ENSG00000144504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000480230 ENSG00000144504 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKMY1 protein_coding retained_intron 5.936129 7.10714 4.264815 0.3049828 0.4166901 -0.7354357 1.3048505 1.9026453 0.5706914 0.08860985 0.20248567 -1.7197258 0.21682500 0.26890000 0.14406667 -0.12483333 5.543726e-01 1.764103e-05 FALSE TRUE
ENST00000489677 ENSG00000144504 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKMY1 protein_coding retained_intron 5.936129 7.10714 4.264815 0.3049828 0.4166901 -0.7354357 0.3667864 0.3074652 0.5486376 0.12575800 0.28235966 0.8153144 0.05710000 0.04500000 0.11706667 0.07206667 8.709033e-01 1.764103e-05   FALSE
MSTRG.20166.12 ENSG00000144504 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKMY1 protein_coding   5.936129 7.10714 4.264815 0.3049828 0.4166901 -0.7354357 0.2143104 0.7786401 0.0000000 0.16984627 0.00000000 -6.3012952 0.03411667 0.11203333 0.00000000 -0.11203333 1.764103e-05 1.764103e-05 TRUE TRUE
MSTRG.20166.17 ENSG00000144504 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKMY1 protein_coding   5.936129 7.10714 4.264815 0.3049828 0.4166901 -0.7354357 0.7478819 0.6501634 0.6384305 0.02308054 0.08999602 -0.0258712 0.13470833 0.09156667 0.14866667 0.05710000 3.615120e-01 1.764103e-05 TRUE TRUE
MSTRG.20166.19 ENSG00000144504 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKMY1 protein_coding   5.936129 7.10714 4.264815 0.3049828 0.4166901 -0.7354357 0.7091492 0.6751196 0.6235995 0.19131632 0.04725475 -0.1127846 0.11998750 0.09293333 0.15130000 0.05836667 6.652333e-01 1.764103e-05 FALSE TRUE
MSTRG.20166.22 ENSG00000144504 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKMY1 protein_coding   5.936129 7.10714 4.264815 0.3049828 0.4166901 -0.7354357 0.3831456 0.1966546 0.3728588 0.07394774 0.15361528 0.8895910 0.07042500 0.02696667 0.08236667 0.05540000 4.964152e-01 1.764103e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144504 E001 1.2550964 0.0133136157 0.2583515011   2 240479422 240479425 4 - 0.171 0.399 1.638
ENSG00000144504 E002 2.2374978 0.0094395677 0.4966828672 0.698679607 2 240479426 240479426 1 - 0.389 0.527 0.707
ENSG00000144504 E003 2.2374978 0.0094395677 0.4966828672 0.698679607 2 240479427 240479428 2 - 0.389 0.527 0.707
ENSG00000144504 E004 2.3683660 0.0089970271 0.4059577907 0.633014442 2 240479429 240479454 26 - 0.389 0.554 0.831
ENSG00000144504 E005 2.1656317 0.0102434397 0.5007337435 0.701282443 2 240479455 240479459 5 - 0.389 0.527 0.705
ENSG00000144504 E006 2.3615391 0.0557241285 0.7852787886 0.887696073 2 240479460 240479491 32 - 0.532 0.499 -0.157
ENSG00000144504 E007 3.2841307 0.0791350905 0.6845670635 0.825658774 2 240479492 240479493 2 - 0.531 0.631 0.451
ENSG00000144504 E008 3.4455463 0.0573798129 0.9230008986 0.963806957 2 240479494 240479494 1 - 0.589 0.630 0.180
ENSG00000144504 E009 12.6389295 0.0517759382 0.0060396214 0.039918527 2 240479495 240479596 102 - 0.726 1.196 1.769
ENSG00000144504 E010 14.9732905 0.1428618851 0.0788628217 0.242555845 2 240479597 240479655 59 - 0.886 1.249 1.321
ENSG00000144504 E011 14.4967417 0.0938681986 0.2079920914 0.439419292 2 240480754 240480936 183 - 1.002 1.214 0.762
ENSG00000144504 E012 19.8886443 0.1625626232 0.1764968714 0.399100266 2 240480937 240480992 56 - 1.092 1.349 0.911
ENSG00000144504 E013 20.2679868 0.1129034060 0.0678525110 0.220272920 2 240480993 240481097 105 - 1.039 1.370 1.172
ENSG00000144504 E014 7.3470057 0.0235425775 0.4634999194 0.675478521 2 240482183 240482261 79 - 0.799 0.922 0.475
ENSG00000144504 E015 2.3194854 0.0096219214 0.3976433258 0.626498149 2 240497105 240497309 205 - 0.591 0.467 -0.586
ENSG00000144504 E016 4.4429883 0.0371757328 0.4228465742 0.645741642 2 240497699 240497892 194 - 0.768 0.669 -0.407
ENSG00000144504 E017 25.0920690 0.0604330733 0.8907206003 0.947032991 2 240499958 240500123 166 - 1.386 1.378 -0.027
ENSG00000144504 E018 18.2401607 0.0019543027 0.4374981462 0.656869962 2 240500452 240500523 72 - 1.276 1.234 -0.148
ENSG00000144504 E019 14.8683470 0.0023620674 0.2004333751 0.430265150 2 240500524 240500543 20 - 1.230 1.136 -0.331
ENSG00000144504 E020 14.1488024 0.0024405026 0.0388592077 0.151775235 2 240500544 240500565 22 - 1.254 1.086 -0.598
ENSG00000144504 E021 12.7532793 0.0087850823 0.0129466207 0.070241652 2 240507560 240507691 132 - 1.242 1.013 -0.824
ENSG00000144504 E022 2.3491052 0.0107033978 0.1184909879 0.313371047 2 240507692 240507864 173 - 0.642 0.400 -1.166
ENSG00000144504 E023 2.5276887 0.0793632620 0.1397149252 0.347055667 2 240509348 240509455 108 - 0.293 0.618 1.712
ENSG00000144504 E024 3.6234281 0.1805966332 0.1756120752 0.397950880 2 240511861 240512001 141 - 0.795 0.555 -1.017
ENSG00000144504 E025 23.9925753 0.0017817389 0.0122524027 0.067445491 2 240512802 240512942 141 - 1.470 1.313 -0.545
ENSG00000144504 E026 0.4952057 0.2892079473 0.2577615308   2 240519755 240520109 355 - 0.295 0.085 -2.163
ENSG00000144504 E027 15.5645244 0.0024179250 0.0882671374 0.260529580 2 240520362 240520454 93 - 1.276 1.149 -0.450
ENSG00000144504 E028 11.8619030 0.0353582570 0.5184816772 0.714037562 2 240520455 240520533 79 - 1.119 1.069 -0.179
ENSG00000144504 E029 0.5953387 0.1330433438 0.2325970495   2 240521938 240521938 1 - 0.000 0.267 10.640
ENSG00000144504 E030 104.9416293 0.0202650691 0.2144202064 0.446844364 2 240521939 240523257 1319 - 1.907 2.018 0.374
ENSG00000144504 E031 45.0181186 0.0030415814 0.7933867564 0.892343394 2 240523258 240523822 565 - 1.599 1.637 0.131
ENSG00000144504 E032 16.8557740 0.0024016754 0.5890288610 0.763005793 2 240523823 240523884 62 - 1.163 1.234 0.254
ENSG00000144504 E033 34.7589405 0.0184598153 0.8180736554 0.906939385 2 240523885 240524009 125 - 1.518 1.524 0.019
ENSG00000144504 E034 66.4472334 0.0202211721 0.4490165853 0.665010359 2 240524010 240524303 294 - 1.823 1.785 -0.129
ENSG00000144504 E035 38.8264539 0.0010647642 0.1277333856 0.328249905 2 240524304 240524381 78 - 1.614 1.549 -0.222
ENSG00000144504 E036 42.1015562 0.0009328066 0.5836370187 0.759372548 2 240525685 240525803 119 - 1.604 1.597 -0.025
ENSG00000144504 E037 25.4955020 0.0124077101 0.2339531172 0.469694888 2 240525804 240525849 46 - 1.441 1.356 -0.295
ENSG00000144504 E038 6.5950737 0.0200612491 0.0002504647 0.003225011 2 240525850 240526228 379 - 0.294 0.955 3.052
ENSG00000144504 E039 2.7192015 0.0214636915 0.1207978363 0.317106458 2 240526229 240526236 8 - 0.294 0.605 1.644
ENSG00000144504 E040 7.2705677 0.3058285913 0.6079201578 0.775483450 2 240526237 240526445 209 - 0.737 0.937 0.779
ENSG00000144504 E041 17.0808433 0.0225911865 0.3269806182 0.566116278 2 240526446 240527881 1436 - 1.116 1.260 0.512
ENSG00000144504 E042 8.7669476 0.0573973327 0.1087742497 0.297026409 2 240529037 240529040 4 - 1.089 0.875 -0.795
ENSG00000144504 E043 29.1892521 0.0013972037 0.0002269344 0.002967482 2 240529041 240529509 469 - 1.583 1.365 -0.748
ENSG00000144504 E044 0.7088986 0.0216535790 0.8523527423   2 240532076 240532135 60 - 0.171 0.217 0.420
ENSG00000144504 E045 1.1433398 0.2401868335 0.1262351384   2 240552742 240552913 172 - 0.529 0.210 -1.940
ENSG00000144504 E046 25.9545682 0.0023889382 0.4266358985 0.648506805 2 240552914 240553033 120 - 1.425 1.391 -0.118
ENSG00000144504 E047 15.2387787 0.0066479957 0.5687058376 0.749333381 2 240553034 240553057 24 - 1.204 1.174 -0.108
ENSG00000144504 E048 5.1225798 0.0054527990 0.2885984251 0.529335930 2 240553058 240554865 1808 - 0.833 0.707 -0.505
ENSG00000144504 E049 23.7270853 0.0015902794 0.4597381571 0.672938163 2 240554866 240554978 113 - 1.384 1.352 -0.111
ENSG00000144504 E050 14.6205412 0.0032022556 0.1110251828 0.300656977 2 240554979 240555055 77 - 1.028 1.211 0.657
ENSG00000144504 E051 3.0824416 0.0732748928 0.8684476442 0.935084004 2 240555056 240555560 505 - 0.534 0.604 0.317
ENSG00000144504 E052 2.0117309 0.0106113204 0.7882757054 0.889516343 2 240557190 240557352 163 - 0.468 0.435 -0.166
ENSG00000144504 E053 0.9172423 0.0651568846 0.6445374462   2 240557353 240557406 54 - 0.295 0.218 -0.572
ENSG00000144504 E054 0.7491197 0.0172671820 0.6370536109   2 240557881 240558021 141 - 0.171 0.269 0.830
ENSG00000144504 E055 2.8505200 0.0472433916 0.4814702181 0.688074640 2 240558304 240558619 316 - 0.467 0.621 0.719
ENSG00000144504 E056 13.7205319 0.1177862481 0.0656953097 0.215486047 2 240560731 240560927 197 - 0.880 1.218 1.238
ENSG00000144504 E057 5.7371066 0.0051316987 0.0792651883 0.243329401 2 240560928 240561035 108 - 0.591 0.872 1.153
ENSG00000144504 E058 12.6167681 0.0127019314 0.4043939551 0.631834860 2 240561036 240564814 3779 - 1.027 1.142 0.417
ENSG00000144504 E059 2.4804556 0.4954027441 0.6987264479 0.834791876 2 240569036 240569209 174 - 0.481 0.523 0.207