ENSG00000143952

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272322 ENSG00000143952 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS54 protein_coding protein_coding 9.178196 4.398608 15.87508 0.8221882 0.4706493 1.849277 2.6359913 0.8590913 4.758926 0.3725728 0.4895360 2.45608488 0.26550833 0.19756667 0.29913333 0.10156667 7.081242e-01 2.45041e-06 FALSE TRUE
ENST00000409558 ENSG00000143952 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS54 protein_coding protein_coding 9.178196 4.398608 15.87508 0.8221882 0.4706493 1.849277 1.6180587 0.9344343 2.623779 0.4967998 0.7711274 1.47961205 0.21529167 0.18510000 0.16530000 -0.01980000 9.748098e-01 2.45041e-06 FALSE TRUE
ENST00000416400 ENSG00000143952 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS54 protein_coding nonsense_mediated_decay 9.178196 4.398608 15.87508 0.8221882 0.4706493 1.849277 1.2527012 1.3949441 1.321474 0.3491198 0.1387392 -0.07748829 0.22173333 0.31396667 0.08293333 -0.23103333 2.450410e-06 2.45041e-06 TRUE TRUE
MSTRG.18514.3 ENSG00000143952 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS54 protein_coding   9.178196 4.398608 15.87508 0.8221882 0.4706493 1.849277 0.8681136 0.5604182 1.593030 0.3848895 0.4925133 1.49070951 0.07428750 0.11420000 0.09870000 -0.01550000 9.380990e-01 2.45041e-06 FALSE TRUE
MSTRG.18514.5 ENSG00000143952 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS54 protein_coding   9.178196 4.398608 15.87508 0.8221882 0.4706493 1.849277 1.4311532 0.1723376 2.458635 0.1723376 1.3769714 3.75902971 0.10747500 0.06073333 0.15860000 0.09786667 7.427452e-01 2.45041e-06 FALSE TRUE
MSTRG.18514.7 ENSG00000143952 HEK293_OSMI2_6hA HEK293_TMG_6hB VPS54 protein_coding   9.178196 4.398608 15.87508 0.8221882 0.4706493 1.849277 1.0580896 0.1904309 2.398065 0.1904309 1.1991909 3.58669708 0.08230833 0.06710000 0.15050000 0.08340000 7.399513e-01 2.45041e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143952 E001 1.237861 0.0196457553 2.213146e-01   2 63892146 63892149 4 - 0.226 0.453 1.430
ENSG00000143952 E002 62.614313 0.0197735992 1.737048e-01 3.954723e-01 2 63892150 63892900 751 - 1.694 1.829 0.456
ENSG00000143952 E003 31.425179 0.0028131360 5.992019e-02 2.026341e-01 2 63892901 63893040 140 - 1.401 1.539 0.475
ENSG00000143952 E004 23.059750 0.0030599359 1.553502e-01 3.699626e-01 2 63893041 63893051 11 - 1.276 1.395 0.415
ENSG00000143952 E005 27.903226 0.0014797127 2.938756e-01 5.345233e-01 2 63893052 63893071 20 - 1.364 1.445 0.279
ENSG00000143952 E006 183.754170 0.0003906611 6.924544e-06 1.524432e-04 2 63893072 63893535 464 - 2.157 2.290 0.443
ENSG00000143952 E007 85.872277 0.0004728946 1.777907e-02 8.829382e-02 2 63897496 63897590 95 - 1.836 1.940 0.350
ENSG00000143952 E008 81.662417 0.0004681524 8.074083e-01 9.006188e-01 2 63899474 63899581 108 - 1.836 1.849 0.044
ENSG00000143952 E009 68.402002 0.0006272948 6.478649e-01 8.021140e-01 2 63912345 63912425 81 - 1.755 1.780 0.083
ENSG00000143952 E010 71.610978 0.0016792850 1.601967e-02 8.188429e-02 2 63912540 63912661 122 - 1.751 1.871 0.406
ENSG00000143952 E011 53.565560 0.0008131888 1.292309e-01 3.305426e-01 2 63913223 63913310 88 - 1.638 1.723 0.290
ENSG00000143952 E012 1.845341 0.0737560722 2.993890e-01 5.397992e-01 2 63913825 63913925 101 - 0.341 0.540 1.047
ENSG00000143952 E013 58.804370 0.0006620567 2.108114e-01 4.427582e-01 2 63914182 63914287 106 - 1.685 1.752 0.230
ENSG00000143952 E014 57.946283 0.0006546530 1.972982e-01 4.262441e-01 2 63916900 63916963 64 - 1.677 1.748 0.239
ENSG00000143952 E015 59.955530 0.0006785998 1.299423e-02 7.042343e-02 2 63919883 63919995 113 - 1.677 1.805 0.435
ENSG00000143952 E016 78.114635 0.0007030197 3.555738e-01 5.921917e-01 2 63920446 63920627 182 - 1.808 1.853 0.152
ENSG00000143952 E017 66.217029 0.0007540805 7.324593e-01 8.556594e-01 2 63921206 63921335 130 - 1.754 1.738 -0.053
ENSG00000143952 E018 119.238934 0.0009369667 2.479820e-01 4.858337e-01 2 63933673 63934013 341 - 2.012 1.966 -0.153
ENSG00000143952 E019 59.794757 0.0007206515 3.591687e-01 5.951872e-01 2 63942465 63942561 97 - 1.718 1.670 -0.164
ENSG00000143952 E020 44.921494 0.0008354731 4.363555e-02 1.642212e-01 2 63944600 63944655 56 - 1.612 1.481 -0.445
ENSG00000143952 E021 52.660782 0.0008641829 4.472431e-03 3.178314e-02 2 63947383 63947490 108 - 1.683 1.507 -0.600
ENSG00000143952 E022 63.194787 0.0051771034 1.440957e-01 3.535216e-01 2 63949037 63949163 127 - 1.747 1.653 -0.318
ENSG00000143952 E023 138.807572 0.0007334727 9.348660e-02 2.701741e-01 2 63962058 63962443 386 - 2.079 2.018 -0.205
ENSG00000143952 E024 43.398902 0.0010082913 9.447950e-01 9.747155e-01 2 63965835 63965875 41 - 1.570 1.575 0.020
ENSG00000143952 E025 56.001860 0.0044596743 6.641562e-01 8.124875e-01 2 63965876 63965966 91 - 1.685 1.658 -0.091
ENSG00000143952 E026 41.975974 0.0009264806 5.253901e-02 1.855704e-01 2 63968957 63968991 35 - 1.583 1.454 -0.442
ENSG00000143952 E027 50.469267 0.0008316956 3.674521e-03 2.734125e-02 2 63972166 63972244 79 - 1.666 1.482 -0.629
ENSG00000143952 E028 0.000000       2 63974986 63975602 617 -      
ENSG00000143952 E029 46.531281 0.0008327423 1.660772e-06 4.432936e-05 2 63981646 63981690 45 - 1.655 1.313 -1.176
ENSG00000143952 E030 65.952011 0.0006597285 5.563094e-06 1.264714e-04 2 63981691 63981845 155 - 1.794 1.531 -0.892
ENSG00000143952 E031 27.620183 0.0206985396 2.186149e-02 1.021062e-01 2 63981846 63981851 6 - 1.428 1.173 -0.892
ENSG00000143952 E032 17.068588 0.0024197331 1.845102e-01 4.098282e-01 2 63981852 63981887 36 - 1.213 1.078 -0.482
ENSG00000143952 E033 47.210690 0.0011000983 4.162233e-03 3.006307e-02 2 63983864 63984019 156 - 1.643 1.454 -0.645
ENSG00000143952 E034 24.996940 0.0016552577 1.585985e-01 3.746669e-01 2 64018938 64019428 491 - 1.314 1.426 0.389