 0.0175331533 9.408989e-01   4 20552428 20552721 294 + 0.243 0.263 0.155
ENSG00000145147 E040 182.8843600 0.0002547642 2.202164e-01 0.4537894608 4 20553805 20553852 48 + 2.270 2.255 -0.049
ENSG00000145147 E041 237.1472751 0.0002042093 8.591554e-01 0.9298896779 4 20553853 20553968 116 + 2.365 2.380 0.048
ENSG00000145147 E042 0.0000000       4 20554308 20554340 33 +      
ENSG00000145147 E043 266.7479728 0.0002006628 2.140128e-01 0.4463639722 4 20567262 20567386 125 + 2.430 2.421 -0.030
ENSG00000145147 E044 247.4699010 0.0005185071 6.718231e-02 0.2187873034 4 20567518 20567615 98 + 2.408 2.383 -0.084
ENSG00000145147 E045 293.5314867 0.0003298414 2.960329e-01 0.5365392188 4 20568865 20569004 140 + 2.470 2.467 -0.012
ENSG00000145147 E046 3.2643112 0.0080532643 8.890726e-01 0.9462156194 4 20569005 20569264 260 + 0.602 0.637 0.155
ENSG00000145147 E047 0.3150090 0.0502179324 8.244730e-01   4 20573234 20573260 27 + 0.138 0.107 -0.427
ENSG00000145147 E048 233.2456702 0.0020274185 8.129257e-01 0.9039764475 4 20589644 20589737 94 + 2.362 2.374 0.039
ENSG00000145147 E049 292.5858640 0.0023053300 2.148989e-01 0.4474318266 4 20595697 20595834 138 + 2.475 2.457 -0.058
ENSG00000145147 E050 389.0943276 0.0025393571 4.950332e-01 0.6974746874 4 20596415 20596655 241 + 2.586 2.587 0.004
ENSG00000145147 E051 253.4383766 0.0003523719 8.456005e-01 0.9224710315 4 20598265 20598352 88 + 2.394 2.409 0.050
ENSG00000145147 E052 185.4047334 0.0003364869 5.824317e-01 0.7586567907 4 20598353 20598395 43 + 2.246 2.281 0.114
ENSG00000145147 E053 303.9911244 0.0028358915 4.863927e-01 0.6915246032 4 20610013 20610167 155 + 2.454 2.495 0.133
ENSG00000145147 E054 8.1890168 0.2343478126 5.834796e-01 0.7592792997 4 20614863 20616909 2047 + 0.872 1.010 0.520
ENSG00000145147 E055 173.2543958 0.0022588478 3.854793e-01 0.6168227074 4 20616910 20616947 38 + 2.207 2.255 0.159
ENSG00000145147 E056 405.1881411 0.0001686023 2.967573e-03 0.0232028442 4 20616948 20617198 251 + 2.562 2.636 0.247
ENSG00000145147 E057 391.2842165 0.0018290491 4.791267e-03 0.0334821526 4 20617439 20617650 212 + 2.531 2.629 0.329
ENSG00000145147 E058 1370.6367879 0.0046803273 2.239787e-03 0.0186591771 4 20618768 20620403 1636 + 3.054 3.181 0.422
ENSG00000145147 E059 110.0432904 0.0210943103 7.544381e-02 0.2357406007 4 20620404 20620561 158 + 1.919 2.111 0.642