ENSG00000143924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318522 ENSG00000143924 HEK293_OSMI2_6hA HEK293_TMG_6hB EML4 protein_coding protein_coding 17.6211 8.793188 27.36163 2.395096 0.9778937 1.636583 12.955541 7.049013 20.806658 1.9899044 0.72239325 1.5602001 0.70956667 0.7941333 0.76126667 -0.03286667 8.290396e-01 3.96321e-12 FALSE TRUE
ENST00000402711 ENSG00000143924 HEK293_OSMI2_6hA HEK293_TMG_6hB EML4 protein_coding protein_coding 17.6211 8.793188 27.36163 2.395096 0.9778937 1.636583 1.008992 0.000000 2.605466 0.0000000 0.13811625 8.0309242 0.03838333 0.0000000 0.09576667 0.09576667 3.963210e-12 3.96321e-12 FALSE TRUE
ENST00000406175 ENSG00000143924 HEK293_OSMI2_6hA HEK293_TMG_6hB EML4 protein_coding retained_intron 17.6211 8.793188 27.36163 2.395096 0.9778937 1.636583 2.091175 1.561470 2.070324 0.3650479 0.05802377 0.4046935 0.18296667 0.1844333 0.07600000 -0.10843333 5.596915e-04 3.96321e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143924 E001 4.0249796 0.2565633104 6.493033e-01 8.030165e-01 2 42169353 42169380 28 + 0.647 0.715 0.287
ENSG00000143924 E002 10.2403644 0.4221343374 4.093569e-01 6.355694e-01 2 42169381 42169390 10 + 0.958 1.115 0.577
ENSG00000143924 E003 26.6226710 0.7187838635 4.296884e-01 6.507949e-01 2 42169391 42169460 70 + 1.344 1.501 0.544
ENSG00000143924 E004 59.1888199 0.9643272833 4.455972e-01 6.625074e-01 2 42169461 42169636 176 + 1.672 1.853 0.610
ENSG00000143924 E005 1.3931897 0.0126181581 6.957596e-01 8.327705e-01 2 42207929 42208082 154 + 0.335 0.417 0.471
ENSG00000143924 E006 96.8758106 0.0125600949 7.076638e-01 8.403415e-01 2 42245505 42245687 183 + 1.943 1.930 -0.044
ENSG00000143924 E007 0.6434498 0.0194935208 2.515088e-01   2 42245688 42245688 1 + 0.249 0.000 -10.943
ENSG00000143924 E008 105.5135882 0.0004459051 1.194119e-04 1.731462e-03 2 42256501 42256630 130 + 2.008 1.866 -0.477
ENSG00000143924 E009 108.4877455 0.0003933135 9.093461e-03 5.423851e-02 2 42261121 42261294 174 + 2.012 1.925 -0.290
ENSG00000143924 E010 1.3260054 0.0136175256 3.245229e-01   2 42261295 42261513 219 + 0.372 0.187 -1.335
ENSG00000143924 E011 116.4918390 0.0004284673 2.023009e-03 1.721417e-02 2 42263178 42263306 129 + 2.046 1.944 -0.342
ENSG00000143924 E012 65.9212163 0.0104734506 1.455128e-02 7.644206e-02 2 42264706 42264731 26 + 1.813 1.639 -0.589
ENSG00000143924 E013 0.3206185 0.0274424043 6.828342e-01   2 42264919 42264951 33 + 0.142 0.000 -9.942
ENSG00000143924 E014 107.2560771 0.0054523782 1.190073e-02 6.602041e-02 2 42280850 42280973 124 + 2.014 1.891 -0.411
ENSG00000143924 E015 88.6965181 0.0004576678 3.438809e-03 2.598379e-02 2 42282823 42282908 86 + 1.931 1.819 -0.376
ENSG00000143924 E016 91.7365565 0.0027263173 4.228186e-03 3.042169e-02 2 42282909 42282972 64 + 1.948 1.825 -0.414
ENSG00000143924 E017 97.1710424 0.0007462187 1.456534e-03 1.331502e-02 2 42284634 42284703 70 + 1.971 1.850 -0.408
ENSG00000143924 E018 13.4726230 0.0561490909 4.048259e-01 6.321710e-01 2 42285923 42286268 346 + 1.144 1.004 -0.507
ENSG00000143924 E019 124.5259688 0.0005013701 5.906805e-02 2.006865e-01 2 42286269 42286379 111 + 2.062 2.008 -0.179
ENSG00000143924 E020 109.6585507 0.0005236822 4.289116e-01 6.502645e-01 2 42288227 42288322 96 + 1.998 1.983 -0.052
ENSG00000143924 E021 0.6600180 0.0193874923 2.509361e-01   2 42288323 42289913 1591 + 0.249 0.000 -10.944
ENSG00000143924 E022 140.3774733 0.0004862164 1.037853e-01 2.885251e-01 2 42295125 42295259 135 + 2.111 2.070 -0.138
ENSG00000143924 E023 166.2224514 0.0002573925 2.590501e-03 2.090210e-02 2 42295381 42295516 136 + 2.193 2.114 -0.264
ENSG00000143924 E024 182.4279268 0.0002980255 9.244831e-02 2.682909e-01 2 42301241 42301392 152 + 2.221 2.186 -0.115
ENSG00000143924 E025 153.0149130 0.0006965026 4.039917e-01 6.315085e-01 2 42303104 42303229 126 + 2.138 2.124 -0.046
ENSG00000143924 E026 136.1448762 0.0059004305 7.037165e-01 8.379475e-01 2 42303315 42303446 132 + 2.088 2.076 -0.040
ENSG00000143924 E027 94.5775650 0.0024999413 9.108570e-01 9.575732e-01 2 42304484 42304551 68 + 1.927 1.936 0.030
ENSG00000143924 E028 102.2865393 0.0033131799 6.047229e-01 7.733296e-01 2 42315962 42316050 89 + 1.954 1.992 0.130
ENSG00000143924 E029 87.0899548 0.0005471598 2.732542e-01 5.131067e-01 2 42317427 42317473 47 + 1.880 1.941 0.208
ENSG00000143924 E030 92.3822224 0.0005024158 3.327608e-01 5.714301e-01 2 42317474 42317524 51 + 1.929 1.905 -0.079
ENSG00000143924 E031 2.1832183 0.0369786562 6.690764e-01 8.155898e-01 2 42319535 42319998 464 + 0.494 0.417 -0.394
ENSG00000143924 E032 118.1286482 0.0005634287 1.384398e-01 3.451821e-01 2 42325467 42325554 88 + 2.039 2.001 -0.129
ENSG00000143924 E033 122.3957713 0.0004626927 2.890256e-01 5.295640e-01 2 42326154 42326252 99 + 2.051 2.028 -0.075
ENSG00000143924 E034 123.3957117 0.0046812592 7.569205e-01 8.708135e-01 2 42328886 42329016 131 + 2.039 2.073 0.114
ENSG00000143924 E035 340.6588266 0.0009682409 5.471627e-01 7.342443e-01 2 42329734 42330268 535 + 2.476 2.509 0.108
ENSG00000143924 E036 565.6960887 0.0021776087 6.864614e-06 1.513986e-04 2 42330269 42331591 1323 + 2.662 2.792 0.433
ENSG00000143924 E037 404.4713691 0.0006519186 2.577370e-15 4.094450e-13 2 42331592 42332589 998 + 2.500 2.682 0.608