ENSG00000144320

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272748 ENSG00000144320 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPK protein_coding protein_coding 14.66618 3.116519 30.75068 0.470018 0.951865 3.298458 5.198679 1.7115403 10.248748 0.35851179 0.2495292 2.575083 0.45328333 0.54023333 0.3336667 -0.20656667 9.260043e-02 3.483321e-05 FALSE TRUE
ENST00000409660 ENSG00000144320 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPK protein_coding protein_coding 14.66618 3.116519 30.75068 0.470018 0.951865 3.298458 5.988876 1.2647092 13.226549 0.23783204 0.3116502 3.376287 0.36477500 0.41206667 0.4305000 0.01843333 9.773240e-01 3.483321e-05 FALSE TRUE
MSTRG.19546.5 ENSG00000144320 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPK protein_coding   14.66618 3.116519 30.75068 0.470018 0.951865 3.298458 1.453419 0.0000000 4.120305 0.00000000 1.1873061 8.690104 0.06005000 0.00000000 0.1319000 0.13190000 3.483321e-05 3.483321e-05 FALSE TRUE
MSTRG.19546.6 ENSG00000144320 HEK293_OSMI2_6hA HEK293_TMG_6hB LNPK protein_coding   14.66618 3.116519 30.75068 0.470018 0.951865 3.298458 0.996018 0.1402697 1.793821 0.01500705 0.8972344 3.585430 0.05795833 0.04766667 0.0601000 0.01243333 9.721531e-01 3.483321e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144320 E001 1.0961042 0.017234317 1.00000000   2 175923882 175923896 15 - 0.227 0.281 0.403
ENSG00000144320 E002 507.0402373 1.600590056 0.35865103 0.59469229 2 175923897 175929172 5276 - 2.443 2.836 1.308
ENSG00000144320 E003 172.8684829 1.441127395 0.49832764 0.69968631 2 175929173 175929859 687 - 2.010 2.255 0.821
ENSG00000144320 E004 68.6139893 0.867841260 0.45083809 0.66626645 2 175929860 175929938 79 - 1.619 1.839 0.746
ENSG00000144320 E005 42.9774354 0.764996729 0.55003498 0.73627539 2 175929939 175929945 7 - 1.431 1.599 0.577
ENSG00000144320 E006 50.0405160 0.799742770 0.47394244 0.68277073 2 175929946 175929968 23 - 1.485 1.712 0.776
ENSG00000144320 E007 133.2488607 1.376933505 0.58306513 0.75904055 2 175929969 175930199 231 - 1.908 2.095 0.626
ENSG00000144320 E008 0.6246688 0.019640531 0.66418791   2 175932088 175932162 75 - 0.164 0.000 -10.250
ENSG00000144320 E009 103.9664400 0.004450844 0.68403377 0.82529104 2 175937344 175937467 124 - 1.820 1.934 0.387
ENSG00000144320 E010 45.4375508 0.038258946 0.37212271 0.60567574 2 175937468 175937477 10 - 1.469 1.536 0.230
ENSG00000144320 E011 62.4517030 0.041169523 0.26364069 0.50292532 2 175937478 175937514 37 - 1.606 1.647 0.139
ENSG00000144320 E012 0.3040503 0.024441170 1.00000000   2 175937515 175937856 342 - 0.090 0.000 -9.249
ENSG00000144320 E013 97.1605699 0.046775087 0.08080209 0.24642279 2 175938313 175938383 71 - 1.802 1.777 -0.082
ENSG00000144320 E014 0.3393995 0.029955535 1.00000000   2 175938384 175938807 424 - 0.090 0.000 -9.252
ENSG00000144320 E015 110.0713054 0.046058032 0.05677310 0.19545844 2 175939552 175939657 106 - 1.858 1.808 -0.169
ENSG00000144320 E016 0.6190593 0.018955673 0.57562297   2 175939658 175939754 97 - 0.128 0.280 1.401
ENSG00000144320 E017 1.9390954 0.025492639 0.49321021 0.69611387 2 175940988 175941080 93 - 0.355 0.281 -0.476
ENSG00000144320 E018 155.3351145 0.053734405 0.39494902 0.62430936 2 175947480 175947692 213 - 1.991 2.059 0.228
ENSG00000144320 E019 69.8501878 0.081973939 0.68384002 0.82517454 2 175964372 175964423 52 - 1.644 1.749 0.357
ENSG00000144320 E020 82.6043111 0.047395823 0.19280006 0.42053875 2 175964506 175964589 84 - 1.728 1.735 0.024
ENSG00000144320 E021 64.3396621 0.078531178 0.19045047 0.41754286 2 175970764 175970804 41 - 1.626 1.591 -0.120
ENSG00000144320 E022 75.5049170 0.067377485 0.06375363 0.21114405 2 175979810 175979868 59 - 1.701 1.602 -0.337
ENSG00000144320 E023 50.6612093 0.080511158 0.07092472 0.22656075 2 175992231 175992238 8 - 1.534 1.419 -0.395
ENSG00000144320 E024 65.1816282 0.070360667 0.09330652 0.26989324 2 175992239 175992273 35 - 1.637 1.565 -0.246
ENSG00000144320 E025 105.6319838 0.065893690 0.02913608 0.12475671 2 175992274 175992418 145 - 1.848 1.721 -0.427
ENSG00000144320 E026 0.0000000       2 175993181 175993181 1 -      
ENSG00000144320 E027 60.0831607 0.068265398 0.01444494 0.07604808 2 175993182 175993223 42 - 1.613 1.427 -0.638
ENSG00000144320 E028 2.0166411 0.011072778 0.08295728 0.25065482 2 175994134 175994144 11 - 0.396 0.000 -11.949
ENSG00000144320 E029 6.8962746 0.052273385 0.13302372 0.33654457 2 175994145 175994280 136 - 0.748 0.571 -0.753
ENSG00000144320 E030 0.1614157 0.032476875 1.00000000   2 175995553 175995557 5 - 0.047 0.000 -8.251
ENSG00000144320 E031 66.2878449 0.047453432 0.02012859 0.09632154 2 175995558 175995646 89 - 1.648 1.520 -0.439
ENSG00000144320 E032 35.6473255 0.046202014 0.05399974 0.18907936 2 176002160 176002294 135 - 1.386 1.282 -0.363
ENSG00000144320 E033 0.8899192 1.765094357 1.00000000   2 176002512 176002839 328 - 0.211 0.000 -10.694