ENSG00000145041

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335891 ENSG00000145041 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF1 protein_coding protein_coding 18.09041 13.74307 24.14113 2.935733 0.6002894 0.8123372 2.5176255 3.307085775 0.000000 0.832195964 0.0000000 -8.3737725 0.167195833 0.23513333 0.00000000 -0.23513333 3.603898e-31 3.603898e-31 FALSE TRUE
ENST00000423656 ENSG00000145041 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF1 protein_coding protein_coding 18.09041 13.74307 24.14113 2.935733 0.6002894 0.8123372 2.5057146 2.345546379 1.617504 0.151963847 0.8097386 -0.5334006 0.150645833 0.19840000 0.06550000 -0.13290000 6.759869e-01 3.603898e-31 FALSE TRUE
ENST00000684031 ENSG00000145041 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF1 protein_coding protein_coding 18.09041 13.74307 24.14113 2.935733 0.6002894 0.8123372 9.5314829 6.558751089 14.999890 2.169615088 1.9540243 1.1922224 0.503600000 0.44783333 0.61803333 0.17020000 5.264964e-01 3.603898e-31 FALSE TRUE
MSTRG.23016.10 ENSG00000145041 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF1 protein_coding   18.09041 13.74307 24.14113 2.935733 0.6002894 0.8123372 0.1904037 0.000000000 1.523229 0.000000000 1.5232293 7.2604297 0.008270833 0.00000000 0.06616667 0.06616667 9.576839e-01 3.603898e-31 FALSE TRUE
MSTRG.23016.16 ENSG00000145041 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF1 protein_coding   18.09041 13.74307 24.14113 2.935733 0.6002894 0.8123372 2.5193667 1.153409120 3.450512 0.271516628 1.4346800 1.5726268 0.127170833 0.08996667 0.14073333 0.05076667 9.287452e-01 3.603898e-31 FALSE TRUE
MSTRG.23016.7 ENSG00000145041 HEK293_OSMI2_6hA HEK293_TMG_6hB DCAF1 protein_coding   18.09041 13.74307 24.14113 2.935733 0.6002894 0.8123372 0.1461678 0.004196481 1.162841 0.002110713 1.1628414 6.3683307 0.006379167 0.00040000 0.05053333 0.05013333 9.558379e-01 3.603898e-31 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000145041 E001 5.8471234 0.3102612554 7.957642e-01 8.939181e-01 3 51389893 51390928 1036 - 0.900 0.667 -0.927
ENSG00000145041 E002 1.3439786 0.0137981987 8.862623e-01   3 51390929 51391081 153 - 0.363 0.342 -0.126
ENSG00000145041 E003 0.3559677 0.5141103262 4.868034e-01   3 51391082 51391219 138 - 0.187 0.000 -9.892
ENSG00000145041 E004 0.0000000       3 51391220 51391245 26 -      
ENSG00000145041 E005 0.0000000       3 51391246 51391271 26 -      
ENSG00000145041 E006 1.6184385 0.0147931022 4.627855e-05 7.786746e-04 3 51391272 51391563 292 - 0.000 0.698 14.222
ENSG00000145041 E007 5.3137670 0.0922040795 2.187110e-05 4.120954e-04 3 51391564 51395866 4303 - 0.309 1.099 3.482
ENSG00000145041 E008 83.6382244 0.8667495756 1.290822e-01 3.303377e-01 3 51395867 51397124 1258 - 1.618 2.161 1.831
ENSG00000145041 E009 18.1593520 0.4189311390 8.823161e-02 2.604602e-01 3 51397125 51397841 717 - 1.046 1.482 1.535
ENSG00000145041 E010 194.1545750 0.0043394480 4.246250e-02 1.611493e-01 3 51397842 51398469 628 - 2.239 2.332 0.309
ENSG00000145041 E011 166.0069276 0.0092225504 2.531455e-01 4.913858e-01 3 51398470 51398666 197 - 2.176 2.260 0.283
ENSG00000145041 E012 131.7491637 0.0052832208 7.557531e-02 2.359884e-01 3 51398667 51398734 68 - 2.068 2.169 0.337
ENSG00000145041 E013 160.2971609 0.0002852033 1.363449e-06 3.720794e-05 3 51398735 51398827 93 - 2.132 2.278 0.487
ENSG00000145041 E014 330.9409688 0.0002349537 7.919791e-06 1.715295e-04 3 51403143 51403391 249 - 2.470 2.568 0.328
ENSG00000145041 E015 113.7867016 0.0030997390 6.363054e-01 7.945244e-01 3 51403392 51403395 4 - 2.043 2.071 0.092
ENSG00000145041 E016 213.5433971 0.0003884054 5.630085e-02 1.943250e-01 3 51412379 51412480 102 - 2.300 2.357 0.191
ENSG00000145041 E017 183.6380983 0.0003572132 6.178715e-02 2.068459e-01 3 51412993 51413066 74 - 2.233 2.292 0.199
ENSG00000145041 E018 192.5951692 0.0004252895 5.366251e-01 7.267827e-01 3 51413282 51413386 105 - 2.269 2.295 0.086
ENSG00000145041 E019 180.9564270 0.0002957290 1.794574e-01 4.032785e-01 3 51413950 51414043 94 - 2.233 2.278 0.150
ENSG00000145041 E020 252.0829989 0.0002325232 3.950806e-04 4.683684e-03 3 51414624 51414857 234 - 2.357 2.447 0.297
ENSG00000145041 E021 118.0580446 0.0004071781 5.906520e-04 6.495680e-03 3 51416787 51416871 85 - 2.012 2.134 0.411
ENSG00000145041 E022 112.9193807 0.0103222462 6.928389e-02 2.233490e-01 3 51418116 51418198 83 - 2.001 2.108 0.358
ENSG00000145041 E023 176.4418365 0.0045791686 2.828645e-01 5.233060e-01 3 51418678 51418876 199 - 2.218 2.269 0.172
ENSG00000145041 E024 512.1246558 0.0001648957 4.714426e-01 6.811726e-01 3 51419734 51420950 1217 - 2.701 2.698 -0.009
ENSG00000145041 E025 79.3010032 0.0005076974 5.544413e-01 7.394191e-01 3 51420951 51420997 47 - 1.901 1.885 -0.052
ENSG00000145041 E026 118.6942565 0.0003819481 6.962990e-01 8.331645e-01 3 51422307 51422431 125 - 2.061 2.083 0.073
ENSG00000145041 E027 77.7355546 0.0029585328 4.179678e-01 6.420964e-01 3 51427372 51427412 41 - 1.903 1.873 -0.101
ENSG00000145041 E028 129.7410889 0.0040234429 6.924753e-01 8.306603e-01 3 51427413 51427541 129 - 2.112 2.106 -0.020
ENSG00000145041 E029 152.8315172 0.0004037440 2.545722e-02 1.136225e-01 3 51429261 51429470 210 - 2.201 2.143 -0.195
ENSG00000145041 E030 131.8969638 0.0003676102 3.257559e-02 1.349026e-01 3 51430033 51430212 180 - 2.137 2.076 -0.203
ENSG00000145041 E031 79.0016771 0.0083740756 8.753406e-02 2.591579e-01 3 51433106 51433158 53 - 1.926 1.832 -0.317
ENSG00000145041 E032 99.3672896 0.0066602353 8.738176e-02 2.589598e-01 3 51433159 51433264 106 - 2.024 1.936 -0.295
ENSG00000145041 E033 102.2363716 0.0027357787 2.737894e-02 1.194281e-01 3 51440970 51441071 102 - 2.037 1.952 -0.285
ENSG00000145041 E034 259.6615046 0.0002620554 5.411640e-12 4.891011e-10 3 51441385 51441738 354 - 2.462 2.308 -0.515
ENSG00000145041 E035 158.6296551 0.0126167954 4.939728e-02 1.781438e-01 3 51441739 51441897 159 - 2.238 2.116 -0.410
ENSG00000145041 E036 135.7637671 0.0005239616 1.567549e-08 7.038759e-07 3 51443766 51443903 138 - 2.190 2.010 -0.604
ENSG00000145041 E037 115.1626009 0.0033047408 5.379575e-08 2.130880e-06 3 51463114 51463227 114 - 2.137 1.905 -0.780
ENSG00000145041 E038 47.8928173 0.0114213258 3.304953e-06 8.067822e-05 3 51466803 51466805 3 - 1.791 1.450 -1.160
ENSG00000145041 E039 80.3255660 0.0086876910 1.414497e-04 1.997623e-03 3 51466806 51466876 71 - 1.978 1.759 -0.736
ENSG00000145041 E040 73.3936049 0.0076844983 4.180366e-03 3.016582e-02 3 51470929 51471005 77 - 1.917 1.753 -0.553
ENSG00000145041 E041 83.7299678 0.0006212684 5.481719e-05 9.012702e-04 3 51483719 51483836 118 - 1.974 1.814 -0.537
ENSG00000145041 E042 1.2153233 0.0830095560 5.805786e-01   3 51483837 51483838 2 - 0.364 0.256 -0.708
ENSG00000145041 E043 27.2127622 0.0050192729 5.477586e-01 7.346898e-01 3 51492389 51492488 100 - 1.454 1.417 -0.130
ENSG00000145041 E044 7.6475558 0.0045396079 8.029248e-01 8.980039e-01 3 51492489 51492513 25 - 0.933 0.913 -0.077
ENSG00000145041 E045 22.7776096 0.0018100922 3.982172e-01 6.268278e-01 3 51496734 51496780 47 - 1.385 1.329 -0.192
ENSG00000145041 E046 47.2771351 0.0025873079 3.866070e-02 1.512726e-01 3 51499873 51500065 193 - 1.719 1.607 -0.381