ENSG00000144366

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359135 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding protein_coding 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.13976167 0.02065659 0.2209702 0.02065659 0.11328817 2.913438 0.05995833 0.04673333 0.02796667 -0.01876667 0.93565618 0.01372975 FALSE TRUE
ENST00000409830 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding protein_coding 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.95404171 0.04483817 1.9172605 0.04483817 0.38835561 5.135227 0.24541667 0.10140000 0.31430000 0.21290000 0.59760098 0.01372975 FALSE TRUE
ENST00000409843 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding protein_coding 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.09110481 0.07673532 0.1797427 0.03840453 0.12120300 1.129352 0.04701250 0.23876667 0.02796667 -0.21080000 0.23294955 0.01372975 FALSE TRUE
ENST00000409927 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding protein_coding 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.66057712 0.00000000 1.3273395 0.00000000 0.82652732 7.063222 0.11817083 0.00000000 0.16146667 0.16146667 0.25444181 0.01372975   FALSE
ENST00000410051 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding protein_coding 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.10347046 0.03670648 0.1217337 0.01845528 0.03788755 1.495930 0.04911667 0.10960000 0.01666667 -0.09293333 0.41840907 0.01372975 FALSE TRUE
ENST00000467422 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding processed_transcript 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.08735005 0.03501543 0.3716175 0.03501543 0.04218256 3.083636 0.02920417 0.12703333 0.05506667 -0.07196667 0.93349689 0.01372975   FALSE
ENST00000476422 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding retained_intron 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.79211385 0.00000000 1.9326723 0.00000000 0.65150847 7.601899 0.12265833 0.00000000 0.26053333 0.26053333 0.01372975 0.01372975 FALSE FALSE
ENST00000478306 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding processed_transcript 3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.02197807 0.06464383 0.0000000 0.06464383 0.00000000 -2.900023 0.04077917 0.14620000 0.00000000 -0.14620000 0.40693001 0.01372975 FALSE TRUE
MSTRG.19638.6 ENSG00000144366 HEK293_OSMI2_6hA HEK293_TMG_6hB GULP1 protein_coding   3.392375 0.3664438 6.993328 0.0486457 1.322022 4.217534 0.23187300 0.06670123 0.4587593 0.06670123 0.24661416 2.611526 0.11572500 0.17480000 0.06093333 -0.11386667 0.95810255 0.01372975 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144366 E001 0.1308682 0.032649190 0.0140115612   2 188291669 188291706 38 + 0.000 0.360 13.868
ENSG00000144366 E002 1.3558153 0.019130692 0.1183637567   2 188291707 188291873 167 + 0.194 0.554 2.202
ENSG00000144366 E003 2.9069904 0.122124276 0.4696413311 0.679786062 2 188291874 188291945 72 + 0.370 0.553 0.936
ENSG00000144366 E004 2.4611132 0.111664452 0.4110398928 0.636851578 2 188291946 188291962 17 + 0.356 0.000 -13.767
ENSG00000144366 E005 5.0434006 0.025218732 0.9889820392 0.996296055 2 188291963 188292013 51 + 0.523 0.556 0.153
ENSG00000144366 E006 5.2048163 0.009836141 0.9870480040 0.995349823 2 188292014 188292039 26 + 0.533 0.555 0.101
ENSG00000144366 E007 9.4632477 0.015321114 0.9058876277 0.955067158 2 188292040 188292166 127 + 0.735 0.791 0.224
ENSG00000144366 E008 0.9475002 0.016537103 1.0000000000   2 188292167 188292219 53 + 0.171 0.000 -12.565
ENSG00000144366 E009 0.0000000       2 188292772 188292831 60 +      
ENSG00000144366 E010 0.0000000       2 188292832 188292838 7 +      
ENSG00000144366 E011 1.9411206 0.010237231 0.2172630573 0.450168546 2 188292839 188293112 274 + 0.256 0.555 1.684
ENSG00000144366 E012 0.1614157 0.036363587 0.4083734829   2 188293113 188293180 68 + 0.034 0.000 -10.284
ENSG00000144366 E013 0.4279040 0.630772844 0.7554832892   2 188293818 188294199 382 + 0.090 0.000 -11.752
ENSG00000144366 E014 0.6246688 0.019621788 1.0000000000   2 188294200 188294393 194 + 0.121 0.000 -12.073
ENSG00000144366 E015 7.9487299 0.014009687 0.6802653928 0.822895901 2 188383763 188383791 29 + 0.678 0.790 0.454
ENSG00000144366 E016 14.4551442 0.002494155 0.6121473431 0.778282112 2 188383792 188383889 98 + 0.890 1.002 0.421
ENSG00000144366 E017 2.2579826 0.047387632 1.0000000000 1.000000000 2 188466475 188466568 94 + 0.312 0.360 0.294
ENSG00000144366 E018 19.5034675 0.017405836 0.2876658442 0.528389775 2 188477659 188477730 72 + 1.019 0.872 -0.552
ENSG00000144366 E019 16.7490954 0.020915522 0.2719723055 0.511841330 2 188483431 188483492 62 + 0.961 0.789 -0.658
ENSG00000144366 E020 0.3206185 0.027442404 1.0000000000   2 188491436 188491594 159 + 0.065 0.000 -11.198
ENSG00000144366 E021 0.0000000       2 188522738 188522755 18 +      
ENSG00000144366 E022 10.7792055 0.003944647 0.4895749099 0.693720026 2 188522756 188522767 12 + 0.794 0.688 -0.430
ENSG00000144366 E023 14.7803263 0.003224615 0.1718630183 0.393033736 2 188522768 188522827 60 + 0.916 0.688 -0.900
ENSG00000144366 E024 0.1614157 0.036363587 0.4083734829   2 188522828 188522922 95 + 0.034 0.000 -10.284
ENSG00000144366 E025 14.7371708 0.002186578 0.1689217109 0.389137312 2 188529097 188529171 75 + 0.916 0.688 -0.901
ENSG00000144366 E026 9.7759258 0.003936038 0.6126729634 0.778688046 2 188529172 188529195 24 + 0.759 0.688 -0.290
ENSG00000144366 E027 18.3963370 0.009412529 0.6089889089 0.776225587 2 188541181 188541318 138 + 0.993 0.942 -0.190
ENSG00000144366 E028 1.7465686 0.013186786 0.1822627942 0.406937931 2 188541319 188542122 804 + 0.237 0.555 1.837
ENSG00000144366 E029 22.5698323 0.009363769 0.4948721674 0.697341847 2 188569239 188569355 117 + 1.074 1.002 -0.263
ENSG00000144366 E030 0.0000000       2 188569592 188569643 52 +      
ENSG00000144366 E031 9.8941512 0.004894390 0.2792144057 0.519354372 2 188570028 188570037 10 + 0.760 0.555 -0.877
ENSG00000144366 E032 13.5183647 0.005401839 0.2516071256 0.489631555 2 188570038 188570082 45 + 0.880 0.689 -0.764
ENSG00000144366 E033 14.3739148 0.002932806 0.4330393104 0.653512063 2 188570083 188570120 38 + 0.899 0.791 -0.418
ENSG00000144366 E034 1.0159857 0.155931681 1.0000000000   2 188582341 188582565 225 + 0.173 0.000 -12.701
ENSG00000144366 E035 26.3944800 0.001469761 0.2168108115 0.449651051 2 188584265 188584403 139 + 1.140 1.002 -0.499
ENSG00000144366 E036 19.8907236 0.001853987 0.9850966127 0.994352469 2 188587855 188587949 95 + 1.018 1.055 0.137
ENSG00000144366 E037 1.3989868 0.012245435 0.5853429759 0.760521324 2 188587950 188588650 701 + 0.216 0.360 1.005
ENSG00000144366 E038 1.4709231 0.174269075 0.6261840657 0.788045909 2 188588651 188589590 940 + 0.233 0.358 0.852
ENSG00000144366 E039 0.2852693 0.332355806 0.6589079432   2 188589591 188589739 149 + 0.064 0.000 -11.291
ENSG00000144366 E040 0.1426347 0.034810485 0.4080540742   2 188589740 188589750 11 + 0.034 0.000 -10.281
ENSG00000144366 E041 7.7660779 0.029422686 0.1683237718 0.388327159 2 188589751 188593939 4189 + 0.687 0.360 -1.580
ENSG00000144366 E042 67.1228684 0.023662540 0.0006216951 0.006765227 2 188593940 188595931 1992 + 1.488 1.809 1.089