ENSG00000144893

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000273432 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding protein_coding 1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.05689076 0.0000000 0.0000000 0.00000000 0.00000000 0.00000000 0.05200417 0.00000000 0.0000000 0.00000000   0.03277558 FALSE  
ENST00000469768 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding processed_transcript 1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.02352408 0.1508693 0.0000000 0.15086925 0.00000000 -4.00781670 0.01707083 0.10623333 0.0000000 -0.10623333 0.88671776 0.03277558    
ENST00000474524 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding protein_coding 1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.39195877 0.3774139 0.6648558 0.20949349 0.13211457 0.80070366 0.37512917 0.33960000 0.5727333 0.23313333 0.76914906 0.03277558 FALSE  
ENST00000491549 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding processed_transcript 1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.04518945 0.1471493 0.0000000 0.14714929 0.00000000 -3.97406380 0.03590833 0.13726667 0.0000000 -0.13726667 0.88744748 0.03277558    
ENST00000686666 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding protein_coding 1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.06074724 0.0000000 0.1204587 0.00000000 0.07632766 3.70552100 0.04342500 0.00000000 0.1013000 0.10130000 0.36743512 0.03277558 FALSE  
ENST00000687756 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding protein_coding 1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.35777694 0.3346616 0.3371243 0.22953802 0.05349903 0.01027156 0.33401667 0.24920000 0.2926333 0.04343333 0.89921736 0.03277558 FALSE  
MSTRG.23923.15 ENSG00000144893 HEK293_OSMI2_6hA HEK293_TMG_6hB MED12L protein_coding   1.154971 1.208973 1.160072 0.1071199 0.04237078 -0.05906892 0.10272282 0.1077812 0.0000000 0.01023939 0.00000000 -3.55803789 0.06047917 0.09123333 0.0000000 -0.09123333 0.03277558 0.03277558 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144893 E001 0.0000000       3 151085286 151085414 129 +      
ENSG00000144893 E002 0.0000000       3 151085664 151085696 33 +      
ENSG00000144893 E003 0.2027342 0.037487074 0.4254975074   3 151085697 151085720 24 + 0.000 0.133 9.202
ENSG00000144893 E004 1.9717702 0.411415226 0.5168621701 0.712952742 3 151085721 151085936 216 + 0.490 0.406 -0.433
ENSG00000144893 E005 0.0000000       3 151086394 151086603 210 +      
ENSG00000144893 E006 0.7254668 0.208805348 0.2914257129   3 151086604 151086677 74 + 0.112 0.321 1.890
ENSG00000144893 E007 1.1061849 0.448405345 0.4233928333   3 151086678 151086797 120 + 0.204 0.399 1.329
ENSG00000144893 E008 3.2747901 0.066805153 0.7606034126 0.872921589 3 151086798 151086888 91 + 0.626 0.592 -0.151
ENSG00000144893 E009 1.4478674 0.019917638 0.9099483247 0.957115681 3 151086889 151086893 5 + 0.391 0.385 -0.036
ENSG00000144893 E010 3.7580098 0.007141571 0.1960755420 0.424661550 3 151086894 151087025 132 + 0.754 0.585 -0.716
ENSG00000144893 E011 6.0795255 0.158691142 0.3367321293 0.575155749 3 151116338 151116442 105 + 0.899 0.765 -0.524
ENSG00000144893 E012 7.5473577 0.097948624 0.2800684801 0.520184939 3 151122783 151122974 192 + 0.986 0.837 -0.568
ENSG00000144893 E013 5.1482808 0.005551040 0.7121295202 0.843154138 3 151127825 151127984 160 + 0.754 0.826 0.284
ENSG00000144893 E014 8.4619359 0.004486382 0.7347513114 0.857136678 3 151156161 151156330 170 + 0.977 0.963 -0.051
ENSG00000144893 E015 7.5797531 0.004261164 0.2055206116 0.436500292 3 151158689 151158799 111 + 0.990 0.869 -0.456
ENSG00000144893 E016 8.0042765 0.003947667 0.1031513758 0.287460476 3 151159832 151160101 270 + 1.027 0.869 -0.594
ENSG00000144893 E017 6.4642706 0.004397998 0.0540215000 0.189121466 3 151163893 151164042 150 + 0.963 0.750 -0.826
ENSG00000144893 E018 7.8500297 0.004613181 0.9062174761 0.955190511 3 151165420 151165519 100 + 0.935 0.946 0.043
ENSG00000144893 E019 8.3758148 0.003832552 0.0661287960 0.216375756 3 151165846 151165982 137 + 0.854 1.080 0.846
ENSG00000144893 E020 8.0333806 0.003728623 0.9682597396 0.985979323 3 151185330 151185461 132 + 0.949 0.979 0.111
ENSG00000144893 E021 6.4239776 0.006982319 0.6034244823 0.772477769 3 151188354 151188480 127 + 0.888 0.848 -0.154
ENSG00000144893 E022 7.6493994 0.051828904 0.8709009662 0.936454964 3 151190717 151190915 199 + 0.938 0.940 0.006
ENSG00000144893 E023 3.2103323 0.183614324 0.8390260091 0.918844722 3 151190916 151190931 16 + 0.630 0.640 0.042
ENSG00000144893 E024 1.8188603 0.738619693 0.6120688838 0.778234796 3 151192550 151192654 105 + 0.408 0.486 0.405
ENSG00000144893 E025 6.8375193 0.092058211 0.8579835107 0.929296540 3 151193490 151193666 177 + 0.874 0.921 0.176
ENSG00000144893 E026 0.1723744 0.054399785 0.4254832135   3 151193667 151193745 79 + 0.000 0.132 11.846
ENSG00000144893 E027 0.0000000       3 151241796 151241868 73 +      
ENSG00000144893 E028 0.0000000       3 151316420 151316746 327 +      
ENSG00000144893 E029 0.2922838 0.025617818 0.9276345883   3 151336507 151337062 556 + 0.111 0.132 0.280
ENSG00000144893 E030 7.4838878 0.067260614 0.1430927197 0.352139351 3 151350059 151350206 148 + 1.017 0.816 -0.760
ENSG00000144893 E031 8.8166296 0.039962292 0.4026253969 0.630479477 3 151355121 151355239 119 + 1.029 0.930 -0.369
ENSG00000144893 E032 9.5316151 0.125033767 0.7522609557 0.868081200 3 151355896 151356039 144 + 1.033 0.991 -0.153
ENSG00000144893 E033 0.1779838 0.043834923 0.5609475144   3 151356040 151356559 520 + 0.112 0.000 -12.289
ENSG00000144893 E034 9.4438028 0.065394991 0.6069191546 0.774825454 3 151357213 151357376 164 + 1.050 0.979 -0.262
ENSG00000144893 E035 0.0000000       3 151357377 151358420 1044 +      
ENSG00000144893 E036 5.4350408 0.006016644 0.4433042437 0.660936953 3 151360474 151360605 132 + 0.853 0.776 -0.302
ENSG00000144893 E037 7.9099252 0.003543495 0.0730777546 0.230956719 3 151364979 151365206 228 + 1.027 0.848 -0.675
ENSG00000144893 E038 5.5834750 0.005249054 0.0307541570 0.129606750 3 151365850 151365991 142 + 0.920 0.659 -1.041
ENSG00000144893 E039 4.4402397 0.016338403 0.7898353460 0.890474726 3 151367646 151367766 121 + 0.707 0.775 0.277
ENSG00000144893 E040 6.1012525 0.008890458 0.7285300862 0.853348407 3 151368150 151368251 102 + 0.817 0.889 0.279
ENSG00000144893 E041 6.7814069 0.004632956 0.6171539013 0.781884508 3 151369436 151369549 114 + 0.904 0.869 -0.133
ENSG00000144893 E042 0.1308682 0.032649190 0.4283489749   3 151372169 151372189 21 + 0.000 0.132 11.901
ENSG00000144893 E043 9.0725463 0.003332889 0.0046954067 0.032977806 3 151372567 151372766 200 + 1.113 0.826 -1.074
ENSG00000144893 E044 10.9383144 0.011356854 0.1116022011 0.301704448 3 151376026 151376214 189 + 1.132 0.981 -0.550
ENSG00000144893 E045 7.2968099 0.065280050 0.6296695091 0.790277344 3 151376800 151376874 75 + 0.938 0.874 -0.244
ENSG00000144893 E046 10.9021498 0.016241806 0.3914739915 0.621599294 3 151376991 151377178 188 + 1.104 1.027 -0.281
ENSG00000144893 E047 7.5433518 0.005085069 0.8961779650 0.949885661 3 151378012 151378173 162 + 0.935 0.945 0.039
ENSG00000144893 E048 6.2491343 0.004578596 0.8198290198 0.907990554 3 151380113 151380224 112 + 0.871 0.869 -0.009
ENSG00000144893 E049 5.8356374 0.005597239 0.5659410441 0.747331389 3 151382656 151382745 90 + 0.854 0.802 -0.201
ENSG00000144893 E050 2.4858271 0.068993322 0.4032047070 0.630874224 3 151383779 151383782 4 + 0.593 0.447 -0.698
ENSG00000144893 E051 5.5994412 0.009038791 0.3977730636 0.626593785 3 151383783 151383888 106 + 0.754 0.889 0.529
ENSG00000144893 E052 5.9495621 0.005219825 0.8130320167 0.904053273 3 151384083 151384218 136 + 0.816 0.870 0.206
ENSG00000144893 E053 9.0542245 0.069175708 0.7921817342 0.891717066 3 151385030 151385191 162 + 0.984 1.052 0.252
ENSG00000144893 E054 12.0761981 0.307369970 0.4756576749 0.683970613 3 151387810 151388172 363 + 1.066 1.176 0.396
ENSG00000144893 E055 7.4362952 0.003918473 0.5647369008 0.746604829 3 151389979 151390135 157 + 0.888 0.979 0.343
ENSG00000144893 E056 3.4879533 0.008502419 0.5776715474 0.755578886 3 151394656 151394666 11 + 0.682 0.623 -0.252
ENSG00000144893 E057 9.0750105 0.003799017 0.8170983213 0.906468224 3 151394667 151394867 201 + 0.977 1.026 0.181
ENSG00000144893 E058 3.9528361 0.029311197 0.2858652708 0.526500422 3 151409243 151409332 90 + 0.593 0.779 0.782
ENSG00000144893 E059 8.8189015 0.003845537 0.5685228805 0.749156252 3 151411278 151411507 230 + 1.015 0.979 -0.133
ENSG00000144893 E060 4.6222869 0.036001729 0.9714406790 0.987590068 3 151413139 151413295 157 + 0.754 0.772 0.075
ENSG00000144893 E061 4.9992467 0.014644014 0.2545179022 0.493030765 3 151416312 151416422 111 + 0.706 0.887 0.716
ENSG00000144893 E062 4.0600014 0.059101122 0.1286652020 0.329729243 3 151430299 151430380 82 + 0.558 0.860 1.256
ENSG00000144893 E063 90.0521588 0.015400564 0.0009476569 0.009483959 3 151432752 151437072 4321 + 1.849 2.066 0.730