ENSG00000144468

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341329 ENSG00000144468 HEK293_OSMI2_6hA HEK293_TMG_6hB RHBDD1 protein_coding protein_coding 8.209921 6.495226 11.4084 0.9707596 0.474651 0.8116895 2.5303973 2.5089326 2.6768159 0.1649383 0.42247378 0.09308496 0.35013750 0.3990000 0.23360000 -0.165400000 2.096766e-01 1.356467e-13 FALSE TRUE
ENST00000423616 ENSG00000144468 HEK293_OSMI2_6hA HEK293_TMG_6hB RHBDD1 protein_coding protein_coding 8.209921 6.495226 11.4084 0.9707596 0.474651 0.8116895 1.1238107 0.0000000 3.4511028 0.0000000 0.40927958 8.43508797 0.09705833 0.0000000 0.30660000 0.306600000 1.356467e-13 1.356467e-13 FALSE FALSE
ENST00000437454 ENSG00000144468 HEK293_OSMI2_6hA HEK293_TMG_6hB RHBDD1 protein_coding protein_coding 8.209921 6.495226 11.4084 0.9707596 0.474651 0.8116895 0.2344164 0.0000000 0.8956092 0.0000000 0.45002216 6.50081667 0.02405000 0.0000000 0.07550000 0.075500000 3.486280e-01 1.356467e-13   FALSE
ENST00000450679 ENSG00000144468 HEK293_OSMI2_6hA HEK293_TMG_6hB RHBDD1 protein_coding processed_transcript 8.209921 6.495226 11.4084 0.9707596 0.474651 0.8116895 0.9633788 1.0304019 1.0840566 0.2365431 0.27975725 0.07254642 0.11410000 0.1571667 0.09336667 -0.063800000 5.038626e-01 1.356467e-13   FALSE
MSTRG.20027.12 ENSG00000144468 HEK293_OSMI2_6hA HEK293_TMG_6hB RHBDD1 protein_coding   8.209921 6.495226 11.4084 0.9707596 0.474651 0.8116895 0.4785301 0.7466972 0.3971566 0.2270164 0.19859038 -0.89413213 0.06419583 0.1088000 0.03586667 -0.072933333 5.841687e-01 1.356467e-13 FALSE TRUE
MSTRG.20027.14 ENSG00000144468 HEK293_OSMI2_6hA HEK293_TMG_6hB RHBDD1 protein_coding   8.209921 6.495226 11.4084 0.9707596 0.474651 0.8116895 1.2932070 0.9694361 1.6144758 0.1171827 0.03708608 0.72995092 0.16428750 0.1506667 0.14180000 -0.008866667 9.538223e-01 1.356467e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144468 E001 0.0000000       2 226835581 226835663 83 +      
ENSG00000144468 E002 0.0000000       2 226835936 226835971 36 +      
ENSG00000144468 E003 0.6182515 0.0438342734 3.068891e-01   2 226835972 226836033 62 + 0.120 0.297 1.625
ENSG00000144468 E004 0.9989696 0.0153787590 3.989913e-01   2 226836034 226836040 7 + 0.214 0.363 1.040
ENSG00000144468 E005 1.2912534 0.0129580391 4.649353e-01   2 226836041 226836043 3 + 0.291 0.421 0.776
ENSG00000144468 E006 1.2912534 0.0129580391 4.649353e-01   2 226836044 226836049 6 + 0.291 0.421 0.776
ENSG00000144468 E007 2.8441233 0.0084619926 7.712764e-01 8.794273e-01 2 226836050 226836053 4 + 0.550 0.596 0.211
ENSG00000144468 E008 2.9159894 0.0233105285 7.653450e-01 8.758595e-01 2 226836054 226836055 2 + 0.550 0.598 0.219
ENSG00000144468 E009 11.3366406 0.0030586316 2.346436e-01 4.704368e-01 2 226836056 226836081 26 + 1.148 1.033 -0.414
ENSG00000144468 E010 14.2712935 0.0022345412 4.057794e-01 6.328873e-01 2 226836082 226836087 6 + 1.220 1.148 -0.254
ENSG00000144468 E011 7.4589118 0.0037456709 2.752396e-03 2.188399e-02 2 226836088 226836199 112 + 0.711 1.071 1.382
ENSG00000144468 E012 18.7196353 0.0311253755 6.110618e-01 7.776530e-01 2 226837236 226837367 132 + 1.321 1.257 -0.227
ENSG00000144468 E013 9.0980484 0.0363046754 5.126399e-01 7.099424e-01 2 226837524 226837547 24 + 1.034 0.954 -0.298
ENSG00000144468 E014 7.9484813 0.0175863685 4.606077e-01 6.735989e-01 2 226837548 226837562 15 + 0.902 0.994 0.347
ENSG00000144468 E015 23.5404966 0.0018203460 7.719354e-01 8.797751e-01 2 226837563 226837770 208 + 1.373 1.396 0.080
ENSG00000144468 E016 10.6070193 0.0070094652 1.915631e-01 4.188510e-01 2 226837771 226837838 68 + 1.118 0.979 -0.506
ENSG00000144468 E017 6.0473617 0.0789071396 5.121209e-01 7.095466e-01 2 226838073 226838154 82 + 0.900 0.779 -0.470
ENSG00000144468 E018 19.5935368 0.0023564064 2.171467e-03 1.821422e-02 2 226839409 226839627 219 + 1.417 1.178 -0.839
ENSG00000144468 E019 26.0255723 0.0014784064 2.422007e-02 1.097569e-01 2 226864604 226864629 26 + 1.503 1.353 -0.518
ENSG00000144468 E020 70.2019173 0.0007767237 5.986988e-06 1.346181e-04 2 226864630 226864856 227 + 1.935 1.745 -0.638
ENSG00000144468 E021 87.8018436 0.0004758973 5.609041e-05 9.202437e-04 2 226864857 226865126 270 + 2.014 1.867 -0.493
ENSG00000144468 E022 59.8506962 0.0006932765 1.530186e-01 3.666413e-01 2 226867186 226867318 133 + 1.813 1.750 -0.211
ENSG00000144468 E023 0.0000000       2 226906712 226906746 35 +      
ENSG00000144468 E024 0.3206185 0.0274424043 2.087506e-01   2 226906747 226906792 46 + 0.214 0.000 -10.117
ENSG00000144468 E025 39.7623087 0.0010741402 6.453691e-01 8.004154e-01 2 226906793 226906850 58 + 1.624 1.601 -0.078
ENSG00000144468 E026 35.0831094 0.0012857449 8.110535e-01 9.029190e-01 2 226906851 226906881 31 + 1.568 1.556 -0.041
ENSG00000144468 E027 0.1779838 0.0340078659 5.015573e-01   2 226906882 226907021 140 + 0.120 0.000 -9.079
ENSG00000144468 E028 0.0000000       2 226908221 226908551 331 +      
ENSG00000144468 E029 40.8277787 0.0010925048 1.807850e-01 4.049879e-01 2 226908822 226908878 57 + 1.583 1.658 0.255
ENSG00000144468 E030 56.0451406 0.0011652942 6.709475e-02 2.186072e-01 2 226914208 226914351 144 + 1.707 1.796 0.300
ENSG00000144468 E031 0.5177432 0.0227200696 5.511356e-01   2 226914352 226914637 286 + 0.120 0.219 1.044
ENSG00000144468 E032 0.0000000       2 226935199 226935425 227 +      
ENSG00000144468 E033 0.4873834 0.3808741092 6.256968e-01   2 226988332 226988498 167 + 0.119 0.221 1.080
ENSG00000144468 E034 520.1726243 0.0003214710 2.921365e-08 1.232584e-06 2 226995431 226999215 3785 + 2.681 2.750 0.229