ENSG00000144357

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272793 ENSG00000144357 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR3 protein_coding protein_coding 7.521257 2.739309 14.89255 0.460313 0.4195526 2.438418 3.0052133 0.9136565 6.1744317 0.1815807 0.29160473 2.743213 0.32491250 0.33040000 0.4153333 0.08493333 5.683499e-01 3.047276e-27 FALSE TRUE
ENST00000392632 ENSG00000144357 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR3 protein_coding protein_coding 7.521257 2.739309 14.89255 0.460313 0.4195526 2.438418 0.3982615 1.0254343 0.0000000 0.1986704 0.00000000 -6.694092 0.15949167 0.37190000 0.0000000 -0.37190000 3.047276e-27 3.047276e-27 FALSE TRUE
ENST00000444475 ENSG00000144357 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR3 protein_coding nonsense_mediated_decay 7.521257 2.739309 14.89255 0.460313 0.4195526 2.438418 0.2265448 0.0000000 0.0984285 0.0000000 0.05879547 3.438672 0.07867917 0.00000000 0.0066000 0.00660000 7.323667e-01 3.047276e-27 FALSE TRUE
MSTRG.19461.5 ENSG00000144357 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR3 protein_coding   7.521257 2.739309 14.89255 0.460313 0.4195526 2.438418 1.1732069 0.1440318 3.0035327 0.1440318 0.32665425 4.290156 0.10602083 0.04396667 0.2007667 0.15680000 2.501357e-01 3.047276e-27 FALSE TRUE
MSTRG.19461.6 ENSG00000144357 HEK293_OSMI2_6hA HEK293_TMG_6hB UBR3 protein_coding   7.521257 2.739309 14.89255 0.460313 0.4195526 2.438418 2.0517409 0.3657183 4.5630423 0.2362524 0.25702015 3.605431 0.21472500 0.13923333 0.3078667 0.16863333 6.112409e-01 3.047276e-27 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144357 E001 0.6294705 0.0229224270 5.975684e-01   2 169827370 169827453 84 + 0.146 0.250 0.961
ENSG00000144357 E002 6.8204944 0.0197816165 8.928972e-02 2.624396e-01 2 169827454 169827759 306 + 0.711 0.982 1.052
ENSG00000144357 E003 3.0755227 0.0100248101 7.930594e-02 2.434337e-01 2 169827760 169827771 12 + 0.436 0.755 1.437
ENSG00000144357 E004 10.7936610 0.0055909403 8.211904e-01 9.087042e-01 2 169827772 169827848 77 + 0.934 0.982 0.179
ENSG00000144357 E005 33.6258217 0.0045279250 5.809756e-02 1.985051e-01 2 169827849 169828052 204 + 1.418 1.259 -0.555
ENSG00000144357 E006 48.9528639 0.0008466871 1.847227e-04 2.503005e-03 2 169872236 169872375 140 + 1.589 1.312 -0.957
ENSG00000144357 E007 24.5003347 0.0015623408 8.658577e-04 8.817087e-03 2 169875791 169875793 3 + 1.308 0.945 -1.309
ENSG00000144357 E008 65.4621428 0.0025766062 2.509250e-05 4.626298e-04 2 169875794 169875949 156 + 1.714 1.426 -0.983
ENSG00000144357 E009 52.0267362 0.0007141251 1.197203e-02 6.634015e-02 2 169877494 169877637 144 + 1.601 1.440 -0.553
ENSG00000144357 E010 48.0240942 0.0029160678 1.523471e-01 3.657505e-01 2 169878525 169878574 50 + 1.555 1.464 -0.311
ENSG00000144357 E011 47.2437765 0.0011984354 1.550627e-01 3.695449e-01 2 169891165 169891231 67 + 1.549 1.464 -0.292
ENSG00000144357 E012 42.8949446 0.0009625340 6.601221e-02 2.161557e-01 2 169895181 169895311 131 + 1.512 1.388 -0.426
ENSG00000144357 E013 68.4527721 0.0011624259 4.830206e-06 1.117243e-04 2 169896507 169896735 229 + 1.728 1.427 -1.026
ENSG00000144357 E014 74.0779570 0.0015200610 8.954704e-05 1.362403e-03 2 169905114 169905293 180 + 1.757 1.518 -0.810
ENSG00000144357 E015 73.1731108 0.0007866970 2.625207e-02 1.160780e-01 2 169906031 169906164 134 + 1.740 1.627 -0.383
ENSG00000144357 E016 50.1546448 0.0011440610 1.214638e-01 3.181907e-01 2 169914060 169914146 87 + 1.576 1.486 -0.308
ENSG00000144357 E017 42.2087188 0.0009330466 1.966280e-02 9.476929e-02 2 169923929 169923994 66 + 1.512 1.344 -0.579
ENSG00000144357 E018 51.5484385 0.0008170554 1.445974e-04 2.034654e-03 2 169924084 169924173 90 + 1.606 1.328 -0.955
ENSG00000144357 E019 70.2313117 0.0010730001 1.059125e-02 6.063576e-02 2 169925619 169925747 129 + 1.726 1.585 -0.480
ENSG00000144357 E020 51.0533896 0.0014924912 9.062340e-02 2.649289e-01 2 169926692 169926744 53 + 1.588 1.486 -0.347
ENSG00000144357 E021 76.7739098 0.0095551929 7.777104e-01 8.833141e-01 2 169926838 169926971 134 + 1.746 1.749 0.010
ENSG00000144357 E022 59.8762393 0.0013165862 8.441221e-01 9.216484e-01 2 169927320 169927405 86 + 1.639 1.650 0.037
ENSG00000144357 E023 69.3148653 0.0010772615 1.446292e-01 3.543544e-01 2 169928727 169928860 134 + 1.710 1.643 -0.230
ENSG00000144357 E024 34.2931954 0.0013711694 6.361247e-02 2.108616e-01 2 169928861 169928868 8 + 1.421 1.278 -0.498
ENSG00000144357 E025 59.1412275 0.0006792528 5.687220e-03 3.818077e-02 2 169932912 169933008 97 + 1.656 1.487 -0.578
ENSG00000144357 E026 65.9626324 0.0007908472 2.333263e-01 4.689529e-01 2 169942493 169942634 142 + 1.687 1.635 -0.176
ENSG00000144357 E027 28.6082542 0.0075896096 7.515008e-01 8.677054e-01 2 169946288 169946309 22 + 1.322 1.373 0.177
ENSG00000144357 E028 49.9050228 0.0011284830 9.630571e-01 9.834887e-01 2 169946310 169946392 83 + 1.560 1.585 0.084
ENSG00000144357 E029 1.2846868 0.0130097280 2.273727e-01   2 169947409 169947541 133 + 0.315 0.000 -12.059
ENSG00000144357 E030 80.6426485 0.0005544630 7.370719e-01 8.586346e-01 2 169947542 169947715 174 + 1.766 1.769 0.011
ENSG00000144357 E031 0.4812263 0.0215223848 4.357763e-02   2 169949482 169949604 123 + 0.054 0.408 3.547
ENSG00000144357 E032 141.0689068 0.0003248714 3.415289e-01 5.794228e-01 2 169949605 169950065 461 + 2.008 1.990 -0.059
ENSG00000144357 E033 57.2793930 0.0014788794 7.644229e-01 8.752703e-01 2 169958438 169958526 89 + 1.617 1.619 0.005
ENSG00000144357 E034 0.5117739 0.0236184320 4.028022e-01   2 169964393 169964538 146 + 0.103 0.251 1.549
ENSG00000144357 E035 53.7526262 0.0008386682 6.607627e-01 8.104231e-01 2 169986645 169986733 89 + 1.593 1.585 -0.026
ENSG00000144357 E036 55.3174514 0.0026711185 5.180209e-01 7.136454e-01 2 169986734 169986794 61 + 1.593 1.658 0.220
ENSG00000144357 E037 68.9133099 0.0054654191 4.134880e-01 6.386519e-01 2 169994323 169994456 134 + 1.688 1.763 0.252
ENSG00000144357 E038 59.3939780 0.0028118686 3.008097e-01 5.412688e-01 2 170001304 170001372 69 + 1.626 1.713 0.295
ENSG00000144357 E039 48.9524997 0.0030496277 6.863086e-01 8.266854e-01 2 170001373 170001414 42 + 1.552 1.601 0.170
ENSG00000144357 E040 84.7973399 0.0088017681 7.135856e-01 8.441120e-01 2 170006990 170007190 201 + 1.792 1.792 0.000
ENSG00000144357 E041 9.8849039 0.0151809989 3.220591e-01 5.614784e-01 2 170007191 170007202 12 + 0.885 1.044 0.592
ENSG00000144357 E042 33.6606957 0.0012254618 6.612430e-01 8.107135e-01 2 170008804 170008839 36 + 1.402 1.388 -0.052
ENSG00000144357 E043 45.9340747 0.0008469990 2.673468e-01 5.069693e-01 2 170008840 170008940 101 + 1.536 1.475 -0.206
ENSG00000144357 E044 1.1412444 0.0159906848 3.748781e-01   2 170013841 170013972 132 + 0.222 0.408 1.225
ENSG00000144357 E045 1.7517910 1.6600872279 4.559216e-01 6.702096e-01 2 170014040 170014439 400 + 0.237 0.707 2.496
ENSG00000144357 E046 0.6765862 0.1892153056 7.218811e-01   2 170014803 170014814 12 + 0.187 0.000 -11.164
ENSG00000144357 E047 1.4203566 0.0302317530 6.006076e-01 7.706144e-01 2 170014815 170014865 51 + 0.287 0.407 0.733
ENSG00000144357 E048 3.0786768 0.2137687586 7.566033e-01 8.705813e-01 2 170014866 170015280 415 + 0.503 0.416 -0.445
ENSG00000144357 E049 47.6820465 0.0009142740 4.144564e-01 6.394129e-01 2 170015281 170015366 86 + 1.546 1.508 -0.128
ENSG00000144357 E050 0.3032425 0.0274424043 1.024737e-02   2 170016833 170016919 87 + 0.000 0.408 14.010
ENSG00000144357 E051 32.6762352 0.0015271623 3.268548e-01 5.660099e-01 2 170029346 170029350 5 + 1.393 1.329 -0.224
ENSG00000144357 E052 61.4994410 0.0006758813 7.328178e-01 8.558629e-01 2 170029351 170029448 98 + 1.644 1.687 0.144
ENSG00000144357 E053 72.0109904 0.0075377252 2.000543e-01 4.297587e-01 2 170040882 170040985 104 + 1.701 1.809 0.366
ENSG00000144357 E054 82.6841192 0.0006389173 8.419615e-02 2.531773e-01 2 170055460 170055584 125 + 1.761 1.871 0.371
ENSG00000144357 E055 79.0936669 0.0110940275 2.240572e-01 4.582351e-01 2 170061079 170061186 108 + 1.742 1.861 0.401
ENSG00000144357 E056 79.7180885 0.0008858692 4.926256e-01 6.957392e-01 2 170061318 170061443 126 + 1.754 1.813 0.199
ENSG00000144357 E057 0.7765309 0.6880324400 6.513556e-01   2 170073404 170073427 24 + 0.187 0.243 0.482
ENSG00000144357 E058 98.8898198 0.0114072087 3.510245e-02 1.418534e-01 2 170073428 170073607 180 + 1.826 1.979 0.515
ENSG00000144357 E059 110.5761148 0.0017715738 1.111970e-04 1.633123e-03 2 170079814 170080023 210 + 1.866 2.061 0.653
ENSG00000144357 E060 0.9806365 0.0153787590 3.674328e-01   2 170080024 170080544 521 + 0.255 0.000 -11.670
ENSG00000144357 E061 73.1203587 0.0051547677 8.841336e-04 8.965559e-03 2 170080545 170080684 140 + 1.685 1.906 0.747
ENSG00000144357 E062 349.5859295 0.0029886224 4.577565e-12 4.202031e-10 2 170081726 170084131 2406 + 2.351 2.594 0.811