ENSG00000144395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000483877 ENSG00000144395 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC150 protein_coding processed_transcript 6.82278 6.095141 8.31151 1.231349 0.1940386 0.4468207 0.23409063 0.3152366 0.08791837 0.3152366 0.08791837 -1.7318384 0.03688750 0.07236667 0.0104000 -0.06196667 1.000000e+00 1.996562e-05   FALSE
MSTRG.19708.10 ENSG00000144395 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC150 protein_coding   6.82278 6.095141 8.31151 1.231349 0.1940386 0.4468207 0.08498388 0.3946126 0.00000000 0.3946126 0.00000000 -5.3384694 0.01686667 0.07233333 0.0000000 -0.07233333 8.549865e-01 1.996562e-05 FALSE TRUE
MSTRG.19708.13 ENSG00000144395 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC150 protein_coding   6.82278 6.095141 8.31151 1.231349 0.1940386 0.4468207 0.65861694 0.0000000 0.79526814 0.0000000 0.23104989 6.3313974 0.09485833 0.00000000 0.0971000 0.09710000 1.996562e-05 1.996562e-05 FALSE TRUE
MSTRG.19708.19 ENSG00000144395 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC150 protein_coding   6.82278 6.095141 8.31151 1.231349 0.1940386 0.4468207 2.01790513 2.3454171 2.09815385 0.5456633 0.34859949 -0.1600024 0.30313333 0.38166667 0.2546000 -0.12706667 4.291395e-01 1.996562e-05 TRUE TRUE
MSTRG.19708.4 ENSG00000144395 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC150 protein_coding   6.82278 6.095141 8.31151 1.231349 0.1940386 0.4468207 0.28011394 0.0000000 0.45650915 0.0000000 0.45650915 5.5438335 0.03151667 0.00000000 0.0534000 0.05340000 9.141073e-01 1.996562e-05 FALSE TRUE
MSTRG.19708.6 ENSG00000144395 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC150 protein_coding   6.82278 6.095141 8.31151 1.231349 0.1940386 0.4468207 0.75579490 0.4000725 1.39739411 0.2573939 0.31388478 1.7790754 0.09822083 0.06640000 0.1685667 0.10216667 5.370526e-01 1.996562e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144395 E001 0.1779838 0.0361965952 0.523445020   2 196639554 196639631 78 + 0.121 0.000 -11.373
ENSG00000144395 E002 1.5690781 0.0202686631 0.099607879 0.28104319 2 196639632 196639698 67 + 0.511 0.218 -1.782
ENSG00000144395 E003 1.5690781 0.0202686631 0.099607879 0.28104319 2 196639699 196639699 1 + 0.511 0.218 -1.782
ENSG00000144395 E004 1.5690781 0.0202686631 0.099607879 0.28104319 2 196639700 196639705 6 + 0.511 0.218 -1.782
ENSG00000144395 E005 1.7470620 0.0300716571 0.065447301 0.21490500 2 196639706 196639707 2 + 0.553 0.218 -1.976
ENSG00000144395 E006 2.1631994 0.0501896640 0.080178756 0.24517785 2 196639708 196639710 3 + 0.625 0.296 -1.715
ENSG00000144395 E007 1.9852156 0.0156044666 0.089513525 0.26291128 2 196639711 196639714 4 + 0.589 0.296 -1.559
ENSG00000144395 E008 1.9852156 0.0156044666 0.089513525 0.26291128 2 196639715 196639715 1 + 0.589 0.296 -1.559
ENSG00000144395 E009 2.2587184 0.0154042360 0.121537031 0.31827941 2 196639716 196639719 4 + 0.623 0.362 -1.297
ENSG00000144395 E010 6.1359767 0.0053153436 0.898645176 0.95117093 2 196639720 196639727 8 + 0.850 0.837 -0.050
ENSG00000144395 E011 17.0739684 0.0021635598 0.357033201 0.59329122 2 196639728 196639778 51 + 1.291 1.221 -0.246
ENSG00000144395 E012 16.1980557 0.0043908153 0.179586357 0.40341663 2 196646341 196646504 164 + 1.284 1.177 -0.378
ENSG00000144395 E013 24.1299326 0.0014402925 0.359237720 0.59524082 2 196656633 196656744 112 + 1.430 1.371 -0.204
ENSG00000144395 E014 28.5202230 0.0016955794 0.105992423 0.29234938 2 196656745 196656853 109 + 1.514 1.411 -0.355
ENSG00000144395 E015 2.2961630 0.0948262907 0.312285903 0.55260320 2 196656854 196656957 104 + 0.622 0.415 -0.991
ENSG00000144395 E016 39.3525584 0.0009046564 0.018632572 0.09117006 2 196656958 196657136 179 + 1.663 1.538 -0.426
ENSG00000144395 E017 0.4466850 0.0263586764 0.093282376   2 196657137 196657429 293 + 0.292 0.000 -12.954
ENSG00000144395 E018 26.6010293 0.0029260793 0.079314018 0.24344481 2 196658792 196658860 69 + 1.501 1.382 -0.411
ENSG00000144395 E019 0.8383617 0.0183124767 0.669474362   2 196665567 196665683 117 + 0.292 0.218 -0.554
ENSG00000144395 E020 3.4715685 0.0163748103 0.551409493 0.73729404 2 196666719 196666848 130 + 0.685 0.595 -0.386
ENSG00000144395 E021 1.6779563 0.0309252535 0.213941158 0.44628035 2 196666849 196667934 1086 + 0.511 0.297 -1.196
ENSG00000144395 E022 18.7113419 0.0018081645 0.375451020 0.60854453 2 196669833 196669876 44 + 1.325 1.262 -0.222
ENSG00000144395 E023 11.8687603 0.0502906685 0.744107806 0.86306565 2 196672345 196672437 93 + 1.123 1.093 -0.106
ENSG00000144395 E024 30.7421568 0.0014378922 0.109787062 0.29868743 2 196674241 196674348 108 + 1.543 1.448 -0.325
ENSG00000144395 E025 17.1747124 0.0170071578 0.588027806 0.76237726 2 196676143 196676168 26 + 1.276 1.234 -0.148
ENSG00000144395 E026 30.2905957 0.0057368244 0.547097554 0.73422544 2 196676169 196676267 99 + 1.509 1.478 -0.106
ENSG00000144395 E027 0.0000000       2 196676268 196676268 1 +      
ENSG00000144395 E028 38.2756196 0.0024467955 0.458260976 0.67189893 2 196676554 196676731 178 + 1.612 1.578 -0.117
ENSG00000144395 E029 15.4894120 0.0524398369 0.798077619 0.89521697 2 196677115 196677192 78 + 1.223 1.213 -0.035
ENSG00000144395 E030 13.6814527 0.0232210117 0.850758515 0.92546112 2 196677293 196677305 13 + 1.159 1.177 0.065
ENSG00000144395 E031 21.2061385 0.0043870777 0.957431449 0.98056811 2 196677306 196677361 56 + 1.350 1.352 0.005
ENSG00000144395 E032 0.1779838 0.0361965952 0.523445020   2 196695043 196695045 3 + 0.121 0.000 -11.374
ENSG00000144395 E033 6.5299365 0.0048476539 0.975486666 0.98955735 2 196695046 196695049 4 + 0.869 0.876 0.029
ENSG00000144395 E034 13.4407760 0.0244896210 0.742271363 0.86180675 2 196695050 196695159 110 + 1.142 1.175 0.119
ENSG00000144395 E035 28.4460102 0.0313765831 0.947625890 0.97612393 2 196701109 196701180 72 + 1.477 1.475 -0.005
ENSG00000144395 E036 31.8177308 0.0165094218 0.288172352 0.52891396 2 196712145 196712252 108 + 1.558 1.485 -0.250
ENSG00000144395 E037 1.3518711 0.0204114201 0.098244290   2 196712253 196712676 424 + 0.510 0.217 -1.783
ENSG00000144395 E038 0.0000000       2 196712677 196712739 63 +      
ENSG00000144395 E039 0.0000000       2 196713099 196713116 18 +      
ENSG00000144395 E040 0.0000000       2 196713117 196713145 29 +      
ENSG00000144395 E041 1.2650980 0.0216991713 0.162439530   2 196713146 196713683 538 + 0.465 0.218 -1.559
ENSG00000144395 E042 0.3751086 0.0249237643 0.193268159   2 196718305 196718502 198 + 0.000 0.218 12.395
ENSG00000144395 E043 30.4951553 0.0021754403 0.026405369 0.11649492 2 196718503 196718573 71 + 1.558 1.422 -0.468
ENSG00000144395 E044 33.7919107 0.0011742987 0.293224061 0.53392842 2 196718574 196718631 58 + 1.566 1.509 -0.195
ENSG00000144395 E045 0.0000000       2 196719279 196719290 12 +      
ENSG00000144395 E046 0.1723744 0.0326491905 0.468619161   2 196719291 196719496 206 + 0.000 0.123 11.392
ENSG00000144395 E047 42.5988050 0.0012640030 0.213460053 0.44578033 2 196719497 196719584 88 + 1.667 1.607 -0.205
ENSG00000144395 E048 38.0483307 0.0014462039 0.227404588 0.46226901 2 196719585 196719666 82 + 1.619 1.555 -0.221
ENSG00000144395 E049 1.8205909 0.0117607086 0.131565212 0.33429288 2 196719667 196719776 110 + 0.551 0.296 -1.388
ENSG00000144395 E050 2.4862502 0.0092172066 0.135992732 0.34132443 2 196720174 196720234 61 + 0.414 0.661 1.164
ENSG00000144395 E051 35.4294501 0.0013126515 0.951295346 0.97762682 2 196720575 196720668 94 + 1.562 1.562 0.000
ENSG00000144395 E052 48.5588555 0.0014393015 0.976909116 0.99023423 2 196721522 196721691 170 + 1.695 1.697 0.007
ENSG00000144395 E053 46.8656386 0.0008215247 0.634796226 0.79342107 2 196725973 196726099 127 + 1.687 1.668 -0.063
ENSG00000144395 E054 14.9431470 0.0380289783 0.061765345 0.20680145 2 196726100 196728011 1912 + 1.285 1.097 -0.667
ENSG00000144395 E055 47.5678872 0.0011372387 0.145962336 0.35632312 2 196729193 196729387 195 + 1.642 1.723 0.275
ENSG00000144395 E056 55.4490621 0.0091757328 0.009430306 0.05566309 2 196729388 196729792 405 + 1.646 1.831 0.625
ENSG00000144395 E057 39.2029864 0.0009283640 0.006030676 0.03987337 2 196729793 196729861 69 + 1.518 1.677 0.543
ENSG00000144395 E058 55.9682803 0.0041770157 0.006117014 0.04029674 2 196729957 196730118 162 + 1.678 1.829 0.509
ENSG00000144395 E059 29.3337007 0.0130499433 0.085651075 0.25576945 2 196730859 196730862 4 + 1.409 1.556 0.506
ENSG00000144395 E060 48.5710638 0.0145775957 0.044085541 0.16533570 2 196730863 196730945 83 + 1.616 1.771 0.526
ENSG00000144395 E061 39.2982117 0.0055044501 0.183043277 0.40786774 2 196732033 196732096 64 + 1.565 1.654 0.303
ENSG00000144395 E062 41.5070101 0.0013226347 0.101210803 0.28398054 2 196732097 196732152 56 + 1.584 1.680 0.326
ENSG00000144395 E063 1.0185584 0.0158279381 0.423876780   2 196732426 196732445 20 + 0.358 0.218 -0.971
ENSG00000144395 E064 65.8356355 0.0007273107 0.012335988 0.06777530 2 196732446 196732801 356 + 1.765 1.878 0.382
ENSG00000144395 E065 3.8507276 0.0302874901 0.500489350 0.70109049 2 196762298 196762483 186 + 0.623 0.721 0.411
ENSG00000144395 E066 1.4298942 0.1022893816 0.154658257 0.36892529 2 196763255 196763490 236 + 0.507 0.220 -1.751