ENSG00000143845

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367201 ENSG00000143845 HEK293_OSMI2_6hA HEK293_TMG_6hB ETNK2 protein_coding protein_coding 19.02708 28.74066 6.372698 6.123415 0.5836592 -2.171357 1.40676903 2.3015159 0.5495435 0.9877827 0.2482475 -2.046517 0.07767917 0.07176667 0.09056667 0.01880000 0.973168289 0.006662401 FALSE TRUE
ENST00000367202 ENSG00000143845 HEK293_OSMI2_6hA HEK293_TMG_6hB ETNK2 protein_coding protein_coding 19.02708 28.74066 6.372698 6.123415 0.5836592 -2.171357 15.78663239 24.6288233 4.5379571 5.0388607 0.2516604 -2.437643 0.82056250 0.86140000 0.71656667 -0.14483333 0.006662401 0.006662401 FALSE TRUE
ENST00000422072 ENSG00000143845 HEK293_OSMI2_6hA HEK293_TMG_6hB ETNK2 protein_coding protein_coding 19.02708 28.74066 6.372698 6.123415 0.5836592 -2.171357 0.08570598 0.0000000 0.6856479 0.0000000 0.6856479 6.120285 0.01139583 0.00000000 0.09116667 0.09116667 0.721451795 0.006662401 FALSE TRUE
ENST00000444817 ENSG00000143845 HEK293_OSMI2_6hA HEK293_TMG_6hB ETNK2 protein_coding protein_coding 19.02708 28.74066 6.372698 6.123415 0.5836592 -2.171357 1.30504871 0.8237218 0.3553617 0.8237218 0.1919303 -1.190241 0.06276667 0.02346667 0.06180000 0.03833333 0.631420363 0.006662401 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000143845 E001 446.0677578 0.8904746487 0.35432696 0.59114134 1 204131062 204131955 894 - 2.317 2.493 0.590
ENSG00000143845 E002 80.2736234 0.0005766775 0.13032206 0.33232752 1 204131956 204131961 6 - 1.622 1.754 0.447
ENSG00000143845 E003 230.0120085 0.4290731246 0.34679697 0.58437212 1 204131962 204132231 270 - 2.091 2.201 0.368
ENSG00000143845 E004 102.1364370 0.1854382795 0.47770123 0.68557224 1 204132232 204132256 25 - 1.803 1.844 0.140
ENSG00000143845 E005 96.9518907 0.0030683134 0.63005030 0.79042644 1 204134515 204134537 23 - 1.815 1.819 0.016
ENSG00000143845 E006 91.9534462 0.0171271359 0.94683757 0.97573786 1 204134538 204134547 10 - 1.785 1.797 0.040
ENSG00000143845 E007 108.2098301 0.0005167724 0.37571339 0.60877971 1 204134548 204134588 41 - 1.872 1.867 -0.019
ENSG00000143845 E008 12.6139207 0.0658284144 0.40575988 0.63287007 1 204134589 204134694 106 - 1.039 0.973 -0.243
ENSG00000143845 E009 77.5362580 0.0006511249 0.82735715 0.91226086 1 204137104 204137111 8 - 1.701 1.728 0.091
ENSG00000143845 E010 137.2938259 0.0003853074 0.20156452 0.43160121 1 204137112 204137212 101 - 1.983 1.968 -0.052
ENSG00000143845 E011 95.9132697 0.0007295497 0.16850574 0.38858830 1 204137213 204137249 37 - 1.842 1.810 -0.107
ENSG00000143845 E012 0.3447487 0.8879242150 1.00000000   1 204138619 204138919 301 - 0.000 0.099 8.953
ENSG00000143845 E013 126.6257454 0.0011752812 0.01872348 0.09146667 1 204140035 204140118 84 - 1.991 1.924 -0.222
ENSG00000143845 E014 0.0000000       1 204141025 204141215 191 -      
ENSG00000143845 E015 0.1723744 0.1342385637 0.75192538   1 204141216 204141314 99 - 0.000 0.051 7.905
ENSG00000143845 E016 151.5537916 0.0072348979 0.54092548 0.72969348 1 204141315 204141457 143 - 1.999 2.012 0.045
ENSG00000143845 E017 1.7688955 0.0117090076 0.56069379 0.74374850 1 204141458 204142026 569 - 0.427 0.326 -0.576
ENSG00000143845 E018 105.2962593 0.0126648579 0.90928760 0.95674662 1 204146642 204146764 123 - 1.822 1.858 0.124
ENSG00000143845 E019 0.3032425 0.0255000838 1.00000000   1 204146765 204146871 107 - 0.000 0.097 8.896
ENSG00000143845 E020 0.1308682 0.0317371245 0.75509745   1 204146872 204146990 119 - 0.000 0.051 7.894
ENSG00000143845 E021 0.4341107 0.0241790595 1.00000000   1 204147460 204147575 116 - 0.000 0.138 9.479
ENSG00000143845 E022 109.2680716 0.0563576798 0.21163119 0.44369629 1 204149703 204149872 170 - 1.921 1.859 -0.208
ENSG00000143845 E023 79.3778210 0.0344072735 0.32503295 0.56424311 1 204149873 204149962 90 - 1.756 1.727 -0.098
ENSG00000143845 E024 0.0000000       1 204150500 204150539 40 -      
ENSG00000143845 E025 0.0000000       1 204151012 204151594 583 -      
ENSG00000143845 E026 133.5785573 0.0861902865 0.65264981 0.80517642 1 204151595 204152044 450 - 1.936 1.957 0.071