ENSG00000144278

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392825 ENSG00000144278 HEK293_OSMI2_6hA HEK293_TMG_6hB GALNT13 protein_coding protein_coding 10.29903 3.142326 17.60743 0.4583733 0.4010171 2.482515 3.5747298 1.2552817 4.529086 0.28855780 1.2918766 1.842943 0.38552083 0.4105 0.26050000 -0.15000000 6.867760e-01 1.205552e-10 FALSE TRUE
ENST00000487047 ENSG00000144278 HEK293_OSMI2_6hA HEK293_TMG_6hB GALNT13 protein_coding processed_transcript 10.29903 3.142326 17.60743 0.4583733 0.4010171 2.482515 1.7295756 0.0000000 3.801618 0.00000000 0.4629746 8.574260 0.10034167 0.0000 0.21500000 0.21500000 1.205552e-10 1.205552e-10 FALSE FALSE
MSTRG.19355.1 ENSG00000144278 HEK293_OSMI2_6hA HEK293_TMG_6hB GALNT13 protein_coding   10.29903 3.142326 17.60743 0.4583733 0.4010171 2.482515 0.8573431 0.2693305 1.202246 0.07546785 0.3502977 2.117637 0.07268333 0.0817 0.06866667 -0.01303333 9.100057e-01 1.205552e-10 FALSE TRUE
MSTRG.19355.3 ENSG00000144278 HEK293_OSMI2_6hA HEK293_TMG_6hB GALNT13 protein_coding   10.29903 3.142326 17.60743 0.4583733 0.4010171 2.482515 2.1271208 0.1795651 3.228006 0.13697964 0.4739725 4.094341 0.16235417 0.0756 0.18326667 0.10766667 4.730115e-01 1.205552e-10 FALSE TRUE
MSTRG.19355.6 ENSG00000144278 HEK293_OSMI2_6hA HEK293_TMG_6hB GALNT13 protein_coding   10.29903 3.142326 17.60743 0.4583733 0.4010171 2.482515 1.5414414 1.0771232 4.204664 0.30697622 1.0833581 1.954902 0.20823750 0.3270 0.23626667 -0.09073333 7.730647e-01 1.205552e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000144278 E001 0.9832093 0.0219205481 0.528990426   2 153871914 153871921 8 + 0.220 0.355 0.946
ENSG00000144278 E002 6.3675503 0.0395941595 0.743459924 0.86266181 2 153871922 153871951 30 + 0.799 0.778 -0.084
ENSG00000144278 E003 8.4437205 0.0439339210 0.800633490 0.89667213 2 153871952 153871952 1 + 0.884 0.958 0.280
ENSG00000144278 E004 11.6714966 0.0625844853 0.936106838 0.97027912 2 153871953 153871977 25 + 1.015 1.060 0.163
ENSG00000144278 E005 15.4468121 0.0154606896 0.732735622 0.85581993 2 153871978 153872027 50 + 1.117 1.189 0.257
ENSG00000144278 E006 19.6572002 0.0116142371 0.699645731 0.83538877 2 153872028 153872176 149 + 1.232 1.224 -0.027
ENSG00000144278 E007 18.3693020 0.0345931677 0.581646965 0.75817965 2 153872177 153872303 127 + 1.209 1.157 -0.183
ENSG00000144278 E008 26.1877238 0.0512881801 0.472094354 0.68161669 2 153900936 153901007 72 + 1.361 1.290 -0.246
ENSG00000144278 E009 0.0000000       2 153926288 153926339 52 +      
ENSG00000144278 E010 47.3583078 0.0215629133 0.069384488 0.22353275 2 153944394 153944497 104 + 1.624 1.479 -0.496
ENSG00000144278 E011 77.7554083 0.0073698476 0.003061699 0.02378205 2 153944498 153944639 142 + 1.839 1.678 -0.543
ENSG00000144278 E012 39.9481893 0.0012232807 0.018085830 0.08931870 2 154140337 154140340 4 + 1.551 1.420 -0.452
ENSG00000144278 E013 85.2394701 0.0006122521 0.006692604 0.04315726 2 154140341 154140505 165 + 1.869 1.776 -0.313
ENSG00000144278 E014 0.5117739 0.0218179172 0.636188037   2 154236046 154236180 135 + 0.124 0.213 0.940
ENSG00000144278 E015 75.0934509 0.0018067787 0.474760794 0.68339269 2 154242030 154242196 167 + 1.796 1.794 -0.005
ENSG00000144278 E016 88.8943028 0.0052161346 0.667324968 0.81452371 2 154242698 154242905 208 + 1.853 1.907 0.181
ENSG00000144278 E017 88.4332642 0.0004378919 0.766158701 0.87633017 2 154245812 154245982 171 + 1.853 1.903 0.167
ENSG00000144278 E018 0.0000000       2 154257567 154257725 159 +      
ENSG00000144278 E019 76.7025463 0.0004859658 0.182978501 0.40781518 2 154259021 154259138 118 + 1.809 1.781 -0.094
ENSG00000144278 E020 89.9067545 0.0005126642 0.316653499 0.55664293 2 154301409 154301578 170 + 1.872 1.864 -0.027
ENSG00000144278 E021 32.1460936 0.0010882067 0.811464408 0.90311438 2 154301579 154301589 11 + 1.432 1.450 0.063
ENSG00000144278 E022 1.1799741 0.0204124218 0.689737205   2 154364368 154364545 178 + 0.261 0.355 0.621
ENSG00000144278 E023 82.1378777 0.0005864590 0.888579180 0.94593472 2 154395991 154396130 140 + 1.826 1.856 0.101
ENSG00000144278 E024 47.4147635 0.0010364820 0.479102997 0.68650439 2 154408984 154409010 27 + 1.604 1.597 -0.024
ENSG00000144278 E025 67.2173679 0.0008265710 0.442211321 0.66022237 2 154409011 154409082 72 + 1.747 1.743 -0.012
ENSG00000144278 E026 0.7497398 0.0379542331 0.076768673   2 154409083 154409340 258 + 0.123 0.461 2.526
ENSG00000144278 E027 57.5562268 0.0042770866 0.671094469 0.81704273 2 154438592 154438653 62 + 1.678 1.686 0.025
ENSG00000144278 E028 62.0109955 0.0008574389 0.412452435 0.63794983 2 154438654 154438726 73 + 1.715 1.707 -0.027
ENSG00000144278 E029 0.3393995 0.0274424043 1.000000000   2 154441721 154441812 92 + 0.124 0.000 -13.314
ENSG00000144278 E030 0.1723744 0.0391061041 0.123729312   2 154446478 154446567 90 + 0.000 0.213 16.160
ENSG00000144278 E031 3.9815115 0.1682799284 0.969400948 0.98654401 2 154446568 154446597 30 + 0.626 0.615 -0.051
ENSG00000144278 E032 7.0516850 0.0277474421 0.846551991 0.92304304 2 154446598 154446765 168 + 0.822 0.825 0.011
ENSG00000144278 E033 521.1395282 0.0094971651 0.005107931 0.03518900 2 154450411 154453979 3569 + 2.597 2.735 0.459